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Amphotericin B 3% Vaginal Cream

Amphotericin B 3% Vaginal Cream is a semisolid formulation dispensed in a tube, specifically designed for convenient and precise application in the vaginal area. This cream is formulated with Amphotericin B, a potent antifungal agent, at a concentration of 3%. It is primarily used to deliver medication and provide therapeutic effects for specific gynecological conditions. The cream is particularly effective in treating fungal infections of the vagina, such as candidiasis, thereby helping to alleviate associated symptoms and discomfort.

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Vaginal Cream
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Formula Information

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Amphotericin B 3% Vaginal Cream is a specially compounded medication designed to treat specific gynecological conditions. This semisolid formulation is dispensed in a tube for easy and precise application in the vaginal area. The active ingredient, Amphotericin B, is a potent antifungal agent that works by binding to the fungal cell membrane, causing it to become permeable and leading to cell death. This mechanism of action makes it effective in treating a variety of fungal infections.

Amphotericin B 3% Vaginal Cream is primarily used to treat vaginal yeast infections, such as Candida, which can cause symptoms like itching, burning, and discharge. It may also be used in cases of recurrent or resistant infections where other treatments have failed. The cream formulation allows for direct application to the affected area, providing targeted treatment and relief from symptoms. It is typically applied once or twice daily, or as directed by a healthcare provider.

Patients using Amphotericin B 3% Vaginal Cream should be aware of potential side effects, which may include local irritation, burning, or itching. These are usually mild and temporary, but if they persist or worsen, medical attention should be sought. It's also important to note that this medication should not be used during menstruation, and sexual intercourse should be avoided while using this medication to allow for the best possible healing environment.

Prescribers should consider patient history and current medications before recommending Amphotericin B 3% Vaginal Cream. While it is generally well-tolerated, it may not be suitable for patients with certain medical conditions or those taking certain medications. As with any medication, it should be used for the full course of treatment, even if symptoms improve before the medication is finished, to ensure the infection is fully cleared and to prevent recurrence.

At Bayview Pharmacy, we are committed to providing high-quality, personalized medications to meet the unique needs of each patient. Our team of compounding pharmacists is always available to answer any questions or concerns about this formulation. Please don't hesitate to reach out to us for more information.

Drug Interactions

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Amphotericin B 3% Vaginal Cream is an antifungal medication used to treat various fungal infections in the vaginal area, such as candidiasis. It works by binding to the fungal cell membrane, causing changes in the membrane's permeability, and leading to cell death. However, like all medications, it can interact with other drugs, potentially altering their effects or increasing the risk of side effects.

One of the most significant interactions to be aware of is with other nephrotoxic drugs, such as aminoglycosides, cyclosporine, and tacrolimus. Concurrent use of these medications with Amphotericin B can increase the risk of kidney damage. Therefore, it's crucial to monitor renal function closely in patients taking these combinations.

Amphotericin B may also interact with antineoplastic agents (cancer drugs), increasing the risk of adverse reactions. If a patient is undergoing cancer treatment, the healthcare provider should carefully consider the benefits and risks before prescribing Amphotericin B.

Furthermore, Amphotericin B can interact with corticosteroids and corticotropin, potentially leading to hypokalemia (low potassium levels). This can increase the risk of cardiac arrhythmias. Therefore, potassium levels should be monitored, and supplementation may be necessary.

It's also important to note that Amphotericin B can interact with digitalis glycosides due to its potential to cause hypokalemia. This can increase the risk of digitalis toxicity. Therefore, patients taking digitalis glycosides should have their potassium levels and cardiac function closely monitored.

Lastly, Amphotericin B may interact with flucytosine, leading to an increased risk of flucytosine toxicity. Therefore, patients taking this combination should be closely monitored for signs of toxicity, such as nausea, vomiting, and bone marrow suppression.

Patients should inform their healthcare provider of all the medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. This will help the healthcare provider to prevent potential drug interactions and ensure the safe use of Amphotericin B.

Prescribers should also be aware of these potential interactions and monitor their patients closely for any signs of adverse reactions. They should adjust the treatment plan as necessary, considering the patient's overall health status, other medications, and the severity of the fungal infection.

If you have any questions about Amphotericin B 3% Vaginal Cream or its potential interactions, please don't hesitate to reach out to us. We are here to provide you with the most accurate and up-to-date information to ensure the safe and effective use of this medication.

How Does it Work

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Amphotericin B 3% Vaginal Cream is a semisolid formulation that is designed to be applied directly to the vaginal area. It is dispensed in a tube for convenient and precise application. The active ingredient in this formulation is Amphotericin B, a polyene antifungal medication that is used to treat a variety of fungal infections.

Amphotericin B works by binding to ergosterol, a component of the fungal cell membrane. When Amphotericin B binds to ergosterol, it forms pores in the cell membrane. These pores allow for the leakage of intracellular components, which leads to cell death. In this way, Amphotericin B is able to kill the fungal cells and treat the infection.

