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Levothyroxine Sodium 19 mcg/Liothyronine 4.5 mcg Oral Capsules

Levothyroxine Sodium 19 mcg/Liothyronine 4.5 mcg Oral Capsules are a solid dosage form consisting of two gelatin or vegetarian shells that encapsulate a combination of thyroid hormones. These capsules are designed for ease of swallowing and to ensure the delivery of an accurate dose of the active ingredients. Levothyroxine sodium is a synthetic form of the thyroid hormone thyroxine (T4), while liothyronine is the synthetic form of triiodothyronine (T3). This formulation is specifically used to treat hypothyroidism, a condition where the thyroid gland does not produce sufficient thyroid hormones. It may also be prescribed to manage other related thyroid disorders as determined by a healthcare provider.

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Levothyroxine Sodium
Liothyronine Sodium
Capsules
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Formula Information

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Levothyroxine Sodium and Liothyronine are synthetic forms of thyroid hormones used to treat hypothyroidism, a condition where the thyroid gland does not produce enough hormones. Levothyroxine Sodium is a synthetic version of thyroxine (T4), while Liothyronine is a synthetic form of triiodothyronine (T3). These hormones are responsible for regulating the body's metabolic processes, and their deficiency can lead to symptoms such as fatigue, weight gain, and depression.

The combination of Levothyroxine Sodium 19 mcg and Liothyronine 4.5 mcg in oral capsule form provides a dual approach to hormone replacement therapy. By including both T4 and T3, the formulation may offer a more balanced replacement therapy for patients who do not adequately convert T4 to T3 with levothyroxine alone. This can be particularly beneficial for patients who continue to experience symptoms of hypothyroidism despite normal T4 levels and adequate levothyroxine treatment.

The solid dosage form of these oral capsules ensures a precise and consistent dose of the active ingredients. The capsules are composed of two gelatin or vegetarian shells, which enclose the medication. This design allows for convenient and easy swallowing, which can improve patient compliance. Additionally, the encapsulation protects the active ingredients from degradation and ensures stability throughout the shelf life of the product.

It is important for prescribers to carefully monitor thyroid hormone levels and adjust dosages as necessary when prescribing this combination therapy. Regular blood tests are essential to ensure that the levels of T3 and T4 are within the therapeutic range and to avoid potential complications such as hyperthyroidism. Patients should be advised to take the medication consistently and to report any side effects or persistent symptoms to their healthcare provider.

Bayview Pharmacy's team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the specific needs of each patient. If you have any questions about this formulation or its use in treating hypothyroidism, please reach out to us for more information and guidance. We are here to support both patients and prescribers in the effective management of thyroid-related conditions.

Drug Interactions

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Levothyroxine sodium and liothyronine are synthetic forms of thyroid hormones used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. Levothyroxine is a synthetic version of thyroxine (T4), while liothyronine is a synthetic form of triiodothyronine (T3). These hormones are responsible for maintaining the body's metabolism, heart, and digestive function, muscle control, brain development, and bone maintenance. By supplementing the body's thyroid hormone levels, levothyroxine and liothyronine can help restore normal metabolic activity and alleviate the symptoms of hypothyroidism.

When taking levothyroxine sodium and liothyronine oral capsules, it is important to be aware of potential drug interactions that can affect the efficacy of the medication or cause adverse effects. Certain medications can affect the absorption of levothyroxine and liothyronine, such as antacids, calcium carbonate, and iron supplements, which should be taken several hours apart from thyroid hormone therapy. Additionally, cholesterol-lowering drugs such as cholestyramine and colestipol can decrease the absorption of thyroid hormones, necessitating adjustments in dosing.

Other medications can increase the metabolism of thyroid hormones, reducing their effectiveness. These include phenobarbital, carbamazepine, and rifampin. Conversely, medications like beta-blockers, amiodarone, and sertraline can decrease the metabolism of thyroid hormones, potentially leading to an increase in their effects. Patients with diabetes should be monitored closely as thyroid hormones may increase blood sugar levels, possibly requiring adjustments in insulin or oral diabetic medication dosages.

