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Formulas

Pyrimethamine 25 mg/Leucovorin 5 mg Capsules

Bayview Pharmacy's Pyrimethamine 25 mg/Leucovorin 5 mg Capsules are solid dosage forms composed of two shells that enclose the medication. These capsules are designed for easy swallowing and provide a precise dosage of the active ingredients. They are used to treat conditions such as toxoplasmosis, pneumocystis pneumonia, malaria, cryptosporidiosis, and isosporiasis.

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Pyrimethamine
Leucovorin Calcium
Capsules
6427079ea64324a0aa51916b
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Formula Information

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Bayview Pharmacy is pleased to present our compounded formulation of Pyrimethamine 25 mg/Leucovorin 5 mg Capsules. This unique combination of medications is specifically designed to treat a range of conditions including toxoplasmosis, malaria, and certain types of anemia. Pyrimethamine, an antiparasitic medication, works by inhibiting the growth of specific parasites. Leucovorin, a derivative of folic acid, is included to mitigate the potential toxic effects of pyrimethamine.

Our capsules are solid dosage forms composed of two gelatin or vegetarian shells that enclose the medication. This design allows for easy swallowing and ensures a precise dosage of the active ingredients. The encapsulation of the medication also aids in the preservation of the medication's potency and extends its shelf life.

Patients should be aware that this formulation may cause side effects such as nausea, vomiting, and diarrhea. It is crucial to adhere to your healthcare provider's instructions and take the medication as prescribed. Regular follow-ups with your healthcare provider are also recommended to monitor your progress and adjust the dosage if necessary.

If you have any questions or concerns about this formulation, please do not hesitate to contact us at Bayview Pharmacy. Our team is committed to providing you with the highest level of care and is ready to assist you with any inquiries you may have regarding this medication. Your health and well-being are our top priority.

Drug Interactions

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This compounded formulation of Pyrimethamine 25 mg/Leucovorin 5 mg Capsules is specifically designed for the treatment of toxoplasmosis, malaria, and other protozoal infections. The medication is enclosed within two gelatin or vegetarian shells, ensuring a precise dosage of the active ingredients and facilitating easy swallowing for the patient.

It is crucial to note that this formulation is contraindicated in patients with a known hypersensitivity to either pyrimethamine or leucovorin. It is also not recommended for use in patients with severe renal impairment or in pregnant women due to potential risks.

Patients using this formulation should be closely monitored for signs of bone marrow suppression, which may manifest as anemia, leukopenia, and thrombocytopenia. Additionally, signs of peripheral neuropathy, such as numbness, tingling, and pain in the extremities, should be watched for.

Interactions may occur between this formulation and other medications, including antacids, cholestyramine, and phenytoin. Therefore, it is essential for patients to inform their healthcare provider of all medications they are currently taking prior to starting this formulation.

If you have any questions or concerns regarding this formulation, please do not hesitate to reach out for further information.

How Does it Work

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Pyrimethamine 25 mg/Leucovorin 5 mg Capsules are a compounded formulation used in the treatment of various diseases such as toxoplasmosis, malaria, and AIDS-related infections. The medication is enclosed in two gelatin or vegetarian shells, allowing for easy swallowing and precise dosage.

Pyrimethamine is an antiparasitic medication that works by inhibiting the growth of certain parasites. On the other hand, Leucovorin is a form of folic acid that helps to reduce the toxic effects of pyrimethamine. The combination of these two active ingredients works synergistically to treat the underlying infection.

When taking Pyrimethamine 25 mg/Leucovorin 5 mg Capsules, it is crucial to adhere to the instructions provided by your healthcare provider. The dosage and frequency of administration are determined based on the severity of the infection and the patient's response to treatment. It is essential to take the medication exactly as prescribed, without skipping doses. To minimize the risk of side effects, it is recommended to take the medication with food.

Common side effects of Pyrimethamine 25 mg/Leucovorin 5 mg Capsules may include nausea, vomiting, diarrhea, and abdominal pain. If any of these side effects occur, it is important to contact your healthcare provider immediately. Other serious side effects may include rash, fever, chills, and difficulty breathing. Always report any unusual or severe side effects to your healthcare provider.

If you have any questions or concerns about Pyrimethamine 25 mg/Leucovorin 5 mg Capsules, do not hesitate to reach out to your healthcare provider or pharmacist. They can provide you with comprehensive information about how this medication works and how to use it safely and effectively.

Other Uses

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This compounded formulation of Pyrimethamine 25 mg/Leucovorin 5 mg capsules is a versatile medication that can be used to treat a variety of conditions. It is particularly effective in treating toxoplasmic encephalitis, congenital toxoplasmosis, and other protozoal infections. This formulation can also be used as a preventative measure against malaria in certain populations, such as those traveling to areas where the disease is endemic.

Leucovorin, a form of folic acid, makes this formulation useful in treating folate deficiency anemia. When treating toxoplasmosis, pyrimethamine and leucovorin are typically administered in conjunction with sulfadiazine. In cases of malaria, pyrimethamine is usually combined with other antimalarial medications. For treating folate deficiency anemia, leucovorin is often given alongside other medications.

However, it is crucial to note that this formulation should not be used by patients with a known hypersensitivity to either pyrimethamine or leucovorin. It is also not recommended for patients with renal or hepatic impairment. Regular monitoring for signs of bone marrow suppression is necessary, as this is a common side effect of pyrimethamine.

If you have any questions about the use of this formulation for other conditions, please do not hesitate to reach out for further information.

Frequently Asked Questions

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What is the Pyrimethamine 25 mg/Leucovorin 5 mg capsule?

This is a compounded formulation of two active ingredients, Pyrimethamine and Leucovorin, enclosed in a solid dosage form. It is designed for easy swallowing and provides a precise dosage of the active ingredients.

What are the active ingredients in this capsule?

The active ingredients in this capsule are Pyrimethamine (25 mg) and Leucovorin (5 mg).

What is the purpose of the gelatin or vegetarian shells?

The shells enclose the medication, making it easier to swallow. They also help to provide a precise dosage of the active ingredients.

How should I take this medication?

You should swallow the capsule whole with a glass of water. Do not chew or crush the capsule as this can affect the release of the medication.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at the same time.

What are the potential side effects of this medication?

Side effects can vary from person to person and may include nausea, vomiting, loss of appetite, and diarrhea. If you experience any severe or persistent side effects, you should contact your healthcare provider immediately.

Can I take this medication if I am pregnant or breastfeeding?

Before taking this medication, you should discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Can I take this medication with other medications?

Before starting this medication, you should inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, vitamins, and herbal supplements.

How should I store this medication?

This medication should be stored at room temperature, away from light and moisture. Keep out of reach of children and pets.

What should I do in case of an overdose?

If you suspect an overdose, seek immediate medical attention or call your local poison control center.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.