This formulation is specifically designed for the treatment of vaginal fungal infections, such as Candida. Candida is a type of yeast that can cause infections in the vagina, also known as yeast infections or thrush. Symptoms of a vaginal yeast infection include itching, burning, and a thick, white discharge. Amphotericin B 3% Vaginal Cream can help to alleviate these symptoms by killing the Candida cells and treating the infection.

It is important to use this medication as directed by your healthcare provider. The cream should be applied to the affected area in the amount and frequency as prescribed. It is also important to continue using the medication for the full course of treatment, even if symptoms improve before the infection is completely cleared. This helps to ensure that all of the fungal cells are killed and reduces the risk of the infection returning.

As with any medication, there may be potential side effects with the use of Amphotericin B 3% Vaginal Cream. These may include local irritation, burning, or itching at the application site. If these side effects persist or worsen, or if you experience any other side effects, it is important to contact your healthcare provider.

If you have any questions about Amphotericin B 3% Vaginal Cream, or if you would like more information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

Other Uses

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Amphotericin B 3% Vaginal Cream is primarily intended to treat various gynecological conditions, however, its therapeutic properties can also be utilized in managing other diseases. Notably, Amphotericin B is a potent antifungal agent and can be used in the handling of certain systemic or localized fungal infections. Given its formulation, the cream could potentially be applied to external areas with yeast or fungal infections, such as skin folds, under the breasts, and other moist areas on the body. Patients suffering from oral thrush might also find this formulation beneficial, provided it is used under the guidance of a healthcare provider.

In patients who are resistant or allergic to other antifungal agents such as clotrimazole or miconazole, Amphotericin B, with its different mechanism of action, is a likely alternative that healthcare providers might consider. This formulation could also be particularly useful for patients with compromised immune systems, where systemic fungal infections are more likely to occur.

Though Amphotericin B has potent antifungal capabilities, it is important for prescribers and patients to remember that the medication should be used with caution as it can cause several side effects, including but not limited to irritation at the application site, fever, chills, and kidney damage. Hence, it is crucial to use this cream under the close supervision of a healthcare provider. Inform your doctor if you have any known allergies or kidney disease before you start using this medication.

Despite its potential uses, it should be noted that the utilization of this cream for any other reasons than those prescribed by a healthcare provider is not recommended without their supervision. Always consult with your provider before using this formulation for a new, unlisted indication to ensure safe and effective use.

If you have any questions or concerns regarding the use of Amphotericin B 3% Vaginal Cream, feel free to reach out to us at Bayview Pharmacy. We are a dedicated team of compounding pharmacists, and we are here to provide you with the comprehensive information you need to ensure safe medication use.

Frequently Asked Questions

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What is Amphotericin B 3% Vaginal Cream?

This is a semisolid formulation that is dispensed in a tube. It is designed for convenient and specific application in the vaginal area and delivers medication to treat specific gynecological conditions.

What conditions is this cream used to treat?

Amphotericin B 3% Vaginal Cream is typically used to treat fungal infections in the vaginal area. However, it is always recommended to use this product as prescribed by your healthcare provider.

How is Amphotericin B 3% Vaginal Cream applied?

This cream is designed for vaginal application. It is dispensed in a tube for accurate and convenient application. Always follow the specific directions provided by your healthcare provider or pharmacist for the best results.

Is Amphotericin B 3% Vaginal Cream safe to use during pregnancy?

If you are pregnant, plan on becoming pregnant, or are breastfeeding, you should discuss the benefits and risks of using this medication with your doctor. They can provide advice tailored to your individual situation.

Can I use this cream if I am on other medication?

Before using Amphotericin B 3% Vaginal Cream, you should share your current list of medications, over the counter products, allergies, pre-existing diseases, and current health conditions with your doctor. This is to avoid any potential adverse effects or interactions.

What if I miss a dose of this medication?

If you miss a dose, use it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not apply extra doses to make up for a missed dose.

Are there any potential side effects?

All medications have potential side effects. With Amphotericin B 3% Vaginal Cream, these may include irritation, burning, or itching at the application site. If you experience any severe or persistent side effects, please contact your healthcare provider.

Should I use this cream before or after sex?

Typically, it's recommended to avoid having sexual intercourse while treating a vaginal infection. Follow your healthcare provider's specific advice.

What should I do if I experience severe discomfort or allergic reactions after application?

If you experience severe discomfort such as burning, stinging, rash, or signs of an allergic reaction such as swelling, difficulty breathing, or dizziness, stop using the medication and seek immediate medical attention.

Is Amphotericin B 3% Vaginal Cream available over the counter?

Amphotericin B 3% Vaginal Cream is often a prescription medication. Always check with your local pharmacy or healthcare provider to ensure the best and safest care for your specific health condition.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.