This topical cream is a compounded formulation containing Lidocaine HCl 2%, Metronidazole 2%, Misoprostol 0.0024%, and Phenytoin 2%, designed to provide a multifaceted approach to skin healing and pain management. Dispensed in a convenient pump mechanism, it allows for controlled application directly to the affected area, promoting localized treatment and absorption of the active ingredients.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in the body, providing fast-acting relief from pain and discomfort at the site of application. At a concentration of 2%, it effectively reduces sensations of pain, itching, and burning associated with various skin conditions.

Metronidazole is an antimicrobial and anti-inflammatory agent commonly used in topical preparations to treat skin infections and inflammatory conditions. At a 2% concentration, it helps eliminate bacteria and reduces inflammation, aiding in the treatment of skin conditions where bacterial overgrowth and inflammation are present.

Misoprostol, at a minimal concentration of 0.0024%, is a prostaglandin E1 analog that promotes wound healing by increasing blood flow and stimulating the production of protective mucus. Its inclusion in the formulation supports tissue repair and regeneration, enhancing the healing process of the skin.

Phenytoin, present at 2%, is traditionally known as an anticonvulsant medication but has been found to possess wound-healing properties when applied topically. It promotes cell proliferation and collagen synthesis, contributing to faster and more effective skin repair.

The combination of these active ingredients in a single topical cream provides a comprehensive treatment option for various skin conditions requiring pain relief, antimicrobial action, anti-inflammatory effects, and enhanced healing. The pump mechanism ensures precise dosing and hygienic application, making it convenient for patients to use.

Patients should apply the cream as directed by their healthcare provider, typically to clean, dry skin on the affected area. It is important to wash hands before and after application to prevent contamination and spread of infection. Avoid contact with eyes, nose, and mouth, and do not apply to open wounds unless advised by a healthcare professional.

Prescribers may consider this formulation for patients who require a synergistic approach to managing complex skin conditions, such as chronic wounds, ulcers, or inflammatory skin disorders, where pain management and enhanced healing are desired outcomes.

As with all medications, patients should be monitored for any signs of adverse reactions, such as allergic responses, skin irritation, or unwanted systemic effects. It is important to discuss any existing medical conditions, allergies, or medications with the healthcare provider before using this

This topical cream formulation contains Lidocaine HCl 2%, Metronidazole 2%, Misoprostol 0.0024%, and Phenytoin 2%, each contributing to its therapeutic effects. Lidocaine is a local anesthetic that helps to relieve pain by blocking nerve signals in the affected area. Metronidazole is an antibiotic and antiprotozoal agent that reduces inflammation and treats infections caused by bacteria and parasites. Misoprostol is a prostaglandin analog that can help in wound healing and reducing inflammation. Phenytoin, traditionally used as an anticonvulsant, has properties that promote wound healing and tissue repair when applied topically.

When using this formulation, it is important to consider potential drug interactions, especially for patients who are on systemic medications. Lidocaine, when absorbed systemically, can interact with antiarrhythmic drugs, potentially leading to additive cardiac effects. Patients using other local anesthetics or medications that affect cardiac conduction should be monitored closely. Metronidazole, although primarily acting locally in this formulation, can interact with alcohol, leading to a disulfiram-like reaction, and with warfarin, potentially increasing the anticoagulant effect. Patients should be advised to avoid alcohol consumption during treatment and to inform their healthcare provider if they are taking anticoagulants.

Misoprostol, while present in a very low concentration, should be used with caution in women of childbearing potential, as systemic absorption could theoretically lead to uterine contractions. Patients should be advised to inform their healthcare provider if they are pregnant or planning to become pregnant. Phenytoin, when absorbed systemically, can interact with a wide range of medications, including other anticonvulsants, anticoagulants, and certain antibiotics, potentially altering their effects. Patients should be monitored for signs of phenytoin toxicity, such as dizziness, ataxia, or nystagmus, especially if they are on other medications that affect phenytoin metabolism.

For prescribers, it is crucial to evaluate the patient's current medication regimen and medical history to assess the risk of interactions. Consideration should be given to the potential for systemic absorption of the active ingredients, especially in cases of extensive application or compromised skin integrity. Regular follow-up and monitoring may be necessary to ensure patient safety and therapeutic efficacy. If you have any questions or need further information, please reach out to us at Bayview Pharmacy.

