Phenoxybenzamine HCl 12.5 mg/ml Oral Liquid is a specially compounded medication designed for oral use, providing a precise 12.5 milligrams of Phenoxybenzamine Hydrochloride per milliliter of liquid. This formulation is particularly beneficial for patients who have difficulty swallowing pills, such as those in pediatric or geriatric populations, or for those with conditions that impair their ability to ingest solid forms of medication. The liquid form allows for flexible dosing, which can be easily adjusted according to the specific needs of the patient.

Phenoxybenzamine is an alpha-adrenergic blocker, which works by inhibiting the action of certain chemicals in the body that constrict blood vessels and stimulate the smooth muscles. This medication is primarily used in the treatment of pheochromocytoma, a rare tumor of the adrenal gland which can cause high blood pressure. By blocking the effect of adrenaline, Phenoxybenzamine reduces hypertension associated with this condition. It is also used off-label for other conditions such as Raynaud's disease and certain types of hyperhidrosis (excessive sweating), where its vasodilatory effects can be beneficial.

It is important for prescribers to consider the half-life and duration of action of Phenoxybenzamine when determining the dosing schedule, as it has a long-lasting effect. Patients should be monitored for potential side effects, including postural hypotension, nasal congestion, and reflex tachycardia. Due to its potential to cause significant hypotension, titration of the dose to the individual patient's response is crucial. Additionally, patients should be counseled on the potential for drowsiness or dizziness, and advised to avoid activities requiring alertness until they know how the medication affects them.

As compounding pharmacists at Bayview Pharmacy, we ensure that each batch of Phenoxybenzamine HCl 12.5 mg/ml Oral Liquid is prepared to the highest standards of quality and consistency. We are available to answer any questions or concerns from both patients and prescribers regarding this formulation. Our goal is to provide a tailored medication solution that meets the unique needs of each patient, ensuring efficacy and safety. If you have any questions or require further information about this compounded medication, please do not hesitate to reach out to us.

Phenoxybenzamine HCl is an alpha-adrenergic blocker used to treat conditions such as hypertension and sweating associated with pheochromocytoma, as well as to manage urinary retention caused by neurogenic bladder. When considering the use of phenoxybenzamine HCl 12.5 mg/ml oral liquid, it is crucial to be aware of potential drug interactions that may affect the efficacy of the medication or increase the risk of adverse effects.

Phenoxybenzamine can interact with other alpha-blockers or blood pressure-lowering medications, leading to an additive hypotensive effect. Caution is advised when co-administering with drugs such as prazosin, terazosin, or doxazosin, as well as with beta-blockers, ACE inhibitors, calcium channel blockers, and diuretics. Patients should be monitored closely for signs of hypotension, such as dizziness, lightheadedness, or fainting.

Concomitant use of phenoxybenzamine with drugs that affect the central nervous system, such as sedatives, hypnotics, opioids, or anxiolytics, may result in increased sedation and drowsiness. Patients should be advised to avoid activities requiring mental alertness, such as driving or operating heavy machinery, until they know how the combination affects them.

Phenoxybenzamine may also interact with sympathomimetic agents, including decongestants and bronchodilators containing pseudoephedrine or phenylephrine, as well as with amphetamines. These interactions can reduce the efficacy of phenoxybenzamine and lead to uncontrolled hypertension. It is important to review all over-the-counter medications and dietary supplements with a healthcare provider to avoid such interactions.

Patients receiving general anesthetics should inform their anesthesiologist that they are taking phenoxybenzamine, as it may potentiate the effects of anesthetics, leading to pronounced cardiovascular effects such as hypotension.

Phenoxybenzamine is metabolized by the liver, and drugs that affect hepatic enzyme activity may alter the metabolism of phenoxybenzamine. For example, CYP3A4 inducers can decrease the plasma concentration of phenoxybenzamine, potentially reducing its effectiveness, while CYP3A4 inhibitors can increase plasma concentrations, raising the risk of adverse effects.

Alcohol consumption should be limited or avoided while taking phenoxybenzamine, as alcohol can enhance the hypotensive effect and increase the risk of dizziness and fainting.

