The Hydrocortisone 2.5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a compounded medication designed to deliver a combination of anti-inflammatory, analgesic, and anesthetic effects directly to the site of application. Hydrocortisone, a corticosteroid, works by reducing inflammation and suppressing the immune response in the skin. This makes it effective for treating various dermatological conditions, such as eczema, psoriasis, and allergic reactions, where inflammation is a key component of the disease process.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), further enhances the anti-inflammatory action and provides additional analgesic effects, making this gel particularly useful for conditions involving pain and swelling, such as musculoskeletal injuries or arthritis. By inhibiting the enzymes involved in prostaglandin synthesis, ketoprofen helps to alleviate both pain and inflammation at the site of application.

Lidocaine HCl, a local anesthetic, provides immediate relief from pain by blocking the transmission of pain signals along the nerves. This component is especially beneficial for patients experiencing acute pain or for procedures that require numbing of the skin. The inclusion of lidocaine in the formulation allows for a more comfortable application and rapid onset of pain relief.

The gel is formulated to be dispensed through a pump mechanism, which offers several advantages. It ensures that the medication is delivered in a consistent dose, reduces the risk of contamination, and allows for a non-messy application. The semisolid consistency of the gel allows it to be easily spread over the affected area, providing a uniform distribution of the active ingredients. The gel base also facilitates the absorption of the active ingredients into the skin, ensuring that the medication reaches the target tissues effectively.

This combination gel is particularly suited for patients who require a multimodal approach to manage their symptoms, combining the benefits of anti-inflammatory, analgesic, and anesthetic agents in a single formulation. It is important for prescribers to consider the individual patient's condition and medical history when recommending this medication, as the presence of multiple active ingredients may increase the risk of side effects or interactions with other medications.

Patients should be instructed on the proper use of the gel, including the amount to apply, frequency of application, and any specific precautions to observe. They should also be made aware of potential side effects, such as skin irritation or systemic absorption, particularly with prolonged use or application over large areas of the body.

For more detailed information or to address specific concerns regarding this formulation, prescribers and patients are encouraged to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide expert guidance and support to ensure the safe and effective use of this compounded medication.

The Hydrocortisone 2.5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a compounded medication designed for topical application. Hydrocortisone is a corticosteroid that reduces inflammation and can be used to treat a variety of skin conditions such as eczema, psoriasis, and allergic reactions. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that also reduces inflammation and can provide pain relief. Lidocaine is a local anesthetic that can help to numb the skin, providing relief from pain and discomfort. When using this combination gel, it is important to consider potential drug interactions.

Patients should be advised to inform their healthcare provider of all medications they are currently taking, including over-the-counter drugs, vitamins, and herbal supplements. The use of additional topical corticosteroids or NSAIDs should be approached with caution, as there may be an increased risk of systemic absorption leading to additive side effects. Concurrent use of other local anesthetics may increase the risk of systemic toxicity, especially if applied to large areas of the body or used over an extended period.

Systemic absorption of ketoprofen may interact with anticoagulants such as warfarin, increasing the risk of bleeding. Patients on anticoagulant therapy should be closely monitored. Similarly, ketoprofen may interact with other NSAIDs, aspirin, or selective serotonin reuptake inhibitors (SSRIs), enhancing the risk of gastrointestinal ulcers or bleeding. The use of alcohol with this medication may also increase the risk of gastrointestinal side effects.

Hydrocortisone, although less likely to cause systemic effects due to its low concentration in this formulation, may still interact with drugs that induce or inhibit CYP3A4 enzymes, as these can affect the metabolism of corticosteroids. Patients taking medications such as certain antifungals, anticonvulsants, or macrolide antibiotics should be monitored for potential interactions.

Lidocaine, when absorbed systemically, can interact with antiarrhythmic drugs, beta-blockers, and cimetidine, potentially altering its metabolism and increasing the risk of lidocaine toxicity. Caution is advised when using this medication in patients with pre-existing heart conditions or those taking medications that affect cardiac conduction.

It is also important to consider the potential for cross-sensitivity reactions in patients allergic to aspirin or other NSAIDs when using ketoprofen. Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs should not use this medication without consulting their healthcare provider.

Lastly, the application of this gel to broken or damaged skin can increase systemic absorption of the active ingredients, potentially leading to an increased risk of adverse effects. Patients should be instructed to apply the gel only to intact skin and to follow the prescribed dosage and application instructions carefully.

