Sumatriptan 100 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, sumatriptan, for local or systemic absorption. This route of administration can be particularly beneficial for patients who may have difficulty swallowing oral medications or for those experiencing nausea and vomiting, which are common symptoms associated with migraine attacks. Sumatriptan is a selective serotonin receptor agonist that works by constricting blood vessels in the brain, thereby relieving the pain of a migraine headache. It also blocks the release of substances that can trigger migraine symptoms such as pain, nausea, and sensitivity to light and sound.

The rectal suppository form of sumatriptan provides an alternative to oral and injectable routes, offering a potentially faster onset of action compared to tablets and a non-invasive option compared to injections. This can be particularly advantageous for patients who require rapid relief from migraine symptoms or when a migraine attack is accompanied by severe nausea, making oral administration challenging. The 100 mg dose of sumatriptan in the suppository allows for the delivery of a sufficient amount of the medication to alleviate the symptoms of acute migraine attacks.

Sumatriptan is indicated for the acute treatment of migraine attacks with or without aura in adults. It is not intended for the prophylactic therapy of migraine or for the management of cluster headaches. The use of sumatriptan is contraindicated in patients with a history of coronary artery disease, cerebrovascular syndromes, peripheral vascular disease, uncontrolled hypertension, or hypersensitivity to sumatriptan. Caution is advised when prescribing sumatriptan to patients with risk factors for vascular disease. As with any medication, the potential benefits should be weighed against the risks, and patients should be monitored for any adverse effects during treatment.

For patients and prescribers considering the use of Sumatriptan 100 mg Rectal Suppository, it is important to understand the specific indications, potential side effects, and the proper method of administration. Patients should be instructed on how to properly insert the suppository to ensure effective delivery of the medication. Additionally, prescribers should be aware of the patient's complete medical history, including any concurrent medications, to avoid possible drug interactions and contraindications.

If you have any questions or require further information about the Sumatriptan 100 mg Rectal Suppository, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing comprehensive support and guidance to ensure the safe and effective use of this medication for the relief of migraine symptoms.

Sumatriptan is a medication commonly used to treat migraine headaches by narrowing blood vessels around the brain and reducing substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. When formulated as a 100 mg rectal suppository, sumatriptan is used for its rapid onset of action and is particularly useful for patients who experience nausea and vomiting with their migraines, making oral administration challenging.

However, sumatriptan has several important drug interactions that both patients and prescribers should be aware of. Concurrent use with monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last two weeks can lead to significant increases in sumatriptan levels in the body, potentially resulting in more severe side effects. These can include serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

Sumatriptan should also be used with caution in patients taking other serotonin receptor agonists (triptans), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, or herbal supplements such as St. John's Wort, as these can increase the risk of serotonin syndrome. The risk is particularly high when these medications are taken together or when the dosages are increased.

Additionally, the use of sumatriptan with ergot-containing drugs (like ergotamine or dihydroergotamine) is contraindicated due to the increased risk of prolonged vasospastic reactions. A minimum interval of 24 hours is recommended between the use of sumatriptan and administration of an ergot-type medication.

Patients with a history of seizures should use sumatriptan with caution, as it may lower the seizure threshold. Sumatriptan may also interact with medications that affect liver enzymes, particularly those that are metabolized by the cytochrome P450 system, as this can alter the metabolism and clearance of sumatriptan, potentially leading to increased side effects.

It is important to note that sumatriptan should not be used within 24 hours of another triptan or within 2 weeks of stopping a MAOI. Patients with hepatic impairment may require lower doses of sumatriptan due to reduced clearance of the medication.

Before using sumatriptan rectal suppositories, patients should inform their healthcare provider of all the medications they are taking, including prescription, over-the-counter, vitamins, and herbal supplements, to avoid potential drug interactions. If you have any questions or concerns about using this formulation, please reach out to us at Bayview Pharmacy for further assistance.

The Sumatriptan 100 mg Rectal Suppository is a solid dosage form designed to be inserted into the rectum, where it dissolves or melts at body temperature. Upon insertion, the suppository base, typically composed of substances like cocoa butter or a synthetic substitute, begins to melt or dissolve, allowing the active drug, sumatriptan, to be released into the rectal mucosa. The rectal route is particularly useful for patients who may have nausea or vomiting associated with their condition, making oral administration difficult or ineffective.

