Lidocaine 7.5 mg/ml/Tetracaine 7.5 mg/ml Topical Gel is a compounded medication designed to provide local anesthesia by topical application. This semisolid formulation is specifically compounded for patients requiring a potent combination of two anesthetic agents, lidocaine and tetracaine, both of which belong to the class of medications known as local anesthetics. The gel is dispensed through a pump mechanism, which allows for easy and precise dosing, ensuring that the medication is applied consistently and accurately to the area of skin requiring treatment.

The mechanism of action for both lidocaine and tetracaine involves the temporary blocking of sodium channels in neuronal membranes, which inhibits the initiation and conduction of nerve impulses. This results in a loss of sensation in the applied area, providing relief from pain or discomfort during minor surgical procedures, needle insertions, and other superficial dermatological procedures. The combination of these two anesthetics in a gel base allows for a synergistic effect, potentially providing a more profound and longer-lasting anesthetic effect compared to either agent alone.

This topical gel is particularly useful in various disease states and conditions where local anesthesia is indicated. It can be used for numbing the skin before procedures such as laser hair removal, tattoo application and removal, and the treatment of superficial skin lesions. Additionally, it may be beneficial for patients with chronic pain conditions that affect the skin, such as neuropathic pain or certain types of neuralgia, where localized topical pain relief is desired.

For prescribers, it is important to note that the concentration of both lidocaine and tetracaine in this formulation is 7.5 mg/ml, and the appropriate amount of gel should be applied as per the medical indication and the size of the area to be treated. The onset of action and duration of anesthesia should be considered when planning any procedure. Patients should be advised not to apply the gel to broken or inflamed skin, as increased absorption may occur, leading to systemic effects. Additionally, patients should be monitored for signs of local and systemic toxicity, particularly in cases of repeated application or application over large surface areas.

Patients should be instructed on how to use the pump dispenser and apply the gel correctly. They should be made aware of the potential for temporary loss of sensation in the treated area and cautioned against engaging in activities that could result in injury due to the lack of sensation. It is also important for patients to understand that they should not cover the treated area with occlusive dressings unless directed by a healthcare provider, as this may increase the absorption of the active ingredients.

Bayview Pharmacy is committed to ensuring the safety and efficacy of our compounded medications. If you have any questions or require further information about the Lidocaine 7.5 mg/ml/Tetracaine 7.5 mg/ml Topical Gel, or if you would like to discuss the suitability of this formulation for your patients, please do not hesitate to reach out to us. Our team of knowledgeable compounding pharmacists is here to provide support and guidance.

The Lidocaine 7.5 mg/ml/Tetracaine 7.5 mg/ml Topical Gel is a combination anesthetic formulation designed for topical application. It is important to consider potential drug interactions when using this medication. As both lidocaine and tetracaine are local anesthetics, they should be used with caution in patients taking class I antiarrhythmic drugs (such as tocainide and mexiletine) due to the additive effects on cardiac conduction. Additionally, the use of other local anesthetics concurrently with this gel should be avoided to prevent excessive systemic absorption, which could lead to increased systemic toxicity.

Patients who are on medications that inhibit hepatic enzymes, particularly CYP1A2 and CYP3A4, may have increased levels of lidocaine, as it is metabolized by the liver. Common inhibitors include fluvoxamine, grapefruit juice, and certain antifungals like ketoconazole. Caution is advised when using this topical gel with these substances, as they may increase the risk of lidocaine toxicity. Similarly, tetracaine metabolism could be affected by enzyme alterations, although specific interactions are less well-defined.

Medications that reduce plasma esterases may also potentially increase the risk of systemic toxicity from tetracaine, as it is hydrolyzed by plasma esterases. The use of this gel in patients taking cholinesterase inhibitors, such as donepezil or rivastigmine, should be approached with caution. Additionally, caution is advised when using this gel in patients receiving other medications that can cause methemoglobinemia, such as sulfonamides, acetaminophen, and nitrates, as both lidocaine and tetracaine can contribute to this condition.

Patients with cardiac, liver, or kidney disease should use this medication with caution, as these conditions may affect the metabolism and excretion of the drugs, increasing the potential for systemic toxicity. It is also important to avoid applying the gel to large areas of skin or over open wounds, as this may increase systemic absorption.

This topical gel is indicated for use in providing local anesthesia to the skin, which can be beneficial in minor surgical procedures, needle insertions, and other superficial dermatological procedures. It is not intended for use in treating systemic disease states but rather for localized, superficial pain relief and anesthesia.

