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Formulas

Ketamine HCl 5%/Phenytoin 5%/Mexiletine HCl 2%/Clonidine HCl 0.2%/Menthol 0.025% Topical Gel

This topical gel combines Ketamine HCl 5%, Phenytoin 5%, Mexiletine HCl 2%, Clonidine HCl 0.2%, and Menthol 0.025% in a semisolid formulation. Dispensed through a pump mechanism, it allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of active ingredients. It is used for the management of conditions such as Trigeminal Neuralgia, Neuropathic Pain, Complex Regional Pain Syndrome, Postherpetic Neuralgia, and Fibromyalgia.

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Topical Gel
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Formula Information

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Bayview Pharmacy is pleased to present a specialized topical gel formulation that combines Ketamine HCl 5%, Phenytoin 5%, Mexiletine HCl 2%, Clonidine HCl 0.2%, and Menthol 0.025%. This unique blend is specifically designed to alleviate a range of conditions such as chronic pain, neuropathic pain, and muscle spasms. The synergistic effect of these active ingredients enhances the overall efficacy of the treatment, making it more potent than any single ingredient used independently.

Ketamine HCl, an anesthetic, is incorporated in this formulation to mitigate pain and induce sedation. Phenytoin, an anticonvulsant, is used to manage neuropathic pain and muscle spasms. Mexiletine HCl, an antiarrhythmic, is included to address chronic pain. Clonidine HCl, an antihypertensive, is utilized to decrease inflammation and pain. Lastly, Menthol, an analgesic, is added to provide relief from pain and itching.

This compounded formulation is dispensed as a semisolid gel through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients, providing fast-acting relief. This formulation is an effective solution for a variety of conditions, including chronic pain, neuropathic pain, and muscle spasms.

If you have any inquiries about this formulation or how it can assist in managing your condition, please do not hesitate to contact us at Bayview Pharmacy. Our team is committed to providing comprehensive information and guidance to help you understand the benefits of this unique topical gel formulation.

Drug Interactions

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Ketamine HCl 5%/Phenytoin 5%/Mexiletine HCl 2%/Clonidine HCl 0.2%/Menthol 0.025% Topical Gel is a compounded formulation designed for the management of pain associated with various conditions. It has demonstrated efficacy in alleviating neuropathic pain, fibromyalgia, and musculoskeletal pain. The unique combination of ketamine, phenytoin, mexiletine, clonidine, and menthol works synergistically to provide analgesic effects, potentially offering anti-inflammatory and antispasmodic benefits as well.

Patients should be informed that this formulation may cause local skin irritation, particularly in those with sensitive skin. Additionally, it may induce drowsiness, and caution should be exercised when driving or operating heavy machinery. Regular monitoring for adverse reactions such as dizziness, nausea, vomiting, and rash is recommended. If any of these symptoms occur, patients should discontinue use and consult their healthcare provider immediately.

Healthcare providers should be aware of potential interactions between this formulation and other medications, including but not limited to anticonvulsants, antihypertensives, and sedatives. Monitoring for signs of drug interactions, such as changes in blood pressure, heart rate, and respiration, is advised. Patients should be encouraged to report any unusual symptoms or changes in their condition.

If you have any questions or concerns about this formulation or potential interactions, please do not hesitate to contact your healthcare provider or pharmacist for further information and guidance.

How Does it Work

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This topical gel is a compounded formulation that combines five active ingredients: Ketamine Hydrochloride 5%, Phenytoin 5%, Mexiletine Hydrochloride 2%, Clonidine Hydrochloride 0.2%, and Menthol 0.025%. Each ingredient plays a crucial role in managing various conditions such as chronic pain, neuropathic pain, and muscle spasms.

Ketamine Hydrochloride is an anesthetic that functions by blocking nerve signals in the brain and spinal cord, thereby reducing pain and muscle spasms. Phenytoin, an anticonvulsant, works by decreasing the activity of certain nerve cells in the brain, making it effective in treating seizures and neuropathic pain.

