The Ketoprofen 130 mg/Lidocaine 130 mg Rectal Suppository is a specially compounded medication designed to deliver both an anti-inflammatory and an anesthetic effect directly to the site of action. This solid dosage form is intended for rectal administration, where it will dissolve or melt, allowing the active ingredients to be absorbed either locally within the rectal tissues or systemically into the bloodstream. The use of this route of administration can be particularly beneficial for patients who may have difficulty swallowing oral medications or for those who require immediate relief in the rectal area.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are substances in the body responsible for pain, inflammation, and fever. By reducing these prostaglandins, ketoprofen can effectively alleviate pain and reduce inflammation. This makes the suppository particularly useful for treating conditions such as hemorrhoids, anal fissures, and other inflammatory diseases of the anorectal area. Additionally, it may be used for systemic relief of pain and inflammation in conditions such as arthritis, when rectal administration is preferred or required.

Lidocaine, on the other hand, is a local anesthetic that provides rapid numbing of the area where it is applied. When included in the rectal suppository, lidocaine helps to relieve local pain, itching, and discomfort, making it an excellent adjunct to ketoprofen for conditions that cause significant anorectal pain and irritation. The combination of these two medications in a single suppository allows for a synergistic effect, targeting both pain and inflammation effectively.

It is important for patients and prescribers to understand that this compounded medication should be used under the guidance of a healthcare professional. The specific dosing and duration of treatment will depend on the individual patient's condition and response to therapy. As with any medication, there may be potential side effects, and patients should be monitored for any adverse reactions. Additionally, patients with certain medical conditions or those taking other medications should consult with their healthcare provider to ensure the safety and appropriateness of this formulation.

Bayview Pharmacy is committed to providing high-quality, customized medications to meet the unique needs of our patients. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide guidance on the use of this formulation. If you have any questions or require further information about the Ketoprofen 130 mg/Lidocaine 130 mg Rectal Suppository, please do not hesitate to reach out to us.

The combination of ketoprofen and lidocaine in a rectal suppository form is designed to provide both anti-inflammatory and analgesic effects, potentially offering relief for conditions that may benefit from the reduction of pain and inflammation in the rectal or surrounding areas. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the synthesis of prostaglandins, which are substances that mediate inflammation and pain. Lidocaine is a local anesthetic that provides temporary relief of pain by blocking nerve signals in the body.

When considering the use of this ketoprofen/lidocaine rectal suppository, it is important to be aware of potential drug interactions that could affect the efficacy and safety of the treatment. Ketoprofen, as an NSAID, can interact with various medications. For instance, concurrent use with other NSAIDs, including aspirin, may increase the risk of gastrointestinal bleeding. Caution is advised when ketoprofen is used with anticoagulants (such as warfarin) or antiplatelet agents (like clopidogrel), as this may further increase the risk of bleeding. Additionally, ketoprofen may reduce the effectiveness of antihypertensive drugs, including ACE inhibitors, angiotensin receptor blockers, beta-blockers, and diuretics. It can also potentially increase serum lithium levels and methotrexate toxicity, so monitoring is recommended when these drugs are used concomitantly.

Lidocaine, on the other hand, may interact with certain medications that affect cardiac function due to its local anesthetic properties. Caution is advised when using lidocaine with antiarrhythmic drugs, such as amiodarone, as the combination may have additive effects on the heart. Additionally, drugs that inhibit hepatic enzymes, particularly CYP1A2 and CYP3A4, may increase lidocaine levels and enhance its effects and potential toxicity. It is also important to consider that the absorption of lidocaine may be increased when used with other medications that cause mucosal damage, potentially leading to higher systemic concentrations.

Patients should be advised to inform their healthcare provider of all medications they are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to ensure that potential interactions are assessed and managed appropriately. Prescribers should carefully evaluate the patient's medication profile for any drugs that could interact with ketoprofen or lidocaine and adjust treatment plans accordingly.

