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Amphotericin B 100 mg Vaginal Suppository

The Amphotericin B 100 mg Vaginal Suppository is a solid dosage form designed for insertion into the vagina. Upon insertion, the suppository dissolves or melts, releasing the antifungal medication, Amphotericin B, for local absorption. This formulation is primarily used to treat various fungal infections in the vaginal area. The dosage and frequency of use are typically determined by the severity of the infection and the patient's response to treatment.

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Amphotericin B
Suppository
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Formula Information

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Amphotericin B 100 mg Vaginal Suppository is a solid dosage form designed for insertion into the vagina. Once inserted, the suppository dissolves or melts, releasing the medication for local absorption. This formulation is specifically designed to deliver the antifungal medication, Amphotericin B, directly to the site of infection, providing targeted treatment and minimizing systemic side effects.

Amphotericin B is a potent antifungal agent that works by binding to the fungal cell membrane, causing changes in the membrane's permeability and leading to cell death. It is effective against a wide range of fungi, including Candida species, which are common causes of vaginal yeast infections. By delivering the medication directly to the site of infection, the Amphotericin B 100 mg Vaginal Suppository can provide rapid relief from symptoms such as itching, burning, and discharge.

This formulation is typically used in the treatment of severe or recurrent vaginal yeast infections that have not responded to other treatments. It may also be used in patients with a high risk of systemic fungal infections, such as those with weakened immune systems. The suppository form allows for a higher concentration of medication to be delivered directly to the site of infection, which can be beneficial in these cases.

As with any medication, the Amphotericin B 100 mg Vaginal Suppository should be used as directed by a healthcare provider. Patients should be aware that side effects may include local irritation or burning sensation upon application. If these side effects persist or worsen, or if symptoms of infection do not improve within a few days, patients should contact their healthcare provider.

Prescribers should consider the patient's overall health status, the severity and type of infection, and the patient's response to previous treatments when deciding to use this formulation. Regular follow-up is recommended to monitor the patient's response to treatment and to adjust the treatment plan as necessary.

If you have any questions about the Amphotericin B 100 mg Vaginal Suppository, or if you would like more information about this or any other compounding formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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Amphotericin B is an antifungal medication that is used to treat serious, potentially life-threatening fungal infections. In the form of a vaginal suppository, it is typically used to treat fungal infections within the vagina, such as candidiasis. The medication works by binding to the fungal cell membrane, causing the cell to leak and eventually die.

While Amphotericin B is generally safe and effective, it can interact with other medications, potentially altering their effects or increasing the risk of side effects. It is important for patients and prescribers to be aware of these potential interactions.

Amphotericin B can interact with certain antifungal medications, such as flucytosine. When used together, these medications can increase the risk of kidney damage. If you are taking flucytosine, your doctor may need to monitor your kidney function closely while you are using Amphotericin B.

Other medications that can interact with Amphotericin B include certain antiviral medications, such as zidovudine, and certain cancer medications, such as cisplatin. These medications can also increase the risk of kidney damage when used with Amphotericin B.

Amphotericin B can also interact with certain medications used to treat high blood pressure, such as captopril, lisinopril, and ramipril. These medications can increase the risk of kidney damage and low blood pressure when used with Amphotericin B.

It is important to tell your doctor about all the medications you are currently taking, including prescription medications, over-the-counter medications, vitamins, and herbal supplements. This will help your doctor to prevent potential drug interactions.

While using Amphotericin B, it is also important to avoid drinking alcohol, as this can increase the risk of side effects, such as nausea, vomiting, and dizziness.

Remember, this is not a complete list of potential drug interactions. Always consult with your healthcare provider or pharmacist for a comprehensive list of drug interactions. If you have any questions about Amphotericin B or its potential interactions, please reach out to us at Bayview Pharmacy. We are here to help.

How Does it Work

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Amphotericin B 100 mg Vaginal Suppository is a solid dosage form that is inserted into the vagina. It is designed to dissolve or melt once inside the body, releasing the medication for local or systemic absorption. This formulation is typically used to treat fungal infections in the vaginal area.

Amphotericin B is an antifungal medication that works by binding to the ergosterol found in the cell membrane of sensitive fungi. This binding disrupts the cell membrane, causing leakage of intracellular components, which eventually leads to cell death. By killing the fungi, Amphotericin B helps to clear the infection.

The suppository form of this medication is particularly effective for vaginal infections as it allows for direct application of the medication to the affected area. This can result in faster relief of symptoms and may reduce the risk of side effects that can occur with systemic (whole body) absorption of the medication.

It's important to use this medication exactly as prescribed by your healthcare provider. The suppository should be inserted into the vagina using the applicator provided. It's usually recommended to do this at bedtime to allow the suppository to dissolve and work while you sleep. You should continue to use this medication for the full course of treatment even if symptoms improve after a few days. Stopping the medication too early may allow the infection to return.

