Lidocaine 1.5%/Prilocaine 1.5%/Tetracaine 4% Topical Gel is a compounded medication designed for topical application to provide localized anesthesia. This semisolid formulation is dispensed through a pump mechanism, which ensures easy and precise dosing. The gel base offers a convenient medium for the active ingredients to be applied directly to the skin, allowing for targeted treatment and effective absorption.

The combination of lidocaine, prilocaine, and tetracaine in this formulation works synergistically to numb the skin and underlying tissues. Lidocaine and prilocaine are both amide-type local anesthetics that block sodium channels, thereby preventing the initiation and conduction of nerve impulses. Tetracaine, an ester-type local anesthetic, enhances the formulation's potency and duration of action by a similar mechanism. This makes the gel particularly useful for procedures requiring a profound depth and duration of anesthesia.

This topical gel is indicated for use in various procedures that require skin anesthesia, such as minor surgical procedures, needle insertions, laser treatments, and the management of chronic pain conditions like neuropathies. It is also used in the treatment of conditions like post-herpetic neuralgia or for providing relief from itching and pain associated with certain skin conditions.

For prescribers, it is important to note that the onset of action and duration of anesthesia will vary depending on the site of application and individual patient factors. The gel should be applied to intact skin only, and care should be taken to avoid contact with the eyes. Patients should be advised not to apply the gel to large areas of skin or to use it for prolonged periods unless directed by a healthcare provider, as systemic absorption can occur, leading to potential adverse effects.

Patients should be counseled on the proper use of the pump dispenser and the amount of gel to apply, as well as the importance of adhering to the prescribed duration of application to minimize the risk of systemic toxicity. They should also be informed about potential side effects, such as transient local reactions like pallor, redness, or altered sensation at the application site.

Bayview Pharmacy's team of compounding pharmacists is committed to providing high-quality, customized medications to meet the specific needs of patients and prescribers. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us. We are here to support and guide you through the treatment process with our expertise.

The Lidocaine 1.5%/Prilocaine 1.5%/Tetracaine 4% Topical Gel is a compounded medication designed for topical use to provide local anesthesia. This combination of active ingredients works synergistically to numb the skin, making it useful for procedures that require local anesthesia or for the treatment of conditions that cause localized pain. Lidocaine and prilocaine are both amide-type local anesthetics, while tetracaine is an ester-type. These agents block sodium channels to prevent the initiation and conduction of nerve impulses, leading to a loss of sensation in the area of application.

When using this topical gel, it is important to consider potential drug interactions. The active ingredients in this formulation can interact with a variety of other medications. For instance, the use of other local anesthetics concurrently, whether topically or systemically, may increase the risk of systemic toxicity. This is particularly important in patients who are receiving multiple local anesthetic procedures, as the cumulative dose can lead to increased blood levels of the anesthetics.

Patients taking anti-arrhythmic drugs, such as Class I agents (e.g., mexiletine, tocainide) or Class III agents (e.g., amiodarone), should use this gel with caution, as there is a potential for additive systemic effects on cardiac conduction and an increased risk of toxicity. Additionally, the metabolism of lidocaine and prilocaine can be affected by drugs that inhibit or induce cytochrome P450 enzymes, particularly CYP1A2 and CYP3A4. For example, CYP3A4 inhibitors like ketoconazole, itraconazole, and erythromycin could potentially increase the plasma concentrations of lidocaine and prilocaine, leading to an increased risk of systemic toxicity.

Patients on beta-blockers or calcium channel blockers should also be monitored closely, as these medications can interact with local anesthetics and potentiate their effects on the cardiovascular system. Moreover, the use of this gel in patients taking monoamine oxidase inhibitors (MAOIs) or certain antidepressants (such as selective serotonin reuptake inhibitors or tricyclic antidepressants) may increase the risk of systemic side effects due to the inhibition of hepatic metabolism of the local anesthetics.

It is also important to consider the potential for methemoglobinemia, a condition in which the oxygen-carrying capacity of the blood is reduced, with the use of prilocaine. Drugs that induce methemoglobinemia, such as sulfonamides, acetaminophen, and nitrates, may have additive effects when used with this gel. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are particularly at risk.

