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Formulas

Lidocaine 15%/Prilocaine 5% Topical Cream

The Lidocaine 15%/Prilocaine 5% Topical Cream is a semisolid preparation that combines the local anesthetic effects of lidocaine and prilocaine in a synergistic ratio. This cream is specifically formulated for topical use and is dispensed in a pump mechanism container, which allows for convenient, controlled, and hygienic application directly to the skin. The formulation is designed to provide localized relief from pain and discomfort associated with various dermatological procedures and conditions.

Indicated for the treatment of disease states such as minor skin procedures, needle insertions, superficial dermatological procedures, and local anesthesia for laser treatments, this cream works by numbing the targeted area, thereby reducing pain sensation. The pump mechanism ensures that the cream is evenly distributed over the treatment area, promoting consistent and effective absorption of the active ingredients.

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Prilocaine Hydrochloride
Lidocaine Hydrochloride
Topical Cream
65b01b9ec39a0a5ff7badf39
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Formula Information

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Lidocaine 15%/Prilocaine 5% Topical Cream is a compounded medication specifically formulated to provide targeted, localized pain relief. This cream combines two potent local anesthetics, lidocaine and prilocaine, which work synergistically to numb the skin and underlying tissues. Lidocaine is known for its rapid onset of action, while prilocaine extends the duration of the anesthetic effect, making this combination particularly effective for procedures requiring both immediate and prolonged pain relief.

The cream is prepared as a semisolid dosage form, ensuring that the active ingredients remain in contact with the treatment area for an adequate period to exert their therapeutic effects. The inclusion of a pump mechanism in the packaging design allows for easy and precise dosing, minimizing waste and ensuring that the correct amount of cream is applied to the skin. This feature is especially beneficial for patients who may have difficulty with manual dexterity or for those who require consistent dosing for repeated applications.

This formulation is commonly used for a variety of dermatological procedures and conditions that require local anesthesia, such as minor surgical procedures, needle insertions, laser treatments, and the management of chronic pain conditions like neuropathies. It is also employed to alleviate pain associated with skin lesions, wounds, and ulcers. By blocking the nerve signals in the treated area, Lidocaine 15%/Prilocaine 5% Topical Cream helps to reduce pain sensation, providing comfort and allowing patients to undergo necessary medical procedures with less discomfort.

For prescribers, it is important to note that the use of this cream should be tailored to the individual patient's needs, taking into account the area to be treated and the expected duration of pain relief required. Patients should be advised on the proper application technique, including the amount of cream to be used and the duration of application before a procedure. It is also crucial to consider the maximum recommended dose to avoid systemic toxicity, particularly in patients with pre-existing heart, liver, or kidney conditions.

Patients should be informed that while side effects are generally mild and transient, they may include local reactions such as erythema, edema, or an abnormal sensation at the site of application. Systemic adverse effects are rare but can occur if the cream is applied over a large area or used for a prolonged period. If any signs of systemic toxicity or allergic reaction occur, such as dizziness, palpitations, or difficulty breathing, patients should seek medical attention immediately.

Bayview Pharmacy is committed to providing high-quality compounded medications to meet the specific needs of our patients and prescribers. Our team of knowledgeable compounding pharmacists is available to answer any questions regarding the formulation, application, or safety of Lidocaine 15%/Prilocaine 5% Topical Cream. Please do not hesitate to reach out to us for further information or guidance.

Drug Interactions

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Lidocaine and prilocaine, the active ingredients in this topical cream, are both local anesthetics that work by blocking nerve signals in your body. When applied to the skin, this combination can provide localized pain relief by numbing the area. This formulation is particularly useful for minor procedures such as needle insertions, superficial skin surgeries, and the treatment of conditions like minor burns, insect bites, or other sources of localized pain or itching.

While the risk of systemic drug interactions with topical lidocaine/prilocaine is lower than with oral or injectable forms, certain interactions may still occur. Patients should be advised to inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Special caution should be exercised when using other local anesthetics or medications that affect the cardiovascular system, as there may be an additive effect leading to increased risk of systemic toxicity.

