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Formulas

Ursodiol 75 mg Oral Capsules

Ursodiol 75 mg Oral Capsules are a solid dosage form consisting of two halves of either gelatin or vegetarian-based shells that encapsulate the active medication. These capsules are designed to be easily swallowed, ensuring patient comfort and adherence to the prescribed therapy. Each capsule delivers a precise 75 mg dose of ursodiol, which is clinically used for the treatment of primary biliary cirrhosis, gallstone dissolution, and the prevention of gallstones in patients undergoing rapid weight loss. Ursodiol acts by reducing the production of cholesterol and by dissolving the cholesterol in bile so that it cannot form stones. The encapsulated form of ursodiol provides a targeted approach to therapy, promoting optimal therapeutic outcomes.

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Ursodiol
Capsules
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Formula Information

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Ursodiol 75 mg Oral Capsules are a solid dosage form consisting of two halves of either gelatin or vegetarian-based shells that encapsulate the active medication. This form of medication is designed to be swallowed easily and to ensure that patients receive an accurate dose of ursodiol. Ursodiol, also known as ursodeoxycholic acid, is a naturally occurring bile acid that is used to treat several hepatobiliary disorders.

Ursodiol works by reducing the amount of cholesterol produced by the liver and by dissolving the cholesterol that has formed into gallstones in the gallbladder. This medication is particularly effective in the treatment of primary biliary cirrhosis, a chronic disease that causes the small bile ducts in the liver to become inflamed and damaged, leading to a buildup of bile. This can cause liver cells to be damaged and may lead to cirrhosis, a condition in which the liver slowly deteriorates and malfunctions due to chronic injury. Ursodiol helps to slow the progression of this disease and improve liver function tests.

Additionally, ursodiol is used to prevent the formation of gallstones in patients who are undergoing rapid weight loss, which can increase the risk of stones due to changes in bile composition. It is also used to dissolve certain types of gallstones in patients who do not want surgery or cannot have surgery to remove gallstones. Ursodiol can help to dissolve small, cholesterol-rich gallstones in patients whose gallbladders are functioning properly.

It is important for patients and prescribers to understand that while ursodiol can be very effective in treating these conditions, it may not be suitable for everyone. Regular monitoring through liver function tests and ultrasound examinations may be necessary to assess the effectiveness and safety of the treatment. Patients should also be aware of potential side effects, which can include diarrhea, constipation, upset stomach, dizziness, back pain, and hair loss, among others.

For those interested in using Ursodiol 75 mg Oral Capsules for the treatment of hepatobiliary disorders, it is crucial to consult with a healthcare provider to ensure it is the appropriate medication for your specific condition. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing you with the knowledge and support you need to manage your health effectively.

Drug Interactions

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Ursodiol, also known as ursodeoxycholic acid, is a bile acid that is used to treat certain diseases of the liver and gallbladder, such as primary biliary cirrhosis and gallstones that do not require surgery. Ursodiol works by decreasing the production of cholesterol and by dissolving the cholesterol in bile so that it does not form stones. When considering the use of ursodiol 75 mg oral capsules, it is important to be aware of potential drug interactions that may affect the efficacy of the treatment or cause adverse effects.

One of the key interactions to be aware of is with cholesterol-lowering medications, particularly those known as bile acid sequestrants (e.g., cholestyramine, colestipol, or colesevelam). These medications can interfere with the action of ursodiol by binding to it in the intestine and preventing its absorption. To minimize this interaction, ursodiol should be taken at least 1 to 2 hours before or 4 to 6 hours after these medications.

Estrogens, oral contraceptives, and certain cholesterol-lowering drugs such as clofibrate may increase hepatic cholesterol secretion, which can promote gallstone formation and reduce the effectiveness of ursodiol. Patients should discuss the use of these medications with their healthcare provider to determine if adjustments are necessary.

Antacids containing aluminum, such as aluminum hydroxide, may also reduce the absorption of ursodiol if taken concurrently. To avoid this interaction, antacids should be taken at least 2 hours before or after ursodiol. Similarly, proton pump inhibitors (PPIs) and H2-receptor antagonists may alter the pH of the stomach and potentially affect the absorption of ursodiol, although the clinical significance of this interaction is not well established.

It is also important to monitor liver function tests regularly while taking ursodiol, as changes in liver enzyme levels may necessitate dosage adjustments. Additionally, ursodiol should be used with caution in patients with biliary tract obstruction, as it may worsen the condition.

Patients should be advised to inform their healthcare provider of all medications they are taking, including prescription drugs, over-the-counter medications, herbal supplements, and vitamins, to ensure that any potential interactions with ursodiol can be managed appropriately. If you have any questions or concerns about the use of ursodiol 75 mg oral capsules or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Ursodiol, also known as ursodeoxycholic acid, is a naturally occurring bile acid that is used in the treatment of certain liver and gallbladder diseases. Ursodiol 75 mg oral capsules are a solid dosage form that consists of two halves of a gelatin or vegetarian-based shell, which are filled with the precise amount of ursodiol powder and then sealed together. This form of encapsulation ensures that patients receive an accurate dose of the medication in a format that is easy to swallow and convenient to take.

The primary mechanism by which ursodiol works is by reducing the cholesterol content of bile. In the liver, ursodiol decreases the production of cholesterol and dissolves it within the bile. This action is particularly beneficial in the treatment of gallstones, as it helps to dissolve cholesterol gallstones that are small and cholesterol-rich. Ursodiol does this by reducing the saturation of cholesterol in bile, which in turn helps to gradually dissolve the stones. It is important to note that this process can take several months and is most effective for stones that are less than 15 mm in diameter.