Given the potential for significant drug interactions, it is crucial for prescribers to review the patient's current medication list before prescribing this topical gel. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy for assistance.

The Lidocaine 1.5%/Prilocaine 1.5%/Tetracaine 4% Topical Gel is a compounded medication designed to provide localized anesthesia by numbing specific areas of the skin. This formulation combines the anesthetic effects of three different agents, each with its unique mechanism of action, to produce a synergistic effect that enhances the overall numbing sensation. Lidocaine and prilocaine are both amide-type local anesthetics, while tetracaine is an ester-type. These agents work by blocking the sodium channels in the neuronal cell membranes, which are essential for the initiation and conduction of nerve impulses. By doing so, they prevent the nerves in the treated area from sending pain signals to the brain, resulting in a numbing effect.

The gel is designed to be a semisolid formulation that can be easily dispensed through a pump mechanism. This allows for precise dosing and targeted application, ensuring that the medication is applied directly to the area requiring treatment. The gel base facilitates the absorption of the active ingredients through the skin, providing a localized effect without significant systemic absorption. This is particularly beneficial for patients who require anesthesia of the skin for minor surgical procedures, such as laser treatments, tattoo application or removal, and minor skin surgeries. It can also be used to numb the skin before needle insertions or other medical procedures that might cause pain or discomfort.

For patients, it is important to understand that this topical gel should be applied as directed by a healthcare professional. The area of application should be clean and dry, and the gel should be applied in a thin layer. It is also crucial to adhere to the recommended application time before any procedure to ensure maximum efficacy. For prescribers, it is essential to consider the maximum safe dosage for each patient, based on their weight and the total area of application, to avoid systemic toxicity, particularly methemoglobinemia, which can be a rare but serious side effect of prilocaine.

As compounding pharmacists at Bayview Pharmacy, we are committed to providing high-quality, customized medications to meet the specific needs of our patients. If you have any questions about this formulation or its appropriate use, please do not hesitate to reach out to us. We are here to ensure that both patients and prescribers have the necessary information to use this medication safely and effectively.

Welcome to Bayview Pharmacy, where our expertise in compounding specialized medications enables us to address a wide array of healthcare needs. The unique formulation of Lidocaine 1.5%/Prilocaine 1.5%/Tetracaine 4% Topical Gel has been crafted to provide substantial relief from local pain and discomfort. This compounded preparation, being a semisolid dispensed through a pump mechanism, ensures that the medication can be applied precisely where it's needed, minimizing waste and maximizing efficacy.

Beyond its primary indication for numbing the skin to prepare for procedures such as injections, piercings, or minor dermatological surgery, this formulation may also have several other uses. For instance, it could be applied to manage the discomfort associated with chronic conditions like neuropathic pain or certain types of eczema that cause severe itching. The gel can potentially be used for the treatment of post-herpetic neuralgia, a painful condition that occurs after shingles. Additionally, its properties may benefit patients experiencing painful hemorrhoids by providing temporary relief from the discomfort during acute flares.

Another potential application for this topical anesthetic includes the use in laser hair removal sessions or tattoo placements and removals, where it can help alleviate the pain associated with these skin-traumatizing procedures. Patients undergoing treatments for varicose veins, such as sclerotherapy, might also find this gel beneficial in managing procedural pain. It is important to note that while the gel can provide temporary pain relief, its application should not exceed the recommended dose or area covered without consulting a healthcare professional.

Moreover, sports medicine could find an application for this gel in the treatment of minor sports-related injuries where skin surface anesthesia is required to alleviate pain or prepare the skin for an invasive procedure. The easy-to-use pump mechanism makes it a convenient option for athletes or sports therapists who need to apply the medication on the go.

As with all medications, the efficacy and safety of using Lidocaine 1.5%/Prilocaine 1.5%/Tetracaine 4% Topical Gel for off-label uses should be carefully considered and discussed with a healthcare provider. It is crucial to follow the specific instructions provided with your prescription and inform your healthcare provider about any known allergies, medical conditions, or concurrent medications you may be taking.

If you have any questions regarding this formulation, or if you are considering it for an alternative application not listed here, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the necessary guidance to ensure safe and effective use of our compounded medications. Your health and well-being are at the forefront of what we do, and we are always ready to assist you with your healthcare needs.