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Valsartan 16 mg/mL Oral Suspension

Valsartan 16 mg/mL Oral Suspension is a liquid dosage form in which valsartan is uniformly dispersed throughout a liquid medium, ensuring a homogeneous mixture for precise administration. This formulation is primarily used to treat hypertension, heart failure, and to improve survival following a heart attack. It provides an effective alternative for patients who have difficulty swallowing tablets, allowing for flexible dosing adjustments.

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Valsartan
Suspension
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Formula Information

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Valsartan 16 mg/mL Oral Suspension is a customized liquid formulation of the medication valsartan, an angiotensin II receptor blocker (ARB). This oral suspension is designed for patients who require an alternative to solid dosage forms, ensuring precise dosing and ease of administration. The homogeneous liquid medium allows for the uniform dispersion of valsartan, providing consistent therapeutic effects with each dose.

Valsartan is primarily used in the management of hypertension (high blood pressure) and heart failure. By blocking the action of angiotensin II, a substance in the body that causes blood vessels to tighten and narrow, valsartan helps relax blood vessels. This relaxation lowers blood pressure and increases the supply of blood and oxygen to the heart, thereby reducing the risk of strokes, heart attacks, and kidney problems.

This oral suspension is particularly beneficial for pediatric patients, elderly patients, or those who have difficulty swallowing tablets or capsules. It allows for flexible dosing, which can be crucial when adjusting doses based on patient response or when treating patients with specific medical conditions that require precise dosing regimens.

For prescribers, the 16 mg/mL concentration facilitates accurate dosing calculations and adjustments. This formulation ensures that patients receive the exact dose prescribed, which is essential for managing conditions like hypertension where precise blood pressure control is necessary. The liquid form also enhances patient adherence to the medication regimen by simplifying administration.

Patients are advised to shake the bottle well before each use to ensure the medication is evenly distributed. Using a proper measuring device, such as an oral syringe or dosing cup provided by the pharmacist, is important to measure the correct dose. Do not use household spoons, as they may not provide an accurate measurement.

It's essential to take this medication exactly as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without consulting your doctor, even if you feel well, as high blood pressure often has no noticeable symptoms. Continuation of therapy is important to maintain blood pressure control and reduce the risk of serious cardiovascular events.

Common side effects may include dizziness or lightheadedness as your body adjusts to the medication. To reduce the risk of dizziness, rise slowly from sitting or lying positions. If any side effects persist or worsen, inform your healthcare provider promptly. Patients should report any signs of kidney problems or high potassium levels, such as changes in the amount of urine, muscle weakness, or irregular heartbeat.

Before starting valsartan, inform your doctor of your medical history, especially of liver disease, dehydration, and electrolyte imbalances. Valsartan may interact with other medications, such as lithium, drugs that increase potassium levels, and certain diuretics. Therefore, it's important to discuss all medications and supplements you're taking with your healthcare provider.

Pregnant women should not use valsartan, especially during the second and third trimesters, due to the risk of harm to the unborn baby. If you become pregnant while taking this medication, contact your doctor immediately. Breastfeeding while using this medication is not recommended; consult your doctor before breastfeeding.

Store the oral suspension at room temperature away from light and moisture. Do not store it in the bathroom, and keep it out of reach of children and pets. Do not use the medication after the expiration date indicated on the bottle.

This compounded oral suspension is prepared by trained compounding pharmacists following strict guidelines to ensure its safety, efficacy, and stability. If you have any questions about Valsartan 16 mg/mL Oral Suspension or how it may benefit your treatment plan, please reach out to us for further information.

Drug Interactions

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Valsartan 16 mg/mL Oral Suspension is a liquid dosage form designed to provide a homogeneous mixture for administration, ensuring consistent dosing and ease of use, particularly for patients who may have difficulty swallowing tablets. Valsartan is an angiotensin II receptor blocker (ARB) commonly used to treat hypertension, heart failure, and to improve survival following a myocardial infarction. By blocking the action of angiotensin II, valsartan helps to relax blood vessels, thereby lowering blood pressure and reducing the workload on the heart.

When considering the use of Valsartan 16 mg/mL Oral Suspension, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of the treatment. One significant interaction is with other antihypertensive agents, such as ACE inhibitors or other ARBs, which may lead to an additive effect, increasing the risk of hypotension, hyperkalemia, and renal impairment. Patients should be monitored closely for signs of low blood pressure and electrolyte imbalances.

Concomitant use of valsartan with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium can increase the risk of hyperkalemia. It is important to monitor serum potassium levels regularly and adjust the treatment regimen as necessary to prevent complications associated with elevated potassium levels, such as cardiac arrhythmias.

Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors, may reduce the antihypertensive effect of valsartan. Additionally, in patients who are elderly, volume-depleted, or have compromised renal function, the concurrent use of NSAIDs and valsartan may lead to a deterioration of renal function, including possible acute renal failure. Monitoring renal function periodically is advised when these medications are used together.

Valsartan may also interact with lithium, leading to increased serum lithium concentrations and potential lithium toxicity. If concurrent use is necessary, it is essential to monitor lithium levels closely and adjust the lithium dosage accordingly to avoid toxicity, which can manifest as tremors, confusion, and renal impairment.

Rifampin, a potent inducer of hepatic enzymes, may decrease the plasma concentration of valsartan, potentially reducing its therapeutic effect. Patients on rifampin may require dose adjustments of valsartan to maintain adequate blood pressure control.

For both patients and prescribers, it is important to review all current medications, including over-the-counter drugs and supplements, to identify potential interactions with valsartan. Regular monitoring and communication with healthcare providers can help manage and mitigate these interactions effectively. If you have any questions or concerns about drug interactions with Valsartan 16 mg/mL Oral Suspension, please reach out to us for further assistance.

