Our compounded Lidocaine HCl 30 mg/Nifedipine 7 mg/Nitroglycerin 0.3 mg suppositories are designed to provide effective relief for individuals suffering from anal fissures or severe hemorrhoids. This unique combination of medications works synergistically to alleviate pain, reduce muscle spasms, and promote healing of the affected tissues.

Lidocaine HCl is a local anesthetic that numbs the affected area by blocking nerve signals responsible for pain and discomfort. By providing immediate pain relief, it helps patients feel more comfortable during the healing process.

Nifedipine, a calcium channel blocker, acts as a vasodilator when applied locally. It relaxes the smooth muscles of the anal sphincter, reducing hypertonicity and spasm. This relaxation improves blood flow to the area, which is essential for healing and reduces the pain associated with muscle tension.

Nitroglycerin is another vasodilator that enhances blood circulation by relaxing the vascular smooth muscles. Improved blood flow accelerates the healing process of anal fissures and reduces pressure within the anal canal, further relieving pain and discomfort.

The suppository dosage form ensures that the medications are delivered directly to the site of action. Upon insertion into the rectum, the suppository melts at body temperature, allowing the active ingredients to be absorbed locally. This targeted delivery maximizes efficacy while minimizing systemic side effects.

Patients using this formulation may experience significant relief from pain and an expedited healing process. It is important to use the medication exactly as prescribed and to report any adverse effects to a healthcare provider. Common side effects may include local irritation, headaches (due to nitroglycerin), or lightheadedness.

For prescribers, this compounded formulation offers a tailored therapeutic option for patients who may not have responded adequately to standard

This compounded formulation of Lidocaine HCl 30 mg, Nifedipine 7 mg, and Nitroglycerin 0.3 mg in suppository form is designed for insertion into a body cavity, such as the rectum or vagina, where it dissolves or melts to release medication for local or systemic absorption. This combination is often used to manage conditions such as anal fissures, hemorrhoids, or other anorectal disorders by providing local anesthetic, vasodilatory, and smooth muscle relaxant effects.

When considering drug interactions, it is important to note that each component of this formulation has its own interaction profile. Lidocaine, a local anesthetic, can interact with other medications that affect cardiac conduction, such as antiarrhythmic drugs, potentially leading to additive effects on the heart. Patients using other local anesthetics or systemic antiarrhythmic medications should be monitored closely for signs of cardiac toxicity, such as arrhythmias or hypotension.

Nifedipine, a calcium channel blocker, can interact with other antihypertensive agents, leading to an enhanced blood pressure-lowering effect. This may result in hypotension, dizziness, or fainting, especially in patients who are also taking beta-blockers, ACE inhibitors, or diuretics. Additionally, nifedipine can interact with grapefruit juice, which can increase its plasma concentration and enhance its effects, potentially leading to adverse reactions.

Nitroglycerin, a nitrate, is known to interact with phosphodiesterase inhibitors such as sildenafil, tadalafil, and vardenafil, which are used for erectile dysfunction. This combination can cause a significant drop in blood pressure, leading to dizziness, fainting, or even a heart attack or stroke. Patients should be advised to avoid using these medications concurrently. Furthermore, nitroglycerin can interact with other vasodilators and antihypertensive drugs, increasing the risk of hypotension.

For prescribers, it is crucial to review the patient's current medication regimen to identify potential interactions and adjust dosages accordingly. Monitoring for signs of adverse reactions or interactions is essential, especially in patients with cardiovascular conditions or those taking multiple medications. Patients should be educated on the potential interactions and advised to report any unusual symptoms or side effects promptly.

If you have any questions or need further information regarding this formulation and its potential interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any concerns or inquiries you may have.

The Lidocaine HCl 30 mg/Nifedipine 7 mg/Nitroglycerin 0.3 mg suppositories are a compounded formulation designed to deliver a combination of medications directly to the site of action within the body. This solid dosage form is typically inserted into a body cavity, such as the rectum or vagina, where it dissolves or melts, allowing the active ingredients to be absorbed either locally or systemically. This method of administration is particularly beneficial for conditions that require targeted relief or when oral administration is not feasible.

