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Liothyronine 25 mcg/mL Oral Liquid

Liothyronine 25 mcg/mL Oral Liquid is a specially compounded medication designed for oral use, offering a precise concentration of liothyronine, a synthetic form of the thyroid hormone triiodothyronine (T3). This liquid formulation is particularly beneficial for patients who have difficulty swallowing pills, including those in pediatric and geriatric populations. The medication is used to treat various thyroid-related disorders, such as hypothyroidism, where the thyroid gland does not produce enough hormones, and in the management of myxedema coma, a severe form of hypothyroidism. It may also be utilized in the suppression of thyroid-stimulating hormone (TSH) for patients with euthyroid goiters and in the diagnostic testing of thyroid function. The liquid form ensures accurate dosing and ease of administration for effective management of these disease states.

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Oral Liquid
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Formula Information

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Liothyronine 25 mcg/mL Oral Liquid is a specially compounded medication designed for oral use, providing patients with a precise dose of liothyronine in a liquid form. This formulation is particularly beneficial for individuals who have difficulty swallowing pills, such as children and the elderly, or for those with conditions that affect the ability to ingest solid dosage forms. The liquid formulation allows for flexible dosing, which can be easily adjusted according to the specific needs of the patient.

Liothyronine is a synthetic form of the thyroid hormone triiodothyronine (T3) and is used to treat various conditions related to thyroid hormone deficiency, including hypothyroidism and certain types of goiter. It is also used in the management of thyroid cancer and as a diagnostic agent in the suppression or stimulation testing for thyroid function. By supplementing the body's natural thyroid hormones, liothyronine helps to regulate the body's energy and metabolism, ensuring that various bodily functions operate efficiently.

For patients, it is important to understand that liothyronine should be taken consistently at the same time each day to maintain stable hormone levels. The liquid formulation allows for easy administration, which can be particularly helpful for those who require a tailored dosage that is not available in standard tablet form. Patients should also be aware of potential side effects, which can include symptoms of hyperthyroidism such as increased heart rate, anxiety, and weight loss, especially if the dose is too high.

Prescribers should consider the patient's complete medical history, including any existing cardiovascular conditions, when initiating treatment with liothyronine. Regular monitoring of thyroid function tests is recommended to ensure the dose remains therapeutic and not excessive, minimizing the risk of adverse effects. The liquid formulation of liothyronine can be compounded to specific concentrations, allowing prescribers to fine-tune the dosage to the individual needs of their patients.

At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to the unique needs of each patient. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide guidance on the use of Liothyronine 25 mcg/mL Oral Liquid. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us.

Drug Interactions

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Liothyronine is a synthetic form of the thyroid hormone triiodothyronine (T3) and is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It is also used in the treatment of myxedema coma and sometimes in the management of thyroid cancer. As a compounding pharmacy, we have formulated liothyronine as a 25 mcg/mL oral liquid to facilitate ease of administration for those who have difficulty swallowing tablets, such as pediatric and geriatric patients.

When considering the use of liothyronine oral liquid, it is important to be aware of potential drug interactions that may affect the efficacy of the medication or increase the risk of adverse effects. Liothyronine should be used with caution in conjunction with medications that affect thyroid hormone levels or the body's response to thyroid hormones. For example, insulin and oral hypoglycemic agents may require dose adjustments because thyroid hormones may increase blood glucose levels.

Medications that can reduce the absorption of liothyronine when taken concurrently include antacids, calcium carbonate, cation exchange resins such as cholestyramine, and proton pump inhibitors. To minimize this interaction, liothyronine should be taken several hours before or after these medications. Additionally, certain drugs such as estrogen-containing products, oral contraceptives, and androgens may alter the binding of thyroid hormones in the blood, necessitating a dosage adjustment of liothyronine.

Cardiac stimulants or sympathomimetic agents, such as epinephrine, can have their effects enhanced by liothyronine, potentially leading to increased heart rate and blood pressure. Caution is advised when these medications are used concurrently. Furthermore, the effectiveness of anticoagulants like warfarin may be increased when taken with liothyronine, which could raise the risk of bleeding. Regular monitoring of coagulation parameters and appropriate dose adjustments are recommended in such cases.