It is also important to note that while the rectal route of administration may reduce some systemic absorption compared to oral administration, systemic absorption can still occur, and thus, systemic interactions are possible. Monitoring for adverse effects and therapeutic efficacy is recommended when initiating treatment with this formulation.

If you have any questions or require further information regarding drug interactions with the ketoprofen/lidocaine rectal suppository, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to ensuring the safe and effective use of compounded medications.

The Ketoprofen 130 mg/Lidocaine 130 mg Rectal Suppository is a specialized medication designed for rectal administration. This solid dosage form is carefully crafted to be inserted into the rectum, where it gradually dissolves or melts at body temperature. Upon dissolution, the active ingredients, ketoprofen and lidocaine, are released directly into the rectal mucosa, allowing for both local and systemic absorption.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins. Prostaglandins are chemical messengers that play a key role in the inflammation process. By reducing their production, ketoprofen effectively decreases inflammation, pain, and fever. This makes the suppository particularly useful in treating inflammatory conditions such as arthritis or other musculoskeletal disorders where inflammation is a primary concern.

Lidocaine, on the other hand, is a local anesthetic that provides symptomatic relief by blocking the sodium channels in nerve cells, which are necessary for the initiation and conduction of nerve impulses. When lidocaine is administered rectally, it helps to numb the local area, providing relief from pain or discomfort caused by conditions such as hemorrhoids, anal fissures, or proctitis. The combination of ketoprofen and lidocaine in a single suppository offers the dual benefits of anti-inflammatory action and local anesthesia, making it an effective treatment for a variety of rectal conditions.

The rectal route of administration offers several advantages, including bypassing the gastrointestinal tract, which can be beneficial for patients with nausea, vomiting, or difficulty swallowing. Additionally, it can provide a more rapid onset of action compared to oral medications and is particularly useful in situations where a local effect on the rectum and surrounding tissues is desired.

It is important for both patients and prescribers to understand that while this formulation provides targeted relief, it should be used with caution in patients with a history of allergic reactions to NSAIDs or local anesthetics. The suppository should be stored in a cool place to maintain its solid form before use and should be handled with clean hands to prevent contamination.

For any questions regarding the use of Ketoprofen 130 mg/Lidocaine 130 mg Rectal Suppository, or to discuss whether this formulation is appropriate for your specific condition, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and guidance you need to make an informed decision about your treatment options.

The ketoprofen 130 mg/lidocaine 130 mg rectal suppository formulation is primarily designed for localized relief of pain and inflammation in the rectal area. However, beyond the common indication of treating conditions such as hemorrhoids, anal fissures, and proctitis, this suppository can have additional applications. Its anti-inflammatory and analgesic properties can be beneficial in managing pain and inflammation in post-surgical settings, especially after anorectal procedures. Patients recovering from surgeries such as hemorrhoidectomy or fistulotomy may experience significant pain during the healing process, and the utilization of this suppository may aid in managing discomfort and inflammation, thereby enhancing the healing.

Another potential utilization of this compounded suppository could be in symptomatic management for patients undergoing endoscopic procedures like colonoscopy or other interventions where local irritation is a consequence. In some situations, the systemic absorption of ketoprofen may exert therapeutic effects that help manage musculoskeletal pain or arthritic conditions, although this is not the primary intention of a rectal administration route.

It's important to note that while the lidocaine component serves as a local anesthetic to provide immediate relief from pain and discomfort, the ketoprofen serves as a nonsteroidal anti-inflammatory drug (NSAID) which can help reduce the prostaglandin-mediated inflammation. This combination could potentially be explored for use in chronic proctological conditions that have both inflammatory and pain components.

The use of this formulation in any other condition should be closely evaluated on a case-by-case basis, taking into account the patient's overall health status, concomitant medications, and risk factors associated with NSAID and local anesthetic use. As with any medication, the risk of potential systemic absorption and interaction with other medications, as well as possible side effects, must be considered. If you, as a patient or prescriber, are considering this formulation for an off-label application or have questions regarding its potential uses, we at Bayview Pharmacy are always ready to assist with information, guidance, and support to ensure safe and effective patient care.