Lidocaine 10%/Phenylephrine HCl 0.25%/Prilocaine 10% Topical Cream is a compounded medication specifically designed to deliver a combination of local anesthetics and a vasoconstrictor for topical application. Lidocaine and Prilocaine are both amide-type local anesthetics that work by blocking sodium channels, which are necessary for the initiation and conduction of neuronal impulses. This action results in a localized loss of sensation, providing relief from pain and discomfort. The inclusion of Phenylephrine HCl, a selective alpha-1 adrenergic receptor agonist, induces vasoconstriction. This reduces blood flow to the area of application, which can help to decrease swelling and prolong the duration of the anesthetic effect.

The cream is formulated as a semisolid preparation, which allows for a smooth and uniform application to the skin. The pump mechanism is designed to dispense a controlled amount of the cream, ensuring consistent dosing and minimizing the risk of contamination. This dosage form is particularly useful for patients requiring precise application to localized areas for conditions such as minor skin procedures, needle insertions, or other superficial dermatological procedures where pain relief and reduction of swelling are desired.

For prescribers, it is important to note that the combination of Lidocaine and Prilocaine in a 10% concentration each provides a potent anesthetic effect, suitable for procedures that require a deeper or more prolonged numbing sensation. The addition of Phenylephrine HCl at 0.25% serves to enhance the effect by constricting blood vessels, which can be beneficial in controlling bleeding and edema during minor surgical procedures. This formulation is intended for topical use only and should be applied to intact skin. Care should be taken to avoid application to broken or inflamed skin, as this may increase systemic absorption and the potential for adverse effects.

Patients should be advised on the proper use of the cream, including the amount to apply and the frequency of application as directed by their healthcare provider. They should be made aware of the potential for local reactions, such as redness or swelling at the site of application, and systemic effects if applied over a large area or to broken skin. It is also important for patients to understand that the numbing effect of the cream can make them less aware of incidental trauma to the treated area.

If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing you with the highest quality compounded medications and the support you need to ensure the best possible treatment outcomes for your patients.

The topical cream formulation containing Lidocaine 10%, Phenylephrine HCl 0.25%, and Prilocaine 10% is a potent combination used for localized treatment, providing both anesthetic and vasoconstrictive effects. Lidocaine and Prilocaine are local anesthetics that work by blocking nerve signals in the body, which helps to numb the topical area. Phenylephrine is a vasoconstrictor that narrows the blood vessels in the area of application, which can reduce bleeding and enhance the local action of the anesthetics.

When considering the use of this topical cream, it is important to be aware of potential drug interactions. Lidocaine and Prilocaine can both interact with other local anesthetics or medications that affect the cardiovascular system. Concurrent use of other local anesthetics may increase the systemic absorption of Lidocaine and Prilocaine, potentially leading to increased side effects such as CNS toxicity or cardiac toxicity. Patients should inform their healthcare provider of all the medications they are currently taking, including over-the-counter drugs and herbal supplements.

Phenylephrine, being a vasoconstrictor, can interact with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and other sympathomimetic drugs, potentially leading to hypertensive reactions. Caution is advised when using this cream in patients taking such medications. Additionally, beta-blockers may interact with Phenylephrine, leading to an increase in blood pressure and a decrease in heart rate. Patients with pre-existing hypertension or cardiovascular disease should use this cream with caution and under the supervision of a healthcare provider.

It is also important to consider that the systemic absorption of Lidocaine and Prilocaine may be increased if applied to large areas of the skin, broken or inflamed skin, or when occlusive dressings are used. This could potentially lead to increased plasma levels and risk of systemic toxicity. Therefore, the amount of cream applied and the duration of application should be carefully monitored.

Patients with liver disease or reduced liver function may have an increased risk of experiencing side effects due to decreased metabolism and clearance of Lidocaine and Prilocaine. Similarly, patients with kidney disease may have an increased risk of systemic toxicity due to reduced excretion of the drugs.

Lastly, it is important to note that this formulation is for topical use only and should not be applied to mucous membranes or near the eyes due to the risk of systemic absorption and local irritation. If there is any uncertainty regarding potential drug interactions or appropriate use of this topical cream, healthcare providers and patients are encouraged to reach out to us at Bayview Pharmacy for further information and guidance.

