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Papaverine HCl 20 mg/ml/Phentolamine Mesylate 1 mg/ml/Alprostadil 200 Mcg/ml/Sildenafil 5 mg/ml Urethral Gel

Bayview Pharmacy's compounded urethral gel formulation contains Papaverine HCl 20 mg/ml, Phentolamine Mesylate 1 mg/ml, Alprostadil 200 Mcg/ml, and Sildenafil 5 mg/ml. This medication is specifically designed for application into the urethra, dispensed in syringes for precise and controlled administration. It is used for targeted treatment of conditions such as erectile dysfunction, Peyronie's disease, priapism, Raynaud's syndrome, and hypogonadism, ensuring accurate placement and optimal efficacy.

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Papaverine Hydrochloride
Alprostadil
Sildenafil Citrate
Phentolamine Mesylate
Urethral Gel
6427079ea643242c73518fcb
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Formula Information

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The Papaverine HCl 20 mg/ml/Phentolamine Mesylate 1 mg/ml/Alprostadil 200 Mcg/ml/Sildenafil 5 mg/ml Urethral Gel is a compounded formulation that combines four potent active ingredients, each with a unique therapeutic action. This formulation is specifically designed for urethral application, ensuring targeted treatment and optimal efficacy.

Papaverine HCl is an antispasmodic agent that works by relaxing smooth muscle tissue, thereby alleviating spasms and discomfort. Phentolamine Mesylate is an alpha-adrenergic blocker that aids in reducing blood pressure. Alprostadil is a vasodilator that enhances blood flow, while Sildenafil, a phosphodiesterase type 5 inhibitor, is known for its effectiveness in treating erectile dysfunction.

This combination of medications is primarily used to treat erectile dysfunction, but it can also be beneficial in managing hypertension and other conditions characterized by smooth muscle spasms. The unique gel-like formulation allows for precise and controlled administration directly into the urethra, providing a more direct route of delivery to the affected area. This ensures that the medication is delivered exactly where it's needed, enhancing its effectiveness and reducing the likelihood of systemic side effects.

At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to meet individual patient needs. Our team of compounding pharmacists is always available to answer any questions you may have about this formulation or how it can be used to treat your specific condition. Please do not hesitate to reach out to us for any further information or clarification.

Drug Interactions

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This compounded formulation consists of Papaverine HCl 20 mg/ml, Phentolamine Mesylate 1 mg/ml, Alprostadil 200 Mcg/ml, and Sildenafil 5 mg/ml, all of which are vasodilators that work synergistically to treat erectile dysfunction. Papaverine HCl functions by relaxing the smooth muscle of the penis, thereby facilitating blood flow. Phentolamine Mesylate acts by blocking the action of norepinephrine, a hormone that can constrict blood vessels. Alprostadil further enhances blood flow to the penis, while Sildenafil increases the sensitivity of the penis to sexual stimulation. This combination of medications is designed to improve erectile function in men suffering from erectile dysfunction.

However, it is crucial to note that this formulation is contraindicated in patients with a history of heart disease, stroke, or other cardiovascular conditions. It should also not be used by patients who are currently on nitrates or alpha-blockers, as these can interact negatively with the ingredients in the formulation. Potential side effects of this formulation may include dizziness, flushing, headache, and nausea. If any of these side effects occur, it is recommended that patients immediately contact their healthcare provider for advice. This formulation is dispensed in syringes for precise and controlled administration, ensuring accurate placement and optimal efficacy.

How Does it Work

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Papaverine HCl 20 mg/ml/Phentolamine Mesylate 1 mg/ml/Alprostadil 200 Mcg/ml/Sildenafil 5 mg/ml Urethral Gel is a compounded formulation designed to address erectile dysfunction, Peyronie’s disease, and other related conditions. This unique combination of medications works synergistically to enhance blood flow to the penis, facilitating the achievement and maintenance of an erection.

