Metformin HCL 100 mg/ml Oral Liquid is a specially compounded medication designed for oral use, providing patients with a precise 100 mg of metformin hydrochloride per milliliter of solution. This formulation is particularly beneficial for individuals who have difficulty swallowing tablets or capsules, such as pediatric and geriatric patients, or those with dysphagia. The liquid form allows for flexible dosing, which can be adjusted according to the specific needs and tolerability of the patient.

Metformin is a biguanide antihyperglycemic agent used primarily in the management of type 2 diabetes mellitus. It works by decreasing hepatic glucose production, reducing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or healthy subjects (except in special circumstances) and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may decrease.

This oral liquid formulation of metformin HCL is also advantageous for patients requiring titration to minimize gastrointestinal side effects commonly associated with metformin or those with varying blood glucose levels who may need individualized dose adjustments. The liquid dosage form ensures that the medication can be measured and administered accurately, which is crucial for maintaining proper blood glucose levels and achieving optimal therapeutic outcomes.

For prescribers, it is important to note that the efficacy of metformin in lowering blood glucose levels and improving glycemic control is well-documented. It is often used as a first-line therapy due to its low risk of causing hypoglycemia and its beneficial effects on cardiovascular outcomes. When prescribing this liquid formulation, consider the patient's renal function, as metformin is contraindicated in patients with renal impairment. Regular monitoring of renal function is recommended to prevent lactic acidosis, a rare but serious complication of metformin accumulation.

Patients should be counseled on the proper administration of Metformin HCL 100 mg/ml Oral Liquid, including measuring doses with an appropriate device, such as a graduated syringe or dropper. They should also be informed about the potential side effects, such as gastrointestinal disturbances, and the importance of adherence to dietary recommendations and regular blood glucose monitoring. As with any medication, if there are any questions or concerns regarding the use of Metformin HCL 100 mg/ml Oral Liquid, patients and prescribers are encouraged to reach out to us at Bayview Pharmacy for further assistance and guidance.

Metformin HCL (hydrochloride) is an oral antihyperglycemic agent used to treat type 2 diabetes mellitus by improving glucose tolerance and lowering both basal and postprandial plasma glucose. Its mechanism of action includes decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. While metformin is generally well-tolerated, it is important to be aware of potential drug interactions when prescribing or taking this medication in its liquid formulation.

One significant interaction is with iodinated contrast media used for certain radiologic procedures, which can lead to acute alteration of renal function and has been associated with lactic acidosis in patients receiving metformin. It is recommended to discontinue metformin prior to or at the time of the imaging procedure and not restart until at least 48 hours after, and only after renal function has been re-evaluated and found to be normal.

Concomitant use of medications that affect renal function can also alter the effects of metformin. Drugs such as NSAIDs, ACE inhibitors, and diuretics can affect kidney function, which is particularly important as metformin is excreted by the kidneys. Careful monitoring of renal function is advised when initiating or adjusting doses of these medications in patients taking metformin.

Alcohol intake can potentiate the effect of metformin on lactate metabolism, increasing the risk of metformin-associated lactic acidosis. Patients should be warned against excessive alcohol intake while taking metformin.

Other drugs can also influence blood glucose levels, which may require dose adjustment of metformin. For example, corticosteroids, thyroid products, oral contraceptives, and phenothiazines can increase blood glucose and may necessitate a higher dose of metformin. Conversely, certain drugs like sulfonylureas, insulin, or meglitinides can increase the risk of hypoglycemia and may require a lower dose of metformin.

Metformin can also interact with drugs that are highly protein-bound, such as cimetidine, due to competition for renal tubular transport systems, potentially leading to an increase in plasma concentration and a risk of metformin-associated adverse effects.

It is also important to monitor vitamin B12 levels in patients on long-term metformin therapy, as metformin may decrease serum levels of this vitamin. Supplementation may be necessary if a deficiency is detected.

Patients and prescribers should be aware that this is not an exhaustive list of all potential drug interactions. It is always important to discuss all medications, including over-the-counter drugs and herbal supplements, with a healthcare provider to ensure safe and effective use of metformin HCL oral liquid. If you have any questions or concerns about drug interactions with metformin HCL oral liquid, please reach out to us at Bayview Pharmacy for further information and guidance.

Metformin HCL (hydrochloride) is an antihyperglycemic agent used primarily in the management of type 2 diabetes. It works by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike some other types of oral diabetes medications, metformin does not cause an increase in insulin secretion and therefore does not lead to hypoglycemia when used alone.

The formulation of Metformin HCL 100 mg/ml Oral Liquid is designed to provide a consistent and precise dose of metformin in a liquid form. This is particularly beneficial for patients who have difficulty swallowing tablets or capsules, such as children, the elderly, or those with dysphagia or other gastrointestinal issues. The liquid formulation allows for flexible dosing, which can be adjusted according to the specific needs of the patient and the progression of their disease state.

When ingested, the metformin in the liquid formulation is absorbed in the intestine and then works systemically to exert its effects. The onset of action for metformin is typically within 48 hours, with maximum effects occurring over a period of several days to weeks. Consistent use of metformin as prescribed is crucial for maintaining blood glucose control and preventing the long-term complications of diabetes, such as neuropathy, retinopathy, and cardiovascular disease.

It is important for both patients and prescribers to understand that while metformin helps control blood glucose levels, it should be used in conjunction with a proper diet, exercise, and possibly other medications as prescribed by a healthcare provider. Regular monitoring of blood glucose levels is essential to ensure the effectiveness of the treatment and to make any necessary adjustments to the dosage.

For any questions regarding the use of Metformin HCL 100 mg/ml Oral Liquid, its mechanism of action, or its role in the treatment of type 2 diabetes, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the information and support needed to ensure safe and effective use of this medication.

While Metformin HCL is primarily prescribed for the management of type 2 diabetes mellitus by improving glucose tolerance and lowering both basal and postprandial plasma glucose, it has been observed to have other potential applications beyond its main indication. In the context of a 100 mg/ml oral liquid formulation, there are additional uses that may be of interest to patients and prescribers. One such off-label use of metformin is in the treatment of polycystic ovary syndrome (PCOS), where it has been shown to improve the frequency of ovulation, leading to improved fertility outcomes in some women with this condition. Moreover, the medication’s ability to reduce insulin levels and influence weight management can be beneficial in PCOS management.

Emerging research has also explored the potential of metformin in the field of oncology, where its properties might contribute to a lower risk of cancer development or improved cancer prognosis, although more conclusive evidence is required before it becomes a standard treatment in this domain. Additionally, metformin’s possible cardiovascular benefits could be relevant for reducing the risk of heart disease, particularly in those with type 2 diabetes or metabolic syndrome.

Another research avenue is the exploration of metformin as a potential anti-aging agent. Some studies suggest that metformin could influence longevity by impacting pathways related to age-related diseases, although further research is necessary to validate these findings for clinical recommendations. However, these additional uses are still largely under investigation, and metformin should only be used for non-approved indications within the confines of rigorous clinical trials or after a thorough evaluation of the risks and benefits by a healthcare provider.

It is important to recognize that the therapeutic efficacy and any alternative application of metformin as a 100 mg/ml oral liquid would be contingent on patient-specific factors, and it should only be used under the advice and supervision of a healthcare professional. If you have any questions about the expanded uses of this metformin formulation or require additional information about its various applications, we encourage you to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to support both patients and prescribers with expertise and guidance on the safe and effective use of this medication.