This compounded topical cream combines four active ingredients—Lidocaine HCl, Metronidazole, Misoprostol, and Phenytoin—each contributing unique therapeutic properties to address various dermatological and pain-related conditions. The formulation is dispensed in a semisolid preparation with a pump mechanism, ensuring precise dosing and ease of application, which enhances patient compliance and treatment efficacy.

Lidocaine HCl 2% acts as a local anesthetic by blocking sodium channels in neuronal cell membranes, which inhibits the initiation and conduction of nerve impulses. This action effectively reduces pain and discomfort in the treated area, making it particularly useful for conditions involving localized pain or irritation. By providing rapid onset of analgesia, Lidocaine helps improve patient comfort during the healing process.

Metronidazole 2% is an antimicrobial agent with potent activity against anaerobic bacteria and certain parasites. When applied topically, it reduces inflammation and bacterial load on the skin, making it beneficial for treating conditions like rosacea, acne, and other inflammatory dermatoses. Its anti-inflammatory properties also help in reducing redness and swelling, contributing to an overall improvement in skin appearance and comfort.

Misoprostol 0.0024% is a prostaglandin E1 analog that promotes mucosal protection and healing. In topical applications, it enhances local blood flow and stimulates epithelial cell proliferation, which aids in the repair of damaged skin tissues. This makes it particularly effective in treating ulcers, wounds, and other conditions where enhanced healing is desired. Its inclusion in the formulation supports the regenerative processes of the skin, facilitating faster recovery.

Phenytoin 2% is traditionally known for its use in seizure disorders, but it also possesses wound-healing properties when used topically. It promotes fibroblast proliferation and collagen synthesis, which are critical for wound healing and tissue repair. Phenytoin's role in this formulation is to enhance the structural integrity of the skin and support the healing of chronic wounds, ulcers, and other skin injuries.

The combination of these active ingredients in a single topical cream allows for a multifaceted approach to treatment, addressing pain, infection, inflammation, and tissue repair simultaneously. This makes the formulation versatile for a range of dermatological conditions, providing comprehensive care in a single application. The pump mechanism ensures that patients receive a consistent dose with each use, minimizing waste and maximizing therapeutic outcomes.

For both patients and prescribers, this compounded cream offers a tailored solution that can be adjusted to meet specific treatment needs. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.

The Lidocaine HCl 2%/Metronidazole 2%/Misoprostol 0.0024%/Phenytoin 2% Topical Cream, dispensed in a pump mechanism, is primarily formulated for localized treatment on the skin, offering a convenient and controlled application of its active ingredients. While this formulation is typically used for specific dermatological conditions, its unique combination of active ingredients may offer additional therapeutic benefits beyond its primary indications. Lidocaine HCl, a local anesthetic, can be beneficial in providing temporary relief from pain and discomfort associated with minor skin irritations, insect bites, and minor burns. Metronidazole, an antimicrobial agent, may be useful in managing skin conditions characterized by inflammation and bacterial overgrowth, such as rosacea or certain types of dermatitis, by reducing redness and swelling.

Misoprostol, although primarily known for its role in gastric protection and labor induction, may contribute to enhanced wound healing when applied topically, potentially benefiting patients with chronic wounds or ulcers by promoting tissue regeneration. Phenytoin, traditionally used as an anticonvulsant, has shown promise in accelerating wound healing and reducing inflammation, making it a valuable component in the management of non-healing wounds or ulcers. The synergistic effect of these ingredients may also provide relief in conditions involving neuropathic pain or localized inflammatory responses, offering a multifaceted approach to skin care and pain management.

For prescribers, this formulation presents an opportunity to address complex skin conditions that may not respond adequately to standard treatments, providing a tailored therapeutic option that leverages the combined effects of its active components. Patients seeking alternative or adjunctive therapies for persistent skin issues may find this formulation beneficial, particularly when conventional treatments have proven insufficient. As with any compounded medication, it is essential for both patients and prescribers to consider individual patient needs, potential allergies, and the specific characteristics of the skin condition being treated. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy.