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Sildenafil Citrate 10 mg/g Vaginal Gel

Sildenafil Citrate 10 mg/g Vaginal Gel is a gel-like semisolid formulation dispensed in a tube, specifically designed for easy and controlled application in the vaginal area. This formulation is used to treat female sexual arousal disorder (FSAD) and other related gynecological conditions by delivering medication directly to the site, enhancing blood flow and providing therapeutic effects. It also offers lubrication, improving comfort and overall sexual experience.

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Sildenafil Citrate
Vaginal Gel
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Formula Information

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Sildenafil Citrate 10 mg/g Vaginal Gel is a specially compounded formulation designed to enhance blood flow directly to the vaginal tissues. By applying the gel locally, it allows for targeted delivery of sildenafil citrate, potentially improving sexual function and increasing sensitivity for women experiencing sexual dysfunction.

The active ingredient, sildenafil citrate, is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing smooth muscle tissue and dilating blood vessels in the genital area. This mechanism enhances blood flow and can promote natural lubrication, which may be beneficial for conditions such as Female Sexual Arousal Disorder (FSAD) or other forms of sexual dysfunction where increased blood flow can alleviate symptoms.

The gel formulation offers the advantage of localized treatment with potentially fewer systemic side effects compared to oral administration. It is dispensed in a tube for easy and controlled application, ensuring the medication is applied directly where it's needed. This can be especially helpful for patients who may have difficulty swallowing pills or who prefer a topical method of administration.

For patients, this medication may provide an option to address sexual dysfunction by enhancing arousal and comfort during sexual activity. It is important to use the gel as directed by a healthcare professional. Before starting treatment, patients should discuss their medical history, including any other medications they are taking, to avoid potential interactions or contraindications.

Prescribers may consider Sildenafil Citrate Vaginal Gel as a therapeutic option for female patients experiencing sexual arousal disorders or inadequate lubrication. By offering a localized treatment, it may reduce the risk of systemic side effects and improve patient compliance. The 10 mg/g concentration allows for precise dosing and flexibility in managing individual patient needs.

As with any medication, there are potential side effects. Patients may experience local reactions such as irritation, itching, or redness at the application site. Although less common with topical application, systemic side effects like headache, flushing, or dizziness can occur. Patients should be advised to report any adverse effects promptly.

If you have any questions about Sildenafil Citrate 10 mg/g Vaginal Gel or how it may be beneficial, please reach out to us for more information. Our team at Bayview Pharmacy is here to assist both patients and healthcare providers with any inquiries.

Drug Interactions

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Sildenafil Citrate 10 mg/g Vaginal Gel is a specialized formulation designed for application in the vaginal area, providing therapeutic effects for various gynecological conditions. While this formulation is primarily intended for local application, it is important to consider potential drug interactions that may arise due to systemic absorption or local effects. Patients and prescribers should be aware of these interactions to ensure safe and effective use of the medication.

One of the primary concerns with Sildenafil Citrate, even in a topical form, is its interaction with nitrates. Patients using any form of nitrates, such as nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate, should avoid using this gel. The combination can lead to a significant drop in blood pressure, which can be dangerous. Additionally, caution is advised when using this formulation alongside other medications that affect blood pressure, such as alpha-blockers or antihypertensives, as there may be an additive hypotensive effect.

Another consideration is the interaction with other phosphodiesterase type 5 (PDE5) inhibitors. Concurrent use of multiple PDE5 inhibitors can increase the risk of adverse effects, such as headaches, flushing, or dizziness. Patients should inform their healthcare provider of all medications they are currently taking to avoid potential interactions.

Furthermore, certain medications that affect the cytochrome P450 enzyme system, particularly CYP3A4 inhibitors, may alter the metabolism of Sildenafil Citrate. Drugs such as ketoconazole, itraconazole, ritonavir, and erythromycin can increase the levels of Sildenafil in the body, potentially leading to increased side effects. Conversely, CYP3A4 inducers like rifampin may decrease the effectiveness of the gel by reducing Sildenafil levels.

Patients should also be cautious when using this gel in conjunction with other topical or systemic medications applied to the vaginal area, as there may be unforeseen interactions or compounded effects. It is crucial to discuss all current medications, including over-the-counter drugs and supplements, with a healthcare provider to ensure compatibility and safety.

If you have any questions or concerns about potential drug interactions with Sildenafil Citrate 10 mg/g Vaginal Gel, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with any inquiries and provide guidance for the safe use of this formulation.