If you have any questions or require further information regarding potential drug interactions with this formulation, please reach out to us at Bayview Pharmacy. We are here to ensure the safe and effective use of this medication for our patients.

The Hydrocortisone 2.5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a compounded medication designed to deliver a combination of active ingredients directly to the site of inflammation, pain, or discomfort. This semisolid formulation is dispensed through a pump mechanism, which ensures easy and precise application, as well as consistent dosing. The gel-like consistency allows for the medication to be spread smoothly over the affected area, providing a localized effect without systemic absorption typical of oral medications.

Hydrocortisone is a corticosteroid that works by reducing inflammation and suppressing the immune response in the skin. It is effective in treating a variety of dermatological conditions, such as eczema, psoriasis, and allergic reactions. By decreasing inflammation, hydrocortisone can alleviate symptoms like redness, itching, and swelling.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). These enzymes are involved in the production of prostaglandins, which are compounds that contribute to inflammation, pain, and fever. By blocking COX enzymes, ketoprofen reduces the levels of prostaglandins, thereby decreasing inflammation and pain in the affected area. This makes it particularly useful for treating musculoskeletal conditions such as arthritis, strains, and sprains.

Lidocaine HCl is a local anesthetic that works by blocking sodium channels in the neuronal cell membrane. This action inhibits the initiation and conduction of nerve impulses, providing temporary relief from pain. Lidocaine is commonly used to numb the skin before procedures or to relieve pain from conditions like post-herpetic neuralgia or other neuropathic pain syndromes.

When combined, these three active ingredients provide a multifaceted approach to treating conditions that involve pain and inflammation. The hydrocortisone addresses the inflammatory component, ketoprofen adds a potent anti-inflammatory and analgesic effect, and lidocaine offers immediate relief from pain by numbing the affected area. This combination can be particularly beneficial for patients who require both anti-inflammatory and analgesic properties in a topical formulation.

This compounded gel is intended for topical use only and should be applied as directed by a healthcare provider. It is important to use this medication only on the areas prescribed and not to cover treated skin with occlusive dressings unless instructed by a healthcare professional. Patients should be advised to wash their hands before and after applying the gel unless the hands are the area being treated.

If you have any questions about this formulation or its appropriateness for a specific condition, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to both patients and prescribers to ensure the safe and effective use of this medication.

While this specific compounding formulation of Hydrocortisone 2.5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is primarily designed for its anti-inflammatory, analgesic, and anesthetic properties, it may have additional uses beyond the targeted treatment for which it was prescribed. It is important to note that all off-label uses should be considered carefully and only pursued under the guidance of a healthcare professional.

Aside from its main indications, this gel may potentially be used to provide symptomatic relief in other conditions involving pain and inflammation. For instance, patients suffering from localized musculoskeletal pain, such as that associated with minor sprains and strains or soft tissue injuries, might find this formulation beneficial due to the combined action of ketoprofen and hydrocortisone. Lidocaine's presence could offer temporary relief from the associated pain by numbing the affected area. Because of the gel's consistency and delivery mechanism, it may be suitable for applying to localized, hard-to-reach areas. Moreover, individuals with certain skin conditions characterized by inflammation and discomfort, not limited to but including dermatitis or psoriasis, might experience temporary relief of symptoms when using this compound.

Additionally, the formulation might be used in patients who are undergoing treatment for complex and multi-faceted pain syndromes where inflammation is a component of the pain cycle. For example, in cases of localized neuropathic pain, where conventional treatments have not provided sufficient relief, this compounded gel may act synergistically to provide comfort due to the anesthetic action of lidocaine alongside the anti-inflammatory effects of ketoprofen and hydrocortisone.

It is recommended that before considering the use of this formulation for conditions other than prescribed, the healthcare provider evaluates the patient's medical history, current medications, and the potential benefit-risk ratio. Each active ingredient within this compounded gel carries its own set of side effects and contraindications that must be taken into account. Therefore, communication with the prescriber or the consulting compounding pharmacist at Bayview Pharmacy is crucial to ensure optimal and safe use of this medication. If you have any questions regarding the potential applications of this formulation or its suitability for specific conditions, please reach out to us for tailored advice and professional guidance.