The Lidocaine 10%/Phenylephrine HCl 0.25%/Prilocaine 10% Topical Cream is a compounded medication that combines the analgesic and anesthetic effects of lidocaine and prilocaine with the vasoconstrictive properties of phenylephrine HCl. This formulation is designed to provide localized relief from pain and discomfort while minimizing bleeding in the area of application due to the vasoconstrictive action of phenylephrine.

Lidocaine and prilocaine are both local anesthetics that work by blocking sodium channels in neuronal cell membranes. This action inhibits the initiation and conduction of nerve impulses, thereby providing a numbing sensation and pain relief in the area where the cream is applied. The 10% concentration of each anesthetic in this formulation ensures a potent effect, making it suitable for procedures or conditions that require significant analgesia.

Phenylephrine HCl is a selective alpha-1 adrenergic receptor agonist, which induces vasoconstriction when applied topically. By constricting blood vessels in the area of application, phenylephrine reduces blood flow, which can help to control bleeding during minor surgical procedures or after trauma. The 0.25% concentration of phenylephrine HCl is sufficient to elicit a local vasoconstrictive response without producing significant systemic effects.

The cream is dispensed in a pump mechanism, which allows for a controlled and hygienic application. This delivery system ensures that the correct dose is administered each time, reducing the risk of over- or under-dosing. The semisolid preparation of the cream facilitates easy application and adherence to the skin, ensuring that the active ingredients remain in contact with the treatment area for effective absorption and action.

This topical cream is particularly useful in treating conditions that benefit from both localized pain relief and vasoconstriction, such as minor skin surgeries, needle insertions, and other dermatological procedures. It can also be used to manage pain from chronic conditions like certain neuropathies, where localized analgesia is desired.

It is important for patients and prescribers to understand that while this formulation provides effective local treatment, it should be used with caution in patients with a history of cardiac disease, hypertension, or hyperthyroidism due to the potential systemic absorption of phenylephrine. Additionally, the use of this cream should be monitored in patients with a known sensitivity to local anesthetics of the amide type.

For any questions or concerns regarding the use of this compounded formulation, or to discuss its appropriateness for a specific patient or condition, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support to ensure safe and effective treatment outcomes.

The topical cream consisting of Lidocaine 10%, Phenylephrine HCl 0.25%, and Prilocaine 10% is a potent formulation primarily used for providing localized anesthesia and vasoconstriction for minor surgical procedures, such as biopsy, dermal procedures, or dental treatments. Its clinical utility, however, extends to a variety of other situations where the combination of anesthesia and vasoconstriction could be beneficial. For instance, the cream could potentially be employed to manage pain and bleeding in the treatment of hemorrhoids, although it is not the primary indication.

Furthermore, the addition of phenylephrine, a vasoconstrictor, may help in reducing swelling and providing an extended duration of action of the anesthetic agents due to decreased systemic absorption. In dermatology, procedures such as laser therapy, tattoo removal, or even less invasive treatments like micro-needling could be less discomforting when preceded by the application of this cream. Likewise, it might find utility in cosmetology for pain relief during procedures such as filler injections or superficial chemical peels.

Another potential application could be in sports medicine for the temporary relief of pain associated with minor injuries like bruises, sprains, or muscle strains, where the vasoconstrictor effect could also limit swelling and the extent of bruising. It is important to note, however, that while these uses are conceivable, the formulation’s efficacy and safety for such applications should be evaluated on an individual basis by a healthcare provider. Prescribers could also consider this cream for off-label uses carefully assessed for each patient; they must weigh the potential benefits against any risks, including sensitivities to the components, particularly in patients with cardiac conditions where phenylephrine's systemic effects may be a concern.

The topical cream is dispensed in a pump mechanism that allows for precise dosing and minimizes contamination of the product. Patients and healthcare providers should be advised on the correct technique to ensure a consistent dose with each application. They are encouraged to use the minimum amount necessary to cover the affected area and to avoid application on open wounds or mucous membranes unless specifically directed by a healthcare provider.

This cream should not be applied to large areas of the body or under occlusive dressings unless directed by a healthcare provider, as increased absorption could lead to systemic effects. Potential side effects, contraindications, and drug interactions should be reviewed prior to the use of this medication. Anyone with further inquiries or specific concerns regarding this formulation or its appropriate uses may reach out to us at Bayview Pharmacy for more information and guidance.