Side effects can include irritation or burning in the vaginal area. If these side effects persist or worsen, or if you experience systemic side effects such as fever, chills, or rapid breathing, contact your healthcare provider immediately.

As compounding pharmacists, we can customize this medication to meet individual patient needs, including adjusting the dose or changing the base of the suppository to minimize irritation. If you have any questions about Amphotericin B 100 mg Vaginal Suppository, or if you would like to discuss customizing this medication, please reach out to us at Bayview Pharmacy.

Other Uses

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Amphotericin B vaginal suppositories are primarily used for the treatment of fungal infections in the vaginal area. These potent antifungals offer targeted relief to women suffering from conditions like candida induced vulvovaginitis. However, beyond its primary use, there are certain circumstances where Amphotericin B 100 mg Vaginal Suppository may be prescribed for other health conditions.

For instance, other forms of systemic mycoses (fungal infections) that have proven resistant to conventional medications or in patients who are intolerant to other antifungal therapies, may be managed using this formulation. Additionally, Amphotericin B's antifungal properties make it a suitable treatment option for certain types of oral and gastrointestinal fungal infections, particularly in immunocompromised patients, such as those undergoing cancer treatment or people living with HIV/AIDS. It can be used as prophylaxis to prevent invasive fungal infections in these high-risk patient populations.

Also, this form of Amphotericin B could be potentially beneficial for researchers studying the effects of systemic antifungal treatments on different body systems. However, more research is needed in this area to fully understand the scope of possible uses of this medication.

While safe when used as directed by a medical professional, it is worth noting that this treatment may carry risks of common side effects including nausea, vomiting, diarrhea, abdominal pain and potential allergic reactions. Its systemic use may lead to more severe side effects like kidney problems, electrolyte imbalances, and cardiovascular issues. Regular monitoring of kidney function, electrolyte levels, and other organ functions is necessary while on this medication. Extra caution should be implemented in patients with kidney problems or other severe health conditions.

Before prescribing or considering the use of Amphotericin B vaginal suppositories, both patients and healthcare providers should consider the importance of strict adherence to the directed usage, as it can greatly effect the outcome and effectiveness of the treatment.

If you have any further questions about the use, possible side effects or contraindications of Amphotericin B 100 mg Vaginal Suppository, or would like more detailed information, please never hesitate to reach out to us at Bayview Pharmacy. We are a team of trained and knowledgeable compounding pharmacists, always ready to help.

Frequently Asked Questions

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What is Amphotericin B 100 mg Vaginal Suppository?

Amphotericin B 100 mg Vaginal Suppository is a solid dosage form of medication that is inserted into the vagina. Once there, it dissolves or melts to release the drug. This medication is designed for local or systemic absorption.

What is the purpose of using a Vaginal Suppository?

Vaginal suppositories are used to deliver medications directly to the vagina which are then absorbed into the bloodstream. They are typically used for their localized effects, although they can also provide systemic effects.

How does the Amphotericin B 100 mg Vaginal Suppository work?

Once the suppository is inserted into the vagina, it melts or dissolves to release the Amphotericin B medication. This medicine then works to treat the condition or disease locally or it can be absorbed into the bloodstream for systemic effects.

How should I use the Amphotericin B Vaginal Suppository?

For best results, follow the instructions given by your healthcare provider. The medication should be inserted into the vagina using the applicator provided. It is recommended to insert the suppository at bedtime for maximum absorption.

Can this suppository be used rectally?

No, Amphotericin B 100mg Vaginal Suppository is specifically formulated for vaginal use. Do not use it rectally as it might not work as expected and could cause unwanted side effects.

Can I take this medication orally?

No, Amphotericin B 100mg Vaginal Suppository is not designed for oral use. If taken by mouth, it might not work as intended and could cause harmful side effects.

What should I do if I miss a dose?

If you miss a dose, use it as soon as you remember. However, if it's near the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double doses to make up for a missed one.

What are the side effects of Amphotericin B 100 mg Vaginal Suppository?

Like all medications, Amphotericin B 100 mg Vaginal Suppository can cause side effects. These may include local irritation or burning sensation. If you experience any severe or persistent side effects, consult your healthcare provider immediately.

Can I use Amphotericin B 100 mg Vaginal Suppository during menstruation?

It is best to consult your healthcare provider about this, as the effectiveness of the medication might be affected during menstruation due to the menstrual flow.

Can I use this medication during pregnancy?

If you are pregnant or planning to become pregnant, you should consult your healthcare provider before using Amphotericin B 100 mg Vaginal Suppository. The effect of this medication on pregnancy is not fully known.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.