Sumatriptan is a medication belonging to a class of drugs known as triptans, which are specifically used to treat migraine headaches. It works by stimulating serotonin (5-HT) receptors in the brain, which causes the constriction of blood vessels in the brain. This vasoconstriction is thought to alleviate the headache by reducing the transmission of pain signals. Sumatriptan also inhibits the release of certain substances that can trigger migraine pain, inflammation, and other symptoms of migraines and cluster headaches.

The rectal administration of sumatriptan provides a rapid onset of action, which is crucial for the treatment of acute migraine attacks. The absorption of the drug through the rectal mucosa bypasses the gastrointestinal tract, which can be advantageous in migraine sufferers who experience gastroparesis during attacks, as this can delay the absorption of orally administered medication. Additionally, rectal administration can avoid first-pass metabolism in the liver, potentially resulting in more of the drug reaching systemic circulation and a quicker therapeutic effect.

It is important for both patients and prescribers to understand that while sumatriptan can be effective in relieving migraine symptoms, it is not intended for the prophylactic therapy of migraine or for the management of hemiplegic or basilar migraine. Careful consideration should be given to the patient's cardiovascular status before initiating therapy with sumatriptan, as triptans can be associated with coronary artery vasospasm. Patients with a history of stroke or transient ischemic attacks, peripheral vascular disease, or those with risk factors for coronary artery disease should be evaluated for cardiovascular risk before being prescribed sumatriptan.

For optimal use, the suppository should be inserted just before or at the onset of a migraine attack. The suppository form is particularly useful when a rapid onset of action is desired, or when other routes of administration are not feasible. Patients should be instructed on the proper technique for inserting rectal suppositories to ensure the best possible efficacy of the medication.

If you have any questions or require further information about the Sumatriptan 100 mg Rectal Suppository, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Sumatriptan rectal suppositories are primarily indicated for the treatment of migraine headaches, providing relief from migraine-related symptoms such as headache pain, nausea, and sensitivity to light and sound. The rectal route is particularly beneficial for migraine sufferers who experience nausea and vomiting and are unable to tolerate oral medications. Sumatriptan works by stimulating serotonin (5-HT) receptors in the brain, which leads to the constriction of blood vessels around the brain and reduces the inflammation and pain associated with a migraine attack.

Beyond the primary indication for migraines, there might be other off-label or investigational uses for sumatriptan suppositories, though these are not as well established. For instance, sumatriptan has been used to treat cluster headaches, which are severe, unilateral headaches accompanied by symptoms like eye watering or nasal congestion. The use of rectal suppositories in such cases could be advantageous when rapid absorption is desired, and other routes of administration are not suitable. However, sumatriptan's efficacy and safety for indications other than migraine have not been recognized on the same level, and such use would be considered off-label and should be approached cautiously.

Additionally, sumatriptan is generally used when a headache or cluster attack has already begun. It is not intended for the prophylactic treatment of migraines or cluster headaches, to prevent attacks or reduce the number of headaches you have. Patients who have a history of heart disease, peripheral vascular disease, stroke, or uncontrolled high blood pressure should not use sumatriptan suppositories due to the risk of serious cardiovascular side effects.

For more targeted symptom relief, some clinicians have used sumatriptan suppositories in individuals who cannot tolerate other forms of administration due to gastrointestinal issues. In cases where oral medications may be less effective due to poor absorption or rapid gut motility, a rectal suppository can provide an alternative route that bypasses the gastrointestinal system.

When considering the use of sumatriptan suppositories for any of the above conditions, or for uses not listed, both prescribers and patients should engage in a thorough risk-benefit analysis, considering all potential side effects and contraindications. It is also important to note that the safety profile for off-label uses of sumatriptan may not be well-documented, and such uses should only be considered when the potential benefits outweigh the risks, and under the guidance of a healthcare professional. If you have any questions or concerns about the use of sumatriptan rectal suppositories for migraine or other conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with personalized information and support.