Our custom-compounded Hydrocortisone 1%/Ketoconazole 2%/Metronidazole 0.75% Topical Cream is a specialized dermatological preparation designed to address a range of skin conditions that may benefit from the combined anti-inflammatory, antifungal, and antibacterial properties of its active ingredients. This cream is formulated to be applied topically and is dispensed in a pump mechanism container, which ensures a hygienic, convenient, and controlled delivery of the medication to the affected area of the skin.

Hydrocortisone, a mild corticosteroid, works by reducing inflammation and suppressing the immune response in the skin. This makes it effective in treating conditions such as eczema, psoriasis, and allergic reactions. Ketoconazole, an antifungal agent, is included to combat fungal infections of the skin, such as athlete's foot, ringworm, and jock itch, by disrupting the cell membrane of the fungi, leading to their death. Metronidazole, an antibiotic and antiprotozoal, is effective against certain bacteria and protozoa, and is commonly used to treat skin conditions like rosacea or dermatitis caused by susceptible organisms.

The combination of these three active ingredients in one topical cream allows for a multifaceted approach to treatment, targeting inflammation, bacterial infections, and fungal infections simultaneously. This can be particularly beneficial for complex skin conditions that may have multiple contributing factors. The cream is intended for localized application, and the dosage and frequency of use should be as directed by a healthcare provider, based on the specific condition being treated.

Patients should be advised that while this cream can provide relief from symptoms and treat the underlying causes of their skin conditions, it is important to follow the prescribed regimen and to be aware of potential side effects. These may include skin irritation, dryness, or worsening of symptoms, which should be reported to a healthcare provider. It is also important to avoid contact with the eyes, mouth, and other mucous membranes when applying this medication.

Prescribers considering this formulation for their patients can expect a compounded medication that is tailored to address complex skin conditions with a convenient application method. As with any compounded medication, it is essential to work closely with the compounding pharmacy to ensure the formulation meets the specific needs of the patient.

If you have any questions about this formulation or would like to discuss how it can be integrated into your patient's treatment plan, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide support and guidance to both patients and healthcare providers.

The topical cream formulation containing Hydrocortisone 1%, Ketoconazole 2%, and Metronidazole 0.75% is a combination therapy designed to address various skin conditions that may involve inflammation, fungal infections, and bacterial overgrowth. Hydrocortisone is a corticosteroid that reduces inflammation and can help treat skin conditions such as eczema, psoriasis, and allergic reactions. Ketoconazole is an antifungal agent effective against a broad range of dermatophytes and yeasts, and it is commonly used to treat conditions like athlete's foot, ringworm, and seborrheic dermatitis. Metronidazole is an antibiotic and antiprotozoal medication that is used to treat inflammatory lesions of rosacea and certain bacterial infections.

When using this combination topical cream, it is important to consider potential drug interactions. Hydrocortisone, being a corticosteroid, can interact with other topical medications that affect the immune response or skin cell turnover. Concurrent use of other topical steroids should be approached with caution to avoid excessive steroid exposure, which can lead to skin thinning, adrenal suppression, or other systemic effects. Ketoconazole can alter the metabolism of certain drugs by inhibiting cytochrome P450 enzymes, particularly CYP3A4. While systemic absorption of ketoconazole from topical formulations is minimal, caution is advised when applying this cream to large surface areas or to damaged skin, which may increase systemic absorption. Metronidazole, although less likely to be absorbed in significant amounts through the skin, could theoretically interact with blood thinners like warfarin, leading to an increased risk of bleeding. However, this interaction is more relevant to oral or intravenous forms of metronidazole.

Patients should be advised to inform their healthcare provider of all medications they are currently using, including over-the-counter drugs, prescription medications, and herbal supplements, to avoid potential interactions. Additionally, the use of this topical cream should be limited to the prescribed area, and patients should be instructed not to apply it to large areas of the body or to open wounds unless directed by a healthcare professional. It is also important to avoid occlusive dressings over the area where the cream is applied unless recommended by a healthcare provider, as this can increase systemic absorption of the active ingredients.

Alcohol or products containing propylene glycol should be avoided in the areas treated with metronidazole-containing creams, as they may cause a disulfiram-like reaction (flushing, warmth, irritation). Patients should also be aware that the use of hydrocortisone can mask symptoms of infection and may worsen existing infections, so any signs of infection should be promptly reported to a healthcare provider.

