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Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream

The Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream is a specially compounded semisolid preparation intended for direct application to the skin. This formulation is dispensed in a pump mechanism, which allows for convenient and controlled administration of the cream. The combination of glycerin, salicylic acid, and urea works synergistically to hydrate, exfoliate, and soften the skin, making it particularly effective in the treatment of hyperkeratotic and scaling conditions such as psoriasis, ichthyosis, and keratosis pilaris, as well as calluses and corns. The pump dispenser ensures that the correct dose is applied to the affected areas, promoting optimal absorption and efficacy of the active ingredients.

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Topical Cream
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Formula Information

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The Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream is a specially compounded formulation designed to address a variety of dermatological conditions. This semisolid preparation is dispensed in a pump mechanism, which ensures a hygienic, convenient, and controlled application. The cream is intended for localized treatment and facilitates the absorption of active ingredients directly into the skin.

Glycerin, also known as glycerol, is a humectant that attracts water to the skin, providing hydration and a protective barrier. This helps to alleviate dryness and maintain skin moisture, making it particularly beneficial for patients with dry skin conditions. Salicylic Acid is a keratolytic agent that causes shedding of the outer layer of skin. It is effective in treating skin conditions that involve scaling or overgrowth of skin cells such as psoriasis, acne, and keratosis pilaris. By promoting exfoliation, it helps to open clogged pores and neutralize bacteria within, preventing pores from clogging up again by constricting pore diameter, and allowing room for new cell growth.

Urea, at a concentration of 25%, acts as a potent keratolytic and hydrating agent. It enhances the skin's capacity to retain moisture while simultaneously softening and dissolving the horny substance (keratin) that holds the top layer of skin cells together. This results in the shedding of scaly skin, softening of the skin, and an increase in skin elasticity. Urea's high concentration makes this cream particularly effective for conditions such as ichthyosis, xerosis, eczema, corns, and calluses, where excessive skin build-up is a concern.

Together, these ingredients provide a multifaceted approach to skin care, addressing dryness, scaling, and hyperkeratosis. The formulation is suitable for patients seeking relief from the symptoms associated with these conditions. It is important for both patients and prescribers to note that while this cream is effective in managing symptoms, it is not a cure for the underlying conditions. Regular use as directed by a healthcare professional is essential for optimal results. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to support you with your dermatological needs.

Drug Interactions

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The formulation of Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream is designed to treat a variety of skin conditions by providing a combination of hydrating, keratolytic, and moisturizing effects. Glycerin is a humectant that draws water into the skin, thereby hydrating it. Salicylic acid is a beta hydroxy acid that works as a keratolytic agent, helping to remove dead skin cells and potentially treating conditions like psoriasis, keratosis pilaris, and acne. Urea is a component of the skin's natural moisturizing factor and is used for its hydrating and keratolytic properties, particularly in the treatment of dry, rough skin, eczema, and ichthyosis.

When considering drug interactions, it is important to note that while the systemic absorption of these ingredients is minimal when applied topically, there is still a potential for interactions, particularly with salicylic acid. Salicylic acid may enhance the absorption of other topically applied medications due to its keratolytic properties, which could potentially increase the effects or side effects of other drugs. Patients should be advised to inform their healthcare provider of all topical treatments they are using to avoid potential interactions.

Additionally, the use of other topical acne medications, such as benzoyl peroxide or retinoids, in conjunction with this formulation may lead to increased skin irritation or dryness. It is advisable to use such combinations with caution and under the guidance of a healthcare provider. Patients using medications that thin the blood, such as warfarin or aspirin, should also be cautious, as salicylic acid can enhance the effects of these drugs, although the risk is more significant with oral rather than topical salicylic acid.

Patients with diabetes or those with impaired circulation should use this formulation with caution, as urea can increase the risk of skin irritation and breakdown, particularly on the feet. It is also important to avoid applying this cream to any open wounds or irritated skin to prevent systemic absorption and potential interactions.

Lastly, while glycerin is generally considered safe and has minimal interaction potential, it is important to maintain proper hydration when using products containing humectants to prevent them from drawing moisture out of the skin in very dry environments.

For any questions or concerns regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy. We are here to provide guidance and support to ensure the safe and effective use of this topical cream.

How Does it Work

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The Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream is a specially compounded formulation designed to provide relief and treatment for a variety of skin conditions, such as psoriasis, keratosis pilaris, eczema, and ichthyosis. This cream combines the hydrating properties of glycerin, the keratolytic action of salicylic acid, and the moisturizing effects of urea to create a potent topical treatment.

Glycerin, also known as glycerol, is a humectant, which means it attracts water to the skin. At a concentration of 10%, glycerin helps to maintain the skin's moisture balance, reducing dryness and promoting a healthy skin barrier. This is particularly beneficial for patients with conditions that cause dry and flaky skin, as it helps to keep the skin hydrated and less prone to irritation.

Salicylic Acid, a beta hydroxy acid, is well-known for its ability to exfoliate the skin by dissolving the 'glue' that holds skin cells together. At a 5% concentration, it effectively removes the outermost layer of dead skin cells, reducing scaling and smoothing the skin's surface. This exfoliation also helps other therapeutic agents penetrate more effectively. Salicylic acid's keratolytic properties make it an excellent choice for treating hyperkeratotic skin disorders, where an overproduction of skin cells leads to thickened, scaly skin.

