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Formulas

Hyoscyamine Sulfate 0.125 mg/mL/Phenobarbital 15 mg/mL Oral Drops

Hyoscyamine Sulfate 0.125 mg/mL/Phenobarbital 15 mg/mL Oral Drops is a liquid formulation dispensed in a dropper bottle, designed for precise and controlled administration. This formulation is particularly beneficial for patients requiring smaller doses or for pediatric patients who may have difficulty swallowing tablets or capsules. It is used in the management of gastrointestinal disorders such as irritable bowel syndrome and peptic ulcers, as well as in the treatment of certain neurological conditions, including seizure disorders and anxiety. The combination of hyoscyamine sulfate and phenobarbital provides antispasmodic and sedative effects, respectively, to alleviate symptoms associated with these conditions.

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Hyoscyamine Sulfate
Phenobarbital
Oral Drops
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Formula Information

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This oral drop formulation contains Hyoscyamine Sulfate at a concentration of 0.125 mg/mL and Phenobarbital at 15 mg/mL. It is designed for precise dosing and easy administration, especially beneficial for patients who require smaller doses or have difficulty swallowing tablets or capsules, such as pediatric patients or the elderly.

Hyoscyamine Sulfate is an anticholinergic agent that works by relaxing the muscles of the gastrointestinal tract and reducing fluid secretions. It is often used to relieve symptoms of gastrointestinal disorders such as irritable bowel syndrome, peptic ulcers, and colitis. By decreasing muscle spasms in the digestive tract, it helps alleviate cramping, pain, and discomfort.

Phenobarbital is a barbiturate that acts as a central nervous system depressant. It possesses anticonvulsant, sedative, and hypnotic properties. Phenobarbital is commonly used to control seizures and to relieve anxiety. In this formulation, it may aid in calming the nervous system and providing a sedative effect, which can be helpful in managing conditions associated with gastrointestinal distress.

The combination of Hyoscyamine Sulfate and Phenobarbital in a liquid drop form allows for tailored dosing to meet individual patient needs. This is particularly useful when standard dosage forms do not offer the appropriate strength or when dose adjustments are necessary. The dropper bottle enables caregivers and patients to administer the exact number of drops required, ensuring accurate dosing and optimal therapeutic outcomes.

Patients using this medication should be monitored for potential side effects, which may include dry mouth, blurred vision, dizziness, drowsiness, constipation, or changes in mood. It is important to use this medication under the supervision of a healthcare professional who can adjust the dosage as needed and provide guidance on managing any adverse effects.

If you have any questions about this formulation or its use, please reach out to us.

Drug Interactions

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Hyoscyamine Sulfate and Phenobarbital Oral Drops is a combination medication used to treat various conditions such as irritable bowel syndrome, peptic ulcer disease, and certain types of colic. Hyoscyamine sulfate works by reducing muscle spasms in the digestive tract, while phenobarbital acts as a sedative and anticonvulsant, helping to calm the nervous system. This formulation is particularly beneficial for patients who require precise dosing, such as pediatric patients or those who have difficulty swallowing pills.

When using Hyoscyamine Sulfate and Phenobarbital Oral Drops, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of the treatment. Hyoscyamine sulfate can interact with other anticholinergic drugs, such as atropine or scopolamine, potentially leading to increased anticholinergic effects like dry mouth, blurred vision, constipation, and urinary retention. Patients should be monitored for these symptoms, and dosage adjustments may be necessary.

Phenobarbital is a barbiturate and can interact with a wide range of medications due to its enzyme-inducing properties. It can decrease the effectiveness of oral contraceptives, anticoagulants like warfarin, and other medications metabolized by the liver, such as corticosteroids and certain antibiotics. Patients using these medications concurrently should be advised to use additional contraceptive methods and have their blood levels monitored to ensure therapeutic efficacy.

Additionally, phenobarbital can enhance the sedative effects of other central nervous system depressants, including alcohol, benzodiazepines, and opioids. Patients should be cautioned about the increased risk of sedation and respiratory depression when these substances are used together. It is advisable to avoid alcohol and consult with a healthcare provider before using other sedatives or narcotics.

Both hyoscyamine sulfate and phenobarbital can interact with medications that affect the heart rate and rhythm, such as beta-blockers and certain antiarrhythmics. Patients with cardiovascular conditions should be closely monitored, and any changes in heart rate or rhythm should be reported to a healthcare provider immediately.

Patients and prescribers should also be aware of the potential for phenobarbital to interact with other anticonvulsants, such as phenytoin and valproic acid, which may require adjustments in dosing to maintain seizure control. Regular monitoring of drug levels and clinical response is recommended to ensure optimal therapeutic outcomes.

If you have any questions or concerns about potential drug interactions with Hyoscyamine Sulfate and Phenobarbital Oral Drops, please reach out to us for further guidance and support. Our team of compounding pharmacists at Bayview Pharmacy is here to assist you in ensuring safe and effective use of this medication.

How Does it Work

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The Hyoscyamine Sulfate 0.125 mg/mL and Phenobarbital 15 mg/mL oral drops formulation is a compounded liquid medication designed to provide precise dosing for patients who require specific therapeutic effects from both hyoscyamine and phenobarbital. This formulation is particularly beneficial for pediatric patients or those who have difficulty swallowing tablets or capsules, as it allows for easy administration by simply dropping the required dose directly into the mouth.

