Pergolide Mesylate is a dopamine agonist medication that is primarily used in the treatment of Parkinson's disease, a progressive neurological disorder characterized by tremors, stiffness, and difficulty with balance and coordination. Pergolide works by stimulating dopamine receptors in the brain, which helps to improve the motor symptoms associated with the disease. The use of Pergolide Mesylate has been less common due to the risk of heart valve damage, and it is typically considered when other treatments have not been effective or are not tolerated.

The Pergolide Mesylate 0.131 mg Oral Capsules are a solid dosage form consisting of two gelatin or vegetarian shells that encapsulate the medication. This form of delivery is designed to facilitate easy swallowing and ensure that patients receive an accurate dose of the active ingredient. The capsules are intended for oral administration and are usually taken once daily or as directed by a healthcare provider. It is important for patients to follow their prescriber's instructions regarding dosage and administration to optimize treatment outcomes and minimize potential side effects.

For patients with Parkinson's disease, Pergolide Mesylate can help alleviate symptoms such as bradykinesia (slowness of movement), rigidity, and tremors. However, it is essential for patients to be aware of the potential side effects, which may include nausea, dizziness, orthostatic hypotension (a drop in blood pressure upon standing), and the aforementioned risk of heart valve damage. Regular monitoring by a healthcare provider is recommended to assess the efficacy of the treatment and to detect any adverse effects early on.

Prescribers considering Pergolide Mesylate for their patients should be aware of the medication's pharmacological profile, including its mechanism of action, potential drug interactions, and contraindications. It is also crucial to conduct a thorough patient history and physical examination to ensure that Pergolide Mesylate is an appropriate treatment option. Due to the risks associated with this medication, it may be necessary to explore alternative therapies if the patient has a history of cardiac disease or other significant health concerns.

Bayview Pharmacy is committed to providing high-quality compounding services to meet the unique needs of each patient. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide additional information regarding Pergolide Mesylate 0.131 mg Oral Capsules. We encourage both patients and prescribers to reach out to us for guidance on this formulation and its use in treating Parkinson's disease and related conditions.

Pergolide mesylate is a dopamine agonist that is used to treat Parkinson's disease by stimulating dopamine receptors in the brain, which helps to improve symptoms such as tremors, stiffness, and slowness of movement. However, when prescribing or taking pergolide mesylate, it is important to be aware of potential drug interactions that could affect its efficacy or increase the risk of adverse effects.

One significant interaction is with antipsychotic medications, which can antagonize the effects of pergolide and diminish its efficacy. Patients taking antipsychotics should consult their healthcare provider before starting pergolide. Additionally, dopamine antagonists such as metoclopramide, used to treat nausea and vomiting, can also reduce the effectiveness of pergolide and should be used cautiously.

Concomitant use of pergolide with other medications that lower blood pressure, including diuretics, beta-blockers, and calcium channel blockers, may lead to an additive hypotensive effect, increasing the risk of dizziness or fainting. It is important to monitor blood pressure regularly when starting or adjusting doses of these medications.

Medications that inhibit CYP3A4, an enzyme responsible for the metabolism of pergolide, such as macrolide antibiotics (e.g., erythromycin), azole antifungals (e.g., ketoconazole), and protease inhibitors, can increase pergolide levels in the blood and may necessitate dosage adjustments. Conversely, CYP3A4 inducers, such as rifampin and certain anticonvulsants (e.g., phenytoin, carbamazepine), can decrease pergolide levels and reduce its effectiveness.

Combining pergolide with other drugs that increase serotonin levels, such as SSRIs, SNRIs, and triptans, can increase the risk of serotonin syndrome, a potentially life-threatening condition. Symptoms of serotonin syndrome include confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Immediate medical attention is required if these symptoms occur.

Patients should also be cautious when taking pergolide with sedatives, hypnotics, or other central nervous system depressants, as these can exacerbate the sedative effects of pergolide and increase the risk of drowsiness and dizziness.