Patients who are taking anti-arrhythmic drugs (such as tocainide or mexiletine) should use lidocaine/prilocaine cream with caution, as these medications can also affect the heart and potentially lead to adverse effects when combined with local anesthetics. Similarly, the use of other medications that can cause methemoglobinemia, such as sulfonamides, acetaminophen, and nitrates, in conjunction with this cream may increase the risk of this condition. Methemoglobinemia is a serious condition where the oxygen-carrying capacity of the blood is reduced, and it requires immediate medical attention.

Patients with liver disease or those taking drugs known to affect liver enzymes should use lidocaine/prilocaine cream with caution, as these conditions can alter the metabolism and clearance of the drug, potentially leading to increased plasma concentrations and risk of systemic toxicity. Additionally, caution is advised in patients with severe renal impairment, as prilocaine metabolites are excreted by the kidneys and may accumulate in such patients.

It is also important to avoid applying the cream to broken or inflamed skin, as this can increase absorption into the bloodstream and the risk of systemic side effects. The simultaneous application of the cream with other products that may enhance absorption should be avoided unless deemed safe by a healthcare provider.

Lastly, patients should be instructed to use the cream as directed by their healthcare provider and not to exceed the recommended dose or application frequency. Excessive dosing or prolonged application may increase the risk of systemic toxicity, including CNS and cardiovascular effects. If there are any signs of systemic toxicity, such as dizziness, blurred vision, tremors, or irregular heartbeat, patients should seek medical attention immediately.

If you have any questions or concerns regarding the use of this lidocaine/prilocaine topical cream or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and guidance you need to use this medication safely and effectively.

How Does it Work

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Lidocaine 15%/Prilocaine 5% Topical Cream is a compounded medication that combines two local anesthetics, lidocaine and prilocaine, in a semisolid cream base. This formulation is designed to provide localized pain relief by numbing the skin and the tissues just beneath the skin. The cream is dispensed in a pump mechanism, which allows for convenient, hygienic, and controlled application, ensuring that the correct dose is administered each time.

Lidocaine works by blocking sodium channels in the neuronal cell membrane. This action inhibits the initiation and conduction of nerve impulses, thereby providing a local anesthetic effect. Prilocaine has a similar mechanism of action, but it is metabolized differently in the body. When applied to the skin, the combination of lidocaine and prilocaine has a synergistic effect, leading to more effective and longer-lasting local anesthesia compared to either agent alone.

This topical cream is particularly useful in treating conditions that require localized pain relief or anesthesia. It is commonly used for procedures such as needle insertions, minor surgical interventions, and the treatment of painful skin conditions. Additionally, it can be used to numb the skin before laser treatments or superficial dermatological procedures. The cream's formulation allows for the anesthetics to penetrate the skin and reach the target area, providing relief without affecting the surrounding areas.

Patients and prescribers should be aware that the onset of action for this cream is typically within 30 to 60 minutes, and the duration of effect can last for 1 to 2 hours, depending on the site of application and individual patient factors. It is important to apply the cream as directed and to avoid applying it to broken or inflamed skin, as this can increase systemic absorption and the potential for adverse effects.

For any questions regarding the use of Lidocaine 15%/Prilocaine 5% Topical Cream, or to discuss the suitability of this formulation for specific procedures or conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this compounded medication.

Other Uses

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Aside from its traditional indications in providing local anesthesia for superficial skin procedures and relief from chronic painful skin conditions, our compounded Lidocaine 15%/Prilocaine 5% Topical Cream has a range of other potential uses. Due to its efficacious combination of two topical anesthetics, it has been employed off-label for the management of pain associated with other dermatological procedures such as laser hair removal, tattoo application and removal, and superficial cosmetic procedures that can cause discomfort or pain. Furthermore, patients undergoing vascular access procedures or injections may find a significant benefit from the preemptive application of this cream to reduce procedural pain.

In sports medicine and physical therapy settings, the cream may be applied to soothe muscle strains and sprains, as its numbing effect can provide temporary relief from muscular pain and facilitate a more comfortable initiation of rehabilitative exercises. Similarly, individuals with particularly painful forms of neuropathy, not adequately controlled by conventional oral medications, may experience symptomatic relief when this cream is applied to the affected skin areas. Although these uses are less common, they allow for a patient-centered approach by offering an alternative or adjunctive topical treatment option where systemic analgesics may be contraindicated or unsuitable due to systemic side effects or patient preference.

