The Diclofenac Sodium 6%/DMSO 5%/Ibuprofen 6%/Lidocaine 2% Topical Ultrasound Gel is a multi-component formulation designed to serve dual purposes: as a conductive medium for ultrasound procedures and as a topical analgesic treatment. This unique gel is either clear or tinted and possesses a consistency that ensures effective transmission of ultrasound waves by minimizing air pockets between the transducer and the skin. This characteristic is crucial for obtaining high-quality images and for the effective delivery of therapeutic ultrasound waves.

The therapeutic components of the gel include Diclofenac Sodium and Ibuprofen, both nonsteroidal anti-inflammatory drugs (NSAIDs) that work by inhibiting cyclooxygenase (COX) enzymes, which play a key role in the formation of prostaglandins involved in pain, inflammation, and fever. The 6% concentration of each NSAID in the gel allows for localized anti-inflammatory and analgesic effects. DMSO (Dimethyl Sulfoxide) at 5% serves as a penetrating enhancer, increasing the absorption of the active drugs through the skin, thereby enhancing their local effects without significant systemic absorption. Additionally, DMSO has its own analgesic and anti-inflammatory properties, which may contribute to the overall efficacy of the formulation.

Lidocaine, a local anesthetic, is included at a 2% concentration to provide rapid and temporary relief from pain by blocking the transmission of pain signals along the nerves. This can be particularly beneficial in reducing discomfort during and after the application of therapeutic ultrasound or during diagnostic procedures.

This topical ultrasound gel is indicated for patients who require ultrasound diagnostic or therapeutic procedures and who may also benefit from the localized relief of pain and inflammation. Conditions that may be treated with this formulation include but are not limited to musculoskeletal injuries such as sprains, strains, and tendinitis, as well as osteoarthritis and other sources of acute or chronic pain and inflammation. The gel is applied to the skin in the area of interest prior to the use of the ultrasound transducer.

It is important for both patients and prescribers to be aware of the potential for allergic reactions or sensitivities to any of the components in the gel. Additionally, the use of NSAIDs on the skin can still carry risks similar to oral NSAIDs, such as gastrointestinal disturbances, though the risk is generally lower due to the localized application. Patients with a history of NSAID hypersensitivity, asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs should not use this product. Concurrent use with other NSAIDs or medications that increase bleeding risk should be approached with caution.

For optimal results, the specific application protocol, including the amount of gel to be used and the duration of treatment, should be determined by a healthcare professional based on the individual patient's condition and response to therapy. As with any medication, adherence to recommended usage is crucial for effectiveness and safety.

If you have any questions or require further information about the Diclofenac Sodium 6%/DMSO 5%/Ibuprofen 6%/Lidocaine 2% Topical Ultrasound Gel, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing comprehensive support and guidance to ensure the safe and effective use of this specialized formulation.

The topical ultrasound gel formulation containing Diclofenac Sodium 6%, DMSO 5%, Ibuprofen 6%, and Lidocaine 2% is designed to provide anti-inflammatory and analgesic effects, primarily for the treatment of localized pain and inflammation. Diclofenac and Ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that work by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. Lidocaine is a local anesthetic that provides temporary relief of pain by blocking nerve signals. DMSO enhances the penetration of the other active ingredients into the skin, potentially increasing their therapeutic effects.

When using this topical formulation, it is important to consider potential drug interactions, especially if the patient is taking other medications systemically. NSAIDs such as Diclofenac and Ibuprofen can interact with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin, clopidogrel), selective serotonin reuptake inhibitors (SSRIs), and other medications that increase the risk of bleeding. Although the systemic absorption of NSAIDs from topical formulations is lower than from oral forms, the risk of bleeding may still be increased, particularly in patients with compromised skin barriers or when applied over large areas of the body.

Concomitant use of other NSAIDs or corticosteroids, either topically or systemically, may increase the risk of adverse effects, including gastrointestinal ulceration and renal impairment. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements.

Lidocaine applied topically can interact with other local anesthetics or medications that affect cardiac conduction, such as antiarrhythmic drugs. Caution is advised when using this formulation in patients with pre-existing cardiac conditions, and the total dose of lidocaine should be monitored to avoid systemic toxicity.

DMSO can enhance the absorption of other substances through the skin, which may lead to increased systemic exposure and potential toxicity of concomitantly applied topical medications. It is also known to interact with certain prescription drugs, such as anticoagulants, insulin, and corticosteroids, potentially altering their effects. Patients should be advised to discuss the use of any other topical products with their healthcare provider before using this formulation.

