Dimethyl Sulfoxide (DMSO) 10%/Ketoprofen 10%/Lidocaine 10% Topical Gel is a compounded medication designed for topical application to provide pain relief and reduce inflammation. The semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise dosing. The gel consistency ensures that the medication is spread evenly over the affected area, promoting better absorption of the active ingredients through the skin.

DMSO is a solvent that has the ability to penetrate the skin and other biological membranes, which can enhance the absorption of the other active ingredients in the formulation. It also has anti-inflammatory and analgesic properties, which contribute to the overall effectiveness of the medication. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzymes responsible for producing prostaglandins, which are compounds that cause pain, swelling, and inflammation. By reducing the levels of prostaglandins, ketoprofen helps to alleviate pain and reduce inflammation in the affected area.

Lidocaine is a local anesthetic that provides temporary relief of pain by blocking the nerve signals in the body. When applied topically, lidocaine can help to numb the treated area, providing relief from pain associated with conditions such as arthritis, strains, sprains, and other musculoskeletal disorders. The combination of these three active ingredients in a 10% concentration each allows for a multi-modal approach to pain management and inflammation reduction, targeting different pathways involved in pain perception and inflammatory response.

This compounded medication is particularly useful for patients who require targeted, localized treatment for pain and inflammation, and who may benefit from the synergistic effects of the combined active ingredients. It is important for both patients and prescribers to be aware that this formulation should be used as directed, and it is essential to follow the specific dosing instructions provided by the compounding pharmacist. As with any medication, there may be potential side effects, and it is important to monitor for any adverse reactions.

For more detailed information on the use of this compounded formulation, including potential contraindications, drug interactions, and specific dosing recommendations, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide guidance to ensure safe and effective treatment for our patients.

The combination of Dimethyl Sulfoxide (DMSO), Ketoprofen, and Lidocaine in a topical gel formulation is designed to provide pain relief and reduce inflammation directly at the site of application. DMSO is a solvent that can enhance the absorption of other drugs, such as Ketoprofen, an NSAID with anti-inflammatory and analgesic properties, and Lidocaine, a local anesthetic that provides temporary relief of pain by blocking nerve signals. This formulation is commonly used for conditions such as musculoskeletal pain, strains, sprains, and arthritis.

When considering drug interactions, it is important to note that while the systemic absorption of Ketoprofen and Lidocaine is lower with topical administration compared to oral forms, interactions can still occur. DMSO can potentiate the effects of other substances applied to the skin due to its solvent properties, which may increase the risk of adverse effects. Patients should avoid using other topical medications in the same area without consulting a healthcare provider.

Ketoprofen, being an NSAID, may interact with anticoagulants such as warfarin, increasing the risk of bleeding. Caution is advised when using this formulation in patients taking anticoagulants, and monitoring for signs of bleeding is recommended. Additionally, concurrent use with other NSAIDs, including over-the-counter aspirin or ibuprofen, should be avoided to reduce the risk of additive side effects such as gastrointestinal irritation or renal impairment.

Lidocaine may interact with antiarrhythmic drugs, such as mexiletine, due to additive effects on cardiac conduction. Patients with cardiac conditions should use this formulation with caution and under the supervision of a healthcare provider. Furthermore, the use of other local anesthetics concurrently with this formulation may increase the risk of systemic toxicity, and such combinations should be avoided.

Patients with a history of allergic reactions to NSAIDs or local anesthetics should not use this formulation. Additionally, the use of this gel in patients with severe hepatic or renal impairment may require additional caution and monitoring due to the potential for systemic absorption of the active ingredients.

It is also important to consider the potential for DMSO to affect the materials used in the pump mechanism of the dispensing container. Certain plastics or rubbers may dissolve or degrade in the presence of DMSO, which could compromise the integrity of the packaging and potentially alter the formulation. Therefore, the compatibility of the container with DMSO should be confirmed.

As with any medication, it is essential to use this formulation as directed by a healthcare provider. Patients should inform their healthcare provider of all medications they are currently taking, including prescription, over-the-counter, and herbal products, to avoid potential interactions. If you have any questions or concerns regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

The Dimethyl Sulfoxide (DMSO) 10%/Ketoprofen 10%/Lidocaine 10% Topical Gel is a compounded medication designed to deliver its active ingredients directly to the site of pain or inflammation through the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays where it is applied and facilitates absorption into the skin.

