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Formulas

Pergolide mesylate 1 mg/ml Oral Liquid

Pergolide mesylate 1 mg/ml Oral Liquid is a specially compounded medication designed for oral use, offering a precise and manageable method of drug delivery. This liquid formulation is particularly beneficial for patients who experience difficulty swallowing pills or tablets, making it an ideal choice for pediatric and geriatric patients. Pergolide mesylate is primarily used in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by motor symptoms such as tremors, stiffness, and bradykinesia. It functions as a dopamine agonist, mimicking the action of dopamine in the brain, which can help to alleviate some of the symptoms associated with the disease. Additionally, this medication may be prescribed for other health conditions as determined by a healthcare provider.

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Pergolide Mesylate
Oral Liquid
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Formula Information

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Pergolide mesylate 1 mg/ml Oral Liquid is a specially compounded medication designed for oral use, providing patients with a precise 1 mg dose of pergolide in each milliliter of the solution. This liquid formulation is particularly beneficial for patients who have difficulty swallowing pills, such as those in pediatric or geriatric populations, or for individuals with conditions that impair their ability to ingest solid dosage forms. The liquid form allows for flexible dosing, which can be easily adjusted according to the specific needs of the patient.

Pergolide mesylate is a dopamine agonist that mimics the action of dopamine in the brain. It is primarily used in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by tremors, stiffness, and bradykinesia. By stimulating dopamine receptors, pergolide helps to alleviate the motor symptoms associated with the disease, improving the quality of life for patients. Additionally, pergolide has been used off-label for the treatment of hyperprolactinemia, a condition where there is an excess of prolactin in the blood, often leading to various symptoms including infertility and bone loss.

The liquid formulation of pergolide mesylate ensures that the medication is absorbed quickly and efficiently, providing rapid relief from symptoms. It is important for patients and prescribers to be aware that the use of pergolide may be associated with side effects such as nausea, dizziness, and orthostatic hypotension. Regular monitoring and dose adjustments may be necessary to minimize these effects and optimize therapeutic outcomes. As with any medication, adherence to prescribed dosing schedules is crucial for the effectiveness of the treatment.

For prescribers considering this formulation for their patients, it is essential to provide comprehensive instructions on the proper administration and storage of the medication. Patients should be counseled on the importance of shaking the bottle well before each use to ensure the medication is evenly distributed throughout the liquid. The use of a calibrated measuring device is recommended to ensure accurate dosing.

At Bayview Pharmacy, we are committed to providing high-quality, customized medications to meet the unique needs of each patient. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide support to both patients and healthcare providers. If you have any inquiries or require further information about Pergolide mesylate 1 mg/ml Oral Liquid or its use in treating Parkinson's disease and hyperprolactinemia, please do not hesitate to reach out to us.

Drug Interactions

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Pergolide mesylate is a dopamine agonist that is used primarily to treat Parkinson's disease by mimicking the effects of dopamine in the brain, which is typically low in individuals with this condition. It can also be used for other conditions as determined by a healthcare provider. When considering the use of pergolide mesylate 1 mg/ml oral liquid, it is important to be aware of potential drug interactions that may affect the efficacy of the medication or increase the risk of adverse effects.

One significant interaction is with antipsychotic medications, which can antagonize the effects of pergolide and diminish its efficacy. Patients taking antipsychotics should consult their healthcare provider before starting pergolide. Additionally, caution is advised when pergolide is co-administered with other central nervous system depressants, such as benzodiazepines, opioids, or alcohol, as these can exacerbate sedative effects and lead to increased drowsiness or dizziness.

Medications that inhibit CYP3A4, an enzyme important for the metabolism of pergolide, can increase pergolide levels and the risk of side effects. These include certain antibiotics (e.g., erythromycin), antifungals (e.g., ketoconazole), and protease inhibitors. Conversely, CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease pergolide levels and potentially reduce its effectiveness. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements, to assess for potential interactions.