How Does it Work

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Valsartan 16 mg/mL Oral Suspension is a liquid dosage form designed to provide a precise and uniform delivery of the active ingredient, valsartan, which is an angiotensin II receptor blocker (ARB). This formulation is particularly beneficial for patients who have difficulty swallowing tablets or require flexible dosing adjustments. The suspension ensures that valsartan is evenly dispersed throughout the liquid medium, allowing for consistent dosing and optimal therapeutic effects.

Valsartan works by selectively blocking the binding of angiotensin II to the AT1 receptor, which is found in various tissues such as vascular smooth muscle and the adrenal gland. Angiotensin II is a potent vasoconstrictor that plays a critical role in regulating blood pressure and fluid balance. By inhibiting its action, valsartan causes vasodilation, reduces the secretion of aldosterone, and decreases the reabsorption of sodium and water in the kidneys. This leads to a reduction in blood pressure and a decrease in the workload on the heart.

This oral suspension is particularly useful in managing conditions such as hypertension and heart failure. In hypertension, valsartan helps to lower high blood pressure, thereby reducing the risk of cardiovascular events such as heart attacks and strokes. For patients with heart failure, valsartan improves survival, reduces hospitalizations, and enhances the quality of life by improving the heart's efficiency and reducing symptoms such as shortness of breath and fatigue.

The liquid form of valsartan allows for easy administration and dose adjustments, which is crucial for pediatric patients, elderly patients, or those with swallowing difficulties. It also provides an alternative for patients who may have allergies or intolerances to certain excipients found in tablet formulations. The suspension should be shaken well before each use to ensure the active ingredient is evenly distributed, and it should be measured accurately using a dosing syringe or cup to ensure the correct dose is administered.

For prescribers, this formulation offers flexibility in dosing regimens and can be tailored to meet the specific needs of each patient. It is important to monitor patients regularly to assess the effectiveness of the treatment and make any necessary adjustments. Patients should be advised to adhere to their prescribed dosing schedule and report any side effects or concerns to their healthcare provider.

If you have any questions or need further information about Valsartan 16 mg/mL Oral Suspension, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or support you may need.

Other Uses

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Valsartan 16 mg/mL Oral Suspension is primarily used for the management of hypertension, heart failure, and for the reduction of cardiovascular mortality following myocardial infarction. However, this formulation may have other potential uses that are not as widely recognized but could be beneficial in specific clinical scenarios. One such use is in the management of certain types of chronic kidney disease (CKD). Valsartan, as an angiotensin II receptor blocker (ARB), can help in reducing proteinuria and slowing the progression of kidney damage in patients with CKD, particularly in those with diabetic nephropathy. This can be especially useful in pediatric patients or those who have difficulty swallowing tablets, as the liquid suspension allows for precise dosing adjustments and easier administration.

Additionally, Valsartan oral suspension may be considered in the treatment of conditions associated with high levels of aldosterone, such as primary aldosteronism, where it can help in managing blood pressure and reducing the risk of cardiovascular complications. In some cases, it may also be used off-label for the treatment of Marfan syndrome to help reduce the rate of aortic dilation, although this is more commonly associated with other ARBs like losartan. The liquid formulation is particularly advantageous for patients who require titration to achieve optimal therapeutic outcomes or for those who have undergone bariatric surgery and may have altered drug absorption.

For prescribers, it is important to consider the individual patient's needs, potential benefits, and risks when prescribing Valsartan oral suspension for off-label uses. Monitoring for efficacy and adverse effects should be conducted regularly, and dose adjustments may be necessary based on the patient's response and tolerability. Patients should be informed about the potential benefits and risks of using Valsartan for these alternative indications and should be encouraged to report any unusual symptoms or side effects. As always, if you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Valsartan 16 mg/mL Oral Suspension?

Valsartan 16 mg/mL Oral Suspension is a liquid dosage form where Valsartan is uniformly dispersed in a liquid medium, creating a homogeneous mixture for easy administration.

How should I store Valsartan Oral Suspension?

Store Valsartan Oral Suspension at room temperature, away from direct sunlight and moisture. Ensure the bottle is tightly closed when not in use.

How do I measure the correct dose of Valsartan Oral Suspension?

Use a calibrated oral syringe or dosing cup to measure the exact dose as prescribed by your healthcare provider. Do not use household spoons as they may not provide an accurate measurement.

Can Valsartan Oral Suspension be mixed with food or drinks?

Consult your healthcare provider before mixing Valsartan Oral Suspension with food or drinks to ensure it does not affect the medication's efficacy.

What should I do if I miss a dose of Valsartan Oral Suspension?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects associated with Valsartan Oral Suspension?

Common side effects may include dizziness, fatigue, or headache. If you experience severe side effects such as difficulty breathing or swelling, seek medical attention immediately.

Can children take Valsartan Oral Suspension?

Valsartan Oral Suspension may be prescribed for children, but only under the guidance and supervision of a healthcare provider. Dosage will be determined based on the child's specific needs.

How does Valsartan Oral Suspension work?

Valsartan works by blocking the action of certain natural substances that tighten the blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently.

Is it safe to take Valsartan Oral Suspension during pregnancy?

Valsartan is not recommended during pregnancy, especially in the second and third trimesters, due to potential harm to the unborn baby. Consult your healthcare provider for alternatives.

What should I do if I experience an allergic reaction to Valsartan Oral Suspension?

If you experience symptoms of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek immediate medical attention.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.