Urea, at a 25% concentration, serves as a potent keratolytic and hydrating agent. It works by softening the horny substance (keratin) that holds the top layer of skin cells together, which helps the dead skin cells fall off and helps the skin keep more water in, thus softening it. This makes urea an effective treatment for rough, dry skin conditions. Additionally, urea has been shown to enhance the penetration of other medications, making the combination of glycerin, salicylic acid, and urea particularly effective.

The cream is dispensed in a pump mechanism, which allows for a clean, convenient, and controlled application. This delivery system helps to prevent contamination of the product and ensures that the correct dose is applied to the affected area. The semisolid preparation is designed to spread easily and absorb into the skin without leaving a greasy residue, making it suitable for use on various parts of the body.

This formulation is intended for localized treatment and should be used as directed by a healthcare provider. It is important to follow the application instructions provided by the compounding pharmacist to achieve the best results. If you have any questions or concerns about using this topical cream, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with any inquiries you may have regarding the formulation, its use, or its suitability for your specific condition.

Other Uses

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The compounded Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream has been primarily formulated for the treatment of various skin conditions such as keratosis pilaris, psoriasis, and eczema, due to its keratolytic, moisturizing, and hydrating properties. However, its beneficial effects can extend to several other uses. Beyond the treatment of these specific disease states, the cream may also be useful for patients with hyperkeratotic conditions, ichthyosis, calluses, or corns, where excessive skin thickening occurs. The salicylic acid component serves to soften and slough off the top layer of skin cells, while urea provides deep moisturization, and glycerin acts as a humectant, drawing moisture into the skin.

In addition to the above indications, individuals with extremely dry and scaly skin may find symptomatic relief from the intensive moisturizing effect of this formulation. It may also serve as an adjunct therapy for individuals undertaking other dermatological treatments that result in dry skin as a side effect. Its controlled application through a pump mechanism allows for targeted therapy, which can be beneficial for localized plaques or areas of concern.

Furthermore, some healthcare professionals may recommend the off-label use of this formulation for improving skin texture and softness in people with rough, bumpy skin, not specifically diagnosed with a particular skin disorder but who may benefit from the compound's properties. The formulation could also be beneficial for those with aging skin in need of gentle exfoliation and hydration; however, it is vital to use with caution in sensitive areas and under professional guidance, given the potency of salicylic acid and urea.

It is important for both patients and prescribers to note that while this compounded cream has several potential uses, individual responses to treatment may vary, and it should be used under the guidance of a healthcare professional. Inappropriate use or overuse can lead to skin irritation or other undesirable effects. If there is uncertainty about the suitability of this formulation for a particular condition, or if any other questions arise, we encourage reaching out to us at Bayview Pharmacy for further information and personalized advice.

Frequently Asked Questions

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What is the purpose of Glycerin 10%/Salicylic Acid 5%/Urea 25% Topical Cream?

This topical cream is formulated to moisturize the skin, remove excess skin cells, and treat dry, scaly skin conditions. Glycerin acts as a humectant, salicylic acid as a keratolytic, and urea as a hydrator and exfoliant, working together to improve the skin's texture and appearance.

How should I apply the cream to my skin?

Cleanse the area to be treated and pat dry. Press the pump to dispense a small amount of cream, then apply a thin layer over the affected area as directed by your healthcare provider. Use enough to cover the area, but do not overapply.

Can I use this cream on my face?

Be cautious when applying the cream to the face or sensitive areas, and it's best to consult with your healthcare provider for specific instructions, as salicylic acid can cause irritation or dryness on sensitive skin.

How often should I use this compounded cream?

The frequency of use will depend on your specific condition and the advice of your healthcare provider. Generally, it may be applied once or twice daily, but follow your provider's directions for the best results.

What should I do if I miss a dose?

If you miss a dose of the cream, apply it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the application to make up for a missed dose.

Are there any side effects I should be aware of?

Possible side effects may include skin irritation, redness, peeling, or itching. If you experience severe or persistent irritation, discontinue use and contact your healthcare provider for guidance.

Can this cream be used alongside other skincare products?

It's important to discuss the use of additional skincare products with your healthcare provider, as combining this cream with other products, especially those containing exfoliants or other acids, can increase skin irritation.

Should I avoid any activities or exposure to certain things while using the cream?

Avoid excessive sun exposure, tanning booths, and sunlamps when using this product, as it can make your skin more sensitive to sunlight. Use sunscreen and wear protective clothing over the treated areas when outdoors.

How should I store this topical cream?

Store the cream at room temperature, away from direct sunlight and heat. Do not freeze. Keep the container tightly closed when not in use to prevent the cream from drying out.

Is this cream suitable for individuals with sensitive skin?

Due to the presence of salicylic acid, the cream may be too strong for individuals with very sensitive skin. It is advisable to consult your healthcare provider before use and conduct a patch test if there is any concern regarding skin sensitivity.

Can I use this cream while pregnant or breastfeeding?

The safety of this cream during pregnancy or breastfeeding has not been fully established. It's essential to consult with your healthcare provider before using this medication if you are pregnant or breastfeeding.

What should I do in case of an accidental ingestion or contact with the eyes?

If the cream is accidentally ingested, seek immediate medical attention or contact a poison control center. In case of accidental contact with the eyes, rinse thoroughly with water and contact your healthcare provider if irritation persists.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.