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Pyrimethamine

Pyrimethamine is a potent antiparasitic agent primarily used in the treatment and prevention of certain parasitic infections, such as toxoplasmosis and malaria. It works by inhibiting the enzyme dihydrofolate reductase, which is crucial for the synthesis of folic acid in parasites, thereby disrupting their growth and replication.

Due to its mechanism of action, pyrimethamine is often utilized in combination with other medications to enhance its efficacy and reduce the risk of resistance. Its use in compounded formulations allows for tailored dosing and delivery methods, catering to specific patient needs and improving therapeutic outcomes. Pyrimethamine's role in managing parasitic infections makes it an essential component in the arsenal of treatments available to healthcare providers.

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Active Ingredient Information

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Pyrimethamine is a potent antiparasitic agent primarily used in the treatment and prevention of certain parasitic infections, such as toxoplasmosis and malaria. As a folic acid antagonist, it works by inhibiting the enzyme dihydrofolate reductase, which is crucial for the synthesis of tetrahydrofolate, a form of folic acid necessary for the production of nucleic acids in parasites.

This mechanism effectively disrupts the replication and survival of the parasites, making pyrimethamine an essential component in combination therapies. In clinical settings, pyrimethamine is often used in conjunction with other agents to enhance its efficacy and reduce the risk of resistance development.

Its role in compounded formulations allows for tailored dosing and delivery methods, optimizing therapeutic outcomes for patients with specific needs. Prescribers should be aware of potential side effects, such as bone marrow suppression, and monitor patients accordingly, especially those with pre-existing conditions or those taking other medications that may interact with pyrimethamine.

Due to its critical function in managing parasitic infections, pyrimethamine remains a valuable tool in the arsenal of healthcare providers, offering targeted treatment options that can be customized through compounding to meet individual patient requirements.

Formulas using

Pyrimethamine

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.