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Clotrimazole 10%/Urea 20% Topical Ointment

The Clotrimazole 10%/Urea 20% Topical Ointment is a semi-solid formulation dispensed in a tube, specifically designed for external application to the skin. This ointment provides a greasy or oily base that aids in the delivery of the active ingredients, clotrimazole and urea, for localized treatment.

Clotrimazole is an antifungal medication that treats skin infections caused by fungus, while urea is a keratolytic agent that helps to soften and remove rough, scaly skin. The combination of these two ingredients makes this formulation effective in treating a variety of disease states, including skin inflammation, fungal skin infections, and conditions that require wound healing.

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Topical Ointment
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Formula Information

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This formulation combines Clotrimazole 10% and Urea 20% in a topical ointment designed for external application to the skin. The semi-solid formulation is dispensed in a tube and provides a greasy or oily base that aids in the delivery of the medication or therapeutic agents for localized treatment. This formulation is typically used for conditions such as skin inflammation, infections, or wound healing.

Clotrimazole is an antifungal medication that works by stopping the growth of fungus. It is used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections (candidiasis). This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs.

Urea is used to treat dry/rough skin conditions (e.g., eczema, psoriasis, corns, callus) and some nail problems (e.g., ingrown nails). It can also be used to help remove dead tissue in some wounds to help wound healing. Urea is known as a keratolytic. It increases moisture in the skin by softening/dissolving the horny substance (keratin) holding the top layer of skin cells together. This effect helps the dead skin cells fall off and helps the skin keep more water in, leading to softer skin and faster healing.

Together, Clotrimazole and Urea in this formulation work synergistically to treat fungal skin infections while promoting skin healing and softening. The greasy or oily base of the ointment aids in the delivery of these therapeutic agents, ensuring they are effectively absorbed into the skin for localized treatment.

It is important for patients and prescribers to understand that while this formulation can be highly effective, it should be used as directed, typically applied to the affected area(s) once or twice daily or as directed by your doctor. The duration of treatment depends on the type of infection being treated. It is also crucial to continue using this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow the fungus to continue to grow, which may result in a return of the infection.

If you have any questions about this formulation, its uses, or its application, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to assist you.

Drug Interactions

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Clotrimazole 10%/Urea 20% Topical Ointment is a combination medication used to treat various skin conditions. Clotrimazole is an antifungal medication that works by stopping the growth of fungus, while Urea is a keratolytic that works by increasing the moisture in the skin and breaking down dead skin cells. This combination is typically used to treat conditions such as skin inflammation, infections, or wound healing.

While Clotrimazole/Urea Topical Ointment is generally safe for use, it's important to be aware of potential drug interactions. Clotrimazole may interact with other topical medications, particularly those that also have antifungal properties. Using multiple antifungal treatments concurrently may increase the risk of side effects and reduce the effectiveness of the medications. Therefore, it's important to inform your healthcare provider of all the products you use, including prescription drugs, nonprescription drugs, and herbal products, before starting treatment with this medication.

Urea, on the other hand, may interact with certain medications that are designed to increase skin exfoliation, such as retinoids, alpha hydroxy acids, and salicylic acid. Using these medications together with Urea may increase the risk of skin irritation. Therefore, it's important to inform your healthcare provider if you are using any products that contain these ingredients.

Furthermore, this medication should not be used on broken or infected skin unless directed by a healthcare provider, as it may worsen the condition or lead to unwanted side effects. It's also important to avoid getting this medication in your eyes, nose, or mouth. If this happens, rinse thoroughly with water.

As with any medication, it's important to use Clotrimazole/Urea Topical Ointment as directed by your healthcare provider. Do not use more of this medication, use it more often, or use it for a longer time than prescribed. Your condition will not improve faster, and your risk of side effects may increase.

If you have any questions about Clotrimazole/Urea Topical Ointment, its uses, or potential drug interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

How Does it Work

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The Clotrimazole 10%/Urea 20% Topical Ointment is a semi-solid formulation designed for external application to the skin. It is dispensed in a tube and provides a greasy or oily base that aids in the delivery of medication or therapeutic agents for localized treatment. This formulation is typically used for conditions such as skin inflammation, infections, or wound healing.

Clotrimazole, the first active ingredient in this formulation, is an antifungal medication that works by inhibiting the growth of fungus. It does this by interfering with the production of the fungal cell membrane. The cell membrane of a fungus is crucial for its survival, as it prevents the cell from losing essential components and protects it against the external environment. By disrupting the production of the cell membrane, clotrimazole causes the fungal cells to leak and die, thereby treating the infection.

