Our custom-compounded transdermal gel combines Diclofenac Sodium, Dimethyl Sulfoxide (DMSO), Indomethacin, and Lidocaine in a unique formulation designed to provide targeted relief from pain and inflammation. Diclofenac Sodium and Indomethacin are both nonsteroidal anti-inflammatory drugs (NSAIDs) that work by inhibiting the enzymes responsible for producing prostaglandins, which are mediators of inflammation. By reducing the production of these inflammatory chemicals, these NSAIDs effectively alleviate pain and swelling associated with various disease states, including osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders.

Dimethyl Sulfoxide is included in the formulation for its ability to enhance the absorption of other drugs through the skin, making it an excellent carrier for the NSAIDs in the gel. DMSO also has anti-inflammatory and analgesic properties, which may contribute to the overall efficacy of the formulation. Lidocaine, a local anesthetic, provides immediate and temporary relief from pain by blocking the transmission of pain signals along the nerves.

The transdermal gel is designed to be applied topically, allowing for direct action at the site of pain and inflammation with reduced systemic exposure and potential side effects compared to oral medications. The semisolid formulation is dispensed through a pump mechanism, which ensures easy and precise dosing. The gel consistency allows for smooth application and rapid absorption into the skin, providing patients with a convenient and non-invasive treatment option.

This compounded medication is particularly useful for patients who may have contraindications to oral NSAIDs or those who prefer a topical treatment approach. It is important to note that while this formulation can provide significant relief from symptoms, it should be used under the guidance of a healthcare professional who can evaluate the appropriateness of the treatment based on the patient's specific medical history and condition.

For patients and prescribers interested in using this transdermal gel formulation, it is essential to understand the potential interactions and contraindications associated with each active ingredient. Regular monitoring and follow-up are recommended to assess the effectiveness of the treatment and to make any necessary adjustments. If you have any questions or require further information about this custom-compounded medication, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to ensure the safe and effective use of our formulations.

The transdermal gel formulation containing Diclofenac Sodium 6%, Dimethyl Sulfoxide (DMSO) 5%, Indomethacin 6%, and Lidocaine 6% is designed for topical application and may offer localized relief from pain and inflammation. However, it is important to consider potential drug interactions when using this combination therapy, especially for patients who are on other medications or have underlying health conditions.

Diclofenac and Indomethacin are both nonsteroidal anti-inflammatory drugs (NSAIDs) and, when used together, may increase the risk of gastrointestinal irritation or ulceration. Caution is advised, and concurrent use with other systemic NSAIDs or corticosteroids should be avoided or closely monitored. Additionally, NSAIDs can potentially interact with anticoagulants such as warfarin, increasing the risk of bleeding. Patients on anticoagulant therapy should be closely supervised, and appropriate laboratory tests should be conducted to ensure safety.

Dimethyl Sulfoxide (DMSO) can enhance the absorption of other compounds through the skin, potentially altering the effects of other topically applied medications. It is important to ensure that the application site is free from any other substances unless directed by a healthcare provider. DMSO may also interact with certain medications by changing their pharmacokinetic profile, although the extent of this interaction when used in a topical formulation is less clear.

Lidocaine, a local anesthetic, may interact with antiarrhythmic drugs such as mexiletine or amiodarone, potentially leading to additive cardiac effects. Caution is advised when using this formulation in patients with pre-existing cardiac conditions or those taking cardiac medications. Additionally, the use of other local anesthetics or medications that affect cardiac conduction should be approached with caution to avoid excessive systemic absorption and toxicity.

It is also important to consider the potential for hepatic and renal impairment with the use of NSAIDs, including Diclofenac and Indomethacin. Patients with existing liver or kidney disease should use this formulation with caution, and renal function should be monitored during prolonged use.

Patients should be advised to avoid applying the gel to broken or irritated skin, as this may increase systemic absorption of the active ingredients. Furthermore, the use of occlusive dressings over the application site should be avoided unless directed by a healthcare provider, as this may also increase systemic absorption and the potential for adverse effects.

