Indomethacin 100 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, indomethacin, for local or systemic absorption. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, substances in the body that play a role in pain and inflammation. By reducing prostaglandin synthesis, indomethacin effectively decreases inflammation and pain.

This formulation is particularly useful for patients who may have difficulties swallowing oral medications or for those who require immediate onset of action, as the rectal route can provide both local and systemic effects. The 100 mg dose of indomethacin in the suppository form is often prescribed for the treatment of various inflammatory conditions such as moderate to severe rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis. It may also be used to treat pain associated with these conditions.

Rectal suppositories like this one can bypass the gastrointestinal tract, which may be advantageous in patients with nausea, vomiting, or gastrointestinal disorders that could affect the absorption of oral medications. Additionally, this route can avoid the first-pass metabolism in the liver, potentially resulting in a more predictable response to the medication.

It is important for patients and prescribers to be aware that, like other NSAIDs, indomethacin can cause side effects, including gastrointestinal irritation and an increased risk of cardiovascular and thrombotic events. Therefore, it should be used with caution in patients with a history of cardiovascular disease or gastrointestinal bleeding. Monitoring for adverse effects is recommended, and patients should be advised to report any unusual symptoms to their healthcare provider.

For optimal use, the suppository should be stored in a cool place to maintain its solid form before administration. Patients should be instructed on the proper technique for inserting rectal suppositories to ensure the medication is delivered effectively.

If you have any questions or require further information about the Indomethacin 100 mg Rectal Suppository formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to both patients and prescribers to ensure the safe and effective use of this medication.

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. When formulated as a 100 mg rectal suppository, indomethacin is used to treat moderate to severe pain, inflammation, and fever. It is particularly useful in conditions such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, and gout. While the rectal route provides a local effect with less systemic absorption compared to oral administration, it is important to be aware of potential drug interactions.

Indomethacin, like other NSAIDs, can interact with various medications, potentially increasing the risk of adverse effects or affecting the therapeutic efficacy of concomitant drugs. Concurrent use of indomethacin with anticoagulants (e.g., warfarin) or antiplatelet agents (e.g., aspirin, clopidogrel) can increase the risk of bleeding. Patients should be monitored closely for signs of bleeding, and dosage adjustments may be necessary.

Combining indomethacin with other NSAIDs, including selective cyclooxygenase-2 inhibitors, should generally be avoided due to the increased risk of gastrointestinal toxicity, including ulceration and bleeding. If combination therapy is deemed necessary, it should be done with caution and under close medical supervision.

Indomethacin may also interact with antihypertensive medications, such as ACE inhibitors, angiotensin receptor blockers, beta-blockers, and diuretics. This interaction can reduce the antihypertensive effect and potentially lead to the deterioration of renal function in susceptible individuals. Blood pressure and renal function should be monitored when initiating or adjusting indomethacin treatment in patients on antihypertensive therapy.

Concomitant use of indomethacin with corticosteroids may increase the risk of gastrointestinal ulceration or bleeding. Patients should be advised to report any signs of gastrointestinal distress promptly. Additionally, indomethacin can decrease the clearance of lithium, leading to increased lithium plasma levels and potential lithium toxicity. Lithium levels should be monitored when starting, adjusting, or discontinuing indomethacin therapy.

Indomethacin may also affect the pharmacokinetics of methotrexate by inhibiting its renal clearance, which can lead to methotrexate toxicity. Close monitoring of methotrexate levels and renal function is advised when these drugs are used together. Furthermore, indomethacin can antagonize the effects of diuretics and antihypertensive agents, and it may potentiate the nephrotoxicity of cyclosporine and other nephrotoxic drugs.

Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs should avoid indomethacin, as severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients. Additionally, caution is advised when indomethacin is administered to patients with preexisting renal or hepatic impairment, as these conditions may be exacerbated.

