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Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel

The Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel is a specialized semisolid formulation designed for targeted application on the skin. This unique compound combines the local anesthetic effects of Lidocaine and Tetracaine with the vasoconstrictive properties of Phenylephrine. The gel is dispensed through a pump mechanism, which ensures easy and precise dosing. The consistency of the gel allows for optimal contact with the skin, promoting efficient absorption of the active ingredients.

This formulation is primarily used for the management of anorectal disorders, providing symptomatic relief from pain, itching, and discomfort associated with conditions such as hemorrhoids and anal fissures. Additionally, the vasoconstrictive action of Phenylephrine helps to reduce swelling and bleeding in the affected area. The transdermal gel may also be used for other conditions as determined by a healthcare provider.

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Topical Gel
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Formula Information

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The Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel is a specialized compounded medication designed for topical application. This semisolid formulation is dispensed through a pump mechanism, which ensures ease of use and precise dosing. The gel base provides a suitable medium for the transdermal delivery of the active ingredients, allowing for targeted treatment directly on the skin. The consistency of the gel facilitates adherence to the application site and potentially enhances the absorption of the active pharmaceutical ingredients.

Lidocaine and Tetracaine are both local anesthetics that work by blocking nerve signals in the body, which helps to numb the topical area to which the gel is applied. Lidocaine, being a well-known anesthetic, is effective in providing rapid and potent numbing effects, while Tetracaine complements this action with its own anesthetic properties, potentially extending the duration of the numbing effect. This combination can be particularly useful in managing localized pain, minor burns, insect bites, and other conditions where surface anesthesia is beneficial.

Phenylephrine is a vasoconstrictor that works by narrowing the blood vessels in the area of application. This can help to reduce swelling and bleeding, making the formulation useful in situations where control of these symptoms is desired, such as in minor surgical procedures or in the treatment of hemorrhoids.

The synergistic effects of these three components make the Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel a versatile option for various dermatological and procedural uses. It is important for both patients and prescribers to be aware that this is a compounded medication, and as such, it should be used under the guidance of a healthcare professional familiar with the patient's medical history and the specific indications for use. Additionally, the formulation's efficacy and safety profile should be considered on a case-by-case basis.

For any questions regarding this formulation, its applications, or to discuss individual patient needs, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is committed to providing high-quality, customized medication solutions to meet the unique requirements of each patient and prescriber.

Drug Interactions

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The Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel is a compounded medication designed for topical application. Lidocaine and tetracaine are local anesthetics that work by blocking nerve signals in the body, providing pain relief and numbing to the applied area. Phenylephrine is a vasoconstrictor that narrows the blood vessels in the skin, which can reduce swelling and promote longer duration of the anesthetic effect.

When using this transdermal gel, it is important to consider potential drug interactions. Lidocaine and tetracaine may interact with other local anesthetics or medications that affect nerve conduction, heart rhythm, or blood pressure. Concurrent use of other local anesthetics should be approached with caution to avoid additive systemic toxicity. Medications such as antiarrhythmic drugs (like amiodarone or mexiletine), beta-blockers, or calcium channel blockers may interact with lidocaine, potentially altering cardiac conduction or function.

Phenylephrine's vasoconstrictive properties can be potentiated by monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and atypical antidepressants, leading to an increased risk of hypertension. Conversely, antihypertensive medications, such as beta-blockers or alpha-blockers, may have reduced efficacy when used concurrently with phenylephrine. Additionally, patients taking digoxin or other cardiac glycosides should be monitored closely, as phenylephrine can affect heart rhythm and contractility.

Patients with a history of cardiovascular disease, hyperthyroidism, diabetes, or glaucoma should use this medication with caution, as phenylephrine can exacerbate these conditions. It is also advisable to avoid using this gel in conjunction with other sympathomimetic drugs to prevent excessive cardiovascular stimulation.

It is essential to inform the healthcare provider of all medications, supplements, and herbal products the patient is currently using before starting treatment with this transdermal gel to avoid potential interactions. This includes over-the-counter medications and any other topical treatments applied to the same area.

This compounded formulation is used to provide local anesthesia and vasoconstriction for minor surgical procedures, such as skin biopsies, or for temporary relief of pain and swelling associated with conditions like hemorrhoids or anal fissures. The precise application through a pump mechanism allows for targeted treatment and controlled dosing.

If you have any questions or require further information regarding drug interactions or the appropriate use of Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure safe and effective treatment for our patients.

How Does it Work

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The Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel is a compounded medication designed to deliver its active ingredients directly through the skin to the targeted area. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel base provides a suitable medium for the active ingredients to be absorbed into the skin, offering localized relief or action without significant systemic effects.

Lidocaine and tetracaine are both local anesthetics that work by blocking sodium channels in neuronal cell membranes. This action inhibits the initiation and conduction of nerve impulses, thereby providing a numbing effect to the area of application. Lidocaine, being a fast-acting anesthetic, initiates the numbing effect, while tetracaine, with a longer duration of action, sustains the anesthesia. The high concentration of lidocaine (20%) ensures a potent and rapid onset of numbness, making the formulation particularly useful for painful skin conditions or procedures requiring local anesthesia.