Medications that affect blood pressure can also interact with pergolide. Since pergolide can cause orthostatic hypotension (a drop in blood pressure upon standing), combining it with antihypertensive drugs may increase the risk of severe hypotension. Similarly, vasodilators and medications that increase blood pressure should be used with caution.

Patients with existing cardiac conditions should be closely monitored, as pergolide has been associated with valvular heart disease. Combining pergolide with other medications that affect heart valves, such as certain migraine medications (ergot alkaloids), may increase this risk.

It is also important to note that pergolide may interact with dopamine antagonists, such as metoclopramide, which are used to treat gastrointestinal disorders. These medications can counteract the effects of pergolide and should be avoided or used with caution.

Due to the potential for interactions and the serious nature of some of these effects, it is crucial for patients and prescribers to maintain open communication regarding all medications being taken. Adjustments to therapy may be necessary to ensure the safe and effective use of pergolide mesylate oral liquid. If you have any questions or concerns about drug interactions with pergolide mesylate, please reach out to us at Bayview Pharmacy for further information and personalized advice.

How Does it Work

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Pergolide mesylate is an ergoline derivative that functions as a dopamine agonist, which means it stimulates dopamine receptors in the brain. Dopamine is a neurotransmitter that plays a significant role in the regulation of movement, and an imbalance of this chemical can lead to motor function issues. Pergolide mesylate is primarily used in the treatment of Parkinson's disease, a condition characterized by tremors, stiffness, and bradykinesia (slowness of movement). By activating dopamine receptors, pergolide mesylate helps to compensate for the reduced levels of dopamine seen in Parkinson's disease, thereby improving symptoms such as tremors and muscle rigidity.

The 1 mg/ml oral liquid formulation of pergolide mesylate provides a precise dosage that can be easily adjusted according to the patient's needs. This is particularly beneficial for patients who require a dosage that is not available in tablet form or for those who have difficulty swallowing pills, such as the elderly or young children. The liquid form allows for the medication to be administered with the aid of a dropper or a syringe, ensuring accurate dosing and potentially improving patient compliance.

Additionally, the oral liquid formulation can be more rapidly absorbed compared to solid dosage forms, which may lead to a quicker onset of action. This can be particularly important for patients who experience sudden episodes of immobility or "off" periods, where the symptoms of Parkinson's disease become more pronounced. The liquid form can also be mixed with certain foods or beverages to improve palatability, making it easier for patients to take their medication as prescribed.

It is important for both patients and prescribers to understand that while pergolide mesylate can alleviate the symptoms of Parkinson's disease, it does not cure the condition. Long-term management and regular monitoring by a healthcare professional are essential to optimize treatment outcomes and to manage any potential side effects. If you have any questions about the pergolide mesylate 1 mg/ml oral liquid formulation or its use in treating Parkinson's disease and other related conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the information and support you need.

Other Uses

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Pergolide mesylate is primarily prescribed for the treatment of Parkinson's disease to control symptoms such as tremors, stiffness, and slowness of movement. However, this medication has also been used off-label for other conditions where dopamine agonist properties may be beneficial. For example, it has been considered in the management of Restless Legs Syndrome (RLS), a neurologic disorder characterized by an uncontrollable urge to move the legs. In addition, in veterinary medicine, pergolide is well recognized for treating pituitary pars intermedia dysfunction (PPID), commonly known as Cushing's disease in horses. This off-label use is specific to veterinary practice and should not be confused with human medicine applications.

Furthermore, there has been a research interest in evaluating the effectiveness of pergolide for other hyperprolactinemia-related disorders due to its ability to inhibit prolactin secretion. This could be relevant for patients with prolactinomas or other conditions leading to an excessive production of prolactin. However, it's important to note that the safety and efficacy of pergolide for these additional uses are less well-documented, and patients should only use the medication for these conditions under the close supervision of a qualified healthcare provider.