As with any medication, it is essential to inform healthcare providers of all prescription, over-the-counter medications, and dietary supplements that are being used to avoid potential interactions. If you have any questions or concerns regarding the use of this transdermal gel formulation or its potential interactions with other medications, please reach out to us at Bayview Pharmacy for further assistance.

The transdermal gel formulation containing Diclofenac Sodium 6%, Dimethyl Sulfoxide (DMSO) 5%, Indomethacin 6%, and Lidocaine 6% is designed to deliver active pharmaceutical ingredients through the skin directly to the site of pain and inflammation. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays in place and facilitates absorption through the skin.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. By reducing the production of these inflammatory mediators, Diclofenac Sodium helps to alleviate pain and reduce inflammation in the affected area. Indomethacin, another NSAID in the formulation, works similarly by inhibiting COX enzymes and has potent anti-inflammatory, analgesic, and antipyretic properties.

Dimethyl Sulfoxide (DMSO) is included for its ability to enhance the penetration of other drugs through the skin, increasing their bioavailability at the site of application. DMSO also has anti-inflammatory and analgesic properties, which contribute to the overall effectiveness of the formulation. Lidocaine, a local anesthetic, provides immediate relief from pain by blocking sodium channels and thus inhibiting the generation and conduction of nerve impulses. This results in a numbing sensation at the site of application, offering symptomatic relief from pain.

This combination of active ingredients is particularly useful in treating localized musculoskeletal conditions such as sprains, strains, arthritis, and other inflammatory disorders. By delivering the medication directly to the site of pain and inflammation, systemic side effects are minimized, and rapid relief can be achieved. The transdermal route of administration also allows for sustained release of the medication, providing longer-lasting effects compared to traditional oral dosing.

Patients and prescribers should be aware that this formulation is intended for external use only and should be applied to intact skin. It is important to follow the prescribed dosing instructions and not to use this medication on open wounds or damaged skin. As with any medication, there may be potential side effects, and it is important to monitor for any adverse reactions. If you have any questions or concerns regarding this formulation or its use in treating specific disease states, please reach out to us at Bayview Pharmacy for further assistance.

While the primary indication for our Diclofenac Sodium 6%/Dimethyl Sulfoxide 5%/Indomethacin 6%/Lidocaine 6% Transdermal Gel is for the treatment of localized pain, inflammation, and arthritis-like symptoms, the unique combination of active ingredients allows for a range of other potential uses. The anti-inflammatory properties of both diclofenac and indomethacin can be beneficial in conditions involving soft tissue inflammation, such as tendinitis and bursitis. Furthermore, the Lidocaine component offers local anesthetic effects which can be helpful for numbing painful areas during minor surgical procedures or after injuries. Dimethyl sulfoxide (DMSO) not only serves as a penetrating enhancer for the other active ingredients, allowing them to deeply infiltrate the affected tissues, but it also exhibits analgesic and anti-inflammatory effects on its own.

Additionally, there is anecdotal evidence to suggest that our transdermal gel might assist in the management of certain neuropathic pain conditions where inflammation contributes to nerve pain. This makes the product a potential option for patients suffering from painful diabetic neuropathy or post-herpetic neuralgia, although these applications fall outside the most common use. Moreover, Lidocaine’s presence in the formulation could provide symptomatic relief from itching and burning sensations associated with certain skin conditions, given its local anesthetic action.

However, it is essential to exercise caution when applying this formulation for off-label uses. Each component carries its own risk profile and the combination product has not been extensively studied for all possible applications. Physicians should weigh the potential benefits against the risks, especially considering the systemic absorption of the medications involved. It's also important that patients consult with their healthcare provider to determine if this transdermal gel is appropriate for their specific condition, and to ensure it is used safely and effectively. Additionally, all users should be aware of the potential for skin irritation related to the DMSO component.

As with any medication, it's crucial to follow the prescribed directions for use, and to be alert for any adverse reactions, particularly when considering 'other uses' not commonly associated with the standard indications of a formulation. If you have questions regarding this product or its potential applications, we encourage both patients and prescribers to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists can provide additional information tailored to individual needs, ensuring safe and proper use of our medications.