The Ketoprofen 20%/Lidocaine 20% Transdermal Gel is a specialized medication designed for topical application to provide targeted relief from pain and inflammation. This semisolid formulation is dispensed through a pump mechanism, which ensures that patients can apply a consistent and precise dose of the medication to the affected area. The gel base allows for the active ingredients to be absorbed through the skin, offering a localized effect while minimizing systemic exposure and potential side effects.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzymes responsible for producing prostaglandins, which are compounds that contribute to inflammation, pain, and fever. By reducing the levels of prostaglandins, ketoprofen effectively alleviates inflammation and pain. This makes the gel particularly useful for treating conditions such as arthritis, muscle sprains, strains, and other musculoskeletal injuries where inflammation is a primary concern.

Lidocaine, on the other hand, is a local anesthetic that provides temporary relief from pain by blocking the transmission of pain signals along the nerves. When combined with ketoprofen, lidocaine enhances the analgesic effects of the formulation, making it highly effective for immediate pain relief. This dual-action gel is therefore beneficial for patients seeking both rapid and sustained relief from pain and inflammation.

The transdermal delivery system of this gel offers several advantages over oral medications, including reduced gastrointestinal side effects and the ability to deliver medication directly to the site of pain. This localized approach can lead to better patient compliance and satisfaction. However, it is important for patients and prescribers to be aware that the skin's absorption rate can be affected by various factors, including the skin's thickness and the presence of skin barriers.

Patients should be instructed on the proper application of the gel, including the amount to be applied and the frequency of use as prescribed by their healthcare provider. It is also important to note that the area of application should be clean and intact skin, avoiding any open wounds or irritated skin. Patients should wash their hands after applying the gel unless the hands are the treated area.

Prescribers considering this formulation for their patients should assess the suitability based on the patient's medical history, current medications, and the specific condition being treated. Monitoring for potential side effects, such as skin irritation or systemic NSAID-related adverse effects, is also recommended.

If you have any questions or require further information about the Ketoprofen 20%/Lidocaine 20% Transdermal Gel, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to ensure the safe and effective use of this medication.

The Ketoprofen 20%/Lidocaine 20% Transdermal Gel is a compounded medication designed for topical application to provide localized relief from pain and inflammation. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. Lidocaine is a local anesthetic that provides temporary numbness and relief from pain by blocking nerve signals in the specific area where it is applied. This combination is particularly useful for treating localized musculoskeletal pain, such as strains, sprains, and arthritis-related discomfort.

When using this transdermal gel, it is important to consider potential drug interactions. Ketoprofen, being an NSAID, can interact with other NSAIDs (including aspirin), increasing the risk of gastrointestinal bleeding or ulcers. It should be used with caution in patients taking anticoagulants like warfarin, as there is an increased risk of bleeding. Additionally, ketoprofen may diminish the antihypertensive effect of beta-blockers and may interact with ACE inhibitors, leading to potential kidney damage. Patients should avoid concomitant use with other topical products that may alter skin barrier function or with other local anesthetics, as this may increase systemic absorption of lidocaine.

Lidocaine, on the other hand, may interact with antiarrhythmic drugs such as tocainide and mexiletine, leading to an additive systemic effect. Caution is advised when using this gel in patients taking Class I antiarrhythmic drugs (such as quinidine, flecainide, and procainamide) or other local anesthetics. The use of lidocaine in patients on anti-epileptic drugs, such as phenytoin or carbamazepine, may require monitoring as these medications can influence the pharmacokinetics of lidocaine.

It is also important to note that the application of heat over the area where the gel has been applied can increase the absorption of both ketoprofen and lidocaine, potentially leading to systemic side effects. Patients should be advised to avoid the use of heating pads or other heat sources on the treated areas. Additionally, patients with a history of allergic reactions to NSAIDs or local anesthetics should not use this product.

Patients should inform their healthcare provider of all medications they are currently taking, including over-the-counter drugs, vitamins, and herbal supplements, to avoid potential interactions. Prescribers should review the patient's medication history to assess for any possible drug interactions before prescribing this transdermal gel.