For any questions or concerns regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

The Hydrocortisone 1%/Ketoconazole 2%/Metronidazole 0.75% Topical Cream is a compounded medication that combines the therapeutic effects of three active ingredients, each targeting different aspects of skin conditions. This formulation is designed to provide a broad-spectrum approach to treating inflammatory skin disorders that may also have bacterial and fungal components.

Hydrocortisone is a corticosteroid that works by reducing inflammation, redness, and swelling. It achieves this by inhibiting the release of substances in the body that cause inflammation. This makes it effective in treating a variety of skin conditions, such as eczema, psoriasis, and allergic reactions. The 1% concentration provides a mild anti-inflammatory effect suitable for sensitive skin areas.

Ketoconazole is an antifungal agent that works by disrupting the fungal cell membrane, leading to the death of the fungus. It is effective against a broad range of fungi that can cause skin infections, such as athlete's foot, ringworm, and jock itch. The 2% concentration in this cream is commonly used for topical treatment of these conditions.

Metronidazole is an antibiotic and antiprotozoal medication that is effective against a variety of bacteria and some protozoa. It is commonly used to treat skin conditions like rosacea, which is characterized by inflammation and redness. The 0.75% concentration helps to reduce the bacterial load, thereby decreasing inflammation and lesions associated with the condition.

The combination of these three ingredients in a single topical cream allows for a multifaceted approach to treatment. The semisolid preparation is dispensed in a pump mechanism, which provides a convenient and controlled method of application. This ensures that the correct dose is delivered each time, minimizing waste and ensuring that the active ingredients are evenly distributed across the affected area. The pump mechanism also helps to prevent contamination of the product, maintaining its integrity throughout its use.

This topical cream is particularly useful for localized treatment of skin conditions where inflammation is accompanied by fungal or bacterial infections. By addressing all these components simultaneously, the cream can help to alleviate symptoms more effectively than treatments targeting only one aspect. It is important for patients and prescribers to understand that while this cream can provide relief from symptoms, it is not a cure for underlying skin conditions and should be used as part of a comprehensive treatment plan.

If you have any questions about this formulation or how it can be integrated into your treatment regimen, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your healthcare.

The primary components of this specially formulated topical cream—hydrocortisone, ketoconazole, and metronidazole—work synergistically to target a range of dermatological conditions. While the combination is commonly prescribed for its anti-inflammatory, antifungal, and antibiotic properties, there are a variety of 'other uses' for which this cream may prove beneficial. This preparation may serve as a treatment for complex cutaneous conditions that exhibit mixed symptoms, such as inflammatory lesions that are also infected with bacterial and/or fungal organisms. For instance, it can be useful in cases of eczematous dermatitis with secondary infection or inflamed tinea infections that have become complicated by additional bacterial colonization.

Beyond these indications, the anti-inflammatory effect of hydrocortisone can also aid in reducing the swelling and discomfort of insect bites or contact dermatitis when infection is suspected. Ketoconazole, the antifungal component, is effective against a broad spectrum of yeasts and dermatophytes, potentially making the cream beneficial in seborrheic dermatitis or pityriasis versicolor. Metronidazole, with its activity against anaerobic bacteria and certain protozoa, might find 'off-label' use in the treatment of rosacea or perioral dermatitis, especially when topical preparation with fewer side effects is desired.

It is also conceivable that this combination could assist in the management of intertriginous eruptions, where both friction and microbial colonization play a role. Since the cream is dispensed in a pump, the risk of contamination is minimized, which is especially desirable for patients with compromised skin barriers or those prone to infections. However, the use of a potent topical combination like this should always be closely monitored by healthcare professionals. Abuse or improper use could lead to worsening of the condition, resistance development, or systemic side effects due to prolonged application over large areas of the body or in skin folds. Use in sensitive areas or on children should be approached with particular caution and under strict medical guidance.

Please note that while we aim to provide an extensive exploration of the possible applications of this formulation, all treatment should be based on a healthcare provider's clinical judgment and tailored to the individual patient's needs. If you are a prescriber or a patient with specific questions or you require guidance related to the use of this cream for indications other than those listed, do not hesitate to reach out to us at Bayview Pharmacy. Our experienced compounding pharmacists are here to provide the necessary support and information.