It is important for prescribers to review the patient's complete medication profile for potential interactions before prescribing indomethacin suppositories. Patients should be instructed to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements. If you have any questions or concerns regarding the use of indomethacin rectal suppositories or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are substances in the body responsible for pain, fever, and inflammation. When formulated as a 100 mg rectal suppository, indomethacin is designed to be inserted into the rectum where it gradually dissolves or melts, releasing the active medication directly at the site of action or allowing for its absorption into the bloodstream for systemic effects.

The rectal route of administration provides several advantages, particularly for patients who may have difficulty swallowing oral medications or for those who are experiencing nausea and vomiting. This route can also be beneficial when a rapid onset of action is desired or when bypassing the gastrointestinal tract is necessary to avoid irritation or to ensure a more complete absorption of the drug.

Upon insertion, the suppository base, typically made from substances like cocoa butter or a glycerinated gelatin, begins to melt or dissolve at body temperature. This process allows the indomethacin to be released and absorbed through the rectal mucosa. From there, the drug enters the rectal blood vessels and is carried into the systemic circulation. A portion of the drug is also directly absorbed into the local tissues, providing relief at the site of inflammation.

Indomethacin suppositories are commonly used to treat various disease states characterized by pain and inflammation. These include inflammatory disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. Additionally, they may be used to treat acute gouty arthritis or other conditions where immediate pain relief is necessary. The rectal administration of indomethacin can lead to a reduction in swelling, pain, and fever, thereby improving patient mobility and quality of life.

It is important for both patients and prescribers to understand that while indomethacin suppositories can provide significant relief from symptoms, they may also be associated with side effects similar to those of other NSAIDs, such as gastrointestinal irritation or an increased risk of bleeding. Monitoring for adverse effects is essential, and the use of this medication should be individualized based on the patient's overall health status and concurrent medications.

If you have any questions about the use of indomethacin 100 mg rectal suppositories or if you require further information on how this formulation works and its suitability for treating specific conditions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need to ensure safe and effective treatment for your patients.

Indomethacin suppositories are primarily prescribed for their anti-inflammatory, analgesic, and antipyretic properties. While they are most commonly associated with treating symptoms of severe inflammatory diseases such as ankylosing spondylitis, rheumatoid arthritis, osteoarthritis, and acute gouty arthritis, there are additional uses for this medication in rectal dosage form which providers may consider. Indomethacin suppositories may also be utilized for pain relief after certain medical procedures, including orthopedic surgery, as they can help reduce inflammation and control pain directly at the source without significant systemic absorption. Furthermore, the rectal route may be particularly beneficial in patients who are unable to take oral medications due to nausea, vomiting, or gastrointestinal issues.

Occasionally, off-label uses for indomethacin suppositories arise. One such example is the off-label management of acute migraine attacks, where its anti-inflammatory effects can help alleviate symptoms. In cases of patent ductus arteriosus (PDA) in premature infants, intravenous or oral forms of indomethacin are typically used, but there could be potential for rectal administration if other forms are not suitable, although this is not a standard practice. Researchers have also explored the potential application of indomethacin suppositories in preventing pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP), a diagnostic and therapeutic procedure for biliary or pancreatic ductal systems.

It is important to note that while there may be other uses for indomethacin rectal suppositories, such applications should only be considered under the guidance of a healthcare professional. The rectal dosage form is specifically designed for targeted therapy with the potential for fewer systemic side effects, making it an alternative route for those who have contraindications for oral administration. Due to the added nuances of using a suppository and indications that may not be broadly studied, prescribers and patients are encouraged to communicate openly to determine the most appropriate and effective treatment plan.

Patients should be advised on proper insertion techniques for rectal suppositories to ensure optimal efficacy of the medication. Indomethacin can cause side effects, especially when used for long durations or in larger doses; potential adverse effects include gastrointestinal disturbances, cardiovascular concerns, and renal impairment, among others. Therefore, both the benefits and risks should be considered on a case-by-case basis. If any questions or concerns arise, or clarification is needed regarding the use of indomethacin rectal suppositories for specific conditions, our team of compounding pharmacists at Bayview Pharmacy is available to assist both patients and prescribers with tailored information and support.