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Terbinafine 100 mg/ml Oral Liquid

The Terbinafine 100 mg/ml Oral Liquid is a specially compounded medication designed for oral use, offering a precise and manageable method of drug delivery. This liquid formulation is particularly beneficial for patients who experience difficulty swallowing pills or tablets, such as children and the elderly. Terbinafine is an antifungal agent used to treat various fungal infections, including onychomycosis (fungal infection of the nails), tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). The liquid form ensures that patients receive the correct dosage of terbinafine to effectively manage and treat these conditions.

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Terbinafine Hydrochloride
Oral Liquid
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Formula Information

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Terbinafine 100 mg/ml Oral Liquid is a specially compounded medication designed for oral use, providing an effective treatment for fungal infections. This formulation is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly, or those with conditions that impair their ability to take solid forms of medication. The liquid form ensures that patients receive an accurate dose of Terbinafine, which is essential for the successful treatment of fungal diseases.

Terbinafine is an antifungal agent that works by inhibiting the enzyme squalene epoxidase, which is a key component in the fungal cell membrane synthesis pathway. By disrupting this pathway, Terbinafine causes the fungal cell membrane to weaken and eventually leads to the death of the fungal cell. This mechanism of action makes Terbinafine effective in treating a variety of fungal infections, including onychomycosis (fungal infection of the nails), tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). It is also used to treat scalp infections and other conditions as prescribed by a healthcare provider.

For patients and prescribers considering Terbinafine 100 mg/ml Oral Liquid, it is important to note that the duration of treatment may vary depending on the location and severity of the infection. It is crucial to adhere to the prescribed treatment regimen to ensure the best possible outcome. Additionally, patients should be monitored for any potential side effects, which may include gastrointestinal disturbances, taste disturbances, or liver enzyme abnormalities, among others. Regular follow-up with the healthcare provider is recommended to assess the effectiveness of the treatment and to make any necessary adjustments.

Bayview Pharmacy is committed to providing high-quality, customized medications to meet the unique needs of each patient. Our team of expert compounding pharmacists is available to answer any questions and provide guidance on the use of Terbinafine 100 mg/ml Oral Liquid. If you have any questions or require further information, please do not hesitate to reach out to us. We are here to support both patients and prescribers in achieving the best therapeutic outcomes with our compounded formulations.

Drug Interactions

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Terbinafine is an antifungal medication that works by inhibiting the enzyme squalene epoxidase, which is a key component in the fungal cell membrane synthesis pathway. This action leads to a deficiency in ergosterol, an essential component of fungal cell membranes, and results in fungal cell death. Terbinafine is commonly used to treat various fungal infections, including onychomycosis (fungal infection of the nails), tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm).

When considering the use of terbinafine 100 mg/ml oral liquid, it is important to be aware of potential drug interactions that may affect the efficacy of the medication or increase the risk of adverse effects. Terbinafine is metabolized primarily through the liver by the cytochrome P450 enzyme CYP2D6, and drugs that affect this enzyme can lead to altered levels of terbinafine. For example, CYP2D6 inhibitors such as fluoxetine, paroxetine, and quinidine may increase terbinafine levels, potentially leading to toxicity. Conversely, inducers of CYP2D6, like rifampin and carbamazepine, may decrease terbinafine levels and reduce its effectiveness.

Terbinafine can also affect the metabolism of other drugs. It may increase the levels of drugs metabolized by CYP2D6, such as tricyclic antidepressants, beta-blockers, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAOIs), which could lead to an increase in their effects and side effects. Additionally, terbinafine may increase the risk of bleeding when taken with anticoagulants like warfarin, as it can increase warfarin levels in the blood. Close monitoring of prothrombin time or international normalized ratio (INR) is recommended when initiating or discontinuing terbinafine in patients on warfarin therapy.

Patients should also be advised to avoid alcohol while taking terbinafine, as concurrent use may increase the risk of liver toxicity. Furthermore, the use of terbinafine with other hepatotoxic drugs should be approached with caution, and regular liver function tests should be considered to monitor for potential liver damage. It is also important to note that terbinafine may decrease the effectiveness of hormonal contraceptives, so alternative or additional non-hormonal birth control methods should be used during treatment.

Before starting terbinafine oral liquid, patients should provide a complete list of all prescription and over-the-counter medications, herbal supplements, and vitamins they are taking to their healthcare provider to assess for potential interactions. If any new medications are prescribed or taken while on terbinafine therapy, patients should consult with their healthcare provider to ensure there are no interactions.

If you have any questions or concerns regarding the use of terbinafine 100 mg/ml oral liquid or its potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure safe and effective treatment.

How Does it Work

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The Terbinafine 100 mg/ml Oral Liquid is a specially crafted medication designed for oral use, providing an effective means of delivering the antifungal agent terbinafine hydrochloride in a liquid form. This formulation is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly, or for those who prefer a liquid dosage form for ease of ingestion. The liquid formulation allows for flexible dosing, which can be precisely measured to ensure the patient receives the exact amount of medication required for their treatment.

Terbinafine is an allylamine antifungal that works by inhibiting the enzyme squalene epoxidase, which is a key component in the fungal cell membrane synthesis pathway. By blocking this enzyme, terbinafine causes a deficiency in ergosterol, an essential component of fungal cell membranes, leading to increased cell membrane permeability and ultimately causing the death of the fungal cell. This mechanism of action makes terbinafine particularly effective against a broad range of dermatophytes and certain other fungi responsible for skin, hair, and nail infections.

