Lidocaine 15%/Prilocaine HCl 5.83% Topical Ointment is a compounded medication specifically designed for topical use to provide localized pain relief. The ointment is formulated as a semi-solid preparation, which is dispensed in a tube for convenient application. The base of the ointment is greasy or oily, which not only facilitates the delivery of the active ingredients to the skin but also provides a protective barrier that can aid in the healing process. This type of formulation is particularly useful for treating conditions that benefit from the numbing effect of local anesthetics, such as skin inflammation, minor skin infections, or during wound healing.

The active ingredients, lidocaine and prilocaine, are both local anesthetics that work by blocking the transmission of pain signals in the nerves of the skin. Lidocaine is known for its rapid onset of action, while prilocaine complements it by providing a longer duration of effect. When applied to the skin, this combination can provide significant pain relief by numbing the treated area. This can be particularly beneficial for procedures that involve needle insertion, such as intravenous cannulation or minor surgical interventions, as well as for the treatment of painful skin conditions like burns, insect bites, or other localized pain syndromes.

For patients, it is important to apply the ointment as directed by a healthcare provider, ensuring that the area of application is clean and dry. The ointment should be used in the prescribed amount and not be covered with airtight dressings unless advised by a healthcare professional, as this could increase the absorption of the active ingredients and potentially lead to systemic side effects. Patients should also be aware of potential side effects, such as local skin reactions or systemic effects if the ointment is applied over a large area or used for prolonged periods.

Prescribers should consider the concentration of the active ingredients when determining the appropriate dose and duration of treatment for their patients. They should also take into account the patient's overall health status, including any pre-existing conditions or concurrent medications that could interact with the local anesthetics. Monitoring for signs of local or systemic toxicity is recommended, especially in patients with compromised liver function, as both lidocaine and prilocaine are metabolized in the liver.

Bayview Pharmacy's team of compounding pharmacists is committed to providing high-quality, customized medications to meet the specific needs of patients and prescribers. If you have any questions about this formulation or its appropriate use, please do not hesitate to reach out to us for further information and guidance.

Lidocaine and prilocaine are both local anesthetics used in combination in this topical ointment to provide localized pain relief by blocking nerve signals in the body. Lidocaine/prilocaine ointment is commonly used for numbing the skin in preparation for minor surgical procedures, as well as for treating conditions that involve pain or discomfort on the skin's surface. When considering the use of this formulation, it is important to be aware of potential drug interactions that could affect its safety and efficacy.

Since this is a topical preparation, systemic absorption is generally low; however, interactions can still occur, particularly with extended use, application to large surface areas, or use on broken or inflamed skin. Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Special caution should be exercised when using other local anesthetics or medications that affect cardiac conduction, as these could potentially increase the risk of additive systemic toxicity or cardiac effects.

Concomitant use of certain anti-arrhythmic drugs (such as Class I antiarrhythmics like tocainide and mexiletine) may increase the risk of systemic lidocaine toxicity. Similarly, the use of other medications that can contribute to methemoglobinemia, such as sulfonamides, acetaminophen, benzocaine, and nitrates, should be approached with caution when combined with this lidocaine/prilocaine formulation, as both lidocaine and prilocaine can induce methemoglobinemia, a condition where the oxygen-carrying capacity of the blood is reduced.

Patients with liver disease or those taking medications that affect liver enzymes (particularly CYP1A2 and CYP3A4) may have altered metabolism of lidocaine and prilocaine, potentially leading to increased levels of the drugs and a higher risk of systemic toxicity. Additionally, the use of this ointment in conjunction with other medications that depress the central nervous system (such as opioids, benzodiazepines, or barbiturates) may result in enhanced sedative effects.

It is also important to consider the potential for pharmacodynamic interactions. For example, the use of other drugs that can cause vasodilation may increase the systemic absorption of lidocaine and prilocaine, potentially leading to increased plasma concentrations and an enhanced risk of adverse effects. Conversely, vasoconstrictors may reduce the absorption and potentially decrease the efficacy of the topical anesthetic.

Patients should be advised to avoid applying other topical medications to the same area being treated with the lidocaine/prilocaine ointment unless directed by a healthcare provider, as this could alter the absorption or effects of either medication. Additionally, the use of occlusive dressings over the application site can increase systemic absorption of the anesthetics and should be used with caution.

Before using this lidocaine/prilocaine topical ointment, it is crucial for patients to discuss their full medical history with their healthcare provider, including any known allergies, pre-existing conditions, and current medication regimen. This will help ensure the safe and effective use of the medication. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy for assistance.