Lidocaine HCl is a local anesthetic that works by blocking sodium channels in nerve cells, which inhibits the initiation and conduction of nerve impulses. This action results in a numbing effect, providing relief from pain and discomfort in the affected area. By delivering lidocaine directly to the site of pain, the suppository formulation ensures rapid onset of action and minimizes systemic side effects that might occur with oral administration.

Nifedipine is a calcium channel blocker that primarily acts on the smooth muscle cells of blood vessels. By inhibiting the influx of calcium ions, nifedipine causes vasodilation, which can help alleviate conditions associated with high vascular tone or spasms. In the context of suppositories, nifedipine can be particularly useful for treating conditions like anal fissures, where reducing sphincter pressure can promote healing and reduce pain.

Nitroglycerin, a well-known vasodilator, works by releasing nitric oxide, which relaxes smooth muscle cells and dilates blood vessels. This action can improve blood flow to the affected area, enhancing tissue oxygenation and promoting healing. In suppository form, nitroglycerin can be effective in treating conditions such as chronic anal fissures by reducing sphincter pressure and improving local blood flow, thereby facilitating the healing process.

The combination of these three active ingredients in a suppository form allows for a multifaceted approach to treatment. Lidocaine provides immediate pain relief, while nifedipine and nitroglycerin work synergistically to reduce vascular tone and improve blood flow, addressing both the symptoms and underlying causes of the condition. This formulation is particularly useful for patients who require localized treatment with minimal systemic exposure, offering a targeted and effective therapeutic option.

For prescribers, this compounded formulation offers a customizable treatment option that can be tailored to the specific needs of the patient. The dosages of each active ingredient can be adjusted based on the severity of the condition and the patient's response to treatment. As with any compounded medication, it is important to consider the individual patient's medical history and potential interactions with other medications they may be taking.

If you have any questions about this formulation or its use in treating specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your treatment options.

The compounded formulation of Lidocaine HCl 30 mg/Nifedipine 7 mg/Nitroglycerin 0.3 mg suppositories is primarily designed for rectal or vaginal administration, where it can provide targeted relief through local or systemic absorption. While this combination is often used for specific conditions such as anal fissures or hemorrhoids, there are other potential uses that may benefit from the unique properties of these active ingredients. Lidocaine, a local anesthetic, can be utilized for its numbing effects to alleviate pain and discomfort in various conditions involving the rectal or vaginal areas. Nifedipine, a calcium channel blocker, may help in reducing smooth muscle spasms and improving blood flow, which can be beneficial in conditions characterized by muscle tension or compromised circulation. Nitroglycerin, a vasodilator, can further enhance blood flow and reduce pressure, potentially aiding in the healing process of tissues by improving oxygen and nutrient delivery.

For patients experiencing chronic pain or discomfort in the pelvic region, this formulation might offer an alternative therapeutic option when conventional treatments are insufficient. Additionally, the combination of these medications could be explored for use in conditions such as proctalgia fugax, a condition characterized by sudden, severe episodes of rectal pain, where the muscle-relaxing and pain-relieving properties of the suppository could provide relief. Similarly, for patients with pelvic floor dysfunction, the suppository may help in reducing muscle tension and improving symptoms.

Prescribers considering this formulation for off-label uses should evaluate the individual patient's condition, medical history, and potential benefits versus risks. It is crucial to monitor for any adverse effects, particularly given the systemic absorption potential of these medications. Patients should be informed about the proper administration technique to ensure optimal efficacy and safety. As with any compounded medication, the formulation can be tailored to meet specific patient needs, allowing for adjustments in dosage or ingredient concentration as deemed appropriate by the healthcare provider.

If you have any questions or require further information about this formulation and its potential uses, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or to provide additional guidance tailored to your specific needs.