The combination of Metronidazole 10 mg/g and Phenytoin 50 mg/g topical cream is a compounded medication designed for the treatment of various skin conditions, particularly those involving chronic wounds and ulcers. This semisolid preparation is dispensed in a pump mechanism, allowing for convenient and controlled application directly to the affected area, enhancing localized treatment and absorption of the active ingredients.

Metronidazole is an antibiotic and antiprotozoal agent known for its effectiveness against anaerobic bacteria and certain parasites. When applied topically, it helps to reduce bacterial load in infected wounds, decreasing inflammation and promoting healing by inhibiting the growth of susceptible bacteria.

Phenytoin, traditionally used as an anticonvulsant medication, has been found to enhance wound healing when applied topically. It promotes tissue regeneration, reduces inflammation, and accelerates the formation of granulation tissue, which is essential in the wound healing process.

The combination of Metronidazole and Phenytoin in a topical cream leverages the antimicrobial properties of Metronidazole with the wound-healing benefits of Phenytoin. This synergistic effect is particularly beneficial in the management of chronic wounds, such as diabetic ulcers, pressure sores, venous stasis ulcers, and other slow-healing skin lesions.

For patients, this formulation offers targeted therapy that can enhance healing times and reduce the risk of infection in chronic wounds. The pump mechanism ensures accurate dosing and minimizes contamination, making the application process straightforward and sanitary.

Prescribers may find this compounded preparation advantageous for patients who have not responded adequately to standard wound care treatments. This formulation can be a valuable addition to a comprehensive wound management plan, addressing both microbial load and promoting tissue repair.

Patients should apply the cream as directed by their healthcare provider, usually to clean, debrided skin to ensure maximum absorption and effectiveness. It's important to monitor the wound for signs of improvement or any adverse reactions.

Possible side effects may include local irritation, redness, or allergic reactions at the application site. Patients should inform their healthcare provider if they experience any unexpected symptoms.

If you have any questions or need further information about this formulation, please reach out to us.

Metronidazole 10 mg/g/Phenytoin 50 mg/g Topical Cream is a compounded formulation designed for localized treatment on the skin, utilizing a pump mechanism for convenient and controlled application. While this formulation is intended for topical use, it is important to consider potential drug interactions, especially for patients who may be using other medications concurrently. Both metronidazole and phenytoin have known interactions when administered systemically, and although the risk is reduced with topical application, it is still prudent to be aware of these interactions.

Metronidazole, an antibiotic and antiprotozoal agent, can interact with alcohol, leading to a disulfiram-like reaction characterized by flushing, nausea, vomiting, and tachycardia. Patients should be advised to avoid alcohol consumption during treatment with this topical formulation, even though systemic absorption is minimal. Additionally, metronidazole may potentiate the anticoagulant effect of warfarin and other coumarin anticoagulants, increasing the risk of bleeding. Patients on anticoagulant therapy should be monitored closely, and dose adjustments may be necessary.

Phenytoin, an anticonvulsant, is known to induce hepatic enzymes, which can lead to decreased plasma concentrations of drugs metabolized by the liver, such as oral contraceptives, corticosteroids, and other anticonvulsants. Although the topical application of phenytoin is less likely to cause systemic enzyme induction, patients should be monitored for any changes in the efficacy of their concurrent medications. Furthermore, phenytoin can interact with folic acid, potentially reducing its effectiveness, which is particularly important for patients who are pregnant or planning to become pregnant.

Patients and prescribers should also be aware of the potential for local skin reactions, such as irritation, redness, or allergic dermatitis, which may be exacerbated by concurrent use of other topical agents. It is advisable to avoid the simultaneous application of other topical medications on the same area unless specifically directed by a healthcare provider.

For patients with a history of hypersensitivity to metronidazole, phenytoin, or any component of the cream, alternative treatments should be considered. Additionally, patients with a history of blood dyscrasias or liver dysfunction should use this formulation with caution, as both metronidazole and phenytoin can affect these conditions when absorbed systemically.