Mexiletine Hydrochloride is an antiarrhythmic medication that operates by blocking sodium channels in the heart, making it useful in treating irregular heartbeats. Clonidine Hydrochloride, on the other hand, decreases the activity of certain nerve cells in the brain and is used to manage high blood pressure and anxiety.

Menthol serves as a topical analgesic, providing a cooling sensation by cooling the skin, which helps reduce pain and inflammation. The gel-like consistency of this formulation allows for easy and precise application on the skin, ensuring that the active ingredients are delivered directly to the affected area for targeted treatment.

This approach allows for a more localized treatment of the condition, enhancing the effectiveness of the medication. If you have any questions about this formulation or its mechanism of action, please do not hesitate to reach out for further clarification.

Other Uses

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This compounded formulation of Ketamine HCl 5%/Phenytoin 5%/Mexiletine HCl 2%/Clonidine HCl 0.2%/Menthol 0.025% in a topical gel form is a versatile treatment option for a wide range of pain-related conditions. It has been effectively used in the management of Trigeminal Neuralgia, Neuropathic Pain, Complex Regional Pain Syndrome, Postherpetic Neuralgia, and Fibromyalgia. Furthermore, it has shown promising results in treating chronic musculoskeletal pain, chronic low back pain, and chronic headaches.

Its efficacy extends to other conditions such as diabetic neuropathy, post-surgical pain, and post-traumatic pain, where it has been found to significantly reduce pain and inflammation. The gel formulation is also beneficial in managing post-stroke pain, post-chemotherapy pain, and post-radiation pain, providing much-needed relief to patients.

Moreover, this compounded formulation can be used to alleviate post-amputation pain, post-burn pain, and post-fracture pain, demonstrating its wide-ranging applicability in pain management. If you have any questions about the use of this formulation for any of these conditions, please do not hesitate to reach out for more information.

Frequently Asked Questions

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What is this compounded formulation of Ketamine HCl 5%/Phenytoin 5%/Mexiletine HCl 2%/Clonidine HCl 0.2%/Menthol 0.025% Topical Gel?

This is a compounded medication that combines several active ingredients into a single topical gel. It is designed to be applied directly to the skin for targeted treatment. The gel is dispensed through a pump mechanism for easy and precise application.

What is the purpose of the different active ingredients in this formulation?

Each active ingredient in this formulation serves a specific purpose. Ketamine HCl is used for pain relief, Phenytoin promotes healing, Mexiletine HCl is used to treat irregular heart rhythms, Clonidine HCl is used to treat high blood pressure and ADHD, and Menthol provides a cooling sensation and helps with minor pain and irritation.

How should I apply this topical gel?

This gel should be applied directly to the skin in the area requiring treatment. The pump mechanism allows for easy and precise application. Always follow your healthcare provider's instructions regarding how much gel to apply and how often to use it.

Can I use this gel on any part of my body?

It's important to only use this gel on the areas of your body as directed by your healthcare provider. Avoid contact with eyes, mouth, and other sensitive areas. If you're unsure, always consult with your healthcare provider.

What should I do if I experience any side effects?

If you experience any side effects such as skin irritation, rash, or other unusual symptoms, stop using the gel and contact your healthcare provider immediately.

Can I use this gel if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should consult with your healthcare provider before using this gel. They will be able to advise you on whether it is safe for you to use.

Can I use this gel with other medications?

Before starting any new medication, including this gel, you should always inform your healthcare provider about any other medications you are currently taking. They can then advise you on whether it is safe to use together.

How should I store this gel?

This gel should be stored at room temperature, away from heat and direct light. Keep the container tightly closed when not in use.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Can children use this gel?

This gel should only be used by children if it has been specifically prescribed for them by a healthcare provider. Always follow the provider's instructions regarding use in children.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.