In addition to its gallstone-dissolving properties, ursodiol also improves liver function in patients with primary biliary cholangitis (PBC), a chronic liver disease that leads to the destruction of bile ducts. Ursodiol helps to protect liver cells from the toxic effects of bile acids that accumulate in the liver due to the disease. It does this by replacing more toxic bile acids in the bile acid pool, thereby reducing liver inflammation and fibrosis. Ursodiol has been shown to slow the progression of PBC and improve liver tests.

For patients with chronic cholestatic liver diseases, such as primary sclerosing cholangitis (PSC), ursodiol can help to improve liver function tests and may slow disease progression, although its effect on long-term outcomes in PSC is less clear. Ursodiol is also used in certain pediatric liver disorders and cystic fibrosis-related liver diseases to improve bile flow and reduce liver enzyme abnormalities.

It is important for patients and prescribers to understand that while ursodiol can be effective in treating these conditions, it is not suitable for everyone. Patients with calcified gallstones, non-functioning gallbladders, or certain types of liver disease may not be candidates for ursodiol therapy. Additionally, the medication must be taken consistently and as prescribed to be effective, and treatment may need to be long-term.

As with any medication, ursodiol may have side effects, and it should be used under the guidance of a healthcare professional. If you have any questions about ursodiol 75 mg oral capsules or their use in treating liver and gallbladder diseases, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your health care.

Other Uses

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Ursodiol, which is also known as ursodeoxycholic acid, is primarily known for its role in treating certain liver diseases, such as primary biliary cholangitis (PBC). It is formulated into 75 mg oral capsules, where its solid dosage form ensures a consistent delivery of the active drug. However, beyond its mainstream use, ursodiol has other potential therapeutic applications. Patients and prescribers may find interest in its use in the dissolution of gallstones in individuals who choose not to undergo surgery or who may not be good candidates for surgical intervention due to various medical reasons. Ursodiol works by reducing the cholesterol content of bile, facilitating the gradual dissolution of cholesterol-based gallstones.

In addition to its role in managing liver diseases and gallstones, ursodiol has been investigated for use in other conditions. It may hold promise in treating certain cholestatic liver disorders, where bile flow is reduced or obstructed, such as in some forms of drug-induced cholestasis. Research has also explored its potential in the pediatric population, particularly for the treatment of cystic fibrosis-related liver disease, though such use would be off-label and should only be considered under professional guidance. There is some evidence suggesting that ursodiol may improve liver enzyme levels and histological markers in this subset of patients.

Moreover, ursodiol has been shown to have beneficial effects on cholesterol metabolism. This may extend beyond its role in treating gallstones, potentially impacting other conditions related to dyslipidemia. It may also exert some protective effects on the gastric mucosa, which could theoretically be beneficial for patients suffering from certain gastrointestinal complaints. However, these ancillary benefits should be regarded with caution and further explored with clinical trials before being fully integrated into clinical practice for these purposes.

It's important to note that while there may be multiple potential uses for ursodiol, its efficacy and safety profile should be thoroughly evaluated by healthcare professionals for each individual patient case. Off-label uses are not uncommon, but they warrant a careful consideration of the existing evidence and a risk-benefit assessment. Prescribers are strongly encouraged to remain within the purview of approved indications unless substantial evidence supports alternative applications. Patients considering ursodiol for any of the above-discussed uses should engage in open dialogue with their healthcare provider to assess its appropriateness for their specific condition.

If you have any questions or require further information regarding the additional uses of ursodiol 75 mg oral capsules or wish to discuss the potential benefits and risks in your particular situation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing accurate and comprehensive information to support your healthcare decisions.

Frequently Asked Questions

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What is Ursodiol 75 mg Oral Capsule?

Ursodiol 75 mg Oral Capsule is a medication used to dissolve certain types of gallstones and to treat primary biliary cirrhosis. The capsule contains a precise dose of the active ingredient, ursodiol, which is a bile acid naturally found in the body.

How should Ursodiol 75 mg Oral Capsules be taken?

These capsules should be taken exactly as prescribed by your doctor, typically with meals to increase absorption. Swallow the capsules whole; do not chew or crush them.

Are Ursodiol Oral Capsules suitable for vegetarians?

The suitability for vegetarians depends on whether the capsule shell is made from gelatin or a vegetarian alternative. Check with the manufacturer or your pharmacist to confirm the composition of the capsule shell.

Can Ursodiol Oral Capsules be opened and sprinkled on food?

No, the capsules should not be opened. They are designed to be swallowed whole to ensure the medication is released in the correct area of the digestive system.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at one time to make up for a missed dose.

Are there any side effects associated with Ursodiol 75 mg Oral Capsules?

As with all medications, there may be side effects. Common side effects include diarrhea, constipation, upset stomach, tiredness, or back pain. Contact your doctor if you experience severe or persistent side effects.

Can Ursodiol 75 mg Oral Capsules be taken with other medications?

Some medications may interact with ursodiol. Inform your doctor of all medications, supplements, and herbal products you are taking before starting ursodiol to avoid potential interactions.

How should I store Ursodiol Oral Capsules?

Store the capsules at room temperature away from light and moisture. Keep the medication out of reach of children and pets.

Is it safe to take Ursodiol Oral Capsules during pregnancy?

Consult your doctor if you are pregnant or planning to become pregnant while taking this medication. Your doctor will decide whether ursodiol is safe for you based on your specific circumstances.

What should I avoid while taking Ursodiol Oral Capsules?

While taking ursodiol, you should avoid eating a high-fat diet as it may worsen certain conditions that ursodiol treats. Your doctor may provide you with a specific diet to follow to ensure the best results from the medication.

Can I drink alcohol while taking Ursodiol 75 mg Oral Capsules?

Alcohol may affect the way ursodiol works and can also increase the risk of liver damage. It is advisable to limit or avoid alcohol while taking this medication. Discuss your alcohol use with your doctor.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.