Lidocaine 15%/Prilocaine HCl 5.83% Topical Ointment is a compounded medication specifically designed to provide localized pain relief by numbing the skin and surrounding tissue. The active ingredients, lidocaine and prilocaine, are both local anesthetics that work by blocking the transmission of pain signals through the nerves in the area where the ointment is applied. When the ointment is spread on the skin, these anesthetics penetrate the epidermis and dermis, reaching the nerve fibers that transmit pain signals.

Lidocaine works by stabilizing the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Prilocaine has a similar mechanism of action but is a slightly less potent anesthetic than lidocaine. However, when combined at these concentrations, the two agents have a synergistic effect, providing a more effective and longer-lasting analgesic action than either would alone. This makes the formulation particularly useful for procedures that require a significant duration of action.

The semi-solid base of the ointment not only facilitates the delivery of the active ingredients but also provides a protective barrier over the skin, which can be beneficial in the management of skin inflammation and minor wounds. The greasy or oily nature of the base ensures that the ointment stays in place, allowing for sustained release of the anesthetics over the area of application. This is particularly useful in conditions where skin integrity is compromised, as it can help to prevent further irritation or infection while also providing pain relief.

By numbing the skin, this formulation can be used to treat a variety of conditions that involve pain or discomfort of the skin, such as minor burns, insect bites, or needle insertions. It is also commonly used prior to minor dermatological procedures to reduce pain associated with needle punctures, such as those required for tattoo application or removal, and minor surgical procedures like mole or wart removal.

It is important for both patients and prescribers to understand that while this ointment provides effective local anesthesia, it should be used with caution. The application area should be limited to the recommended size, and the duration of application should not exceed the advised time, as excessive use can lead to systemic absorption and potential toxicity. Additionally, this formulation should not be applied to broken or inflamed skin unless under the supervision of a healthcare provider, as this can increase the rate of systemic absorption.

For any questions or concerns regarding the use of Lidocaine 15%/Prilocaine HCl 5.83% Topical Ointment, or to discuss the suitability of this formulation for a specific patient or condition, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the necessary guidance and support to ensure safe and effective treatment outcomes.

As compounding pharmacists, we understand that the Lidocaine 15%/Prilocaine HCl 5.83% Topical Ointment, while typically prescribed for its local anesthetic properties, may also serve other purposes in clinical practice. In addition to its primary indication to provide localized pain relief during minor surgical procedures, skin treatments, or needle insertions, this compound ointment can be used off-label for a number of dermatological conditions where numbing of the skin is beneficial. For example, patients undergoing tattoo applications or laser hair removal sessions may find this formulation provides significant reduction in discomfort associated with these cosmetic procedures.

Moreover, this topical anesthetic can be valuable in the management of painful chronic conditions such as neuropathic pain or post-herpetic neuralgia, where the numbing effect can offer temporary respite from pain sensations. Furthermore, another potential use includes treating superficial skin erosions or ulcerations, where the painful area might benefit from analgesia during the healing process. It is important to note, however, that while there may be a range of alternative uses for this compound, it is always essential to use such medications under the supervision and prescription of a healthcare professional.

For healthcare providers considering prescribing this formulation, it is crucial to consider the potential for systemic absorption, especially in cases where application involves large surface areas of the skin or mucous membranes. A patient's total body exposure to lidocaine and prilocaine should not exceed recommended doses, due to the potential risk of systemic toxicity. As with any compounded medication, care should be taken when determining suitability for each patient, which includes reviewing their medical history and any potential drug interactions. Additionally, this ointment should only be applied to intact skin, avoiding broken or inflamed skin to prevent excessive systemic absorption and adverse effects.

For patients prescribed the Lidocaine 15%/Prilocaine HCl 5.83% Topical Ointment, it is essential to follow the specific instructions for application provided by their healthcare professional. The area of application should be clean and dry before use, and the ointment should be applied in a thin layer, unless otherwise directed. It is also important for patients to be aware of signs of systemic toxicity, such as dizziness, blurred vision, or an irregular heartbeat, and they should seek medical attention immediately if these occur.

Always use the Lidocaine 15%/Prilocaine HCl 5.83% Topical Ointment as directed by a healthcare provider, and never hesitate to reach out to us at Bayview Pharmacy with any questions or concerns regarding the use of this formulation. Our team of compounding pharmacists is here to support both patients and prescribers in optimizing therapeutic outcomes with compounded medications.