The diseases treated by terbinafine include onychomycosis (fungal infection of the nails), tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). These conditions are caused by various dermatophyte fungi, and terbinafine's broad antifungal spectrum ensures that it is effective against most of the common species responsible for these infections. The oral liquid formulation of terbinafine is absorbed in the gastrointestinal tract and distributed to the site of infection, where it exerts its antifungal effects. Treatment duration may vary depending on the location and severity of the infection, and it is important to complete the full course of therapy to ensure the infection is fully eradicated and to prevent resistance.

For patients and prescribers considering the use of Terbinafine 100 mg/ml Oral Liquid, it is important to note that the medication should be used under the guidance of a healthcare professional. The prescriber will determine the appropriate dosage and duration of treatment based on the specific condition being treated and the patient's overall health profile. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance needed to ensure safe and effective treatment with Terbinafine Oral Liquid.

Other Uses

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Terbinafine is primarily known for its antifungal activity, specifically in the treatment of fungal infections of the nails and skin, such as onychomycosis, ringworm, and athlete's foot. However, this versatile compound may have utility in other clinical indications. While Terbinafine 100 mg/ml Oral Liquid is particularly suited for the previously mentioned infections, healthcare providers have explored its use in other fungal infections. Due to terbinafine's mode of action inhibiting the enzyme squalene epoxidase, thereby halting the biosynthesis of ergosterol, an essential component of fungal cell membranes, it may be effective against certain other dimorphic fungi, yeasts, and dermatophytes that rely on this pathway for survival.

There are anecdotal reports and case studies suggesting terbinafine's effectiveness in less common infections like sporotrichosis, chromoblastomycosis, and other deep mycoses where the usual treatments may not be as effective or are contraindicated due to patient-specific factors. Moreover, the oral liquid formulation could allow for more precise dosing adjustments and can be especially beneficial when a tailored dosage regimen is required or when systemic exposure is needed to treat invasive infections.

In addition to its antifungal properties, there is ongoing research looking into terbinafine's anti-inflammatory properties which could potentially widen its therapeutic applications, though these uses are not routinely supported for clinical practice as of the current knowledge base. The oral liquid formulation might also be chosen for its ability to be used in enteral feeding tubes, making it a valuable option for hospitalized patients or those receiving long-term care who cannot swallow pills or require a tube feeding modality.

While these alternative uses suggest a promising scope for terbinafine beyond conventional fungal infections, they remain largely investigational, and the oral liquid formulation should primarily be prescribed for its approved indications. It is crucial for prescribers to consider the evidence, individual patient factors, and to consult the latest clinical guidelines when considering off-label use. Patients and prescribers are encouraged to reach out to our team of compounding pharmacists at Bayview Pharmacy for further information on the potential uses of Terbinafine 100 mg/ml Oral Liquid, as we are equipped to provide guidance on both the established and emerging roles of this medication.

Frequently Asked Questions

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What is Terbinafine 100 mg/ml Oral Liquid used for?

Terbinafine 100 mg/ml Oral Liquid is an antifungal medication used to treat various fungal infections, such as ringworm, athlete's foot, and fungal infections of the fingernails or toenails. It works by stopping the growth of fungi.

How should Terbinafine Oral Liquid be taken?

This medication is taken by mouth, usually once a day or as directed by your healthcare provider. The liquid should be measured with the provided dosing syringe or another accurate measuring device to ensure the correct dose.

Who can take Terbinafine Oral Liquid?

Terbinafine Oral Liquid is suitable for adults and children who have difficulty swallowing pills, such as the pediatric and geriatric populations. However, a healthcare provider must be consulted to determine if this medication is appropriate for a specific individual.

Can Terbinafine Oral Liquid be taken with food?

Yes, Terbinafine Oral Liquid can be taken with or without food. However, taking it with food may reduce the chances of an upset stomach.

Are there any side effects associated with Terbinafine Oral Liquid?

Like all medications, Terbinafine Oral Liquid can cause side effects. Common side effects include upset stomach, diarrhea, headache, or temporary taste disturbances. If you experience more severe side effects, such as persistent nausea, vomiting, fatigue, right upper abdominal pain, yellowing eyes/skin, dark urine, or persistent flu-like symptoms, contact your healthcare provider immediately.

How should Terbinafine Oral Liquid be stored?

Terbinafine Oral Liquid should be stored at room temperature away from light and moisture. Do not store in the bathroom, and keep all medications out of reach of children and pets.

What should I do if I miss a dose of Terbinafine Oral Liquid?

If you miss a dose, take it as soon as you remember unless it is near the time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Can I drink alcohol while taking Terbinafine Oral Liquid?

It is advisable to avoid alcohol while taking Terbinafine Oral Liquid, as alcohol can increase the risk of liver damage and may also interfere with the effectiveness of the medication.

Is Terbinafine Oral Liquid safe for pregnant or breastfeeding women?

The safety of Terbinafine Oral Liquid during pregnancy and breastfeeding has not been fully established. You should discuss the risks and benefits with your healthcare provider before taking this medication if you are pregnant or breastfeeding.

How long does it take for Terbinafine Oral Liquid to work?

It may take several weeks for you to notice an improvement in your symptoms as fungal infections are slow to clear. You may need to take Terbinafine Oral Liquid for several months to ensure the infection is completely treated and prevent it from returning.

Should I avoid any activities or foods while taking Terbinafine Oral Liquid?

There are no specific activities or foods you need to avoid while taking Terbinafine Oral Liquid, but you should follow your healthcare provider's instructions regarding any restrictions. Additionally, avoid alcohol consumption during treatment.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.