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Hydrocortisone 1%/Mupirocin 2%/Nystatin 100/000 IU/g Topical Cream

The Hydrocortisone 1%/Mupirocin 2%/Nystatin 100,000 IU/g Topical Cream is a multi-functional semisolid preparation, specifically formulated to address a variety of dermatological conditions. This cream is dispensed in a user-friendly pump mechanism, ensuring a hygienic, convenient, and controlled application. The combination of hydrocortisone, an anti-inflammatory corticosteroid, with mupirocin, an antibiotic, and nystatin, an antifungal agent, makes this cream particularly effective for the treatment of skin infections that are complicated by inflammation and/or a fungal component. It is commonly prescribed for conditions such as eczema with secondary bacterial infections, cutaneous candidiasis, and intertrigo where mixed infection with bacteria and Candida may be present. The pump dispenser helps to apply the cream directly to the affected areas, minimizing waste and contamination.

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Topical Cream
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Formula Information

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The Hydrocortisone 1%/Mupirocin 2%/Nystatin 100,000 IU/g Topical Cream is a specially compounded medication designed to provide a multifaceted approach to treating various skin conditions. This cream combines the anti-inflammatory properties of hydrocortisone, the antibacterial action of mupirocin, and the antifungal benefits of nystatin, making it an effective treatment for skin infections that have multiple causative factors. Hydrocortisone, a corticosteroid, works by reducing redness, itching, and swelling. Mupirocin is an antibiotic that halts the growth of certain bacteria on the skin, while nystatin is an antifungal that stops the growth of certain fungi.

The cream is formulated as a semisolid preparation and is dispensed in a pump mechanism container. This delivery system is designed for ease of use, allowing for a clean, convenient, and controlled application. The pump helps to ensure that the correct dose is administered each time, minimizing waste and reducing the risk of contamination that can occur with jar packaging. This is particularly beneficial for patients who require a consistent and hygienic application to affected areas of the skin.

This combination cream is indicated for the treatment of skin conditions where there is a mixed infection involving inflammation, susceptible bacteria, and fungi. Such conditions may include but are not limited to, secondary bacterial infections of eczema or psoriasis, cutaneous candidiasis, and certain types of dermatitis. By addressing all three components of these complex skin infections, this cream helps to alleviate symptoms and promote healing.

Patients should be advised to apply the cream to the affected area as directed by their healthcare provider, usually two to three times a day, depending on the severity of the condition. It is important to use the medication for the full prescribed treatment period, even if symptoms improve before the medication is finished, to prevent the recurrence of infection. Side effects may include local irritation, burning, itching, or dryness at the application site. More serious side effects, such as signs of systemic absorption or allergic reactions, should be reported to a healthcare provider immediately.

Prescribers should consider the patient's medical history, including any known allergies to the active ingredients or excipients, before recommending this formulation. Additionally, the use of this cream should be monitored, especially in the case of long-term treatment, to avoid potential side effects such as skin atrophy from prolonged corticosteroid use or antibiotic resistance from mupirocin.

For further information or questions regarding this compounded medication, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is available to provide additional details and support to ensure the safe and effective use of this topical cream for both patients and prescribers.

Drug Interactions

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The topical cream formulation containing Hydrocortisone 1%, Mupirocin 2%, and Nystatin 100,000 IU/g is designed to treat a variety of skin conditions that may involve inflammation, bacterial infections, and fungal infections. Hydrocortisone is a corticosteroid that reduces inflammation and swelling. Mupirocin is an antibiotic that prevents bacterial growth on the skin, and Nystatin is an antifungal medication that stops the growth of fungi.

When using this combination topical cream, it is important to consider potential drug interactions. Although systemic absorption of topical preparations is generally low, interactions can still occur, especially with prolonged use, application over large surface areas, or use under occlusive dressings. Hydrocortisone, being a corticosteroid, may interact with other topical medications that affect the hypothalamic-pituitary-adrenal (HPA) axis, potentially leading to systemic side effects such as Cushing's syndrome or adrenal suppression if absorbed in significant amounts. Patients should avoid using other topical steroids concurrently unless directed by a healthcare provider.