It is essential for patients and prescribers to review all current medications, including prescription, over-the-counter, and herbal supplements, before starting treatment with phenoxybenzamine HCl oral liquid. Adjustments to therapy or additional monitoring may be necessary to safely use this medication. If you have any questions or concerns regarding potential drug interactions with phenoxybenzamine HCl oral liquid, please reach out to us at Bayview Pharmacy for further assistance.

Phenoxybenzamine HCl 12.5 mg/ml Oral Liquid is a specially compounded medication designed for oral use, providing a precise and consistent dose of phenoxybenzamine hydrochloride in a liquid form. This formulation is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly, or for those who require a dosage that is not readily available in commercial tablet or capsule forms.

The active ingredient, phenoxybenzamine hydrochloride, is a non-selective, irreversible alpha-adrenergic antagonist. It works by blocking alpha-1 and alpha-2 adrenergic receptors, which are found on the smooth muscles of blood vessels and other tissues. By inhibiting these receptors, phenoxybenzamine decreases vascular resistance and leads to vasodilation, which in turn lowers blood pressure. This mechanism of action makes it particularly effective in treating conditions such as pheochromocytoma, a rare tumor of the adrenal gland that can cause high blood pressure. It is also used to manage sweating and other symptoms associated with pheochromocytoma.

In addition to its use in pheochromocytoma, phenoxybenzamine is sometimes used off-label for other conditions that involve hyperadrenergic states or sympathetic overactivity, such as certain types of Raynaud's phenomenon or complex regional pain syndrome. By blocking the effects of adrenaline and noradrenaline, phenoxybenzamine can help alleviate symptoms associated with these conditions.

It is important for patients and prescribers to understand that due to its irreversible binding to adrenergic receptors, the effects of phenoxybenzamine can last for a relatively long period and its action may continue to accumulate with repeated dosing. Therefore, careful titration and monitoring of the dose are essential to minimize potential side effects, such as orthostatic hypotension, nasal congestion, and reflex tachycardia.

As compounding pharmacists at Bayview Pharmacy, we meticulously prepare this formulation to ensure the highest quality and consistency. We use pharmaceutical-grade ingredients and follow strict compounding procedures. If you have any questions about this formulation or its appropriate use, please do not hesitate to reach out to us. We are here to provide the necessary support and guidance to both patients and healthcare providers to ensure safe and effective treatment outcomes.

While Phenoxybenzamine HCl is primarily prescribed for the management of pheochromocytoma to control episodes of hypertension, this medication has been utilized off-label for a variety of other conditions. Notably, it serves as a long-acting, non-selective, alpha-adrenergic antagonist which can make it useful in conditions where sympathetic inhibition is beneficial. One such secondary indication is for the treatment of Raynaud's phenomenon, where it helps to reduce peripheral vascular resistance and improve blood flow to extremities. Additionally, Phenoxybenzamine has been used in complex regional pain syndrome (CRPS) for its potential to decrease pain and improve range of motion in affected limbs.

Furthermore, pediatric and urological applications have been identified where Phenoxybenzamine plays a therapeutic role. It is sometimes administered for the management of bladder dysfunction, including conditions like neurogenic bladder, where it helps by reducing bladder neck resistance and the occurrence of urinary retention. In congenital heart surgery, phenoxybenzamine has been used off-label for its vasodilatory effects to control pulmonary hypertension and reduce systemic vascular resistance postoperatively.

It is important to note that while there may be emerging or anecdotal evidence supporting these additional uses, they may not be approved by regulatory agencies such as the Food and Drug Administration (FDA). Physicians should exercise their clinical judgment and consider current research when prescribing this compound for off-label uses. Patients should also be made aware of the potential risks and benefits associated with the use of Phenoxybenzamine HCl for conditions beyond its approved indications. If you have any questions or require further clarification regarding the use of Phenoxybenzamine HCl 12.5 mg/ml Oral Liquid for these or any other conditions, please, do not hesitate to reach out to us at Bayview Pharmacy. We are dedicated to providing comprehensive information and guidance to both patients and prescribers. We are here to help ensure the safe and effective use of compounded medications.