For any questions or concerns regarding the use of Ketoprofen 20%/Lidocaine 20% Transdermal Gel, or to report any adverse effects or unexpected interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

The Ketoprofen 20%/Lidocaine 20% Transdermal Gel is a specialized medication designed for topical application to provide localized relief from pain and inflammation. This semisolid formulation is dispensed through a pump mechanism, which ensures that patients can apply a consistent and precise dose of the medication to the affected area. The gel base allows for the active ingredients to be delivered directly to the site of pain or inflammation, offering a targeted therapeutic effect.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the body's production of certain substances that cause inflammation and pain. When applied topically, ketoprofen penetrates the skin to reach the underlying tissues where it reduces the synthesis of prostaglandins, which are compounds involved in the mediation of pain, swelling, and inflammation. This makes the ketoprofen component particularly effective for treating localized musculoskeletal conditions, such as strains, sprains, and arthritis-related discomfort.

Lidocaine, on the other hand, is a local anesthetic that provides temporary relief from pain by blocking the transmission of pain signals along the nerves. When applied to the skin, lidocaine causes a numbing effect in the targeted area, which can be beneficial for patients experiencing sharp, shooting, or burning types of pain. This can be especially useful in conditions like neuropathic pain or when the skin is especially sensitive due to inflammation or injury.

The combination of ketoprofen and lidocaine in a 20% concentration for each provides a synergistic effect, with ketoprofen addressing inflammation and lidocaine providing rapid pain relief. The transdermal gel formulation allows for the active ingredients to be absorbed through the skin over a period of time, which can result in sustained relief from symptoms without the systemic side effects often associated with oral medications.

Patients and prescribers should note that this formulation is intended for external use only and should be applied to intact skin. It is important to follow the prescribed dosing instructions and not to apply the gel to open wounds or irritated skin. Additionally, patients should be advised to wash their hands after applying the gel unless the hands are the treated area.

For any questions regarding the use of Ketoprofen 20%/Lidocaine 20% Transdermal Gel, or to discuss whether this formulation is appropriate for a specific patient's needs, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

The Ketoprofen 20%/Lidocaine 20% Transdermal Gel is commonly used for its analgesic and anti-inflammatory properties, primarily to relieve local pain and inflammation associated with conditions such as arthritis, tendinitis, bursitis, and localized muscle pain. However, this formulation may have other therapeutic applications due to the active ingredients' broad pharmacological actions. Beyond musculoskeletal conditions, this gel has been found useful for managing neuropathic pain syndromes such as post-herpetic neuralgia or painful diabetic neuropathy. The combination of ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), with lidocaine, a local anesthetic, allows for the dual effect of addressing the pain at its inflammatory source while also diminishing the sensation of pain through its anesthetic action. This can be particularly beneficial for patients who prefer a non-systemic approach or those who have difficulty tolerating oral medications.

Furthermore, since the formulation is designed for transdermal delivery, it may offer a favorable alternative for those patients who have gastrointestinal sensitivities to NSAIDs or those who are at risk for systemic side effects associated with oral NSAIDs. The transdermal application allows for local treatment with potentially minimal systemic absorption, resulting in reduced risk of systemic side effects. However, it is important to note that although the systemic absorption is less with transdermal therapy, systemic side effects, including those related to NSAID use such as renal impairment or exacerbation of hypertension, can still occur and patients should be monitored accordingly.

Additionally, some patients with skin conditions that result in pain or inflammation, such as localized scleroderma or certain inflammatory dermatoses, may experience symptomatic relief from this gel, although this is a secondary use and should be pursued under the guidance of a healthcare professional with caution, given the potential for skin irritation or adverse effects from prolonged use. It is also imperative to note that the safety and effectiveness for uses beyond the labeled indications have not been established through controlled trials and the evidence available may be anecdotal or based on smaller, uncontrolled studies.

Patients and prescribers should also be aware that using this combination of active ingredients topically does not preclude the possibility of drug interactions with other medications the patient may be using, especially other NSAIDs or anticoagulants. Moreover, due to the presence of Lidocaine, care should be taken in patients with a history of cardiac conduction abnormalities or those taking class I antiarrhythmic drugs, as there may be an increased risk of arrhythmic events with lidocaine, even when applied topically.

If there are any questions regarding the formulation or its potential applications, or if guidance is needed about potential drug interactions or specific patient circumstances, do not hesitate to reach out to us at Bayview Pharmacy. We are always available to provide further information and to ensure the safe and effective use of our compounded medications.