Urea is a highly versatile active pharmaceutical ingredient commonly used in dermatological formulations for its keratolytic and moisturizing properties. It is a naturally occurring compound that plays a crucial role in the skin's natural moisturizing factor, helping to maintain skin hydration and integrity. Urea works by breaking down the intercellular matrix, which results in the softening and dissolution of the keratin layer, making it an effective treatment for hyperkeratotic conditions such as psoriasis, eczema, and ichthyosis.

In addition to its keratolytic action, urea also enhances the skin's ability to retain moisture by increasing water uptake in the stratum corneum. This dual action makes it particularly beneficial in formulations aimed at treating dry, rough, and scaly skin. Urea's ability to penetrate the skin barrier allows it to deliver hydration deep into the skin layers, improving skin texture and elasticity. Its use in compounded formulations can be tailored to specific patient needs, offering varying concentrations to address different dermatological conditions.

Urea is well-tolerated by most patients, with minimal risk of irritation or adverse effects, making it a preferred choice for long-term management of chronic skin conditions. It is often combined with other active ingredients to enhance its therapeutic effects, providing a synergistic approach to skin care. The inclusion of urea in compounded formulations allows for customization, ensuring that patients receive a treatment that is specifically designed to meet their unique skin care needs.