Our specially compounded Dimethyl Sulfoxide 15%/Fluconazole 1%/Ibuprofen 2%/Tea Tree Oil 3% Topical Nail Lacquer is a liquid formulation expertly crafted for direct application to the nails. This unique combination of ingredients is designed to address a variety of nail conditions, including fungal infections, brittleness, and discoloration. The lacquer formulation ensures that the active ingredients are delivered in a convenient and efficient manner, directly to the site of infection or damage, promoting healthy nail growth and improving the overall appearance of the nails.

Dimethyl Sulfoxide (DMSO) serves as a penetrating carrier for the other active ingredients, enhancing their absorption into the nail bed and surrounding tissues. Its inclusion at 15% ensures that the antifungal and anti-inflammatory agents are delivered deeply into the affected areas. Fluconazole, at a 1% concentration, is a well-established antifungal agent that works by inhibiting the growth of a wide range of fungi, making it particularly effective against nail fungal infections, also known as onychomycosis. This targeted action helps in restoring the natural structure and color of the nails affected by fungal overgrowth.

Ibuprofen, included at 2%, is a nonsteroidal anti-inflammatory drug (NSAID) that provides relief from pain and inflammation that can accompany nail infections or trauma. Its analgesic properties can be particularly beneficial for those suffering from discomfort due to nail conditions. Tea Tree Oil, present at 3%, is a natural essential oil known for its antiseptic, antifungal, and antimicrobial properties. It complements the action of fluconazole by providing an additional layer of defense against fungal pathogens and contributes to the overall health of the nail and surrounding skin.

This topical nail lacquer is intended for use under the guidance of a healthcare professional. Patients should apply the lacquer as directed, typically once or twice daily, to clean, dry nails. Consistent use as prescribed is crucial for the effectiveness of the treatment. The formulation is contraindicated in patients with known hypersensitivity to any of the ingredients. Side effects may include local irritation or allergic reactions, and patients should be advised to monitor for these and report any adverse events to their healthcare provider.

For prescribers, this formulation offers a multifaceted approach to nail care, combining antifungal, anti-inflammatory, and antiseptic properties. It is important to consider the patient's medical history, including any allergies or contraindications, before prescribing this nail lacquer. Monitoring the patient's progress throughout the treatment course is recommended to ensure efficacy and safety.

If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to both patients and healthcare providers.

The formulation combines Dimethyl Sulfoxide (DMSO), Fluconazole, Ibuprofen, and Tea Tree Oil into a topical nail lacquer designed to treat various nail conditions, including fungal infections, brittleness, and discoloration. DMSO serves as a penetration enhancer, increasing the absorption of the other active ingredients into the nail bed. Fluconazole is an antifungal agent that works by inhibiting the growth of fungal cells, making it effective against nail fungus. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can help reduce inflammation and pain associated with nail infections or trauma. Tea Tree Oil is known for its antiseptic, antifungal, and anti-inflammatory properties, which can contribute to the overall health of the nails.

When considering drug interactions, it is important to note that while this formulation is intended for topical use, systemic absorption of the ingredients may still occur. DMSO can enhance the absorption of other topical medications applied to the same area, potentially increasing their effects and risk of systemic side effects. Patients should avoid using other topical treatments on the nails unless advised by a healthcare provider. Fluconazole, even when used topically, may interact with systemic medications metabolized by the cytochrome P450 enzyme system, particularly CYP2C9 and CYP3A4. Caution is advised when patients are taking drugs such as warfarin, certain antidiabetic medications, and other antifungals.

Ibuprofen, although used topically in this formulation, may still pose a risk of systemic NSAID-related side effects, especially if used concomitantly with oral NSAIDs or other drugs that increase the risk of bleeding, such as anticoagulants and antiplatelet agents. Patients with a history of gastrointestinal ulcers or bleeding, or those taking high doses of other NSAIDs, should use this medication with caution. Tea Tree Oil is generally considered safe for topical use, but it may cause skin irritation or allergic reactions in some individuals. It should be used cautiously in patients with a history of skin sensitivity or allergic reactions to topical products.

Overall, while the risk of systemic drug interactions with this topical formulation is lower than with oral medications, it is still present. Patients should be advised to inform their healthcare providers of all medications and supplements they are taking, including over-the-counter products. Prescribers should evaluate the patient's medication profile for potential interactions and contraindications before recommending this nail lacquer. If you have any questions or require further information regarding this formulation and its potential interactions, please reach out to us at Bayview Pharmacy for assistance.

