Phenytoin Sodium 200 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, phenytoin sodium, for systemic absorption. Phenytoin is a well-established anticonvulsant drug used primarily in the management of epilepsy. It works by stabilizing the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing the membrane sodium gradient. This action helps to limit the spread of seizure activity and reduces the seizure's occurrence without causing sedation.

This particular formulation is beneficial for patients who are unable to take oral medications due to various reasons such as vomiting, unconsciousness, or difficulty swallowing. Rectal administration can provide a more consistent absorption rate in such cases and is particularly useful in emergency situations where rapid control of seizure activity is necessary. Phenytoin's efficacy extends to the prevention and treatment of seizures occurring during or after neurosurgery.

Phenytoin suppositories are compounded with precision to ensure the correct dosage and uniformity of the active ingredient. It is crucial for prescribers to be aware that the dosing of phenytoin via the rectal route may differ from oral dosing due to variations in absorption. Monitoring of phenytoin serum levels may be necessary to adjust the dose accordingly. Additionally, patients should be monitored for potential side effects, which can include ataxia, nystagmus, slurred speech, and mental confusion, among others. Long-term use of phenytoin may lead to folate deficiency, and supplementation may be advised.

It is important for both patients and prescribers to understand that while phenytoin rectal suppositories are an alternative route of administration, they should be used in accordance with a healthcare professional's guidance. For any questions regarding the formulation, dosing, administration, or potential side effects of Phenytoin Sodium 200 mg Rectal Suppository, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is committed to providing support and information to ensure the safe and effective use of this medication.

Phenytoin sodium is an anticonvulsant medication used to treat and manage seizures. When formulated as a 200 mg rectal suppository, it is intended for administration via the rectal route, which can be particularly useful in patients who are unable to take medications orally. The rectal suppository form allows for the medication to be absorbed through the rectal mucosa and enter the systemic circulation, providing therapeutic effects similar to those achieved with oral or intravenous routes.

However, phenytoin is known to interact with a wide range of medications, and these interactions can affect the drug's efficacy and the patient's safety. Phenytoin is a potent inducer of hepatic cytochrome P450 enzymes, which can lead to decreased plasma concentrations and reduced efficacy of drugs metabolized by these enzymes. For example, the effectiveness of certain anticoagulants (such as warfarin), corticosteroids, and oral contraceptives may be reduced when used concurrently with phenytoin. Patients should be closely monitored for changes in the efficacy of these medications and dosage adjustments may be necessary.

Conversely, drugs that inhibit cytochrome P450 enzymes, such as isoniazid, fluconazole, and certain SSRIs, can increase phenytoin levels, potentially leading to toxicity. Signs of phenytoin toxicity include nystagmus, ataxia, slurred speech, and mental confusion. It is crucial to monitor phenytoin serum levels and adjust the dosage as needed when initiating or discontinuing drugs that may affect its metabolism.

Phenytoin also affects the metabolism of other anticonvulsants, such as valproic acid and phenobarbital, which can lead to either increased toxicity or decreased efficacy of these drugs. Additionally, phenytoin's absorption may be affected by drugs that alter gastrointestinal motility, such as anticholinergic agents, which could lead to variable plasma levels and therapeutic effects.

It is also important to note that phenytoin can interact with certain supplements and food. Chronic alcohol use can alter phenytoin metabolism, and acute alcohol intake may either increase or decrease phenytoin serum levels. Folate supplementation may be required as phenytoin can interfere with folate absorption, potentially leading to deficiency.

Given the complexity of these interactions, it is essential for prescribers to thoroughly review a patient's medication regimen before prescribing phenytoin rectal suppositories. Patients should be advised to inform their healthcare provider of all medications, supplements, and herbal products they are taking. Regular monitoring of drug levels and clinical response should be performed to ensure therapeutic effectiveness and to avoid adverse effects. If you have any questions or require further information regarding drug interactions with phenytoin rectal suppositories, please reach out to us at Bayview Pharmacy for assistance.

Phenytoin Sodium is an anticonvulsant medication that is commonly used to manage and prevent seizures in various forms of epilepsy. The 200 mg Phenytoin Sodium Rectal Suppository is a solid dosage form designed for rectal administration, which can be particularly useful in patients who are unable to take medications orally due to vomiting, unconsciousness, or other conditions that affect the gastrointestinal tract.

The rectal suppository is inserted into the rectum, where it begins to dissolve or melt at body temperature. As the suppository base dissolves, it releases the active ingredient, Phenytoin Sodium, which is then absorbed through the rectal mucosa. The rectal route bypasses the stomach and first-pass metabolism in the liver, which can be advantageous for drugs like phenytoin that have variable oral bioavailability. This allows for more consistent plasma levels of the medication, which is critical for the management of seizure disorders.

Once absorbed, Phenytoin Sodium works by stabilizing the neuronal membrane and reducing the excitability of the central nervous system. It does this by inhibiting voltage-gated sodium channels, which decreases the repetitive firing of action potentials in the neurons. This action helps to prevent the spread of seizure activity in the brain and can terminate ongoing seizures. Phenytoin is effective in treating partial seizures, tonic-clonic seizures, and can be used in the prevention of seizures following neurosurgery.

It is important for patients and prescribers to understand that the dosing of phenytoin must be individualized and carefully monitored due to its narrow therapeutic index and nonlinear pharmacokinetics. Blood levels of phenytoin should be checked regularly to ensure therapeutic levels are maintained and to avoid toxicity. Additionally, patients should be aware of potential side effects, including dizziness, drowsiness, and ataxia, among others.

For those interested in using the Phenytoin Sodium 200 mg Rectal Suppository, it is crucial to follow the specific instructions provided by the healthcare provider and the compounding pharmacy for proper administration. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with your medication needs and to ensure the safe and effective use of Phenytoin Sodium suppositories.

Phenytoin sodium is a medication typically known for its anticonvulsant properties, traditionally used in the treatment of tonic-clonic (grand mal) seizures and complex partial seizures. When prepared as a 200 mg rectal suppository, this formulation is primarily designed to deliver phenytoin systemically when oral administration is not feasible due to various reasons such as gastrointestinal disturbances, surgery, or impaired consciousness. Patients and prescribers should note that while the primary indication of this dosage form is to manage seizures, phenytoin has been investigated for its potential off-label uses as well.

For instance, phenytoin suppositories might be employed in the management of neuropathic pain. Phenytoin’s mechanism of stabilizing neuronal membranes could theoretically alleviate pain by decreasing the aberrant electrical activity of damaged nerves that is responsible for neuropathic pain sensations. Another potential application of phenytoin is in the treatment of arrhythmias, particularly in situations where parenteral administration of other antiarrhythmic drugs is not possible or contraindicated. However, the use of phenytoin for arrhythmias through a rectal suppository formulation would require careful consideration and special monitoring due to its narrow therapeutic index and potential for adverse effects.

Moreover, in the field of dermatology, there has been experimentation with topical phenytoin for wound healing due to its reported effects on stimulating fibroblast proliferation and increasing collagen synthesis. While the rectal suppository is not designed for topical use, it underscores the multifaceted actions of phenytoin beyond seizure control. Nevertheless, the use of phenytoin in conditions other than seizures, via any route, should always be supported by substantiated research or professional medical guidance, considering also the risk of systemic side effects such as gingival hyperplasia, hirsutism, and hypotension, among others.

All these potential 'other uses' require thorough understanding and careful monitoring by healthcare professionals. Patients and prescribers interested in exploring alternative applications of phenytoin sodium 200 mg rectal suppository should approach such considerations with caution and always rely on clinical evidence and expert opinion. The role of a compounding pharmacist is crucial in providing not just the tailored formulation but also the necessary guidance and education on its safe and effective use, tailored to individual patient needs. If you have any questions about this medication or its potential uses, please reach out to our team at Bayview Pharmacy, and we will be ready to assist you with the personalized care and information you require.