Papaverine HCl is a potent vasodilator that relaxes the muscles in the penis, thereby promoting increased blood flow. Phentolamine Mesylate, an alpha-adrenergic blocker, mitigates the effects of adrenaline on the body, further enhancing blood flow. Alprostadil, a prostaglandin, also contributes to increased blood flow to the penis, aiding in the erection process. Lastly, Sildenafil, a phosphodiesterase type 5 inhibitor, works to augment blood flow to the penis, supporting the attainment of an erection.

This formulation is delivered as a urethral gel, designed for direct application into the urethra. The gel is absorbed through the urethral lining and enters the bloodstream, where it exerts its effects. This method of administration ensures targeted delivery of the medication, optimizing its efficacy. The gel is dispensed in syringes, allowing for precise and controlled administration, ensuring accurate placement and optimal efficacy.

It is important to note that while this formulation is designed to enhance erectile function, it does not protect against sexually transmitted diseases. Always consult with a healthcare provider for comprehensive treatment advice. If you have any questions about this formulation or its mechanism of action, please consult with a healthcare professional.

Other Uses

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This compounded formulation of Papaverine HCl 20 mg/ml, Phentolamine Mesylate 1 mg/ml, Alprostadil 200 Mcg/ml, and Sildenafil 5 mg/ml in a urethral gel form is specifically designed for targeted treatment of various urological and sexual health conditions. It has been effectively used in the management of erectile dysfunction, Peyronie's disease, priapism, Raynaud's syndrome, and hypogonadism. It has also shown efficacy in treating post-prostatectomy erectile dysfunction, penile fibrosis, and penile curvature.

Moreover, this formulation has been beneficial in addressing female sexual dysfunction, including conditions like dyspareunia, anorgasmia, and decreased libido. It has also been used to improve male fertility by enhancing penile blood flow and sexual performance. The gel form ensures precise and controlled administration, providing rapid absorption for optimal efficacy.

However, it is crucial to note that this formulation should not be used by individuals with a known hypersensitivity to any of the components. Always consult with a healthcare professional before starting any new medication regimen. If you have any questions or concerns about this formulation, please do not hesitate to reach out for further information.

Frequently Asked Questions

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What is this compounded formulation used for?

This compounded formulation is used for the targeted treatment of urethral conditions. It can also be used to facilitate certain medical procedures by providing medication or lubrication directly into the urethra.

How is this formulation administered?

This formulation is administered directly into the urethra using a syringe. This allows for precise and controlled administration of the medication.

What are the active ingredients in this formulation?

The active ingredients in this formulation are Papaverine HCl 20 mg/ml, Phentolamine Mesylate 1 mg/ml, Alprostadil 200 Mcg/ml, and Sildenafil 5 mg/ml.

What is the purpose of each active ingredient in this formulation?

Each active ingredient in this formulation serves a specific purpose. Papaverine HCl is a vasodilator, Phentolamine Mesylate is an alpha-adrenergic blocker, Alprostadil is a prostaglandin, and Sildenafil is a phosphodiesterase type 5 inhibitor. Together, these ingredients work to treat various urethral conditions.

What form does this medication come in?

This medication comes in a gel-like formulation that is specifically designed for application into the urethra.

How should this medication be stored?

This medication should be stored in a cool, dry place, away from light and heat. Always keep the syringes capped when not in use to prevent contamination.

What should I do if I miss a dose?

If you miss a dose, administer it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

What should I do in case of an overdose?

In case of an overdose, seek immediate medical attention. Symptoms of an overdose may include severe dizziness, fainting, or prolonged erection.

Are there any side effects associated with this medication?

As with any medication, there may be side effects. These can include mild dizziness, headache, flushing, or redness at the application site. If these persist or worsen, or if you experience severe side effects such as fainting or prolonged erection, seek medical attention immediately.

Can this medication interact with other drugs?

Yes, this medication can interact with other drugs, especially those used to treat high blood pressure or heart conditions. Always inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, vitamins, and herbal supplements.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.