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Lidocaine 6%/Tetracaine 4% Topical Ointment

The Lidocaine 6%/Tetracaine 4% Topical Ointment is a semi-solid formulation intended for external application to the skin. This ointment is dispensed in a tube and possesses a greasy or oily base, which facilitates the delivery of the active ingredients, lidocaine and tetracaine, to the site of application. Lidocaine and tetracaine are both local anesthetics that work by blocking nerve signals in the body, providing localized pain relief.

This topical ointment is specifically formulated to treat a variety of disease states that require localized anesthesia or analgesia. It is commonly used for the temporary relief of pain and discomfort associated with conditions such as minor skin irritations, insect bites, minor burns, and sunburns. Additionally, it may be used to numb the skin in preparation for minor dermatological procedures, thereby reducing procedural pain and discomfort.

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Topical Ointment
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Formula Information

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Lidocaine 6%/Tetracaine 4% Topical Ointment is a compounded medication specifically designed for external application to the skin. This semi-solid formulation is dispensed in a tube and is characterized by its greasy or oily base, which not only facilitates the application process but also enhances the penetration of the active ingredients into the skin. The combination of lidocaine and tetracaine, both of which are local anesthetics, provides a synergistic effect that results in potent topical anesthesia. This is particularly beneficial for patients experiencing pain or discomfort associated with various skin conditions.

The lidocaine component, a well-known amide local anesthetic, works by blocking sodium channels in the neuronal cell membrane. This action inhibits the initiation and conduction of nerve impulses, thereby providing a numbing effect. Tetracaine, on the other hand, is an ester local anesthetic that functions similarly to lidocaine but is generally more potent and has a longer duration of action. When combined at concentrations of 6% lidocaine and 4% tetracaine, the ointment delivers a rapid onset of anesthesia with an extended duration, making it highly effective for procedures requiring prolonged numbing of the skin.

This topical ointment is commonly used for a variety of dermatological procedures, including but not limited to, laser hair removal, tattoo application and removal, and minor surgical procedures. It is also beneficial for patients with skin inflammation, certain types of infections, or those in need of wound healing, as it can provide pain relief and comfort during the healing process. The ointment's base also serves a protective function, creating a barrier that can help to keep the skin moisturized and shielded from external irritants.

For prescribers considering this formulation, it is important to note that the ointment should be applied to intact skin only and should not be used on mucous membranes or in patients with a known hypersensitivity to lidocaine, tetracaine, or other amide or ester local anesthetics. The duration of application and the amount of ointment to be used will depend on the procedure and the area being treated. As with all compounded medications, this formulation should be prescribed and used under the guidance of a healthcare professional familiar with the patient's medical history and the specific clinical scenario.

Patients should be advised to apply the ointment as directed by their healthcare provider and to report any adverse reactions, such as persistent redness, swelling, or allergic symptoms. It is also crucial to keep the medication out of reach of children and to avoid applying near the eyes or on open wounds unless directed by a healthcare professional.

If you have any questions regarding the Lidocaine 6%/Tetracaine 4% Topical Ointment or its use in treating specific disease states, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive information and support to both patients and prescribers to ensure the safe and effective use of this medication.

Drug Interactions

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Lidocaine and tetracaine are both local anesthetics used topically to numb the skin and surrounding tissues. When combined in a 6%/4% topical ointment, they work synergistically to provide a more potent and longer-lasting anesthetic effect. This formulation is particularly useful for procedures that require skin anesthesia, such as minor surgical procedures, needle insertions, and laser treatments. It is also used to relieve pain from conditions such as burns, insect bites, and other skin irritations.

While the risk of systemic drug interactions with topical lidocaine and tetracaine is generally low due to minimal systemic absorption, certain interactions may still occur, especially in cases of prolonged use, application over large surface areas, or use on broken or inflamed skin. Patients should be advised to inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.

Concomitant use of other local anesthetics should be approached with caution, as the additive systemic effects could increase the risk of systemic toxicity, characterized by symptoms such as CNS depression, seizures, cardiac arrhythmias, and even cardiac arrest. Patients using anti-arrhythmic drugs, particularly those in Class III (e.g., amiodarone), should be monitored closely, as the systemic absorption of lidocaine and tetracaine may contribute to additive cardiac effects.