It is also important to note that thyroid hormones can affect the action of anticoagulant medications, such as warfarin, by increasing the body's response to these drugs and potentially leading to an increased risk of bleeding. Close monitoring of coagulation times and adjustment of anticoagulant doses may be necessary. Additionally, the use of selective serotonin reuptake inhibitors (SSRIs) can lead to an increased risk of side effects from thyroid hormones.

Patients should also be aware that certain foods and dietary fibers may affect the absorption of levothyroxine and liothyronine. To ensure consistent absorption, it is generally recommended to take thyroid hormone capsules on an empty stomach with a full glass of water, at least 30 to 60 minutes before breakfast or any other medications.

It is crucial for patients and prescribers to maintain open communication regarding all medications, including over-the-counter drugs, supplements, and herbal products, to avoid potential interactions with levothyroxine and liothyronine. Regular monitoring of thyroid function tests is recommended to ensure the appropriate therapeutic levels of thyroid hormones are maintained. If you have any questions or concerns about drug interactions with levothyroxine sodium and liothyronine oral capsules, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Levothyroxine Sodium and Liothyronine are synthetic forms of thyroid hormones used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. Levothyroxine Sodium is a synthetic version of thyroxine (T4), while Liothyronine is a synthetic form of triiodothyronine (T3), both of which are naturally produced by the human thyroid gland. These hormones are critical for maintaining the body's metabolism, heart function, digestive function, muscle control, brain development, and bone maintenance.

In this formulation, Levothyroxine Sodium 19 mcg/Liothyronine 4.5 mcg Oral Capsules, the active ingredients are precisely measured and encapsulated within either gelatin or vegetarian shells to create a solid dosage form. The capsules are designed to be swallowed whole, releasing the medication into the digestive system where it is absorbed into the bloodstream. Once absorbed, the synthetic hormones work by replacing or supplementing the low levels of thyroid hormones in the body. The presence of both T4 and T3 may provide a more physiologic hormone replacement, as T3 is the more active form of the hormone that can be used directly by the body's cells.

The precise dosing of Levothyroxine and Liothyronine in these capsules ensures that patients receive a consistent amount of thyroid hormones with each dose, which is crucial for managing hypothyroidism effectively. The balance of T4 and T3 can be tailored to the individual needs of the patient, which can be adjusted based on regular monitoring of thyroid function tests by healthcare providers. This personalized approach helps to normalize the levels of thyroid hormones in the body, thereby alleviating the symptoms of hypothyroidism such as fatigue, weight gain, cold intolerance, and depression.

It is important for patients and prescribers to understand that thyroid hormone replacement therapy with Levothyroxine Sodium and Liothyronine must be carefully monitored and adjusted as necessary. Over-replacement can lead to symptoms of hyperthyroidism, while under-replacement can leave hypothyroid symptoms unresolved. Regular blood tests are necessary to ensure the correct dosage is being administered and to maintain the proper therapeutic levels of thyroid hormones in the body.

If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing you with the knowledge and support needed to effectively manage hypothyroidism with customized medication solutions.

Other Uses

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Levothyroxine Sodium and Liothyronine oral capsules provided in this solid dosage form are primarily indicated for the treatment of hypothyroidism, a condition in which the thyroid gland does not produce sufficient levels of thyroid hormones. This combination medication, including both Levothyroxine (a synthetic form of thyroxine or T4) and Liothyronine (a synthetic form of triiodothyronine or T3), is sometimes prescribed for patients who do not respond optimally to Levothyroxine alone, providing a closer mimicry to the body's natural levels of thyroid hormones.