It is essential for patients to use this product under the guidance of a healthcare professional and to report any unusual symptoms or side effects immediately. Prescribers should evaluate the patient's complete medication profile to assess the potential for drug interactions and adjust therapy as needed. If you have any questions or require further information regarding this formulation and its use, please reach out to us at Bayview Pharmacy.

The formulation of Diclofenac Sodium 6%/DMSO 5%/Ibuprofen 6%/Lidocaine 2% Topical Ultrasound Gel is a multi-component medication designed to provide both diagnostic and therapeutic benefits when used in conjunction with ultrasound procedures. This gel is a clear or tinted viscous substance that serves as a coupling medium to enhance the transmission of ultrasonic waves from the transducer to the patient's skin, ensuring clear imaging and effective delivery of therapeutic ultrasound.

Diclofenac Sodium and Ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs) that work by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain. By reducing their production, these NSAIDs effectively alleviate inflammation and provide analgesic effects. The inclusion of both agents in the gel allows for a potent anti-inflammatory response, which can be beneficial in treating conditions such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders.

DMSO, or dimethyl sulfoxide, is a compound with anti-inflammatory properties and the ability to penetrate the skin and other biological membranes. When used topically, DMSO can enhance the absorption of other drugs, such as Diclofenac Sodium and Ibuprofen, into the tissues, potentially increasing their efficacy. Additionally, DMSO has analgesic properties and may reduce pain by blocking peripheral nerve C fibers.

Lidocaine is a local anesthetic that works by blocking sodium channels, which are necessary for the initiation and conduction of nerve impulses. When applied topically, Lidocaine can provide rapid and localized pain relief by numbing the treated area. This can be particularly useful in reducing discomfort during and after the application of therapeutic ultrasound or during diagnostic procedures.

The combination of these four active ingredients in a gel base allows for the simultaneous delivery of anti-inflammatory, analgesic, and anesthetic effects directly to the site of pain or inflammation. This can be especially beneficial for patients with localized musculoskeletal pain or injuries. The gel formulation is designed to be compatible with ultrasound equipment, ensuring that it does not damage the transducer or interfere with the quality of the ultrasound image or therapy.

It is important for both patients and prescribers to understand that while this formulation can provide symptomatic relief and support the therapeutic effects of ultrasound, it is not a cure for underlying conditions. Patients should be advised on the appropriate use of the gel, including the amount to apply and the frequency of use, as well as potential side effects and contraindications. Prescribers should consider the patient's overall medical history, including any allergies or sensitivities to the components of the gel, before recommending its use.

If you have any questions or require further information about this formulation and its use in specific disease states, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need to ensure the safe and effective use of this medication.

This particular formulation, combining Diclofenac Sodium, DMSO, Ibuprofen, and Lidocaine, serves primarily as a powerful anti-inflammatory and analgesic topical gel. While its main use alongside ultrasound procedures is to enhance the transmission of ultrasound waves, the ingredients in this gel provide additional therapeutic benefits. For instance, the anti-inflammatory properties of Diclofenac Sodium and Ibuprofen may also assist with the reduction of localized inflammation in soft tissue injuries or conditions such as tendonitis, arthritis, or bursitis. The incorporation of DMSO enhances skin penetration, allowing the other active agents to reach deeper tissue layers more effectively, potentially offering symptomatic relief in deeper musculoskeletal issues.

Lidocaine, as a local anesthetic, can provide temporary relief of pain due to minor sports injuries or overuse syndromes by numbing the affected area. Additionally, the formulation might also be applied in the management of neuropathic pain, where conventional treatment options have been insufficient. It's vital for patients and prescribers to know that while there may be off-label uses due to the components' properties, the primary objective of this combination is to support ultrasound procedures. If there is interest in utilizing this formulation for other indications, we advise a thorough assessment of the patient’s condition and a consideration of the potential benefits against any risks. Our pharmacy team at Bayview Pharmacy is readily available for consultations and can answer any questions regarding the appropriate use of this unique topical ultrasound gel formulation.

Use of this formulation for purposes other than enhancing ultrasound transmission should be approached with caution, and under the guidance of a healthcare provider. It is important to obtain a detailed medical history, including any known allergies, current medications, and pre-existing conditions, prior to usage to avoid potential contraindications or interactions. If you have any questions or require further information regarding this formulation and its potential uses, please do not hesitate to reach out to us at Bayview Pharmacy for professional advice and personalized care.