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Formulas

Lidocaine 7%/Prilocaine HCL 7% Topical Cream

The Lidocaine 7%/Prilocaine HCL 7% Topical Cream is a semisolid preparation that combines two potent local anesthetics. This cream is specifically formulated for topical administration and is dispensed in a pump mechanism container, which allows for convenient, controlled, and hygienic application. The dual anesthetic action of lidocaine and prilocaine provides effective dermal analgesia by temporarily numbing the skin and surrounding tissue.

This formulation is primarily indicated for the treatment of conditions requiring local anesthesia of the skin, such as minor surgical procedures, needle insertions, superficial dermatological procedures, and the management of mild to moderate pain associated with skin irritations or conditions like lichen planus. Additionally, it may be used to alleviate discomfort from chronic painful skin conditions or before certain types of laser treatments.

Patients are advised to apply a thin layer of the cream to the affected area as directed by a healthcare professional, ensuring that the medication is used in a manner that is safe and effective for the treatment of the specified disease states.

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Lidocaine Hydrochloride
Prilocaine Hydrochloride
Topical Cream
65b0808529e2aaadb06a17c3
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Formula Information

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Lidocaine 7%/Prilocaine HCl 7% Topical Cream is a compounded medication specifically designed to provide localized analgesic effects when applied to the skin. This formulation combines two potent local anesthetics, lidocaine and prilocaine, both at a concentration of 7%, to synergistically numb the targeted area, offering relief from pain and discomfort. The cream is prepared as a semisolid dosage form, ensuring a uniform and consistent application of the active ingredients to the skin. The inclusion of a pump mechanism in the packaging allows for controlled dosing, minimizing the risk of over-application and ensuring that the correct amount of medication is delivered with each use.

The dual anesthetic action of lidocaine and prilocaine works by blocking sodium channels in the neuronal membrane, which inhibits the propagation of nerve impulses. This results in a temporary loss of sensation in the area where the cream is applied. The formulation is particularly useful for procedures requiring superficial anesthesia of the skin, such as minor surgical interventions, needle insertions, and the treatment of minor burns or other painful skin conditions. It can also be used to alleviate pain from chronic conditions like neuropathies or certain inflammatory skin diseases.

For patients, it is important to apply the cream as directed by a healthcare professional, ensuring that the area of application is clean and intact. The cream should not be applied to broken skin or mucous membranes. Patients should be aware of the potential for systemic absorption, especially when applied to large areas or used over an extended period, which could lead to higher blood levels of the anesthetics and increase the risk of systemic side effects. For prescribers, it is essential to consider the patient's overall health status, including any pre-existing conditions or concurrent medications that may interact with local anesthetics. The maximum safe dose should be calculated based on the patient's weight and the total area of application to avoid toxicity.

Bayview Pharmacy's team of compounding pharmacists ensures that each batch of Lidocaine 7%/Prilocaine HCl 7% Topical Cream is prepared to the highest standards of quality and consistency. We are available to answer any questions or concerns from both patients and prescribers regarding the formulation, its use, or its suitability for specific patients or procedures. Our goal is to provide effective pain management solutions tailored to individual needs, ensuring both safety and efficacy. If you have any questions, please reach out to us for personalized assistance.

Drug Interactions

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The Lidocaine 7%/Prilocaine HCL 7% Topical Cream is a local anesthetic formulation intended for use on the skin to provide localized pain relief. When considering drug interactions, it is important to note that while systemic absorption of lidocaine and prilocaine from topical application is generally low, there is still potential for interaction with other medications, particularly when applied to large surface areas or when used over an extended period.

Patients should be advised to inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Special caution should be exercised if the patient is on anti-arrhythmic drugs such as tocainide and mexiletine, as these may have additive effects on the heart when combined with lidocaine and prilocaine, potentially leading to cardiac abnormalities. Similarly, caution is advised when using other local anesthetics or medications that affect hepatic enzyme CYP1A2, such as fluvoxamine and verapamil, as they may alter the metabolism of lidocaine and prilocaine, leading to increased plasma concentrations.