How Does it Work

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Sildenafil Citrate 10 mg/g Vaginal Gel is a specialized formulation designed to deliver sildenafil citrate directly to the vaginal tissue. This gel-like semisolid formulation is dispensed in a tube, allowing for easy and controlled application. The primary mechanism of action of sildenafil citrate involves the inhibition of phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, sildenafil citrate increases the levels of cGMP, leading to the relaxation of smooth muscle and vasodilation. This process enhances blood flow to the targeted area, which can be beneficial for various gynecological conditions.

In the context of vaginal application, the increased blood flow can help address conditions such as female sexual arousal disorder (FSAD) by improving genital blood flow, potentially enhancing sexual arousal and response. Additionally, the gel formulation provides a lubricating effect, which can alleviate discomfort during intercourse, particularly in individuals experiencing vaginal dryness or atrophy. The localized application ensures that the medication acts directly where it is needed, minimizing systemic absorption and reducing the risk of systemic side effects.

For prescribers, it is important to consider the patient's overall health status and any contraindications associated with sildenafil citrate, such as concurrent use of nitrates or certain cardiovascular conditions. The 10 mg/g concentration allows for precise dosing, and the gel form ensures that the medication is evenly distributed across the vaginal mucosa. This formulation can be particularly useful for patients who may not tolerate oral sildenafil due to gastrointestinal side effects or those who require localized treatment for specific gynecological issues.

Patients using Sildenafil Citrate 10 mg/g Vaginal Gel should follow the application instructions provided by their healthcare provider to ensure optimal results. It is recommended to apply the gel as directed, typically before sexual activity, to allow sufficient time for the medication to take effect. Patients should be aware of potential side effects, such as local irritation or allergic reactions, and report any adverse effects to their healthcare provider.

If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your health and treatment options.

Other Uses

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Sildenafil Citrate 10 mg/g Vaginal Gel, while primarily formulated for specific gynecological purposes, may have other potential uses that could be of interest to both patients and prescribers. This gel-like semisolid formulation is designed for easy and controlled application in the vaginal area, which allows for localized delivery of medication. Beyond its primary indications, this formulation may be explored for its potential benefits in enhancing sexual function by increasing blood flow to the vaginal tissues, which could improve lubrication and sensitivity, potentially benefiting individuals experiencing sexual dysfunction or discomfort during intercourse.

Additionally, the vasodilatory effects of Sildenafil Citrate might be investigated for their potential to alleviate symptoms associated with certain pelvic conditions, such as pelvic congestion syndrome, where increased blood flow could help reduce discomfort. The gel formulation also offers a unique advantage in providing a soothing and lubricating effect, which may be beneficial for individuals experiencing vaginal dryness or irritation, whether due to hormonal changes, menopause, or other factors. This could improve overall vaginal health and comfort, making it a versatile option for those seeking relief from such symptoms.

Furthermore, the localized application minimizes systemic absorption, potentially reducing the risk of systemic side effects commonly associated with oral administration of Sildenafil. This makes it a potentially safer alternative for individuals who may be sensitive to systemic effects or who are taking other medications that could interact with oral Sildenafil. As with any medication, it is important for patients and prescribers to discuss the potential benefits and risks, considering individual health conditions and treatment goals. If you have any questions or need further information, please reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Sildenafil Citrate 10 mg/g Vaginal Gel used for?

This gel is used for delivering medication or providing lubrication and therapeutic effects for various gynecological purposes. It is specifically formulated for easy and controlled application in the vaginal area.

How should I apply the Sildenafil Citrate Vaginal Gel?

The gel should be applied as directed by your healthcare provider. Typically, it is dispensed from a tube and applied directly to the vaginal area for optimal therapeutic effects.

Can I use this gel if I am pregnant or breastfeeding?

You should consult your healthcare provider before using this gel if you are pregnant or breastfeeding to ensure it is safe for you and your baby.

Are there any side effects associated with Sildenafil Citrate Vaginal Gel?

Some users may experience mild irritation or discomfort. If you experience severe side effects or an allergic reaction, discontinue use and consult your healthcare provider immediately.

How often should I use the Sildenafil Citrate Vaginal Gel?

The frequency of use should be determined by your healthcare provider based on your specific needs and condition. Follow their instructions carefully.

Can I use this gel with other vaginal products?

Before using this gel with other vaginal products, consult your healthcare provider to avoid potential interactions or reduced effectiveness.

How should I store the Sildenafil Citrate Vaginal Gel?

Store the gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is a prescription required for Sildenafil Citrate Vaginal Gel?

Yes, a prescription is typically required for this medication. Consult your healthcare provider to determine if it is appropriate for you.

Can men use Sildenafil Citrate Vaginal Gel?

This gel is specifically formulated for vaginal use and is not intended for use by men. Consult a healthcare provider for appropriate treatments for male conditions.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.