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Levothyroxine Sodium 112 mcg/Liothyronine 28 mcg Oral Capsules

Levothyroxine Sodium 112 mcg/Liothyronine 28 mcg Oral Capsules are a solid dosage form that combines two active thyroid hormones in precise quantities. Encased within either gelatin or vegetarian shells, these capsules are designed for ease of swallowing and consistent delivery of medication. This formulation is specifically used in the treatment of hypothyroidism, a condition where the thyroid gland does not produce sufficient thyroid hormones, and for thyroid hormone replacement therapy. By providing both levothyroxine (T4) and liothyronine (T3), this combination therapy can help to restore normal hormone levels, thereby improving metabolic function and alleviating symptoms associated with thyroid hormone deficiency.

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Formula Information

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Levothyroxine Sodium and Liothyronine are synthetic forms of thyroid hormones used to treat hypothyroidism, a condition where the thyroid gland does not produce enough hormones. Levothyroxine Sodium is a synthetic version of thyroxine (T4), while Liothyronine is a synthetic form of triiodothyronine (T3). These hormones are crucial for maintaining the body's metabolism, heart, and digestive function, muscle control, brain development, and bone maintenance. By supplementing the body's natural thyroid hormones with Levothyroxine Sodium and Liothyronine, this formulation helps to restore the proper hormone levels, thereby improving symptoms of thyroid deficiency such as fatigue, weight gain, and cold intolerance.

The combination of Levothyroxine Sodium 112 mcg and Liothyronine 28 mcg in oral capsule form provides a tailored approach to thyroid hormone replacement therapy. This specific ratio mimics the natural secretion of the thyroid gland, potentially offering a more physiologic hormone replacement. The solid dosage form ensures a precise dose of the active ingredients in each capsule, which is essential for the narrow therapeutic index of thyroid hormones. The capsules are designed to be swallowed easily, which is beneficial for patients who may have difficulty with other dosage forms.

It is important for prescribers to monitor thyroid function tests regularly to adjust the dosage as needed, ensuring the patient remains euthyroid. Patients should be advised to take the medication consistently, preferably on an empty stomach, to maximize absorption. They should also be aware of potential drug interactions and advised to inform their healthcare provider of all medications they are taking. Due to the individualized nature of thyroid hormone replacement therapy, this formulation may not be suitable for all patients with hypothyroidism, and it is not indicated for the treatment of obesity or for weight loss.

Bayview Pharmacy's team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the unique needs of each patient. If you have any questions about this formulation or its appropriateness for your condition, please do not hesitate to reach out to us. We are here to ensure that you receive the most effective and safe treatment for your thyroid-related health concerns.

Drug Interactions

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Levothyroxine sodium and liothyronine are synthetic forms of thyroid hormones used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. Levothyroxine is a synthetic version of thyroxine (T4), while liothyronine is a synthetic form of triiodothyronine (T3). These hormones are responsible for maintaining the body's metabolism, heart, and digestive function, muscle control, brain development, and bone maintenance. By supplementing the body's thyroid hormone levels, this combination medication helps to restore normal energy levels and metabolism.

When taking levothyroxine sodium and liothyronine oral capsules, it is important to be aware of potential drug interactions that can affect the efficacy of the medication or cause adverse effects. Certain medications can decrease the absorption of thyroid hormones, such as calcium carbonate, ferrous sulfate (iron), and antacids containing aluminum or magnesium. To avoid this interaction, it is recommended to take thyroid hormones at least 4 hours before or after these medications.

Other drugs, such as estrogen-containing products, bile acid sequestrants (e.g., cholestyramine, colestipol), and ion exchange resins (e.g., sevelamer), can also affect thyroid hormone levels and may necessitate dosage adjustments. Medications that induce hepatic enzymes, such as rifampin and phenobarbital, can increase the metabolism of thyroid hormones, potentially leading to a decrease in their effectiveness. Conversely, certain drugs like amiodarone, lithium, and sertraline can increase the risk of hypothyroidism when used concurrently with thyroid hormone therapy.

Additionally, thyroid hormones can increase the effect of anticoagulants (blood thinners) such as warfarin, which may require closer monitoring of blood clotting times and possible dose adjustments of the anticoagulant. Diabetes medications may also need to be adjusted, as thyroid hormones can affect blood sugar levels. It is crucial to monitor glucose levels closely when starting or adjusting thyroid hormone therapy.

It is also important to note that certain foods and dietary fibers may affect the absorption of thyroid hormones. To ensure consistent absorption, it is generally recommended to take levothyroxine sodium and liothyronine on an empty stomach, at least 30 to 60 minutes before breakfast.

Patients should inform their healthcare provider of all medications, supplements, and over-the-counter products they are taking to avoid potential interactions. Regular monitoring of thyroid function tests is necessary to ensure the appropriate dosage of thyroid hormones and to adjust the dose as needed. If you have any questions or concerns about drug interactions with levothyroxine sodium and liothyronine oral capsules, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Levothyroxine Sodium and Liothyronine are synthetic forms of thyroid hormones used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. Levothyroxine Sodium is a synthetic version of thyroxine (T4), while Liothyronine is a synthetic form of triiodothyronine (T3). These hormones are crucial for maintaining the body's metabolism, heart, and digestive function, muscle control, brain development, and bone maintenance.

In this formulation, Levothyroxine Sodium 112 mcg/Liothyronine 28 mcg Oral Capsules are solid dosage forms that consist of two halves of a gelatin or vegetarian-based shell. These shells are filled with the precise amount of the powdered active ingredients and then sealed together. The capsule form is designed to be easily swallowed, and once ingested, the shell dissolves, releasing the medication for absorption into the bloodstream. The use of capsules ensures a consistent and accurate dose of the medication is delivered each time.

