Lidocaine 3%/Prilocaine 3%/Tetracaine 4% Topical Cream is a compounded medication specifically designed to provide localized anesthesia by numbing the skin and surrounding tissues. This formulation combines the anesthetic effects of three different agents: lidocaine, prilocaine, and tetracaine, each at their respective concentrations of 3%, 3%, and 4%. Lidocaine and prilocaine are both amide-type local anesthetics, while tetracaine is an ester-type. The combination of these three agents works synergistically to provide a more potent and longer-lasting anesthetic effect than any of the individual components alone.

The cream is compounded into a semisolid preparation that is dispensed in a pump mechanism. This delivery system is designed for ease of use, allowing for convenient and controlled application. The pump helps to ensure that the correct dose is administered each time, reducing the risk of over- or under-dosing. The topical cream is intended for external use only and should be applied to intact skin to minimize discomfort from various procedures or conditions that require local anesthesia.

This triple-anesthetic cream is commonly used in dermatological procedures, such as laser hair removal, tattoo application and removal, and minor surgical procedures where surface anesthesia is required. It is also beneficial in the treatment of painful skin conditions such as sunburns, minor burns, and insect bites. The formulation's efficacy in numbing the skin makes it a valuable option for patients undergoing procedures that might otherwise be uncomfortable or painful.

For prescribers, it is important to note that the combination of lidocaine, prilocaine, and tetracaine in this formulation provides a broad spectrum of anesthetic activity, which can be particularly useful for patients who may not respond adequately to a single agent. The cream should be applied as directed, typically some time before the procedure to allow the anesthetics to take effect. The duration of effect will vary depending on the amount applied and the site of application. Prescribers should consider the maximum recommended dose and the potential for systemic absorption, especially in patients with a history of sensitivity to local anesthetics or those with significant hepatic dysfunction.

Patients should be advised to use the cream only as directed by their healthcare provider and to avoid application to broken or inflamed skin. They should also be informed about the potential for local side effects, such as temporary redness, swelling, or a pale area on the skin, as well as the rare possibility of systemic side effects if the cream is used excessively. It is crucial for patients to report any unusual sensations or reactions following the application of the cream.

If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this compounded medication.

The Lidocaine 3%/Prilocaine 3%/Tetracaine 4% Topical Cream is a compounded medication that combines three local anesthetics for the purpose of providing localized pain relief and anesthesia. This formulation is particularly used for procedures that require numbing of the skin, such as minor surgical procedures, needle insertions, and superficial dermatological procedures. The active ingredients work by blocking nerve signals in the body, which helps to reduce pain sensation in the area where the cream is applied.

When using this compounded topical cream, it is important to consider potential drug interactions. Lidocaine, prilocaine, and tetracaine are all metabolized by the liver, and therefore, drugs that affect liver enzymes could potentially alter the metabolism of these anesthetics. For example, certain anti-seizure medications, such as phenytoin, and antibiotics like erythromycin, may increase the levels of local anesthetics by inhibiting their breakdown, potentially leading to increased risk of systemic toxicity.

Concomitant use of other local anesthetics or medications with similar metabolic pathways should be approached with caution, as the systemic absorption of lidocaine, prilocaine, and tetracaine could be additive, increasing the risk of adverse effects such as CNS depression, cardiac arrhythmias, and methemoglobinemia, particularly with prilocaine. Patients with congenital or idiopathic methemoglobinemia are at higher risk when using prilocaine-containing products.

Patients taking class III antiarrhythmic drugs (e.g., amiodarone) should be monitored closely, as the combination with local anesthetics may result in an additive effect on cardiac conduction. Additionally, the use of this topical cream in conjunction with other medications that can cause methemoglobinemia, such as sulfonamides, acetaminophen, and nitrates, should be done with caution and under close supervision.

It is also important to consider the application site of the cream, as the absorption can be increased if applied to mucous membranes or broken skin, which could lead to higher systemic concentrations of the anesthetics. This is particularly relevant for patients who are already taking systemic anesthetic agents or medications that may potentiate the effects of local anesthetics.

Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to assess for potential drug interactions. Additionally, patients with liver disease or impaired hepatic function should use this medication with caution, as they may be more susceptible to the systemic effects due to decreased metabolism of the anesthetics.