As with any medication, it is essential for patients and healthcare providers to communicate openly about all medications being used, including over-the-counter drugs and supplements, to ensure safe and effective treatment. If you have any questions or concerns regarding the use of Metronidazole 10 mg/g/Phenytoin 50 mg/g Topical Cream, please reach out to us for further guidance and support.

The Metronidazole 10 mg/g/Phenytoin 50 mg/g Topical Cream is a compounded semisolid preparation specifically designed for targeted application on the skin. This formulation is dispensed in a pump mechanism, ensuring a convenient and controlled dosage with each use. The cream is intended for localized treatment, allowing the active ingredients to be absorbed directly at the site of application, which can enhance therapeutic outcomes while minimizing systemic exposure and potential side effects.

Metronidazole is an antibiotic and antiprotozoal agent that works by inhibiting nucleic acid synthesis in microorganisms, leading to their death. When applied topically, metronidazole is effective in reducing inflammation and bacterial load on the skin. It is commonly used to treat conditions such as rosacea, acne, and other inflammatory skin disorders where bacterial infection or overgrowth is a contributing factor. By reducing the presence of bacteria and inflammation, metronidazole helps to alleviate symptoms such as redness, swelling, and discomfort.

Phenytoin, on the other hand, is traditionally known as an anticonvulsant medication, but it also possesses wound-healing properties when used topically. Phenytoin promotes the proliferation of fibroblasts and enhances collagen deposition, which are critical processes in wound healing. Additionally, it has anti-inflammatory effects that can further aid in the repair of damaged skin. This makes phenytoin particularly useful in treating chronic wounds, ulcers, and other skin conditions where enhanced healing is desired.

When combined in a topical cream, metronidazole and phenytoin offer a synergistic approach to treating skin conditions that involve both infection and impaired healing. The metronidazole component addresses the microbial aspect, reducing infection and inflammation, while the phenytoin component accelerates the healing process and tissue regeneration. This dual-action formulation can be particularly beneficial for patients with complex skin conditions that require both antimicrobial and reparative interventions.

For prescribers, this compounded formulation provides a customizable treatment option that can be tailored to the specific needs of the patient. The concentration of active ingredients can be adjusted based on the severity of the condition and the patient's response to treatment. The pump mechanism ensures precise dosing, which can improve adherence and outcomes. Patients using this formulation should apply the cream as directed by their healthcare provider, typically to clean, dry skin, and should monitor for any signs of irritation or adverse reactions.

If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide additional information and support to both patients and healthcare providers.

The Metronidazole 10 mg/g/Phenytoin 50 mg/g Topical Cream, dispensed in a pump mechanism, is primarily formulated for the treatment of specific dermatological conditions. However, beyond its primary indications, this formulation may have other potential uses that could be beneficial for both patients and prescribers to consider. Metronidazole, known for its antimicrobial and anti-inflammatory properties, can be utilized in managing conditions characterized by bacterial overgrowth or inflammation. This includes off-label use for certain types of dermatitis, where inflammation and secondary bacterial infection are present. Additionally, its role in reducing redness and irritation makes it a candidate for managing symptoms associated with rosacea or acneiform eruptions.

Phenytoin, traditionally used for its anticonvulsant properties, has shown promise in wound healing due to its ability to promote fibroblast proliferation and collagen synthesis. This makes the cream potentially useful in the management of chronic wounds, such as diabetic ulcers or pressure sores, where enhanced healing is desired. The combination of metronidazole and phenytoin in a topical formulation could provide a dual-action approach, addressing both microbial presence and promoting tissue repair, which may be particularly beneficial in complex wound management scenarios.

For prescribers, considering the pharmacological actions of both active ingredients can guide the exploration of this formulation in other dermatological or wound care contexts. Patients may find the pump mechanism advantageous for precise application, ensuring consistent dosing and minimizing waste. As with any off-label use, it is crucial to weigh the potential benefits against any risks, and to monitor patient outcomes closely. If you have any questions or require further information about the potential uses of this formulation, please reach out to us at Bayview Pharmacy. We are here to assist with any inquiries or support you may need in optimizing patient care.