Besides its main indication for hypothyroidism, the use of these thyroid hormone replacement therapies may extend, off-label, to other clinical scenarios. For example, they are sometimes used in the management of thyroid cancer to suppress the production of thyroid-stimulating hormone (TSH) from the pituitary gland, which can be beneficial following thyroidectomy or radioactive iodine therapy. It is thought that by reducing TSH levels, the growth of any remaining cancer cells may be inhibited. Furthermore, although it is not a conventional indication and can be controversial, some clinicians have explored the use of this combination therapy in the treatment of depression when it is accompanied by subclinical hypothyroidism or in euthyroid patients who have not responded to traditional antidepressants, although evidence for this application is limited and further research is necessary.

Another secondary use of this medication is in the performance of the thyroid suppression test to diagnose mild (subclinical) hyperthyroidism or to determine the effectiveness of the therapy in patients with Graves' disease. However, this is a specialized application and should only be done under careful medical supervision. It's important to acknowledge that all alternative uses of this medication should be approached with caution and only under the direct guidance of an experienced healthcare provider, taking into account the potential risks and benefits for the individual patient.

It's worth noting that while the combination of Levothyroxine and Liothyronine may help in treating these conditions, it is not suitable for use in the treatment of obesity or for weight loss in individuals with normal thyroid function, as excessive thyroid hormones can lead to serious or even life-threatening effects. Prescribers and patients should also be aware of the potential for adverse reactions, which may necessitate adjustment of the dosage or discontinuation of the therapy.

Patients should always consult with their healthcare provider to understand the potential benefits and risks of using Levothyroxine Sodium and Liothyronine oral capsules, and they should be instructed on the signs and symptoms of improper dosage, whether it be over-replacement (leading to symptoms of hyperthyroidism) or under-replacement (failing to adequately treat hypothyroidism). If you have any questions regarding this medication or its uses, feel free to reach out to us for more detailed information and guidance tailored to your specific situation.

Frequently Asked Questions

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What is the purpose of the Levothyroxine Sodium 19 mcg/Liothyronine 4.5 mcg Oral Capsules?

This compounded medication is designed to treat hypothyroidism, which is a condition where the thyroid gland does not produce enough thyroid hormones. The combination of Levothyroxine Sodium and Liothyronine replaces or provides more of these hormones.

How should I take these oral capsules?

Take these capsules orally with water, preferably at the same time each day. Follow your healthcare provider's instructions regarding timing and whether to take it with or without food.

Are the capsules made of gelatin, and is there a vegetarian option available?

The capsules are typically made of gelatin, but a vegetarian capsule option is also available. Be sure to specify your preference when the medication is being compounded.

What are the advantages of using a capsule form for this medication?

Using a capsule form provides a precise dosage of the active ingredients, ensures the medication is easy to swallow, protects the stability of the ingredients, and can improve patient compliance.

How are these capsules stored?

Store the capsules at room temperature, away from excess heat and moisture. Do not store them in the bathroom or freezer, and keep them out of the reach of children and pets.

Can I open the capsule and mix it with food or liquids?

Do not open, break, or chew the capsules unless instructed by your healthcare provider, as this could alter the intended delivery of the medication.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses.

Are there any potential side effects I should be aware of?

Possible side effects include, but are not limited to, heart palpitations, increased appetite, weight loss, tremors, headache, and insomnia. If you experience any side effects or symptoms of overdose, such as chest pain or rapid heartbeat, contact your healthcare provider immediately.

Can I take this medication with other prescriptions or over-the-counter products?

Always discuss with your healthcare provider or pharmacist before taking any new medications or supplements, as there may be interactions that could affect how your thyroid medication works.

How long will it take to see improvement in my symptoms?

Improvement in symptoms can vary from person to person. Some may notice improvements within a few weeks, while for others, it might take several months. Consistently taking the medication as prescribed is essential for effective treatment.

Should I be monitored while taking this medication?

Yes, regular monitoring by a healthcare provider is necessary to ensure the medication is working correctly and to adjust the dosage if needed. This typically involves blood tests to check your thyroid hormone levels.

What should I do if I experience an allergic reaction to the capsules?

If you experience any signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing, seek immediate medical attention.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.