Patients on medications that inhibit cytochrome P450 3A4 (CYP3A4) enzymes, such as certain antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., erythromycin), and protease inhibitors (e.g., ritonavir), may have an increased risk of systemic toxicity from lidocaine and tetracaine, as these enzymes are responsible for metabolizing local anesthetics. Caution is advised when using this topical ointment in conjunction with these medications.

Additionally, the use of this formulation in patients taking monoamine oxidase inhibitors (MAOIs) or certain antidepressants (e.g., selective serotonin reuptake inhibitors or SSRIs) may theoretically increase the risk of systemic side effects due to potential interactions that affect metabolic pathways, although this is more of a concern with injectable forms of local anesthetics.

It is important to apply the ointment as directed, avoiding application to large areas of skin or open wounds, to minimize systemic absorption. Patients should also be advised to avoid applying heat to the treated areas, as this can increase the absorption of the active ingredients, potentially leading to increased systemic levels and risk of adverse effects.

For any questions or concerns regarding the use of this formulation or potential drug interactions, healthcare providers and patients are encouraged to reach out to us at Bayview Pharmacy for personalized advice and support.

How Does it Work

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The Lidocaine 6%/Tetracaine 4% Topical Ointment is a compounded medication that combines two potent local anesthetics, lidocaine and tetracaine, in a semi-solid dosage form. This ointment is specifically formulated to provide localized pain relief and is particularly effective in numbing the skin to prepare for minor surgical procedures, injections, or to alleviate pain from conditions such as skin inflammation or wounds. The ointment is designed to be applied directly to the skin, where it acts on the nerve endings to block the transmission of pain signals to the brain.

Lidocaine works by stabilizing the neuronal membrane and preventing the initiation and conduction of nerve impulses, thereby providing a numbing sensation. It is a well-tolerated anesthetic with a rapid onset of action. Tetracaine, on the other hand, is a more potent anesthetic with a longer duration of action. It works similarly to lidocaine but is generally used for procedures that require a deeper and more prolonged anesthesia. When combined, these two anesthetics offer both immediate and extended pain relief, making the formulation highly effective for a variety of dermatological applications.

The ointment base itself is greasy or oily, which not only helps in the delivery of the active medications but also provides a protective barrier on the skin. This can be beneficial in cases of skin inflammation or wounds, as it can prevent further irritation or infection while the anesthetics work to relieve pain. The semi-solid nature of the ointment allows it to stay in place upon application, ensuring that the medication is absorbed where it is needed most.

For prescribers, it is important to note that the concentration of the anesthetics in this formulation is higher than what is typically found in over-the-counter products. Therefore, it is crucial to provide clear instructions on the amount to be applied and the frequency of application to avoid systemic toxicity. Patients should be advised to apply a thin layer of the ointment to the affected area and to avoid applying to large areas of the body or to broken skin, as this could increase the risk of systemic absorption and potential side effects.

As with any medication, there may be potential side effects, including local reactions such as redness, swelling, or allergic reactions. Systemic side effects, although rare, can occur if the medication is absorbed into the bloodstream in significant amounts. It is essential for patients to be aware of these risks and to contact their healthcare provider if they experience any unusual symptoms.

If you have any questions or require further information about the Lidocaine 6%/Tetracaine 4% Topical Ointment, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Other Uses

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Lidocaine 6%/Tetracaine 4% Topical Ointment, beyond its primary indication for skin inflammation, infections, or wound healing, harbors a variety of other potential uses contingent upon the analgesic and anesthetic properties of the active ingredients. Such a formulation might also be considered for the provision of local analgesia in minor surgical procedures, including but not limited to, dermatological procedures, such as biopsies, excisions, or laser treatments. The compounded ointment can be instrumental in reducing discomfort during procedures involving needle insertions, such as intravenous catheter placement or blood draw.