The Dimethyl Sulfoxide 15%/Fluconazole 1%/Ibuprofen 2%/Tea Tree Oil 3% Topical Nail Lacquer is a multi-component formulation designed to address various nail conditions, including fungal infections, inflammation, pain, and other related symptoms. Each component of the formulation plays a specific role in treating these conditions.

Dimethyl Sulfoxide (DMSO) is a solvent that has the ability to penetrate the nail plate and enhance the delivery of other active ingredients into the nail bed. At a concentration of 15%, DMSO acts as a carrier for the other components in the formulation, increasing their bioavailability and effectiveness. Additionally, DMSO has anti-inflammatory properties that can help reduce swelling and discomfort associated with nail infections and trauma.

Fluconazole, present at 1%, is an antifungal agent that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. By disrupting the cell membrane, fluconazole effectively kills the fungal cells, thereby treating the infection. Its inclusion in the nail lacquer targets the fungal pathogens directly at the site of infection, which is particularly useful for onychomycosis (fungal nail infections).

Ibuprofen, at a 2% concentration, is a nonsteroidal anti-inflammatory drug (NSAID) that provides analgesic and anti-inflammatory effects. When applied topically, ibuprofen can help alleviate pain and reduce inflammation directly in the affected nail area, improving patient comfort and potentially accelerating healing.

Tea Tree Oil, included at 3%, is a natural essential oil known for its antiseptic, antifungal, and anti-inflammatory properties. It complements the action of fluconazole by providing an additional mechanism to combat fungal pathogens. Tea Tree Oil also contributes to the overall health of the nail by promoting a healthier nail environment, which can prevent future infections and support nail recovery.

This topical nail lacquer formulation is specifically designed for ease of use and targeted application. Patients are advised to apply the lacquer directly to the affected nails, typically once or twice daily, as directed by a healthcare provider. The lacquer dries quickly and forms a protective layer over the nail, allowing for sustained release of the active ingredients. By combining these four components, the formulation provides a comprehensive approach to treating and managing nail conditions, offering antifungal, anti-inflammatory, analgesic, and antiseptic benefits.

For optimal results, patients should follow the application instructions provided by their healthcare provider and use the nail lacquer consistently as part of their treatment regimen. If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to support both patients and prescribers with any inquiries or guidance needed for effective treatment.

While the primary function of this Dimethyl Sulfoxide 15%/Fluconazole 1%/Ibuprofen 2%/Tea Tree Oil 3% Topical Nail Lacquer is to treat nail conditions such as fungal infections (onychomycosis), brittleness, and discoloration, the unique composition of this lacquer allows for potential use in off-label applications under the direction of a healthcare professional. The antifungal property of Fluconazole, combined with the anti-inflammatory effects of Ibuprofen and the natural antiseptic qualities of Tea Tree Oil, makes this formulation potentially beneficial for a variety of dermatological conditions affecting the skin around the nails, such as paronychia (inflammation of the skin around the nail) or athlete's foot where nail involvement is a concern.

Furthermore, Dimethyl Sulfoxide (DMSO) is known for its ability to penetrate biological membranes, which may enhance the delivery of active ingredients. This property could potentially be useful in facilitating the deeper penetration of antifungal and anti-inflammatory agents in conditions where increased skin or nail bed permeability is desired. However, these additional uses are not typically recommended without adequate consultation and the discretion of a healthcare provider, as the specific formulation has been optimized for nail application.

In addition, patients or prescribers may be curious about the keratolytic potential of this nail lacquer, given DMSO's characteristics. Although not its primary function, the formulation might aid in softening the thickened nails often seen in fungal infections, thus possibly improving the appearance and texture of the affected nails over time. It is important to note that any other uses beyond the indicated treatments should be approached with caution, and only under the guidance of a qualified healthcare professional.

It is crucial for both patients and prescribers to understand that while the combination of these ingredients may have synergistic effects for on-label uses, any additional benefits from off-label uses remain speculative and should be explored with a thorough understanding of the potential risks and benefits. We encourage an open dialogue between patients and their healthcare providers before using this formulation for any non-indicated purposes.

If you have any questions regarding this topical nail lacquer formulation or would like to discuss potential other uses of the product in more detail, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide support and guidance tailored to individual patient needs and unique clinical situations.