Concomitant use of drugs that induce methemoglobinemia, such as sulfonamides, acetaminophen, and nitrates, should be monitored closely, as prilocaine can contribute to methemoglobinemia, a condition where the blood is less able to carry oxygen. If the patient is taking class III antiarrhythmic drugs, such as amiodarone, the risk of adverse cardiac effects may be increased. Additionally, patients on beta-blockers or calcium channel blockers should be monitored for potential additive systemic cardiovascular effects when using large doses of lidocaine and prilocaine cream.

It is also important to consider the potential for pharmacodynamic interactions. For example, the use of other CNS depressants, including opioids, sedatives, or anxiolytics, may increase the risk of CNS depression when used in conjunction with lidocaine and prilocaine. Patients should be counseled on the signs of systemic toxicity, such as dizziness, blurred vision, tremors, depression, or seizures, and advised to seek medical attention if they experience these symptoms.

Regarding the treatment of disease states, this topical cream is primarily used for the management of pain associated with minor skin procedures, such as needle insertions, surgical incisions, and the treatment of minor burns, abrasions, or other skin irritations. It works by blocking sodium channels and thereby inhibiting the initiation and conduction of nerve impulses, leading to a loss of sensation in the applied area.

For any further questions or concerns regarding the use of Lidocaine 7%/Prilocaine HCL 7% Topical Cream, or to discuss specific patient cases and potential drug interactions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing comprehensive support and guidance to ensure the safe and effective use of this medication.

How Does it Work

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Lidocaine 7%/Prilocaine HCL 7% Topical Cream is a compounded medication that combines two local anesthetics, lidocaine and prilocaine, each at a concentration of 7%. This cream is designed to provide localized pain relief by numbing the skin and the tissues just beneath the skin. The mechanism of action for both lidocaine and prilocaine is similar; they work by blocking sodium channels in the neuronal cell membrane. This action inhibits the initiation and conduction of nerve impulses, thereby providing a local anesthetic effect.

When applied to the skin, the cream creates a numbing effect that typically begins to work within 30 to 60 minutes after application. The depth and duration of anesthesia depend on the dose and duration of application. The semisolid preparation of this cream, dispensed in a pump mechanism, allows for a controlled and convenient application. This dosage form ensures that the active ingredients are evenly distributed across the treated area, providing consistent and effective pain relief.

This formulation is particularly useful in treating conditions that require localized anesthesia of the skin and surrounding tissues. It is commonly used for procedures such as needle insertions, superficial surgical procedures, the removal of warts, and for the relief of pain associated with conditions like chronic neuropathic pain or post-herpetic neuralgia. The combination of lidocaine and prilocaine in a 7% concentration each makes the cream highly effective for these purposes.

It is important for both patients and prescribers to understand that while this cream is effective in numbing the skin, it should be used with caution. The cream should not be applied to broken or inflamed skin, and it should not be used in patients with known hypersensitivity to local anesthetics of the amide type. Additionally, the total dose applied should not exceed the recommended amount, as systemic absorption of local anesthetics can lead to adverse effects.

For optimal results, the cream should be applied as directed by the prescriber, and the area of application should be covered with an occlusive dressing to enhance absorption if recommended. Patients should be advised to wash their hands immediately after applying the cream unless the hands are the area being treated.

If you have any questions about the Lidocaine 7%/Prilocaine HCL 7% Topical Cream or its application, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Other Uses

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Lidocaine 7%/Prilocaine HCl 7% Topical Cream is a well-established anesthetic formulation commonly employed for its local numbing effect. While its primary indication is to provide local anesthesia before minor dermatological procedures, it has a range of ancillary uses which rest on its ability to produce superficial analgesia. For instance, it has been found efficacious in the management of chronic pain conditions like postherpetic neuralgia, where repeated application can lead to sustained periods of pain relief. Additionally, it may be used off-label to lessen the discomfort associated with needle insertions, such as those occurring during tattoo application or invasive cosmetic procedures like laser therapy and micro-needling.

Possible, albeit less common, uses of this formulation include the treatment of mild to moderate burns to alleviate pain and facilitate dressing changes without additional trauma. In the field of sports medicine, the cream may be utilized to temporarily relieve the pain from muscle strains or sprains, particularly in instances where oral pain relief is not advisable. Another potential application, though off-label and under the guidance of a healthcare provider, is the use prior to venipuncture or the placement of intravenous catheters, particularly in patients who have a documented history of needle phobia.