DMSO is a solvent that has the unique ability to penetrate the skin and other biological membranes. When used in a topical formulation, DMSO can carry other active ingredients through the skin and into deeper tissues. In this gel, DMSO serves as a carrier for ketoprofen and lidocaine, enhancing their penetration and increasing their therapeutic effects at the site of application. DMSO itself also has anti-inflammatory and analgesic properties, which contribute to the overall effectiveness of the formulation.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). These enzymes are involved in the production of prostaglandins, which are compounds that mediate inflammation, pain, and fever. By reducing the production of prostaglandins, ketoprofen effectively decreases inflammation and pain in the affected area.

Lidocaine is a local anesthetic that provides rapid and effective pain relief by blocking the sodium channels in nerve cells, which are necessary for the initiation and conduction of nerve impulses. When applied topically, lidocaine can reduce the sensation of pain in the area of application without affecting consciousness or causing a loss of sensation elsewhere in the body.

This combination of DMSO, ketoprofen, and lidocaine in a topical gel form is particularly useful for treating localized musculoskeletal conditions such as sprains, strains, and arthritis. The anti-inflammatory action of ketoprofen, coupled with the analgesic effects of DMSO and lidocaine, can provide significant relief from pain and swelling. The gel formulation allows for targeted therapy, which is beneficial for patients who require localized treatment or those who may experience gastrointestinal side effects from systemic NSAIDs.

It is important for both patients and prescribers to understand that this is a specially compounded medication and should be used under the guidance of a healthcare professional. The precise dosing and application instructions will vary based on the individual needs of the patient and the specific condition being treated. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide support and guidance to ensure the safe and effective use of this medication.

Aside from its primary indications, the compounding formulation of Dimethyl Sulfoxide (DMSO) 10%, Ketoprofen 10%, and Lidocaine 10% Topical Gel may exhibit a range of alternative uses due to the unique properties and synergistic effects of its constituent medications. DMSO, a solvent with anti-inflammatory and analgesic properties, can also function as a penetrant enhancer for the other active ingredients, helping them to more effectively reach the underlying tissues. For patients with localized areas of deep-seated pain not specified in the primary indications, such as certain neuropathies or musculoskeletal problems, this formulation could provide off-label symptom relief.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. While typically employed for conditions like arthritis or tendonitis, its inclusion in this topical gel may also help soften the discomfort and inflammation related to other soft tissue injuries, bursitis, or even complex pain syndromes that have an inflammatory component. It is important, however, to consider the overall NSAID exposure to the patient, particularly in those with conditions that caution systemic use, such as renal impairment or a history of ulcers.

Lidocaine, a local anesthetic, can provide temporary relief of pain by blocking nerve signals. In this formulation, it may be particularly beneficial for patients experiencing surface or localized pain of neuropathic origin or post-herpetic neuralgia. Moreover, lidocaine's inclusion could provide procedural pain relief during minor dermal procedures, such as needle insertions, by applying the gel beforehand.

This compounded formulation, with its convenience of application through a pump mechanism, might also see use in sports medicine for localized treatment of specific muscle or joint pain experienced by athletes during or after their activities. Anecdotal evidence might suggest possible applications in the management of certain dermatological conditions where pain and inflammation are prominent symptoms, though such uses should always be explored in consultation with healthcare providers.

Additionally, considering the compounded nature of this gel, prescribers may find it valuable for patients who have struggled with the side effects or inadequate relief from commercially available medication combinations. It's worth mentioning that while the potential uses of this formulation expand beyond the mentioned disease states, the safety and effectiveness for off-label uses should be assessed on a case-by-case basis. Healthcare providers should also monitor for possible adverse effects, such as skin irritation or systemic absorption issues, particularly with long-term or widespread use.

For healthcare providers interested in this formulation for alternative applications, or patients seeking further information on the potential benefits and risks, we encourage direct consultation with us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is available to discuss tailored treatment options and provide guidance to ensure safe and effective use of this versatile compounded medication.