Phenylephrine is a vasoconstrictor that works by stimulating alpha-adrenergic receptors in the vascular smooth muscle, leading to vasoconstriction. This action reduces blood flow to the area of application, which can help to decrease swelling and bleeding. The inclusion of phenylephrine at 2% concentration serves to enhance the local effect of the anesthetics by prolonging their duration of action and reducing systemic absorption. This can be particularly beneficial in procedures where control of bleeding and edema is desired.

This transdermal gel formulation is used to treat various disease states that benefit from localized anesthesia and vasoconstriction. It can be applied before minor surgical procedures, such as skin biopsies or laser treatments, to provide local pain relief and minimize bleeding. It is also useful in the management of painful skin conditions like certain types of dermatitis or anal fissures where both analgesia and reduction of swelling are required.

For patients and prescribers considering the use of this formulation, it is important to understand that the gel should be applied to intact skin only and should not be used on open wounds or mucous membranes. The precise dosing pump allows for consistent dosing, but the total amount applied should not exceed the recommended dose to avoid systemic toxicity. As with all compounded medications, this formulation should be used under the guidance of a healthcare professional who can monitor its efficacy and safety.

If you have any questions about the Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel or its application, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure safe and effective treatment for your patients.

Other Uses

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The lidocaine/phenylephrine/tetracaine transdermal gel is commonly used for its local anesthetic and vasoconstrictive properties. Aside from its primary application to alleviate pain through local anesthesia, patients and prescribers have found several other therapeutic uses for this compound. For example, it can be particularly beneficial in minor surgical procedures such as skin biopsies, laser treatments, or before administering injections to reduce local discomfort. The inclusion of phenylephrine, a vasoconstrictor, also helps in limiting bleeding on the application site, making it useful for minor dermatological procedures where capillary bleeding might be a concern.

The gel's properties may also lend itself to use in sports medicine, where it could be applied to manage the acute pain from soft tissue injuries such as sprains or strains, allowing athletes a temporary respite from discomfort. Additionally, in cosmetic procedures such as microdermabrasion or after minor cosmetic injectables, the gel could soothe the skin and minimize both pain and swelling. Due to its vasoconstrictive effects, it may reduce the occurrence of bruising post-procedure.

Chronic pain conditions that affect the skin and superficial tissues, like neuropathies or certain inflammatory conditions, could potentially benefit from the analgesic effect of the multi-agent gel. However, its use should be well-considered by healthcare providers in the context of the patient's overall treatment plan and in accordance with any other medications the patient may be using, as there could be interactions or contraindications to consider.

It is essential for patients and prescribers to note that while this transdermal gel may have several potential off-label uses, it should only be used under the guidance and prescription of a healthcare professional who can assess the appropriateness of the formulation for the specific condition being treated. As with all compounded medications, the risks, benefits, and alternative therapies should be evaluated before initiating treatment.

If you have any questions regarding additional applications of this transdermal gel formulation or if you would like to discuss how it could be incorporated into your treatment plan, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing personalized care and information to ensure safe and effective use of our compounded medications.

Frequently Asked Questions

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What is Lidocaine 20%/Phenylephrine 2%/Tetracaine 4% Transdermal Gel?

This is a compounded formulation that combines the local anesthetic effects of Lidocaine and Tetracaine with the vasoconstrictive properties of Phenylephrine. It is designed to be applied topically on the skin to provide targeted pain relief and reduce swelling at the site of application.

How do you use this transdermal gel?

To use the gel, apply a small amount to the affected area using the pump mechanism. The pump allows for precise dosing and easy application. Rub the gel gently into the skin until it is absorbed.

How often can I apply the gel?

It is important to follow the dosing instructions provided by your healthcare provider. Typically, the application may be limited to 2-4 times a day, but this can vary based on individual patient needs and physician recommendations.

Can this gel be used for any type of pain?

This compounded formulation is specifically intended for localized areas of pain or discomfort. It is not suitable for all types of pain. Discuss with your healthcare provider about the appropriateness of this gel for your specific condition.

Are there any side effects of using this transdermal gel?

As with any medication, side effects are possible. Common side effects may include local irritation, redness, or itching at the application site. If you experience severe side effects such as difficulty breathing or an allergic reaction, seek medical attention immediately.

How should I store the transdermal gel?

Store the gel at room temperature, away from direct sunlight and heat. Keep the container tightly closed when not in use. Make sure to keep it out of reach of children and pets.

What should I do in case I miss a dose?

If you miss a dose, apply the gel as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double doses to make up for a missed one.

Is this transdermal gel suitable for children?

This medication may not be suitable for children or it may require careful dosing adjustments. Always consult a pediatrician or healthcare provider before using this formulation in children.

Can I cover the area after applying the gel?

It's generally best to let the gel absorb fully into the skin before covering the area. If you must cover it, consult with your healthcare provider on the appropriate type of covering to use.

Will using the gel affect my ability to drive or operate machinery?

As the formulation is applied topically and is localized, it should not affect your ability to drive or operate machinery. However, if you feel drowsy or dizzy after using the gel, avoid these activities until these effects have subsided.

Can I use this gel with other medications?

As with all medications, there is potential for drug interactions. Inform your healthcare provider of all the medications you are taking to determine if there is any risk when using this compounded gel concurrently with other drugs.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.