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Formulas

Nifedipine 5 mg/2.5 mL Oral Liquid

The Nifedipine 5 mg/2.5 mL Oral Liquid is a specially compounded medication designed for oral use, offering a precise and manageable method of drug delivery. This liquid formulation is particularly beneficial for patients who experience difficulty swallowing pills, such as children and the elderly. Nifedipine is a calcium channel blocker that is commonly prescribed to treat various cardiovascular conditions, including hypertension (high blood pressure) and angina pectoris (chest pain caused by reduced blood flow to the heart). By providing nifedipine in a liquid form, this medication ensures accurate dosing and ease of administration for those requiring treatment for these disease states.

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Nifedipine Hydrochloride
Oral Liquid
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Formula Information

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Nifedipine is a calcium channel blocker that is primarily used to treat hypertension (high blood pressure) and angina (chest pain). The mechanism of action involves the inhibition of calcium ions from entering the smooth muscle cells of the heart and arteries. By blocking these calcium channels, nifedipine causes the muscles to relax, leading to a decrease in blood pressure and an increase in the supply of blood and oxygen to the heart, which can help to prevent or reduce the pain of angina.

The Nifedipine 5 mg/2.5 mL Oral Liquid formulation is designed to provide a precise dose of medication in a liquid form, which is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly, or for those with conditions that affect the ability to swallow solid dosage forms. The liquid formulation allows for flexible dosing, which can be adjusted according to the specific needs of the patient. It also offers a more palatable option for those who may be averse to the taste or texture of tablets or capsules.

For prescribers, it is important to note that the bioavailability of nifedipine can be affected by factors such as food intake, so it is recommended to provide clear instructions on how to take the medication. Additionally, the liquid form of nifedipine should be used with caution in patients with gastrointestinal disorders that may alter the absorption of the drug. Monitoring of blood pressure and heart rate is advised to ensure therapeutic effectiveness and to adjust the dose as necessary.

Patients should be counseled on the importance of adhering to the prescribed dosing schedule and to not adjust the dose without consulting their healthcare provider. They should also be made aware of potential side effects, such as dizziness, flushing, headache, and peripheral edema, and instructed to report any severe or persistent adverse reactions. As with any medication, there may be interactions with other drugs, so a thorough medication history should be reviewed to avoid potential contraindications.

Bayview Pharmacy is committed to providing high-quality, customized medications to meet the unique needs of each patient. Our team of compounding pharmacists is available to answer any questions and provide additional information regarding the Nifedipine 5 mg/2.5 mL Oral Liquid formulation. We encourage both patients and prescribers to reach out to us for guidance on the use of this medication to ensure optimal treatment outcomes.

Drug Interactions

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Nifedipine is a calcium channel blocker that is used to treat hypertension (high blood pressure) and angina (chest pain). When formulated as a 5 mg/2.5 mL oral liquid, it is particularly useful for patients who have difficulty swallowing pills or require precise dosage adjustments. However, nifedipine can interact with a variety of medications and substances, which can alter its effectiveness or increase the risk of adverse effects.

One significant interaction is with strong CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, and clarithromycin. These medications can increase the concentration of nifedipine in the blood, potentially leading to an increased risk of hypotension (low blood pressure) and other side effects. Conversely, CYP3A4 inducers like rifampin and St. John's Wort can decrease nifedipine's plasma concentration, reducing its efficacy.

Beta-blockers, when used concomitantly with nifedipine, may exacerbate heart failure or lead to significant hypotension. Careful monitoring is required when these medications are used together. Additionally, nifedipine can increase the exposure to digoxin, so monitoring of digoxin levels is recommended when starting or adjusting the dose of nifedipine.

Grapefruit juice is known to inhibit the metabolism of nifedipine, leading to increased drug levels and a higher risk of adverse effects. Patients should be advised to avoid grapefruit and its juice while taking nifedipine. Concurrent use of magnesium sulfate and nifedipine in pregnant women may lead to an excessive drop in blood pressure, which could be harmful to both the mother and the fetus.

Anti-hypertensive effects can be potentiated when nifedipine is taken with other blood pressure-lowering agents, which may necessitate a dose adjustment. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effects of nifedipine, so blood pressure should be monitored when initiating or discontinuing NSAIDs.

It is important for patients and prescribers to be aware of these and other potential drug interactions. This is not an exhaustive list, and other medications, including over-the-counter drugs and herbal supplements, may also interact with nifedipine. Patients should be encouraged to inform their healthcare provider of all medications and supplements they are taking. For any questions or concerns regarding the use of nifedipine oral liquid or potential drug interactions, please reach out to us at Bayview Pharmacy for personalized advice and support.

How Does it Work

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Nifedipine is a medication belonging to a class of drugs known as calcium channel blockers. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle during depolarization. This action leads to the relaxation of the smooth muscles in the blood vessels, causing them to dilate, particularly in the coronary arteries and peripheral arterioles. By dilating the arteries, nifedipine reduces the resistance that the heart has to work against to pump blood around the body (afterload) and also improves the supply of oxygen to the heart muscle itself. This dual action makes it effective in treating conditions such as hypertension (high blood pressure) and angina pectoris (chest pain caused by reduced blood flow to the heart muscle).

The formulation of nifedipine as a 5 mg/2.5 mL oral liquid is particularly beneficial for patients who have difficulty swallowing tablets or capsules, such as young children, the elderly, or those with dysphagia. The liquid form allows for flexible dosing, which can be precisely measured to ensure the patient receives the exact amount of medication required. This is crucial for maintaining the appropriate therapeutic levels of nifedipine in the bloodstream to effectively manage the symptoms of hypertension and angina. Additionally, the oral liquid formulation can be more rapidly absorbed compared to solid dosage forms, potentially leading to a quicker onset of action.

