Hyoscyamine Sulfate 0.112 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, hyoscyamine sulfate. This compound is an anticholinergic agent, which means it works by blocking the action of acetylcholine, a neurotransmitter that can cause muscle spasms and fluid secretions. By inhibiting acetylcholine, hyoscyamine sulfate helps to reduce muscle spasms in the gastrointestinal tract and other organs, making it useful in the treatment of various conditions.

Hyoscyamine is particularly effective in managing symptoms of irritable bowel syndrome (IBS), such as abdominal pain, cramping, and diarrhea. It is also used to control the muscle spasms associated with disorders of the bladder, stomach, and intestines. Additionally, hyoscyamine can be prescribed for the symptomatic relief of peptic ulcer disease, as it reduces stomach acid secretion and gastrointestinal motility. In some cases, it may be used to alleviate the symptoms of Parkinson's disease and to control the excessive salivation associated with certain medical conditions.

The rectal suppository form of hyoscyamine sulfate offers certain advantages, such as bypassing the digestive system, which can be particularly beneficial for patients who are unable to take oral medications or for those who require rapid symptom relief. The 0.112 mg dosage provides a precise amount of medication, allowing for consistent dosing and minimizing the risk of side effects associated with systemic absorption.

Patients and prescribers should be aware that hyoscyamine sulfate can cause anticholinergic side effects, such as dry mouth, blurred vision, constipation, and urinary retention. It is important to use this medication under the guidance of a healthcare professional, who can monitor for these effects and adjust the treatment as necessary. Additionally, hyoscyamine sulfate may interact with other medications, so a thorough medication review is essential before starting treatment.

For those considering the use of Hyoscyamine Sulfate 0.112 mg Rectal Suppository, or for more detailed information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to answer any questions and provide the necessary support for both patients and prescribers to ensure safe and effective treatment.

Hyoscyamine sulfate is an anticholinergic medication that works by blocking the action of acetylcholine, a neurotransmitter that mediates various functions in the body. This action helps to reduce muscle spasms in the gastrointestinal tract and bladder, as well as to decrease the secretions from certain organs. Hyoscyamine sulfate is commonly used to treat a variety of conditions, including irritable bowel syndrome, spastic bladder, peptic ulcer disease, and others that involve hypermotility or hypersecretory states.

When considering the use of hyoscyamine sulfate rectal suppositories, it is important to be aware of potential drug interactions that may affect the efficacy of the medication or increase the risk of adverse effects. Anticholinergic drugs like hyoscyamine can interact with a variety of other medications, including but not limited to antihistamines, antipsychotics, benzodiazepines, MAO inhibitors, tricyclic antidepressants, and other anticholinergics. These interactions can lead to increased anticholinergic effects, such as dry mouth, urinary retention, constipation, confusion, and blurred vision.

Additionally, the absorption of hyoscyamine sulfate may be affected by the concomitant use of antacids or other gastrointestinal medications. These can alter the gastric pH or motility, potentially affecting the release and absorption of the medication from the rectal suppository. It is also important to consider the potential for additive effects when used with other medications that have anticholinergic properties or that can cause drowsiness, such as opioid pain relievers, muscle relaxants, and sleep aids.

Patients with certain medical conditions should use hyoscyamine sulfate with caution, as the anticholinergic effects can exacerbate issues such as glaucoma, obstructive uropathy, obstructive diseases of the gastrointestinal tract, and myasthenia gravis. It is also important to avoid alcohol while using this medication, as it can increase drowsiness and further reduce the motility of the gastrointestinal tract.