Mupirocin has minimal interactions with systemic medications due to its limited absorption through the skin. However, it is important to avoid combining it with other topical preparations that may have similar antibacterial properties to prevent excessive bacterial killing that could disrupt the natural skin flora balance. Concurrent use of other topical antibiotics should be approached with caution and under the guidance of a healthcare provider.

Nystatin is not absorbed through intact skin or mucous membranes, so systemic interactions are unlikely. However, it is still important to avoid using other topical antifungal agents in the same area without medical advice, as this may increase the risk of skin irritation or alter the effectiveness of the medications.

Patients should be advised to inform their healthcare providers of all the medications they are currently using, including over-the-counter drugs, prescriptions, and herbal supplements, to avoid potential interactions. Additionally, patients should be aware of signs of local skin reactions, such as increased irritation, burning, or allergic contact dermatitis, which may require medical attention.

It is also important to note that while the risk of systemic absorption is low, the use of this cream on broken or damaged skin can increase the absorption of the active ingredients, potentially leading to increased risk of systemic side effects. Therefore, patients should use this medication only as directed and report any adverse effects to their healthcare provider promptly.

For any questions or concerns regarding the use of this topical cream or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the necessary information and support to ensure safe and effective treatment.

How Does it Work

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The Hydrocortisone 1%/Mupirocin 2%/Nystatin 100,000 IU/g Topical Cream is a specially compounded medication that combines the therapeutic effects of three active ingredients, each targeting different aspects of skin conditions. This cream is formulated to provide a comprehensive treatment for a variety of dermatological issues, including inflammatory skin disorders, bacterial skin infections, and fungal skin infections.

Hydrocortisone, the first active ingredient, is a corticosteroid that works by reducing inflammation, redness, and swelling. It achieves this by inhibiting the release of substances in the body that cause inflammation. This makes it effective in treating conditions such as eczema, psoriasis, and allergic reactions. At a concentration of 1%, hydrocortisone is potent enough to provide relief from these symptoms without causing significant side effects that are associated with higher strengths of corticosteroids.

Mupirocin, the second active ingredient, is an antibiotic that stops the growth of certain bacteria on the skin. At a concentration of 2%, it is particularly effective against Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Streptococcus pyogenes. By eradicating bacteria at the site of infection, mupirocin helps to clear up bacterial skin infections such as impetigo, folliculitis, and infected wounds or ulcers.

Nystatin, the third component, is an antifungal medication that binds to sterols in the fungal cell membrane, altering the permeability and resulting in leakage of cellular contents. With a potency of 100,000 IU/g, nystatin effectively treats cutaneous candidiasis and other skin fungal infections, ensuring the eradication of the yeast and preventing its growth on the skin.

The cream is dispensed in a pump mechanism, which allows for a hygienic, convenient, and controlled application. This delivery system ensures that the correct dose is administered each time, minimizing waste and reducing the risk of contamination. The semisolid preparation is designed to be easily spreadable and absorbable, facilitating the delivery of the active ingredients to the affected area of the skin for localized treatment.

This combination cream is particularly useful for patients who are suffering from complex skin conditions that may involve a combination of inflammatory, bacterial, and fungal elements. By addressing all these components simultaneously, the cream can provide a more comprehensive treatment approach compared to monotherapy with a single agent.

For patients and prescribers considering this formulation, it is important to note that the cream should be used as directed, typically applied to the affected area two to three times a day or as prescribed by a healthcare professional. It is also crucial to use this medication for the full prescribed length of time, even if symptoms improve before the infection is completely cleared. As with any medication, there may be potential side effects, and it is important to monitor for any adverse reactions.

If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Other Uses

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The hydrocortisone, mupirocin, and nystatin combination topical cream is primarily formulated for the treatment of certain skin conditions where inflammation, bacterial, and yeast infections are present. While not explicitly indicated, this cream may also be utilized for other related dermatological issues where its components can provide therapeutic effects. These might include mild dermatoses accompanied by secondary infections, where a broad approach to diminish inflammation and eradicate both bacterial and fungal organisms is beneficial.

Hydrocortisone, being a mild corticosteroid, helps reduce inflammation and alleviate itching and redness associated with various skin conditions such as eczema, dermatitis, allergies, and rashes. Mupirocin, an antibiotic, is effective against a range of Gram-positive bacteria, including certain Staphylococcus and Streptococcus species, and is often employed in treating impetigo as well as secondary infections of skin wounds. Nystatin, an antifungal, is utilized for its capacity to combat cutaneous yeast infections such as those caused by Candida species. The potential use of this compound cream could extend to intertrigo, diaper rash accompanied by yeast or bacterial superinfections, or other skin disorders with complicated infectious etiologies.

