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Formulas

Clindamycin 2%/Dapsone 4%/Hydrocortisone 1%/Metronidazole 1% Topical Cream

This formulation is a compounded topical cream containing Clindamycin 2%, Dapsone 4%, Hydrocortisone 1%, and Metronidazole 1%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. The active ingredients in this formulation are intended for localized treatment or absorption.

Clindamycin is an antibiotic that fights bacteria in the body, Dapsone is an anti-infective medication, Hydrocortisone is a corticosteroid that reduces inflammation, and Metronidazole is an antibiotic and antiprotozoal medication. This combination of medications is used to treat various skin conditions such as acne, rosacea, dermatitis, and certain types of skin infections.

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Topical Cream
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Formula Information

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This formulation is a compounded topical cream containing Clindamycin 2%, Dapsone 4%, Hydrocortisone 1%, and Metronidazole 1%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. The purpose of this formulation is to provide localized treatment or absorption of active ingredients.

Clindamycin is an antibiotic that prevents bacteria from growing on the skin. It is used to treat severe acne and helps to decrease the number of acne lesions. Dapsone is an anti-infective medication that is used in combination with other drugs for the treatment of leprosy. In this formulation, it is used for its anti-inflammatory properties to treat acne. Hydrocortisone is a corticosteroid that reduces redness, itching, and swelling. It is used in this formulation to treat a variety of skin conditions such as eczema, dermatitis, allergies, and rash. Metronidazole is an antibiotic and antiprotozoal medication. It is used to treat various infections including rosacea, a skin condition that causes redness and pimples on the face.

This formulation is designed to treat a variety of skin conditions. The combination of these four active ingredients provides a broad spectrum of action against bacteria, inflammation, and skin irritation. It is important to note that this formulation should be used as directed by a healthcare provider. Overuse or misuse can lead to resistance and decreased effectiveness of the medication.

Patients should apply the cream to the affected area as directed by their healthcare provider. The cream should be rubbed in gently and thoroughly. It is important to wash hands after applying unless the hands are the area being treated. Patients should avoid getting this medication in the eyes, nose, or mouth. If this occurs, rinse thoroughly with water.

Prescribers should consider the patient's overall health status, other medications, and the specific skin condition being treated when prescribing this formulation. It is important to monitor the patient's response to treatment and adjust the dosage or frequency of application as necessary. Prescribers should also educate patients about potential side effects, which may include dryness, burning, itching, peeling, redness, and oily skin.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This formulation combines four active ingredients: Clindamycin, Dapsone, Hydrocortisone, and Metronidazole. Each of these ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to note that this information is not exhaustive and other interactions may exist. Always consult with a healthcare provider for personalized advice.

Clindamycin, an antibiotic, can interact with neuromuscular blocking agents, potentially enhancing their effects. It may also interact with erythromycin, another antibiotic, which could inhibit the antibacterial effect of Clindamycin. Dapsone, an anti-infective agent, can interact with a number of drugs including, but not limited to, clofazimine, rifampin, and folic acid antagonists. These interactions can lead to changes in the blood, such as methemoglobinemia or hemolysis.

Hydrocortisone, a corticosteroid, can interact with drugs like insulin, warfarin, and cyclosporine, potentially altering their effects. It may also interact with estrogens, leading to increased levels of hydrocortisone in the body. Metronidazole, an antibiotic and antiprotozoal, can interact with alcohol, leading to a disulfiram-like reaction. It may also interact with warfarin, potentially enhancing its anticoagulant effect.

This formulation is designed to treat a variety of skin conditions. Clindamycin and Metronidazole have antibacterial properties, making them effective against acne and rosacea, respectively. Dapsone is used to treat dermatitis herpetiformis and other skin conditions. Hydrocortisone is a corticosteroid that can reduce inflammation and alleviate symptoms of various skin conditions, including eczema and psoriasis.

It's crucial to inform your healthcare provider about all the medications you're currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This will help your healthcare provider to prevent potential interactions and ensure the safe use of this formulation. If you experience any unusual symptoms while using this formulation, contact your healthcare provider immediately.

If you have any questions about this formulation or its potential interactions, don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

How Does it Work

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This formulation is a combination of four active ingredients: Clindamycin, Dapsone, Hydrocortisone, and Metronidazole, each playing a unique role in treating various skin conditions. The cream is designed to be applied topically, directly onto the skin, where it can be absorbed into the affected area to provide localized treatment.

Clindamycin is an antibiotic that works by stopping the growth of bacteria. It is used to treat a wide variety of bacterial infections, including those that cause acne. It helps to decrease the number of acne lesions. Clindamycin is also used to treat bacterial infections that cause inflammation and redness on the skin.