As with any medication, it is essential to use this compounded topical cream as directed by a healthcare professional. If you have any questions or concerns about the use of this medication or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance and guidance.

The Lidocaine 3%/Prilocaine 3%/Tetracaine 4% Topical Cream is a compounded medication that combines the anesthetic effects of three different local anesthetics: lidocaine, prilocaine, and tetracaine. This cream is formulated to provide localized relief from pain by numbing the specific area of application. The mechanism of action for each of these active ingredients is similar; they work by blocking the sodium channels in the neuronal cell membrane. This blockage inhibits the propagation of nerve impulses near the site of application, which in turn prevents the sensation of pain from reaching the central nervous system.

Lidocaine is a well-known amide local anesthetic that provides rapid onset of action. Prilocaine, another amide, complements lidocaine in its anesthetic effect and has a slightly longer duration of action. Tetracaine, an ester local anesthetic, enhances the overall efficacy of the cream with its potent and longer-lasting anesthetic properties. The combination of these three agents in a single formulation allows for a synergistic effect, resulting in effective and prolonged anesthesia suitable for a variety of minor surgical procedures, such as laser hair removal, tattoo application and removal, and the treatment of localized skin disorders that involve pain or discomfort.

The cream is designed as a semisolid preparation, which ensures that it stays in place upon application to the skin, providing targeted relief. The pump mechanism of the container allows for controlled dispensing, which helps to ensure that the correct dose is applied each time, minimizing waste and reducing the risk of applying too much or too little of the medication. This dosage form is particularly user-friendly and is designed to maintain the stability and potency of the active ingredients.

For patients, it is important to apply the cream as directed by a healthcare provider, usually to intact skin to minimize discomfort before a procedure. For prescribers, it is crucial to consider the maximum recommended dose and the total surface area of application to avoid systemic toxicity, especially in patients with pre-existing heart, liver, or kidney conditions. The onset of action typically occurs within 30 to 60 minutes after application, and the duration of effect can last for 1 to 2 hours, depending on the procedure and individual patient factors.

If you have any questions or require further information about this formulation and its use in specific disease states, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this compounded medication.

The Lidocaine 3%/Prilocaine 3%/Tetracaine 4% Topical Cream is primarily formulated for delivering local anesthesia to the skin. Its usual indications include providing analgesia for procedures like laser treatments, tattooing, and piercing, or superficial surgical procedures that require numbing of the skin. Additionally, it may be used to alleviate pain from minor burns, insect bites, or other minor skin irritations.

Beyond these common applications, this topical cream can serve as a utility in diagnostics where the reduction of skin sensation is necessary, such as in minor dermatological procedures or in the removal of skin lesions. It also reveals potential for use in chronic pain management for localized neuropathic pain conditions, where the aim is to numb a specific area of the skin that is hypersensitive due to nerve damage or irritation.

Another off-label use of this combination anesthetic cream could be for the management of pruritus—itchiness of the skin—which may be brought on by dermatologic conditions like eczema or psoriasis. Some practitioners may recommend its application to alleviate itching, although it should not be applied to open or weeping lesions.

However, it is important to recognize that while these alternative uses might be beneficial, the safety and efficacy for such applications may have varying degrees of evidence supporting them. Prescribers should assess the benefits and risks when considering the cream for off-label use. Patients are advised to use this medication only as directed by their healthcare provider.

Our formulary version of this cream lends itself to convenient and controlled dosing through the pump mechanism, which helps ensure consistent application. Additionally, the cream base is designed to enhance the permeability of the active ingredients, allowing for effective numbing with potentially reduced onset time. Regardless, it’s crucial to avoid using this cream over large areas of skin or for prolonged periods unless directed by a healthcare practitioner, due to the potential for systemic absorption and related adverse effects.

The formulation is not suitable for all patients, and it should not be utilized by individuals with known hypersensitivity to local anesthetics of the amide or ester type. Since the formulation comprises both types, caution should be exercised, and a thorough patient history should be obtained to rule out allergic reactions.

If you have any questions or require additional information about the use of Lidocaine 3%/Prilocaine 3%/Tetracaine 4% Topical Cream, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always ready to provide you with the information you need for the safe and effective use of our customized medications.