Moreover, this cream may be used off-label to manage certain other cutaneous conditions that might benefit from its multi-action properties, provided that the benefit outweighs the risk and it is prescribed by a healthcare professional. However, care should be taken not to use this medication inappropriately or without proper diagnosis, as the misuse of antibiotics and steroids can lead to resistance and other complications. Additionally, nystatin should not be used for infections caused by bacteria or viruses, as it is specifically an antifungal agent.

The pump dispenser of this topical cream ensures controlled and hygienic application, minimizing the potential for contamination and overuse. Patients must follow the prescriber's directions regarding dosage and length of treatment, as prolonged use, especially of corticosteroids, can lead to adverse effects such as skin thinning and systemic absorption, among others. It is also recommended that this cream should not be applied to open wounds or to areas of skin affected by viral infections such as herpes or varicella.

It is paramount to consult with a healthcare professional before using this formulation to establish its suitability for individual cases, particularly for off-label use. For example, those with skin conditions not primarily caused by inflammation, bacterial, or fungal infections may require different treatment modalities. If you have any questions or require further clarification on the potential applications of this compound cream, please do not hesitate to reach out to us at Bayview Pharmacy. We are here to provide the necessary guidance and support for both patients and prescribers in the optimal use of this medication.

Frequently Asked Questions

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What is Hydrocortisone 1%/Mupirocin 2%/Nystatin 100,000 IU/g Topical Cream used for?

This compounded formulation is used to treat various skin conditions that may involve inflammation, bacterial infections, and fungal infections. Hydrocortisone reduces swelling and itching, Mupirocin treats bacterial infections, and Nystatin is an antifungal medication effective against certain types of fungal infections.

How should this topical cream be applied?

Clean and dry the affected area before applying a thin layer of the cream. Use the pump mechanism to dispense the cream and spread it gently over the skin. It is typically applied two to three times a day or as directed by your healthcare provider. Do not cover the treated area with a bandage unless instructed by your doctor.

Can this cream be used for any type of skin infection?

Not all skin infections will be responsive to this cream. It is formulated to treat certain bacterial and fungal infections, as well as inflammatory skin conditions. It should be used only if prescribed by your healthcare provider, who will diagnose the type of infection and decide whether this treatment is appropriate.

Are there any side effects associated with this cream?

As with any medication, there can be side effects. Common side effects might include mild burning, itching, or irritation at the application site. If you experience severe side effects, such as intense redness, blistering, or signs of a systemic allergic reaction, seek medical attention immediately.

How does the pump mechanism benefit the application of the cream?

The pump mechanism provides a controlled and hygienic way to dispense the cream, reducing the risk of contamination and ensuring that a consistent quantity of medication is applied with each use. It also makes the application process more convenient, especially when treating hard-to-reach areas.

What should I do if I miss a dose?

If you miss a dose, apply the cream as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for a missed dose.

Can I use other skin products on top of this cream?

It's best to consult your healthcare provider before applying other skin products on top of this cream. Other products may affect how this medication works or increase the risk of side effects.

Is it safe to use this compounded cream during pregnancy or while breastfeeding?

You should discuss with your healthcare provider before using this medication if you are pregnant or breastfeeding to ensure it is safe for you and your baby. Your provider will weigh the risks and benefits before making a recommendation.

How should this cream be stored?

Store the cream at room temperature, away from heat and direct sunlight. Keep the container closed when not in use. Make sure to keep it out of reach of children and pets.

Can the formulation of Hydrocortisone, Mupirocin, and Nystatin cause skin discoloration?

Skin discoloration is not commonly reported with these medications, but individual reactions can vary. If you notice changes in skin color, contact your healthcare provider for advice.

How long does it take for the topical cream to work?

The time it takes for the cream to work can vary depending on the specific condition being treated and the severity of the infection or inflammation. Some patients may notice improvements within a few days, while others may require a longer period of consistent use. Follow your healthcare provider’s instructions and report any concerns regarding efficacy.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.