Moreover, some patients have been reported to use this formulation to alleviate the discomfort caused by severe sunburns or other minor burns, though care should be taken to avoid application on broken or blistered skin. While the range of potential applications is extensive, individual responses to treatment may vary, and optimal treatment regimens, including dosage and frequency of application, should be tailored to each patient’s specific needs and medical history. As with any medication, off-label use should be done under the advice and ongoing management of a qualified healthcare provider to ensure patient safety and efficacy of the treatment.

Patient education is vital when considering any off-label application of compounded medications. Patients should be thoroughly briefed on the appropriate use of this formulation, including the importance of using it on intact skin, avoiding sensitive body areas, and the necessity of washing hands before and after application unless the hands are the treatment site. It should be communicated to avoid occlusive dressings unless directed by a physician, as enhanced absorption could unintendedly increase systemic exposure. Awareness of potential side effects, although rare when used topically and as directed, should also be part of patient counseling.

If you have any questions or require more information regarding the potential uses of our Lidocaine 15%/Prilocaine 5% Topical Cream or advice on its application, please do not hesitate to reach out to us. Our team at Bayview Pharmacy remains committed to supporting both patients and prescribers in making informed decisions about compounding medication regimens and ensuring the safe and effective use of this formulation.

Frequently Asked Questions

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What is Lidocaine 15%/Prilocaine 5% Topical Cream used for?

Lidocaine 15%/Prilocaine 5% Topical Cream is used for providing localized relief from pain or anesthesia to a specific area of the skin. It can be beneficial for procedures such as laser hair removal, tattoo application, minor skin surgeries, or needle insertions.

How do you apply Lidocaine 15%/Prilocaine 5% Topical Cream?

The cream should be applied onto clean, intact skin in the area that requires pain relief. Press the pump to dispense the cream and spread a thin layer over the area with clean hands, following the specific dosage instructions provided by your healthcare provider. Do not rub in vigorously.

How long does it take for Lidocaine 15%/Prilocaine 5% Topical Cream to work?

The onset of action can vary based on the application site and individual differences, but typically, it starts to numb the applied area within 30 to 60 minutes after application.

How often can I use Lidocaine 15%/Prilocaine 5% Topical Cream?

Use the cream as directed by your healthcare provider. Do not exceed the recommended dose or frequency as this could increase the risk of serious side effects, including systemic toxicity.

Can Lidocaine 15%/Prilocaine 5% Topical Cream be used on broken skin?

No, this cream should not be applied to cuts, abrasions, or broken skin as it may lead to increased absorption of the active ingredients and a higher risk of side effects.

Can children use Lidocaine 15%/Prilocaine 5% Topical Cream?

This cream may be used in children; however, it should be under the direct supervision of a healthcare provider. Dosing for children may be different than for adults, and precautions must be taken to avoid excessive absorption.

What should I do if I miss a dose?

If you forget to apply your dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Are there any known side effects of using Lidocaine 15%/Prilocaine 5% Topical Cream?

Some common side effects include mild local reactions such as redness, swelling, a burning sensation, or changes in skin pigmentation at the application site. Severe reactions can occur if the cream is overused or applied to a large area of skin.

What should I avoid while using Lidocaine 15%/Prilocaine 5% Topical Cream?

Avoid using the cream near the eyes, inside the nose, mouth, or ears, or on any mucus membranes. Also, avoid occlusive dressings unless directed by your healthcare provider. It is essential to avoid activities that can cause heavy perspiration as this might increase systemic absorption.

Can Lidocaine 15%/Prilocaine 5% Topical Cream interact with other medications?

Yes, it can interact with certain medications, particularly those that affect the heart rhythm, other local anesthetics, and certain medications metabolized by the liver. Always inform your healthcare provider of all the medications you are currently taking before using this cream.

How should I store Lidocaine 15%/Prilocaine 5% Topical Cream?

Store at room temperature, away from heat and direct sunlight. Do not freeze. Keep out of reach of children and pets.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.