The combination of Levothyroxine and Liothyronine in these capsules is intended to provide a more comprehensive replacement therapy by supplying both T4 and T3 hormones. While Levothyroxine is the standard treatment for hypothyroidism, adding Liothyronine can be beneficial for patients who have symptoms that persist on Levothyroxine alone. This is because some individuals have difficulties converting T4 into the more active T3 in their bodies, and direct supplementation of T3 can help alleviate these symptoms.

By restoring the levels of thyroid hormones to their normal range, this medication helps to alleviate the symptoms of hypothyroidism, which may include fatigue, weight gain, cold intolerance, and depression. It is important for patients to take this medication consistently and as prescribed, as fluctuations in thyroid hormone levels can lead to symptoms returning or worsening. Additionally, thyroid hormone levels and symptoms should be monitored regularly by a healthcare provider to ensure the dosage remains appropriate.

It is essential for both patients and prescribers to understand that thyroid hormone replacement therapy must be tailored to the individual. Factors such as age, weight, the severity of hypothyroidism, and other medical conditions can influence the dosage required. Therefore, it is crucial to work closely with a healthcare provider to determine the most effective treatment plan.

If you have any questions about this formulation or how it works in treating hypothyroidism, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to manage your condition effectively.

Other Uses

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Levothyroxine Sodium and Liothyronine are primarily prescribed for managing hypothyroidism, which is a condition characterized by an underactive thyroid gland that does not produce sufficient thyroid hormones. These hormones are essential for regulating the body's energy and metabolism, and a deficiency can lead to symptoms such as fatigue, weight gain, and depression.

In addition to treating hypothyroidism, physicians sometimes prescribe this combination therapy for thyroid hormone resistance syndrome, where the body does not respond adequately to thyroid hormones. Even though this use is less common, the tailored ratio of Levothyroxine Sodium to Liothyronine can be beneficial for patients who require a more nuanced thyroid hormone replacement strategy, especially those not responding optimally to Levothyroxine alone.

Furthermore, some prescribers have utilized this combination of Levothyroxine Sodium and Liothyronine for patients undergoing thyroid cancer treatment. After a thyroidectomy (surgical removal of the thyroid gland), patients need thyroid hormone replacement, and this combination can be an essential part of the suppressive treatment to lower the risk of cancer recurrence. However, this is typically initiated under close medical supervision and is generally more specialized, considering the complexities of cancer therapy.

This compounded formulation's oral capsule form provides convenience and consistency in dosing. The gelatin or vegetarian capsule shells are designed for patients who may have difficulties with other dosage forms, such as liquids or large tablets. These capsules may also offer an advantage for patients who have allergies, sensitivities, or dietary restrictions that necessitate avoiding certain inactive ingredients found in commercially available tablet forms.

It is imperative to note that while there are secondary uses for Levothyroxine Sodium and Liothyronine combination therapy, these should always be discussed with a healthcare professional who can factor in the specific needs and medical history of the patient. Any other use of this formulation should be considered off-label and pursued only under the guidance and supervision of a qualified prescriber. If you are a patient or prescriber with questions regarding this formulation or its diverse uses, please do not hesitate to reach out to us at Bayview Pharmacy for further information and consultation.

Frequently Asked Questions

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What is the use of Levothyroxine Sodium 112 mcg/Liothyronine 28 mcg Oral Capsules?

Levothyroxine Sodium and Liothyronine are thyroid hormones used to treat hypothyroidism, which is a condition where the thyroid gland does not produce enough thyroid hormone. This medication helps to restore the normal level of thyroid hormone in the body.

How should I take my Levothyroxine Sodium/Liothyronine capsules?

These capsules should be taken on an empty stomach, ideally 30 to 60 minutes before breakfast. They should be swallowed whole with a full glass of water to ensure the capsule is delivered directly to your stomach for the release and absorption of the medication.

Why are the capsules made with two types of shells?

The capsules are made with either gelatin or vegetarian shells to cater to different dietary requirements and preferences. Both types of shells serve to encase the medication securely and provide an effective way to ingest the active ingredients.

Are there any dietary restrictions while taking this medication?

It is recommended to avoid foods high in soy, cottonseed meal, walnuts, and dietary fiber close to the time of taking the medication, as these can affect the absorption of thyroid hormones. Consult your healthcare provider for specific dietary instructions.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once.

How should I store these capsules?

Store the capsules at room temperature, away from direct light, heat, and moisture. Keep the medication in its original container and out of reach of children and pets. Do not store in the bathroom.

Can I open the capsule and sprinkle the contents on food?

No, you should not open the capsule. Opening the capsule can affect the stability and effectiveness of the medication and may also cause you to receive an incorrect dose. Always swallow the capsule whole.

Are there any side effects I should watch for?

Possible side effects may include chest pain, rapid or irregular heartbeat, shortness of breath, nervousness, irritability, sleeplessness, or weight loss. Contact your healthcare provider if you experience any side effects or if they become severe.

Can I take other medications while on Levothyroxine Sodium/Liothyronine capsules?

Some medications can interact with thyroid hormones, so you should always inform your healthcare provider about all the medications you're taking, including over-the-counter drugs and supplements. They may affect the absorption and efficacy of your thyroid medication.

Do I need to have regular blood tests while taking this medication?

Yes, regular blood tests are necessary to monitor your thyroid hormone levels and to adjust your dosage if needed. Your healthcare provider will guide you on how often you should have your blood tested.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.