Additionally, this combination is sometimes employed off-label to minimize pain during cosmetic procedures, including microblading, tattoo application, and the removal of skin lesions. The numbing effect provided by this ointment can also be beneficial for patients experiencing painful skin conditions like certain types of dermatitis, particularly when pruritus (itching) leads to a discomfort that necessitates a topical anesthetic agent. However, it is imperative that both patients and prescribers understand that when using this formulation for unapproved indications, the potential benefits must be weighed against the risks, and such use should be undertaken with a pharmacist's guidance.

It should also be noted that while Lidocaine and Tetracaine are both local anesthetics, they work slightly differently, and therefore, the combination provides a synergistic effect that may enhance the duration and efficacy of topical anesthesia compared to either agent alone. This collectively attributes to the versatility of the formulation. However, it is vital that any other uses beyond those for which the ointment has been primarily formulated be discussed with a healthcare provider to ensure safety and efficacy. Each patient's medical history, concomitant medications, and potential for adverse reactions must be considered before the ointment is applied for alternate uses.

Prescribers and potential patients are encouraged to consult with our compounding pharmacy team at Bayview Pharmacy for in-depth guidance regarding the compounding ointment and its possible applications. We are dedicated to ensuring that the formulation meets the specific needs of the patient while providing a safe and effective treatment pathway. If you have any questions or require tailored advice for a unique situation, please do not hesitate to reach out to us. Our expert team is always ready to help you navigate the use of Lidocaine 6%/Tetracaine 4% Topical Ointment for a variety of therapeutic needs.

Frequently Asked Questions

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What is Lidocaine 6%/Tetracaine 4% Topical Ointment used for?

Lidocaine 6%/Tetracaine 4% Topical Ointment is used to provide localized relief from pain and discomfort on the skin due to conditions such as skin inflammation, minor burns, insect bites, or during certain medical procedures that might cause pain.

How should I apply Lidocaine/Tetracaine Topical Ointment?

The ointment should be applied to clean, intact skin in a thin layer. Gently rub in the ointment over the entire affected area as directed by your healthcare provider. Do not bandage or wrap the treated area unless advised to do so.

Can this ointment be used on open wounds?

No, Lidocaine/Tetracaine Topical Ointment should not be applied to open wounds or broken skin. It is intended for use on intact skin only to avoid potential complications or increased absorption of the medication into the bloodstream.

Is there anyone who should not use Lidocaine 6%/Tetracaine 4% Topical Ointment?

Individuals with a known allergy to lidocaine, tetracaine, or any other amide or ester-type local anesthetics should not use this ointment. Those with certain medical conditions or who are pregnant or breastfeeding should consult with a healthcare provider before use.

How often can I apply the ointment?

The frequency of application will depend on the advice of your healthcare provider, but it is typically applied 2-3 times a day or as needed for pain relief. Do not exceed the recommended dose or frequency without consulting a healthcare professional.

Does Lidocaine/Tetracaine Topical Ointment have any side effects?

As with any medication, there can be side effects. These may include mild skin irritation at the application site, redness, or swelling. If you experience any severe reactions, such as difficulty breathing or a severe rash, seek medical attention immediately.

Can I cover the area after applying the ointment?

Unless your healthcare provider instructs you otherwise, you should avoid covering the treated area with occlusive dressings or bandages as this can increase the absorption of the active ingredients.

Is it safe to use Lidocaine/Tetracaine Topical Ointment before a procedure?

Yes, this formulation is often used to numb the skin before certain medical procedures. However, use it only under the supervision and direction of a healthcare provider to ensure safe and appropriate application.

How does Lidocaine/Tetracaine Topical Ointment work?

Lidocaine and tetracaine work by blocking nerve signals in the body, which helps to numb the topical area it is applied to. This action helps to provide temporary relief from pain and discomfort associated with skin conditions or procedures.

How should I store this ointment?

Store the ointment at room temperature, away from direct light and heat. Keep the cap tightly closed when not in use. Make sure to keep it out of reach of children and pets.

What should I do if I accidentally ingest the ointment?

If the ointment is accidentally ingested, seek medical attention immediately or contact a poison control center. Do not induce vomiting unless instructed to do so by medical personnel.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.