Other medications, including sertraline, phenobarbital, rifampin, and carbamazepine, may increase the metabolism of thyroid hormones, potentially necessitating a higher dose of liothyronine. Conversely, medications such as amiodarone, lithium, and iodine-containing compounds can decrease thyroid hormone production and may require a reduction in the dose of liothyronine.

It is also important to note that liothyronine may affect the therapeutic response to digitalis glycosides, and patients on these medications may require close monitoring and possible dose adjustments. Additionally, patients should be advised to avoid consuming foods high in soybean flour, cottonseed meal, walnuts, dietary fiber, and grapefruits, as these can affect the absorption of thyroid hormones.

Given the complexity of these interactions, it is crucial for patients and prescribers to work closely with their pharmacist to ensure that all medications, including over-the-counter drugs and supplements, are reviewed for potential interactions with liothyronine. Adjustments to therapy should be made under the guidance of a healthcare professional. If you have any questions or concerns regarding the use of liothyronine oral liquid or its interactions with other medications, please reach out to us at Bayview Pharmacy for personalized assistance.

How Does it Work

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Liothyronine is a synthetic form of triiodothyronine (T3), a hormone naturally produced by the thyroid gland. This hormone plays a crucial role in regulating the body's metabolic rate, heart and digestive functions, muscle control, brain development, and maintenance of bones. When the thyroid gland does not produce enough T3, either due to disease, surgery, or radiation treatment, it can lead to a condition known as hypothyroidism. Symptoms of hypothyroidism include fatigue, weight gain, cold intolerance, and depression, among others. Liothyronine 25 mcg/mL Oral Liquid is specifically designed to replace or supplement the natural hormone, thereby helping to restore normal metabolic activity and alleviate the symptoms of hypothyroidism.

The oral liquid formulation of liothyronine ensures that patients who have difficulty swallowing pills, such as the elderly or children, or those with conditions that affect the esophagus, can still receive their necessary medication. The liquid form allows for flexible dosing, which is particularly important given the narrow therapeutic index of thyroid hormones. This means that each patient's dose must be carefully tailored to their individual needs to avoid under- or over-treatment. The 25 mcg/mL concentration allows for precise dosing adjustments, which can be critical in achieving the desired therapeutic effect while minimizing potential side effects.

Upon ingestion, liothyronine is rapidly absorbed into the bloodstream, predominantly in the small intestine. It then enters the body's cells and exerts its effect by binding to thyroid hormone receptors in the nucleus, which in turn initiates the transcription of genes involved in the regulation of metabolic processes. By mimicking the action of natural T3, liothyronine helps to accelerate the metabolic rate, which can lead to an increase in oxygen consumption, heat production, and overall energy expenditure. This action is essential in managing the symptoms of hypothyroidism and ensuring that patients can maintain a normal, active lifestyle.

It is important for both patients and prescribers to understand that the management of hypothyroidism with liothyronine requires regular monitoring of thyroid function tests. This is to ensure that the dose of liothyronine remains within the therapeutic range, as both under-treatment and over-treatment can lead to significant health issues. Patients should also be aware that consistency in the timing of doses and in the brand or formulation of liothyronine used can affect treatment effectiveness.

For those interested in using Liothyronine 25 mcg/mL Oral Liquid, or for more detailed information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to answer any questions and provide guidance on the appropriate use of this medication to ensure optimal treatment outcomes.

Other Uses

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Liothyronine, as an active pharmaceutical ingredient, is primarily utilized for its synthetic analogue of the triiodothyronine (T3) hormone, which is useful in the management of hypothyroidism where there is a deficiency of thyroid hormone synthesis. Apart from its prime application in treating various states of thyroid hormone underproduction, the formulation of Liothyronine 25 mcg/mL Oral Liquid can potentially have off-label utility in certain clinical circumstances.

For instance, this particular oral liquid formulation may be considered by healthcare professionals for use in patients who have undergone thyroidectomy as part of thyroid cancer treatment and require T3 for thyroid hormone replacement therapy. In addition, due to the precise control of the dosage, it can sometimes be employed in complex treatment regimens such as the management of myxedema coma, where an intricate balance of thyroid hormones is critical, although this is normally managed in an intensive care setting.