It is crucial for patients and prescribers to review all current medications, including over-the-counter drugs and herbal supplements, to identify any potential interactions before starting treatment with hyoscyamine sulfate rectal suppositories. Monitoring for side effects and adjusting the dose accordingly is important to ensure the safe and effective use of this medication. If you have any questions or concerns regarding the use of hyoscyamine sulfate or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

Hyoscyamine sulfate is an anticholinergic medication, which means it works by blocking the action of acetylcholine, a neurotransmitter that mediates various functions in the body. Acetylcholine is involved in transmitting nerve impulses responsible for muscle contractions, including those in the gastrointestinal tract, bladder, and other organs. By inhibiting the action of acetylcholine, hyoscyamine sulfate reduces muscle spasms and the production of bodily secretions such as saliva, sweat, and stomach acid.

When formulated as a 0.112 mg rectal suppository, hyoscyamine sulfate is designed to be inserted into the rectum where it dissolves or melts. The rectal route is particularly effective for delivering medications that act locally or systemically, as the rectal mucosa has a rich blood supply that allows for the rapid absorption of the active ingredient. This bypasses the digestive system, which can be beneficial for patients with gastrointestinal issues or those who cannot take oral medications.

The hyoscyamine sulfate rectal suppository is used to treat various disease states that involve muscle spasms and hypermotility of the gastrointestinal tract. These conditions include irritable bowel syndrome (IBS), colic, diverticulitis, and bladder spasms. It is also used to control the symptoms of Parkinson's disease and to reduce the side effects of certain medications that cause extrapyramidal reactions. Additionally, it can be used preoperatively to reduce salivary, tracheobronchial, and pharyngeal secretions.

By delivering the medication directly to the systemic circulation through the rectal mucosa, the suppository form of hyoscyamine sulfate ensures a more consistent and predictable response, which is particularly important for conditions that require rapid relief from symptoms. The use of a suppository can also be advantageous for patients experiencing nausea and vomiting, as it avoids the potential for the medication to be expelled before it can be absorbed.

It is important for both patients and prescribers to understand that while hyoscyamine sulfate can provide significant relief from symptoms, it may also cause side effects such as dry mouth, blurred vision, dizziness, and urinary retention due to its anticholinergic properties. Patients should be monitored for these effects, and the medication should be used with caution in individuals with certain medical conditions, such as glaucoma, enlarged prostate, or heart problems.

If you have any questions about the use of hyoscyamine sulfate rectal suppositories or would like more information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Hyoscyamine sulfate is primarily known for its anticholinergic properties, which make it beneficial in the treatment of various gastrointestinal disorders, such as irritable bowel syndrome, peptic ulcer disease, and colitis. By inhibiting the action of acetylcholine on smooth muscles, it reduces muscle spasms and the production of stomach acid.

In addition to these uses, hyoscyamine sulfate suppositories may be employed for their antispasmodic effects in managing urologic conditions, such as bladder spasms. They can also provide symptomatic relief from the renal or biliary colic by diminishing smooth muscle contractions in the urinary and biliary tracts, respectively. Furthermore, in the palliative care setting, hyoscyamine sulfate suppositories can be a useful alternative for systemic anticholinergic therapy when oral administration is not feasible or if the patient prefers not to use oral medication.

Another therapeutic application of hyoscyamine sulfate in a rectal suppository form includes its use in the treatment of hyperhidrosis, excessive sweating, due to its anticholinergic activity. In this off-label use, the goal is to reduce the overactivity of sweat glands. Although less common, the suppository can also be used to alleviate the symptoms of Parkinson's disease, such as rigidity and tremors, by reducing the cholinergic activity in the central nervous system.

It is important to note that while the suppository form of hyoscyamine sulfate may offer convenience and relief for certain conditions, the suitability of this delivery method depends on the individual patient's circumstances, and it should only be prescribed after a thorough evaluation by a healthcare professional. Additionally, this medication,like all medications, may cause side effects and may not be appropriate for every patient. As compounding pharmacists, we at Bayview Pharmacy are available to discuss the potential benefits and risks associated with hyoscyamine sulfate suppositories, as well as alternative treatments, with both patients and prescribers. If you have any questions or need guidance on the best use of this medication for a particular patient, please do not hesitate to reach out to us.