For patients with hypertension, nifedipine works to lower blood pressure by relaxing the blood vessels, which reduces the workload on the heart and helps to prevent the complications of high blood pressure such as stroke and heart attack. In patients with angina, the dilatation of coronary arteries helps to improve blood flow to the heart muscle, thereby reducing the frequency and severity of angina attacks. It is important to note that while nifedipine helps to control these conditions, it is not a cure and should be taken as part of a comprehensive treatment plan that may include lifestyle changes and other medications.

It is essential for patients and prescribers to understand that the effectiveness and safety of nifedipine oral liquid depend on proper dosing and administration. The medication should be taken exactly as prescribed, and patients should not alter the dose or frequency without consulting their healthcare provider. Regular monitoring of blood pressure and heart function may be necessary to ensure the medication is working effectively and to adjust the dose if needed.

If you have any questions about this formulation or how it works to treat hypertension and angina, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to effectively manage your health or the health of your patients.

Other Uses

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Nifedipine is a medication that is customarily used to treat hypertension (high blood pressure) and angina pectoris (chest pain caused by reduced blood flow to the heart). However, beyond these common indications, nifedipine's ability to act as a calcium channel blocker makes it useful in various other clinical scenarios. For instance, nifedipine can be beneficial in the treatment of Raynaud's phenomenon, a condition where blood flow to the fingers and toes is restricted, causing them to feel numb and cold in response to stress or low temperatures. Nifedipine works by dilating blood vessels and thus increasing blood flow to these affected extremities.

Additionally, nifedipine has been used off-label for the management of preterm labor to delay birth. It works in this context by relaxing the smooth muscle of the uterus, hence reducing the frequency and intensity of contractions, though it should be used with caution and only under the supervision of an obstetrics specialist due to potential risks to both mother and baby. Another less common use is in the treatment of esophageal spasms — painful, irregular muscle contractions of the esophagus that can interfere with normal swallowing.

Choosing a liquid formulation of nifedipine provides several advantages. It allows for flexibility in dosing, which is particularly useful in pediatric and geriatric patients where dose adjustment is often required based on weight or the presence of multiple health conditions that can affect drug metabolism and response. Liquid form is also beneficial for patients with dysphagia (difficulty swallowing) or those who require enteral feeding tubes, ensuring these individuals have access to essential medications without compromising their ability to ingest them.

The administration of a liquid formulation should be done with care, measuring the dose precisely with an appropriate measuring device. While Nifedipine 5 mg/2.5 mL Oral Liquid formulation provides therapeutically necessary doses, it is essential to avoid any potential overdose or underdose. It is also critical to recognize that while this formulation offers multiple therapeutic advantages, it should only be used under proper medical guidance, especially considering its potential use in conditions beyond its primary indications for hypertension and angina.

If you have any further questions or require guidance on the clinical applications of Nifedipine 5 mg/2.5 mL Oral Liquid, whether it be for its primary uses or the additional applications described here, please do not hesitate to reach out to us at Bayview Pharmacy. Our team is always ready to assist healthcare professionals and patients with accurate information, ensuring safe and effective medication use.

Frequently Asked Questions

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What is Nifedipine oral liquid used for?

Nifedipine oral liquid is used to treat certain types of chest pain (angina) and to manage high blood pressure (hypertension). By relaxing blood vessels, it helps to reduce the workload on the heart and the amount of oxygen that the heart muscle needs.

How should Nifedipine oral liquid be stored?

This medication should be stored at room temperature, away from light and moisture. Keep the bottle tightly closed when not in use and ensure that it is out of reach of children and pets.

Can children take Nifedipine oral liquid?

While this dosage form is convenient for pediatric use, the decision to use Nifedipine oral liquid in children should be made by a healthcare provider, taking into account the child's specific medical needs and conditions.

How do I take Nifedipine oral liquid?

The liquid should be measured with an accurate measuring device, such as a medicine syringe or a special dose-measuring spoon or cup. Do not use a regular household spoon since you may not get the correct dose. Take the medication exactly as prescribed by your doctor.

What should I do if I miss a dose of Nifedipine oral liquid?

If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Are there any potential side effects with Nifedipine oral liquid?

As with any medication, side effects are possible. Common side effects of Nifedipine can include swelling (edema), headache, dizziness, and fatigue. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

Can Nifedipine oral liquid be taken with food?

Nifedipine oral liquid can usually be taken with or without food. However, you should follow your doctor's instructions regarding food intake, as sometimes the presence of food can affect medication absorption.

Is Nifedipine oral liquid suitable for geriatric patients?

Yes, the liquid form of Nifedipine can be suitable for geriatric patients, especially those who have difficulty swallowing pills. However, dosage may need to be adjusted based on the individual health needs and renal function of the patient.

Can I drink alcohol while taking Nifedipine oral liquid?

It's generally advised to limit or avoid alcohol while taking Nifedipine, as alcohol can lower your blood pressure further and may increase some of the side effects of the drug, such as dizziness or drowsiness.

What should I do if I accidentally take too much Nifedipine?

In the event of an overdose, seek immediate medical attention or call a poison control center. Overdose symptoms might include severe dizziness, fainting, or a fast heartbeat.

Will Nifedipine oral liquid affect my daily activities?

Nifedipine may cause dizziness or drowsiness. Until you know how the medication affects you, it's wise to avoid driving, operating heavy machinery, or performing any other task that requires alertness.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.