Trilostane 30 mg Oral Capsules are a solid dosage form designed to treat conditions such as Cushing's syndrome (hypercortisolism) and Addison's disease (hypoadrenocorticism) in a targeted and effective manner. These capsules consist of two halves, either gelatin-based or made from vegetarian alternatives, which encapsulate the precise 30 mg dose of the active pharmaceutical ingredient, trilostane. This compound specifically inhibits the enzyme 3β-hydroxysteroid dehydrogenase, which is involved in the biosynthesis of several key corticosteroids, including cortisol. By doing so, trilostane effectively reduces the overproduction of cortisol, thereby alleviating the symptoms associated with Cushing's syndrome. In the case of Addison's disease, trilostane is used in a carefully controlled manner to fine-tune the levels of steroids in the body.

For patients, it is important to understand that the use of trilostane requires regular monitoring by a healthcare professional to ensure the correct dosage and to adjust as necessary based on response to treatment and any side effects. Patients should be aware of potential side effects, which can include gastrointestinal disturbances, fatigue, and in some cases, adrenal insufficiency. It is crucial to follow the prescribed regimen and not to alter or discontinue the medication without consulting a healthcare provider.

Prescribers should note that trilostane capsules must be prescribed with caution, considering the patient's medical history and current state of health. Regular follow-up and monitoring of serum cortisol levels are recommended to ensure therapeutic efficacy and to minimize the risk of adverse effects. Dose adjustments may be necessary based on the patient's response and any lab results. It is also important to counsel patients on the potential side effects and the importance of adherence to the prescribed treatment plan.

At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to the needs of individual patients. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide additional information regarding trilostane 30 mg Oral Capsules or any other compounded medications. If you have any questions or require further assistance, please do not hesitate to reach out to us.

Trilostane is an adrenostatic agent used primarily to treat Cushing's syndrome (hypercortisolism) and, less commonly, for the treatment of aldosterone-producing adrenal tumors. It works by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, which is involved in the biosynthesis of several steroids, including cortisol. When prescribing trilostane, it is crucial to consider potential drug interactions that may affect its efficacy or increase the risk of adverse effects.

One significant interaction is with other medications that can also affect adrenal gland function. For example, concurrent use of trilostane with corticosteroids (such as prednisone or dexamethasone) may necessitate adjustments in dosing or increased monitoring due to the potential for either additive effects or opposing effects on steroid synthesis. Patients should be closely monitored for signs of adrenal insufficiency or excessive cortisol suppression.

Drugs that inhibit cytochrome P450 enzymes, particularly CYP3A4, may increase trilostane levels and enhance its effects, potentially leading to an increased risk of side effects. These include certain antifungals (like ketoconazole), some antibiotics (such as erythromycin), and certain protease inhibitors used in the treatment of HIV. Conversely, medications that induce CYP3A4, such as rifampicin and some anticonvulsants (like phenytoin), may decrease the plasma concentration of trilostane, reducing its effectiveness.

Angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) used in the management of hypertension or cardiac conditions may interact with trilostane. Since trilostane can also lower blood pressure by reducing aldosterone production, there is a potential for hypotension when these medications are used concurrently. Blood pressure should be monitored, and dose adjustments may be necessary.

Diuretics, particularly potassium-sparing diuretics, may interact with trilostane by increasing the risk of hyperkalemia, as both can decrease aldosterone levels. It is important to monitor serum potassium levels and renal function when these drugs are used together. Nonsteroidal anti-inflammatory drugs (NSAIDs) may also interact with trilostane by exacerbating potential gastrointestinal side effects or renal dysfunction.

Patients should be advised to inform their healthcare providers of all medications they are taking, including over-the-counter drugs, herbal supplements, and vitamins, to ensure safe and effective use of trilostane. Regular monitoring of adrenal function, blood pressure, electrolytes, and other clinical parameters is recommended to manage potential interactions and side effects effectively.

If you have any questions or require further information regarding trilostane interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support to both patients and prescribers to ensure the safe and effective use of trilostane oral capsules.

Trilostane 30 mg Oral Capsules are a solid dosage form that consists of two halves of either gelatin or vegetarian-based shells. These shells are designed to encapsulate the precise amount of the active pharmaceutical ingredient, trilostane, ensuring that patients receive an accurate dose with each administration. The capsules are intended to be taken orally and are easily swallowed, making them a convenient option for patients who may have difficulty with other dosage forms.

Trilostane works by inhibiting an enzyme known as 3β-hydroxysteroid dehydrogenase, which is involved in the biosynthesis of several key adrenal steroids, including cortisol and aldosterone. By inhibiting this enzyme, trilostane reduces the production of these steroids. This is particularly useful in the treatment of diseases such as Cushing's syndrome (hyperadrenocorticism) and primary aldosteronism, where there is an overproduction of these hormones. In Cushing's syndrome, excess cortisol can lead to a variety of symptoms including weight gain, high blood pressure, and skin changes. By reducing cortisol production, trilostane can help alleviate these symptoms. In primary aldosteronism, the overproduction of aldosterone can cause high blood pressure and low potassium levels; trilostane's inhibitory effect can help normalize these conditions.

It is important for both patients and prescribers to understand that while trilostane can effectively manage the symptoms of these diseases, it is not a cure. Patients will typically need to continue taking the medication for the long term, and regular monitoring of adrenal function and electrolyte levels is necessary to ensure the medication is working effectively and to adjust the dose as needed. Additionally, trilostane should be used with caution in patients with certain medical conditions, and it may interact with other medications. Therefore, a thorough medical history and medication review are essential before starting trilostane therapy.

For any questions regarding the use of Trilostane 30 mg Oral Capsules, or to discuss the suitability of this medication for a particular patient, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide the necessary support and guidance to ensure safe and effective treatment outcomes.

Trilostane 30 mg oral capsules, as solid dosage forms, are primarily indicated for the treatment of Cushing's syndrome (hypercortisolism) and Addison's disease (primary hypoadrenocorticism) in humans. They are formulated to reduce the amount of cortisol produced by the adrenal glands. In veterinary medicine, trilostane capsules are also commonly used to manage Cushing's disease (hyperadrenocorticism) in dogs and occasionally in cats, under the guidance of a veterinarian. It is important for prescribers and patients to note that the use of these capsules should be based on an appropriate diagnostic assessment and under strict monitoring due to the potential for severe side effects and the need for dosage adjustments.

Outside of their primary use, trilostane capsules do not have widely recognized or approved applications; however, researchers have explored their off-label potential in managing atypical Cushing's syndrome in dogs, which is due to excessive adrenal sex hormone production. Additionally, rare cases in human medicine have investigated the off-label use in the treatment of polycystic ovary syndrome (PCOS) and congenital adrenal hyperplasia (CAH), where the drug's cortisol-lowering effect may assist in managing the overproduction of androgens. However, these uses are not standard, and outcomes can be variable and unpredictable.

Given the specificity of trilostane as a cortisol synthesis inhibitor, it should not be used without careful consideration and approval from a healthcare professional. The safety profile, risk of adrenal insufficiency, and potential drug interactions require careful attention. Any off-label use in humans or animals should only be pursued with thorough understanding and caution, often within a research or specialized clinical setting. For any questions or further information regarding the diverse applications of trilostane 30 mg oral capsules, prescribers and patients are encouraged to reach out to us at Bayview Pharmacy, and we will be happy to assist with expert compounding advice and support.