Hyoscyamine sulfate is an anticholinergic agent that works by inhibiting the action of acetylcholine on smooth muscles and secretory glands. This action helps to reduce muscle spasms in the gastrointestinal tract, bladder, and other organs, making it effective in treating conditions such as irritable bowel syndrome (IBS), peptic ulcers, and bladder spasms. By decreasing the production of stomach acid and relaxing the muscles of the gut, hyoscyamine sulfate can alleviate symptoms such as abdominal pain, cramping, and diarrhea.

Phenobarbital, on the other hand, is a barbiturate that acts as a central nervous system depressant. It enhances the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve transmission in the brain, leading to a calming effect. This makes phenobarbital effective in managing seizure disorders, anxiety, and certain types of sleep disorders. By stabilizing electrical activity in the brain, phenobarbital helps to prevent seizures and reduce anxiety symptoms.

When combined in this liquid formulation, hyoscyamine sulfate and phenobarbital offer a synergistic effect that can be particularly useful in treating conditions where both muscle relaxation and central nervous system depression are desired. For instance, patients with gastrointestinal disorders accompanied by anxiety or stress-related symptoms may benefit from the dual action of this medication. The precise dosing capability of the dropper bottle ensures that patients receive the exact amount of medication needed, minimizing the risk of over- or under-dosing.

For prescribers, this formulation provides a customizable option to tailor treatment to the specific needs of the patient, especially in cases where standard dosage forms are not suitable. The liquid form allows for easy dose adjustments and can be particularly advantageous in pediatric care, where weight-based dosing is often required.

If you have any questions about this formulation or its use in treating specific conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.

Other Uses

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The Hyoscyamine Sulfate 0.125 mg/mL/Phenobarbital 15 mg/mL oral drops formulation is primarily used for its antispasmodic and sedative properties, often prescribed for conditions such as irritable bowel syndrome, peptic ulcer disease, and certain types of colic. However, this combination may have other potential uses that can be beneficial for both patients and prescribers to consider. The anticholinergic effects of hyoscyamine can be utilized in managing symptoms of Parkinson's disease, such as tremors and muscle stiffness, by helping to reduce the overactivity of muscles. Additionally, its ability to decrease bodily secretions can be advantageous in pre-operative settings to reduce saliva and other secretions, thereby minimizing the risk of aspiration during surgery.

Phenobarbital, a barbiturate, is well-known for its anticonvulsant properties and can be used in the management of seizure disorders, particularly in pediatric patients who may have difficulty with other forms of medication. Its sedative effects can also be beneficial in treating anxiety or tension, providing a calming effect that can help patients manage stress-related symptoms. Furthermore, phenobarbital's ability to induce sleep can be useful in treating short-term insomnia, especially in patients who require a quick onset of sleep due to its rapid action when administered in liquid form.

For patients with gastrointestinal disorders, the combination of hyoscyamine and phenobarbital can help alleviate symptoms such as abdominal pain and cramping by relaxing smooth muscles and reducing spasms. This can be particularly useful in conditions like diverticulitis or chronic pancreatitis, where pain management is a significant concern. Additionally, the liquid formulation allows for precise dosing, making it suitable for pediatric patients or those with swallowing difficulties, ensuring they receive the correct dosage without the need for tablets or capsules.

Prescribers should consider the potential for off-label uses of this formulation, particularly in cases where traditional therapies may not be suitable or effective. The combination of antispasmodic and sedative effects can provide a multifaceted approach to symptom management, offering relief in a variety of clinical scenarios. As always, it is important to weigh the benefits against potential side effects and to monitor patients closely for any adverse reactions. If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Hyoscyamine Sulfate 0.125 mg/mL/Phenobarbital 15 mg/mL Oral Drops used for?

This compounded formulation is typically used to manage symptoms of gastrointestinal disorders, such as irritable bowel syndrome, and to provide relief from muscle spasms. It may also be used for its sedative properties in certain conditions.

How should I administer the oral drops?

The oral drops should be administered using the dropper bottle provided. Carefully measure the prescribed number of drops and place them directly into the mouth. Follow your healthcare provider's instructions for the correct dosage.

Who can use this medication?

This medication is often prescribed for pediatric patients who have difficulty swallowing tablets or capsules, as well as adults who require precise dosing. Always consult with a healthcare provider to determine if it is appropriate for you or your child.

Are there any side effects associated with this medication?

Common side effects may include dry mouth, dizziness, drowsiness, and blurred vision. If you experience severe side effects or signs of an allergic reaction, seek medical attention immediately.

Can I use this medication with other drugs?

Hyoscyamine and phenobarbital may interact with other medications. It is important to inform your healthcare provider of all medications and supplements you are taking to avoid potential interactions.

How should I store the oral drops?

Store the oral drops at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed and out of reach of children and pets.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Can I drive or operate machinery while taking this medication?

This medication may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how the medication affects you.

Is it safe to use during pregnancy or breastfeeding?

Consult your healthcare provider before using this medication if you are pregnant or breastfeeding, as it may not be safe for use during these periods.

How long does it take for the medication to work?

The onset of action can vary depending on the individual and the condition being treated. Some patients may experience relief within a few hours, while others may require a longer period to notice the effects. Follow your healthcare provider's guidance for optimal results.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.