It is essential for both patients and prescribers to be aware of these potential interactions and to monitor for signs of toxicity, such as CNS excitement, dizziness, blurred vision, tremors, depression, or cardiac irregularities. If you have any questions or concerns regarding the use of Lidocaine 7.5 mg/ml/Tetracaine 7.5 mg/ml Topical Gel or its interactions with other medications, please reach out to us at Bayview Pharmacy for further assistance.

The Lidocaine 7.5 mg/ml/Tetracaine 7.5 mg/ml Topical Gel is a compounded medication designed to provide localized pain relief by combining the anesthetic effects of both lidocaine and tetracaine. Lidocaine is a well-known local anesthetic and antiarrhythmic drug, while tetracaine is another powerful local anesthetic. Both of these agents work by blocking sodium channels on neuronal membranes, which inhibits the initiation and conduction of nerve impulses. When applied to the skin, this action results in a numbing sensation, providing relief from pain and discomfort.

The formulation is a semisolid gel, which allows for a controlled and targeted application to the skin. The gel base is specifically designed to enhance the penetration of the active ingredients through the skin, ensuring effective local anesthesia. The pump mechanism of the container dispenses a consistent amount of gel with each use, which helps in maintaining dosing accuracy and ease of use for both patients and healthcare providers.

This topical gel is particularly useful in treating conditions that require localized pain relief or anesthesia. It can be used for procedures such as laser hair removal, tattoo application and removal, superficial skin surgeries, and other dermatological procedures that may cause pain or discomfort. The combination of lidocaine and tetracaine in this formulation provides a rapid onset of action with a prolonged duration of effect, making it an excellent choice for both short and extended procedures.

For patients, it is important to apply the gel as directed by a healthcare professional, and it should only be used on intact skin. The area of application should be clean and dry before applying the gel. Patients should be aware of the potential for systemic absorption and the risks of side effects, although these are generally minimal when the product is used as directed. For prescribers, it is crucial to consider the patient's overall health status, including any history of heart disease or allergies to local anesthetics, before recommending this formulation.

If you have any questions or require further information about the Lidocaine 7.5 mg/ml/Tetracaine 7.5 mg/ml Topical Gel, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance needed to ensure safe and effective use of this compounded medication.

Lidocaine and tetracaine are both local anesthetics used topically to numb the surface of the skin. The combination of 7.5 mg/ml of each in a topical gel formulation is primarily designed for numbing the skin in preparation for medical procedures such as minor surgical interventions, venipuncture, insertion of IV lines, or other diagnostic or therapeutic procedures that might cause pain. However, beyond its primary indications, this formulation may have other potential uses that can benefit patients.

The numbing effect of this lidocaine/tetracaine gel can be harnessed in the management of conditions that cause chronic or acute pain on the surface of the skin. Patients with certain types of neuralgia, such as postherpetic neuralgia resulting from shingles, may find that application of the gel to the affected area can provide temporary relief from the burning and pain often associated with this condition. Furthermore, the analgesic properties of the gel can be useful in the treatment of painful skin ulcers or wounds, aiding in comfort during routine care and dressing changes.

Another potential use of this formulation is to alleviate discomfort associated with skin conditions that cause irritation or itching, such as insect bites, minor burns, or allergic reactions. By numbing the area, the gel may help prevent scratching or further irritation, allowing for a more comfortable healing process. Additionally, the formulation may be used aesthetically; prior to undergoing cosmetic procedures such as laser hair removal or tattoo application, this combination gel might be applied to reduce pain sensitivity.

For patients experiencing musculoskeletal conditions, such as strains or sprains with localized, superficial pain, the gel may offer some symptomatic relief due to the numbing effect on sensory nerves in the skin. However, it should be noted that this is not a primary use and the gel does not possess anti-inflammatory properties, nor is it designed to penetrate deeply to affect muscle or joint pain.

It is important to remember that any off-label uses should be conducted under the advice and supervision of a qualified healthcare provider. Dosage, application technique, and patient health status must be taken into consideration. To ensure the safe use of lidocaine/tetracaine gel for conditions beyond its typical indications, clinicians should assess the suitability on a case-by-case basis. For both patients and prescribers interested in exploring additional applications of this lidocaine/tetracaine topical gel, or if there are any questions concerning its administration and safety, please do not hesitate to reach out to us at Bayview Pharmacy. Our compounding pharmacists are committed to providing comprehensive information and guidance to support your healthcare needs.