As a liquid dosage form of pergolide mesylate, this 1 mg/ml oral preparation may offer distinct advantages for certain patient populations. The liquid form is particularly useful for patients who experience difficulty swallowing tablets or capsules, such as those with dysphagia. This may include individuals with neurological conditions, esophageal disorders, or those who require enteral feeding tubes. Moreover, the precise dosing attainable with a liquid formulation can be advantageous when titrating the dose according to the patient's response and tolerability, thus potentially reducing side effects and optimizing therapeutic outcomes.

It is vital that patients and prescribers are aware that using pergolide in ways not fully supported by evidence requires careful consideration and monitoring. Decisions to use pergolide for off-label conditions should involve a comprehensive assessment of the potential risks and benefits, with thorough discussions of patient-specific factors. If you have any questions or need advice on the suitability of pergolide mesylate oral liquid for any particular condition, or require additional information on the "Other Uses" of this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to support and guide you through the appropriate and safe use of this medication.

Frequently Asked Questions

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What is Pergolide mesylate 1 mg/ml Oral Liquid?

Pergolide mesylate 1 mg/ml Oral Liquid is a specifically formulated medication for oral use designed to deliver an accurately measured dose of pergolide mesylate. It is used in certain medical conditions that require treatment with pergolide, and it is particularly beneficial for patients who have difficulty swallowing pills or tablets.

How should I take Pergolide mesylate Oral Liquid?

You should take Pergolide mesylate Oral Liquid exactly as prescribed by your healthcare provider. The medication is to be taken by mouth, and it's important to use the dosing syringe or cup provided to measure the correct dose. Do not mix with other liquids unless instructed by your healthcare provider.

Can Pergolide mesylate Oral Liquid be taken with food?

Yes, Pergolide mesylate Oral Liquid can be taken with or without food. Follow your healthcare provider's instructions regarding food and medication intake to ensure proper absorption and efficacy of the medication.

Is Pergolide mesylate Oral Liquid suitable for children and elderly patients?

Yes, this liquid formulation is particularly beneficial for pediatric and geriatric patients who may find swallowing solid dosage forms challenging. The appropriateness of this medication for an individual, regardless of age, should be determined by their healthcare provider based on their specific health needs.

What should I do if I miss a dose?

If you miss a dose of Pergolide mesylate Oral Liquid, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and proceed with your regular dosing schedule. Do not double up doses to compensate for a missed one.

Does Pergolide mesylate Oral Liquid have any side effects?

Like all medications, Pergolide mesylate Oral Liquid can have side effects, although not everyone will experience them. Common side effects may include headaches, nausea, dizziness, and fatigue. Contact your healthcare provider if you experience any side effects that persist or worsen.

How should I store Pergolide mesylate Oral Liquid?

Store Pergolide mesylate Oral Liquid at room temperature away from light and moisture, and keep the bottle tightly closed to prevent contamination. Always keep medications out of reach of children and pets.

Can Pergolide mesylate Oral Liquid be used with other medications?

It is important to tell your healthcare provider about all the medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements. Pergolide mesylate Oral Liquid may interact with other medications, which can affect how your medications work or increase your risk for serious side effects.

How is Pergolide mesylate Oral Liquid different from other forms of pergolide?

Pergolide mesylate Oral Liquid is tailored for individuals who have difficulty swallowing solid forms of medication, such as pills or capsules. The liquid formulation allows for more flexible dosing and may provide a more convenient way to take this medication.

What should I do in case of overdose with Pergolide mesylate Oral Liquid?

If you suspect an overdose of Pergolide mesylate Oral Liquid, seek immediate medical attention or call a poison control center. Symptoms of overdose may require prompt medical intervention to prevent severe complications, so do not delay in getting help.

Do I need a prescription for Pergolide mesylate Oral Liquid?

Yes, Pergolide mesylate Oral Liquid is a prescription medication. You must have a prescription from your healthcare provider to obtain this medication. Always use it as directed by your healthcare provider and do not share it with others, even if their condition appears to be the same as yours.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.