Individuals with specific genetic polymorphisms that affect thyroid hormone conversion may also benefit from this type of T3 formulation if they do not respond adequately to the standard T4 therapies. Additionally, Liothyronine oral liquid may be utilized in psychiatric practices for augmentation in the treatment of major depressive disorders, based on evidence that suggests T3 can enhance the efficacy of antidepressants, although this practice should be based on a thorough evaluation of the individual patient and a careful consideration of the potential risks and benefits.

It is important to note that the use of Liothyronine in conditions other than conventional hypothyroidism should be approached with caution and should be based on clinical expertise, patient-specific factors, and current clinical guidelines. Any decision for off-label use needs to be backed by adequate scientific evidence and undertaken with informed patient consent. This formulation may not be appropriate for all of these potential uses, and it is critical for prescribers to consider the individual needs of each patient.

For patients and prescribers interested in exploring the potential other uses of Liothyronine 25 mcg/mL Oral Liquid, it is strongly advised to engage in detailed discussions regarding the desired outcomes, possible side effects, and monitoring requirements. If there are any questions regarding the possible applications or the suitability of this formulation for a given individual, please do not hesitate to reach out to us at Bayview Pharmacy. Our compounding pharmacists are equipped to provide you with tailored information and support to help ensure optimal therapeutic outcomes.

Frequently Asked Questions

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What is Liothyronine 25 mcg/mL Oral Liquid?

Liothyronine 25 mcg/mL Oral Liquid is a specially compounded formulation of the thyroid medication liothyronine, designed for oral use. It offers an alternative for those who require a more precise dosage or have difficulty swallowing solid forms of medication.

Who might benefit from using Liothyronine Oral Liquid instead of a tablet form?

This liquid form of liothyronine is ideal for patients who have trouble swallowing pills, such as children, the elderly, or those with dysphagia. It also provides the option for dosage flexibility, which is particularly beneficial for those needing individualized dosing.

How should Liothyronine Oral Liquid be stored?

Liothyronine Oral Liquid should be stored in a cool, dry place, away from direct sunlight and heat. It is important to keep this medicine out of reach of children and to store it in the original container. Always check the expiration date and specific storage instructions provided by the pharmacy.

How do you take Liothyronine Oral Liquid?

The liquid should be measured with a provided dosing syringe, dropper, or cup to ensure the correct dose is administered. It is typically taken once a day, following the prescribed dosage. This medication should be taken on an empty stomach, ideally an hour before or two hours after meals, to enhance absorption.

Can you mix Liothyronine Oral Liquid with food or beverages?

It is not recommended to mix Liothyronine Oral Liquid with food or beverages, as this could affect the medication's efficacy. It should be taken on an empty stomach unless instructed otherwise by your healthcare provider.

Are there any potential side effects of taking Liothyronine Oral Liquid?

Similar to other forms of liothyronine, possible side effects can include heart palpitations, rapid weight loss, tremors, anxiety, insomnia, and others. Any side effects should be reported to your healthcare provider. Patients should be monitored closely to tailor the dose to their specific needs, thereby minimizing side effects.

Is Liothyronine Oral Liquid suitable for vegans or individuals with lactose intolerance?

As a compounded formulation, the ingredients can usually be personalized to suit dietary restrictions, including veganism or lactose intolerance. However, it is crucial to inform your pharmacist about any dietary needs or allergies to ensure the product meets these requirements.

What happens if you miss a dose of Liothyronine Oral Liquid?

If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take extra medicine to make up for the missed dose.

Can you adjust your dose of Liothyronine Oral Liquid if your symptoms change?

Dose adjustments should never be made without consulting your healthcare provider. They will provide guidance based on laboratory tests and symptom assessments. Self-adjusting the dose can lead to serious health consequences.

Is Liothyronine Oral Liquid covered by insurance?

Coverage for compounded medications like Liothyronine Oral Liquid varies by insurance company and plan. You should contact your insurance provider directly to determine if this formulation is covered under your policy, and if so, to what extent.

Can Liothyronine Oral Liquid be compounded with other medications?

Compounding pharmacies may be able to formulate this medication with other compatible prescriptions to simplify your medication regimen. However, this must be done under the guidance of a healthcare provider and with careful consideration of potential interactions.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.