Amphotericin B is a potent antifungal agent widely used in the treatment of severe systemic fungal infections. It belongs to the polyene class of antifungals and works by binding to ergosterol, a key component of fungal cell membranes, leading to increased membrane permeability and ultimately cell death. This mechanism makes Amphotericin B effective against a broad spectrum of fungi, including Candida, Aspergillus, and Cryptococcus species.

Despite its efficacy, Amphotericin B is known for its potential nephrotoxicity and infusion-related reactions, which necessitate careful monitoring and management during treatment. In compounding pharmacy settings, formulations of Amphotericin B are tailored to optimize therapeutic outcomes while minimizing adverse effects. These formulations may include lipid-based preparations that have been shown to reduce toxicity and improve patient tolerance.

Amphotericin B is often reserved for serious infections where other antifungal treatments have failed or are not suitable, underscoring its importance in the antifungal armamentarium. Prescribers should consider patient-specific factors, such as renal function and potential drug interactions, when selecting Amphotericin B as a treatment option. The versatility of compounded formulations allows for personalized dosing regimens, which can be crucial in managing complex fungal infections effectively.