Dapsone is an anti-infective medication that has both antibacterial and anti-inflammatory properties. It is commonly used to treat dermatitis and other skin conditions. Dapsone works by reducing inflammation and killing the bacteria that cause skin infections. This helps to improve the appearance and texture of the skin.

Hydrocortisone is a corticosteroid that works by reducing inflammation, redness, and itching. It is used to treat a variety of skin conditions, including eczema, dermatitis, allergies, and rash. Hydrocortisone provides relief from itching and discomfort and helps to speed up the healing process.

Metronidazole is an antibiotic that is used to treat certain types of bacterial and parasitic infections. In this formulation, it is used to treat certain skin conditions such as rosacea, a type of adult acne. It works by stopping the growth of bacteria and parasites.

This combination of ingredients in a single formulation provides a broad spectrum of action against various skin conditions. The cream is dispensed in a pump mechanism, which allows for convenient and controlled application. This ensures that the right amount of medication is applied to the affected area, maximizing its effectiveness while minimizing potential side effects.

As with any medication, it is important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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Aside from the specified disease states, this compounded formulation of Clindamycin 2%/Dapsone 4%/Hydrocortisone 1%/Metronidazole 1% Topical Cream may also offer additional potential uses. Clindamycin, an antibiotic, can be utilized in the management of bacterial infections. Local application potentially minimizes systemic antibiotic exposure, reducing the risk for antibiotic resistance development and systemic side effects.

Dapsone, despite primarily being used for leprosy, may also serve as a potential treatment for dermatitis herpetiformis, a chronic blistering skin condition. Its anti-inflammatory properties may offer relief from other inflammatory skin conditions, although this should be determined on a case-by-case basis in close consultation with a healthcare provider.

Hydrocortisone, a corticosteroid, is often used for its anti-inflammatory effects. It might be beneficial in the management of various skin conditions characterized by inflammation and pruritus, including but not limited to psoriasis, eczema, and allergies. Please note, however, long-term use of topical corticosteroids should be avoided as it may lead to skin thinning and other adverse effects.

Metronidazole, while commonly used to treat certain types of bacterial and parasitic infections, may also be useful in treating dermatological conditions such as rosacea. Its anti-inflammatory properties could potentially extend its use to other inflammatory skin conditions. As ever, the decision to use this compound for off-label indications should be made by a prescribing healthcare provider familiar with the patient’s medical history.

Ultimately, the choice to use this specific compounded formulation can be dependent on a variety of factors, such as other concurrent therapies, personal medical history, allergies, and overall tolerance for medications. All of this information should be taken into consideration when deciding upon a course of treatment. For any questions, inquiries or further clarification, please feel to reach out to us and ask.

Frequently Asked Questions

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What is Clindamycin 2%/Dapsone 4%/Hydrocortisone 1%/Metronidazole 1% Topical Cream?

This is a compounded formulation of various active ingredients, Clindamycin, Dapsone, Hydrocortisone, and Metronidazole, all combined to make a topical cream meant for direct application to skin conditions that need localized treatment.

How is this cream applied?

The cream is dispensed via a pump mechanism designed for controlled, convenient application directly to the affected skin area.

Does this topical cream require a specific dose?

Yes, like any other medication, it is important to follow the prescribed dosage your healthcare provider indicates for you. Using too much or too little can affect the efficacy of the treatment.

What conditions can this cream treat?

It is primarily used for localized skin conditions. However, the final decision regarding the treatment suitability lies with a healthcare professional who will assess the skin condition and decide whether this particular compounded cream is the best course of action.

Can this cream cause any side effects?

As with any medication, the possibility of side effects exists. However, most people do not experience serious side effects. Common side effects may include mild itching or burning. If you notice severe redness, skin peeling, or persistent discomfort after use, please contact your healthcare provider immediately.

Can I use this cream on other parts of my body?

Focused and localized use on the affected areas is recommended. Avoid areas close to the eyes and mouth. If you have doubts, please consult your prescribing healthcare professional.

What do I do if I miss a dose?

If you miss a dose, apply the cream as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your normal dosing schedule. Do not double up to make up for a missed dose.

Is it safe to use this cream while pregnant or breastfeeding?

Please inform your healthcare provider if you are pregnant, planning a pregnancy, or breastfeeding. They will make an appropriate judgement on the use of this cream based on your specific circumstance.

How should I store this cream?

Keep this medication at room temperature, away from heat and light. Do not store in the bathroom. Keep all medication away from children and pets.

Can I apply other skincare products on top of this cream?

We recommend allowing the cream to fully absorb before applying any other skincare products. Use any other products only if recommended by your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.