It is essential to note that this cream should be used with caution in individuals with known sensitivities to either lidocaine or prilocaine, and its use is generally contraindicated in patients with methemoglobinemia, a rare blood disorder. Careful consideration should also be given to the maximum dosage applied, as systemic absorption can lead to toxicity if excessive amounts are used or if applied to very large areas of broken skin. Furthermore, when applying near the eyes, it is important to avoid direct contact, as this could lead to serious adverse reactions, including eye irritation and potential harm to corneal tissues.

While the specified formulation provided in a pump mechanism is designed for topical application, it is advisable that patients wash their hands immediately after applying the cream unless the hands are the area being treated. The pump mechanism ensures a controlled dose, reducing the likelihood of applying too much of the product. Specific dosing instructions, such as the amount of cream to apply and the duration of application prior to a procedure, should be strictly followed as provided by a healthcare practitioner.

Patients and prescribers should be aware of the potential for systemic side effects, in line with the pharmacokinetics of lidocaine and prilocaine, and should monitor for signs of toxicity. Signs of systemic toxicity might include CNS manifestations, such as nervousness, dizziness, blurred vision, tremors, depression, or drowsiness, as well as cardiac effects like irregular heartbeat. Should you experience any adverse effects or have any concerns or questions about other possible uses of Lidocaine 7%/Prilocaine HCl 7% Topical Cream, please do not hesitate to reach out to us at Bayview Pharmacy for assistance.

Frequently Asked Questions

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What is Lidocaine 7%/Prilocaine HCL 7% Topical Cream?

Lidocaine 7%/Prilocaine HCL 7% Topical Cream is a compounded medication consisting of two active ingredients, Lidocaine and Prilocaine, each at a concentration of 7%. It is a topical anesthetic cream intended for use on the skin to provide localized pain relief.

How should Lidocaine/Prilocaine cream be used?

This cream should be applied to the skin area where pain relief is needed. Use the pump mechanism to dispense the cream, and spread it gently and evenly over the area. Be sure to follow the specific dosing instructions provided by your healthcare provider.

Can I use this cream on any area of my body?

It should be used only on the specific area of skin as directed by your healthcare provider. Avoid sensitive areas such as the eyes, inside the mouth or nose, and genital areas unless specifically instructed by a health professional.

How does the pump mechanism work?

The pump mechanism is designed for convenient and controlled delivery of the cream. To use, simply press down on the pump to dispense a small amount of the cream onto your skin. The mechanism helps to ensure a consistent dose with each application.

Is Lidocaine/Prilocaine cream suitable for children?

The suitability of this cream for children depends on the specific circumstances and should be determined by a healthcare provider. Always consult with a pediatrician before using this medication on a child.

How often can I apply Lidocaine/Prilocaine cream?

The frequency of application will depend on the condition being treated and the advice of your healthcare provider. Do not exceed the recommended dose or frequency as this could increase the risk of side effects.

What should I do if I miss a dose?

If you miss a dose, apply the cream as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose to catch up.

Can I cover the treated area with a bandage after applying the cream?

You may cover the treated area with a breathable bandage if instructed to do so by your healthcare provider. Do not use an airtight or occlusive dressing unless your provider specifically recommends it.

Are there any possible side effects of using Lidocaine/Prilocaine cream?

Some common side effects include temporary redness, a pale or whitened appearance of the skin, or a mild burning or tingling sensation where the cream is applied. If you experience any severe reactions or signs of an allergic reaction, seek immediate medical attention.

Can I use this cream if I am pregnant or breastfeeding?

Consult with your healthcare provider before using Lidocaine/Prilocaine cream if you are pregnant or breastfeeding. They will assess the potential benefits and risks to determine whether it is suitable for you.

How should I store Lidocaine/Prilocaine cream?

Store the cream at room temperature, away from heat and direct sunlight. Keep the container tightly closed when not in use. Make sure to keep the medication out of reach of children and pets.

Can I use other medications or topical treatments while using Lidocaine/Prilocaine cream?

Before using other medications or topical treatments in conjunction with this cream, consult with your healthcare provider. They will advise you whether it is safe to use other products and will help prevent potential interactions.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.