The second active ingredient, Urea, is a keratolytic agent. Keratolytics work by softening and breaking down the outermost layer of the skin, known as the stratum corneum. This allows for the shedding of scaly skin, promotes the healing of the skin underneath, and improves the penetration of the clotrimazole into the skin. Urea also has humectant properties, meaning it can attract and retain moisture in the skin, which helps to hydrate and soften the skin, reducing itching and flaking.

Together, these two ingredients work synergistically to treat skin conditions. The Urea softens and hydrates the skin, allowing the Clotrimazole to penetrate more effectively and treat the underlying fungal infection. This formulation is particularly useful for conditions where the skin is thickened or scaly, as the Urea can help to break down this barrier and allow the Clotrimazole to reach the site of infection.

It's important to note that while this formulation can be very effective, it should only be used under the guidance of a healthcare professional. Overuse or misuse can lead to skin irritation or other side effects. If you have any questions about this formulation, or if you're unsure whether it's right for you, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

Other Uses

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Clotrimazole 10%/Urea 20% Topical Ointment is primarily prescribed for treating skin conditions such as fungal infections, dermatitis, and other inflammatory skin diseases. However, it has additional applications which can be beneficial in a range of other circumstances. Patients experiencing psoriasis, a condition characterized by an accelerated skin cell life cycle causing red patches and scales, may find relief by application of this formulation, as its urea component acts as a keratolytic, helping to soften and shed the excessive skin. Clotrimazole, with its strong anti-fungal properties, may also help alleviate symptoms of other fungal diseases such as tinea infections (jock itch, athlete's foot, and ringworm).

This compound can also be used to treat hyperkeratotic conditions, where the skin becomes excessively hard or thick. The high concentration of urea hydrates and helps to remove dead skin cells, which can help with conditions such as corns, calluses and keratosis. Although not its primary function, it can potentially be used cautiously and sparingly for off-label purposes such as seborrheic dermatitis, intertrigo, and certain nail fungus cases, although this should always be under the strict supervision of a healthcare provider.

Additionally, the urea component can also elevate the penetration of other drugs or ingredients that are used in combination, which makes it an excellent candidate for a multitasking ointment. While this formulation is generally well-tolerated, it may produce side effects such as skin irritation, burning, or stinging in some patients. Always consult your healthcare provider or pharmacist regarding any concerns related to medication usage.

If you or your prescriber have any further questions on this formulation or its applications, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of experienced compounding pharmacists is always ready to provide insight and guidance. It's important to remember that while we make every effort to provide comprehensive and current information, our suggestions should never replace professional medical advice.

Frequently Asked Questions

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What is Clotrimazole 10%/Urea 20% Topical Ointment?

It is a semi-solid formulation, dispensed in a tube, designed for external application to the skin. This ointment is specially compounded with the active ingredients Clotrimazole and Urea. It aids in the delivery of these medications for the treatment of localized skin conditions.

What is the purpose of the oily or greasy base in this formulation?

The greasy or oily base serves as a vehicle for the therapeutic agents, Clotrimazole and Urea. It aids in the delivery of these medications, ensuring they are fully absorbed into the skin for maximum effectiveness.

What skin conditions can this ointment be used for?

This ointment is typically used for conditions such as skin inflammation, infections or wound healing. It might be particularly beneficial for fungal infections of the skin due to the presence of Clotrimazole.

How should Clotrimazole 10%/Urea 20% Topical Ointment be applied?

The ointment should be applied as directed by your healthcare provider, typically onto the affected areas of the skin. It is important to follow the instructions on the label, or as prescribed by your pharmacist or doctor.

What is the role of Clotrimazole in this formulation?

Clotrimazole is an antifungal agent that helps in treating fungal infections by preventing the growth of fungus. The inclusion of this ingredient makes the ointment highly beneficial for treating skin conditions caused by fungus.

What is the role of Urea in this ointment?

Urea is a keratolytic agent. It helps to moisturize the skin and promotes the shedding of dead skin cells. This aids in the treatment of dry, rough and scaly skin conditions and helps wounds to heal.

Is Clotrimazole 10%/Urea 20% Topical Ointment safe for all skin types?

While the ointment is generally safe for most skin types, individuals with hypersensitivity to Clotrimazole, Urea, or any other component of the formulation should avoid its use. It's always best to discuss with your healthcare provider if you have any concerns.

Are there any side effects associated with this ointment?

Side effects can occur with any medication. Some common side effects may include skin irritation, redness or peeling. If you experience severe or worrying side effects, it is advised to consult your healthcare provider immediately.

Can I use this ointment with other skincare products?

It's important to discuss this with your healthcare provider as certain products may interfere with the effectiveness of the ointment. Generally, other skincare products should be applied only after the ointment has fully absorbed into the skin.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not use extra ointment to catch up.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.