It is essential for patients and prescribers to review all current medications, including over-the-counter drugs and herbal supplements, to identify any potential interactions before starting treatment with pergolide mesylate. Adjustments to therapy or additional monitoring may be necessary to ensure safe and effective use of this medication. If you have any questions or concerns regarding drug interactions with pergolide mesylate, please reach out to us at Bayview Pharmacy for further assistance.

Pergolide mesylate is a medication that falls under the category of dopamine agonists, which means it functions by stimulating dopamine receptors in the brain. Dopamine is a neurotransmitter that plays a crucial role in the regulation of movement, and an imbalance of this chemical can lead to motor function disorders. Pergolide mesylate is specifically used to treat the symptoms of Parkinson's disease, a progressive neurological disorder characterized by tremors, stiffness, and bradykinesia (slowness of movement). It is also used in the treatment of hyperprolactinemia, a condition where there is an excess of prolactin in the blood.

The active ingredient in the formulation, pergolide mesylate, works by mimicking the action of dopamine, thus helping to restore the balance of this neurotransmitter in the brain. By activating the dopamine receptors, pergolide mesylate can alleviate some of the symptoms associated with Parkinson's disease, such as difficulty in initiating movements and controlling muscle function. In the case of hyperprolactinemia, pergolide mesylate's dopamine agonist activity leads to a decrease in prolactin secretion, thereby addressing issues such as infertility, sexual problems, and bone loss associated with the condition.

The 0.131 mg oral capsules of pergolide mesylate are a solid dosage form that provides a precise amount of medication in a convenient manner. The capsules are made up of two halves that fit together to enclose the medication. These can be composed of either gelatin or vegetarian-based materials, depending on patient preference or dietary restrictions. The encapsulated form of pergolide mesylate ensures that the drug is protected from degradation by environmental factors until it reaches the stomach, where it is then released and absorbed into the bloodstream.

For patients and prescribers considering this formulation, it is important to note that the use of pergolide mesylate should be individualized and closely monitored due to the potential for side effects and interactions with other medications. It is also essential to adhere to the prescribed dosage and administration schedule to achieve the best therapeutic outcomes. If you have any questions or require further information about pergolide mesylate 0.131 mg oral capsules, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need.

Pergolide mesylate is a medication that is primarily prescribed for the treatment of Parkinson's disease. It functions as a dopamine agonist, mimicking the action of dopamine in the brain, which is typically reduced in patients with Parkinson's disease. This can help reduce symptoms such as stiffness, tremors, spasms, and poor muscle control. However, besides its main use in the management of Parkinson's disease, pergolide has had some historical application in the treatment of restless legs syndrome (RLS) and hyperprolactinemic disorders. In cases of RLS, pergolide may be utilised for its dopaminergic effects, which can help alleviate the uncomfortable sensations and urgings to move that characterize the condition. Meanwhile, for individuals with conditions that result in elevated levels of prolactin, such as prolactinomas (prolactin-secreting tumors), this medication has been considered for its ability to suppress prolactin secretion and alleviate associated symptoms.

It is important to note that the use of pergolide for indications other than Parkinson's disease may not be as common today due to the discovery of its potential association with heart valve damage. As a result, other dopamine agonists with a more favorable safety profile may be preferred for these alternative indications. Therefore, the prescribing of pergolide, particularly in these less common applications, should be approached with caution and under the guidance of a healthcare professional who can carefully weigh the benefits and risks. Additionally, due to the reduced usage and concerns regarding adverse effects, pergolide may not be readily available or considered a first-line treatment in some of these cases.

For patients and prescribers considering pergolide mesylate for uses other than Parkinson's disease, it is critical to discuss the patient's complete medical history, potential drug interactions, and the comprehensive risk profile of the medication. Individual patient monitoring is essential to ensure safety and efficacy if pergolide is used off-label. If you have any questions or need further information regarding the formulation or alternative uses of Pergolide Mesylate 0.131 mg Oral Capsules, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is ready to provide you with the expertise and guidance to support the optimal use of this medication.